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Laurie Archbald-Pannone, MD, MPH

Laurie Archbald-Pannone, MD, MPH

Professor, Internal Medicine

Email
[email protected]

Bio & Overview

My research focus is in three main areas. The first is the field of geriatric infections, in particular, the impact and severity of Clostridioides difficile (C. difficile) infection in elderly and hospitalized patients, as well as non-antibiotic treatment to control disease and prevent relapse. As PI (NIH/NIAID 1K23AI074681), I successfully completed a cohort study of 362 hospitalized patients with C. difficile infection. From this study, we developed a predictive model for mortality following infection. We also highlighted and continue to investigate the association of poor outcome, delirium and increased intestinal inflammation. In addition, as PI with funding from TechLab, Inc., we followed a cohort of patients with recurrent C. difficile infection treated with either fecal microbiota transplant or traditional antibiotics to determine the impact of treatment on intestinal microbiota, inflammation, and quality of life. Currently, I serve as Co-investigator on a Phase 2, randomized clinical trial evaluating the impact of alanyl-glutamate supplementation on clinical outcomes in hospitalized patients with initial episode of CDI. I also serve as co-investigator on a project to evaluate the microbiome changes seen in patients with dementia. The second area of research is innovative curriculum for geriatric education in Undergraduate Medicine Education (UME) and Graduate Medical Education (GME). With an aging population, it is critical that we ensure the next generation of medical professions has a deep understanding of the care of the elderly, especially in the hospitalized setting. As PI, I created and evaluated a curriculum weekly inter-disciplinary teaching rounds with GME Internal Medicine residents, nurses, physical therapist, and occupational therapist.to educate internal medicine housestaff in the hospital-based management of the most common geriatric syndromes and care transitions (IRB-SBS # 2015028000). The third and newest area of research focus is telemedicine and collaborative care for older adults. Specifically, starting in March 2020, I led a team that focused on telemedicine services for residents in post-acute and long-term care facilities in response the COIVD-19 pandemic. We developed the UVA Geriatric Engagement and Resource Integration for Post-acute and Long-term care facilities (GERI-PaL) team with COVID-19 prevention and response programs. Since March 2020, we have successfully created, implemented, and published the creation of our model and initial outcomes. We implemented telemedicine consultation subspecialty services in 13 of our local PA/LTC facilities, as well as actively responded to 9 COVID-19 outbreaks and shown decreased mortality and hospitalization rates among these vulnerable patients with three peer-reviewed publications (https://doi.org/10.1089/tmj.2021.0108; http://doi.org/10.1089/tmj.2020.0236; https://doi.org/10.1016/j.jamda.2020.05.044). Our program was recognized with the Health Quality Innovator of the Year, 2nd place, HQI’s CMS Quality Improvement Organization (QIO) for Virginia, GERI-PaL initiative, in November 2020 as well as featured in numerous regional and national media sites. In 2021, in collaboration with West Health Institute and Mid-Atlantic Telehealth Resource Center (MATRC), we built upon this experience and convened the Collaborative for Telehealth for Aging, bringing together approximately 50 content experts from over 30 organizations across the country to determine the principles and guideline for age-inclusive telehealth, as well as resources for implementation available through the Center of Excellence for Telehealth and Aging (CE4TA) online portal (https://ce4ta.matrc.org/). Dr. Archbald-Pannone serves as PI and national Medical Director for this initiative. In 2022, with Dr. Archbald-Pannone as PI and medical director, we received funding from Virginia Department of Health and Centers for Disease Control and Prevention to lead the Virginia IMPACT (Infection Mitigation, Prevention and Control through Technology) initiative, as part of the Virginia Long-term Care Infrastructure Pilot Projects Grant. Virginia IMPACT provides education on infection control in congregate care communities and optimization of telehealth use in these environments. Through community outreach, we created a network of over 130 congregate care facilities, 105 that specifically serve older adults, throughout Virginia. We convene monthly meetings of this community of practice of approximate 30 facility based medical practitioners and administrators from around Commonwealth of Virginia, including 33 of 35 health districts. Virginia IMPACT team consults directly with congregate care facilities to improve their infection control preparedness through optimization of their telemedicine program.

Academic Information

Department
Internal Medicine
Academic Title
Associate Professor

Primary Education

  • MD, Medicine, Vanderbilt University, 2002
  • Residency, Internal Medicine, University of Virginia, 2005
  • MPH, Public Health, University of Virginia, 2007
  • Clinical Fellowship, Geriatric Medicine, University of Virginia, 2008
  • Research Fellowhip, Infectious Diseases, University of Virginia, 2008

Other Appointments

  • Postdoctoral Researcher, Medicine- Infectious Diseases and International Health

Research Interests

Impact of infection on function and cognition, infection control in long-term care facilities and age-inclusive telehealth

Selected Publications

 

  1. Flickinger, T, Mathews, M., Gordon, D., Nappi, A., Ryall, A., Patterson, M., Wibberly, K., Collins, S., Pannone, A., Archbald-Pannone, L.* “Four I Framework for Telehealth Optimization in Congregate Care Communities.” Telemed J E Health. 2025 Jun;31(6):799-805. doi: 10.1089/tmj.2024.0218. Epub 2025 Feb 7. PMID: 39918874.
  2. Mathews, M., Flickinger, T., Nappi, A., Gordon, D., Ryall, A., Wibberly, K., Collins, S.,, Archbald-Pannone, L. “Anticipated and Experienced Barriers and Benefits to Telehealth in Congregate Care Facilities Across Virginia” JAMDA, 2024 Jun;25(6):104974. doi: 10.1016/j.jamda.2024.02.012. Epub 2024 Apr 1. PMID: 38575114 DOI: 10.1016/j.jamda.2024.02.012 https://www.jamda.com/article/S1525-8610(24)00165-8/fulltext
  3. Archbald-Pannone L*, Sanjay, K, Wardlow, L. “Age-Inclusive Telehealth: What is it? How can we achieve it?” J Gerontol Geriatr Med 2023, 9: 172. DOI: 10.24966/GGM-8662/100172
  4. Archbald-Pannone L* (2023) “Women in Anti-infective Therapy: How do we best manage Clostridioides difficle infections in the elderly?” Expert Review of Anti-infective Therapy, 21:5, 499-501, DOI: 10.1080/14787210.2023.2158814
  5. Jenior ML, Leslie JL, Kolling GL, Archbald-Pannone L, Powers DA, Petri WA, Papin JA. Systems-ecology designed bacterial consortium protects from severe Clostridioides difficile infection. bioRxiv. 2023 Aug 10;. doi: 10.1101/2023.08.08.552483. PubMed PMID: 37609255; PubMed Central PMCID: PMC10441344.
  6. Warren CA, Shin JH, Bansal EN, et al Archbald-Pannone, L. “Alanyl-glutamine supplementation for Clostridioides difficile infection treatment (ACT): a double-blind randomised controlled trial study protocol.” BMJ Open 2023;13:e075721. doi: 10.1136/bmjopen-2023-075721. PMID: 3747418. PMCID: PMC10357635. DOI: 10.1136/bmjopen-2023-075721.
  7. Wardlow L, Leff B, Biese K, Roberts, C, Archbald-Pannone L, et al. “Development of Telehealth Principles and Guidelines for Older Adults: A Modified Delphi Approach.” Journal of American Geriatrics Society, Published online 19 December 2022. J Am Geriatr Soc. 2022;1‐12. doi:10.1111/jgs.18123. Volume71, Issue2, February 2023, Pages 371-382. https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/jgs.18123. PMID: 36534900
  8. Tillotson G, Archbald-Pannone L, Johnson S, Ng S, Ando M, Harvey A, Bancke L, Feuerstadt P. “Microbiota-Based Live Biotherapeutic RBX2660 for the Reduction of Recurrent Clostridioides difficile Infection in Older Adults With Underlying Comorbidities.” Open Forum Infect Dis. 2022 Dec 30;10(1):ofac703. doi: 10.1093/ofid/ofac703. PMID: 36686631; PMCID: PMC9846189.
  9. Wardlow, L, Roberts, Carly, Archbald-Pannone, L*. “Perceptions and Uses of telehealth in the care of older adults.” Telemedicine and e-Health, Published online 8 December 2022. https://www.liebertpub.com/doi/10.1089/tmj.2022.0378
  10. Prokosch, L, Little J, Childress, M, Kon R, Archbald-Pannone L.* “Intergenerational Connection in the COVID-19 Pandemic.” Academic Medicine: August 2022 - Volume 97 - Issue 8 - p 1097. doi: 10.1097/ACM.0000000000004729. PMID: 35917540 PMCID: PMC9311276
  11. L. Archbald-Pannone*, D. Harris, R. Steele, J. Kaur, K. Albero, J. Mutter, D. Cattell-Gordon, K. Rheuban. “Virtual Daily Rounding for COVID-19 Facility Outbreaks: A standardized, telehealth-centered approach may reduce hospital transfers and mortality.” Telemedicine and e-Health, August: 27(8): August 2021. https://doi.org/10.1089/tmj.2021.0108. Cited 6 times, IF = 3.536, Rank 36 of 108 in Health Care Sciences & Services journals. PMID: 34143671. Awarded 2021 Rosalind Franklin Society (RFS) Awards in Science
  12. Harris D*, Archbald-Pannone L, Kaur J, Cattell-Gordon D, Rheuban K, Ombres R, Albero K, Steele R, Bell T, Mutter J, “Rapid Telehealth-Centered Response to COVID-19 Outbreaks in Post-acute and Long-Term Care Facilities.” Telemedicine and e-Health, January; 27(1): Jan 2021.102-106. http://doi.org/10.1089/tmj.2020.0236.
  13. L. Archbald-Pannone*, D. Harris, K. Albero, R. Steele, A. Pannone, J. Mutter. “COVID-19 collaborative model for an academic hospital and long-term care facilities” J Am Med Dir Assoc. 2020, Online publication 25May 2020, Volume 21, Issue 7, Pages 939-942. https://doi.org/10.1016/j.jamda.2020.05.044
  14. Frentzel E*, Jump R, Archbald-Pannone L, Nace D, Schweon S, Gaur S, Naqvi F, Pandya N, Mercer W; Infection Advisory Subcommittee of AMDA, The Society for Post-Acute and Long-Term Care Medicine. “Recommendations for Mandatory Influenza Vaccinations for Health Care Personnel From AMDA's Infection Advisory Subcommittee. J Am Med Dir Assoc. 2020 Jan; 21(1):25-28.e2. doi: 10.1016/j.jamda.2019.11.008. PMID: 31888863 PMCID: PMC6996022.
  15. Jae Hyun Shin *, Ashley Chaplin, R. Ann Hays, Sheila Vance, Glynis Kolling, Richard Guerrant, Laurie Archbald-Pannone, Cirle Warren. “Outcomes of a Multi-Disciplinary Clinic in Evaluating Recurrent Clostridioides difficile Infection Patients for Fecal Microbiota Transplant: A Retrospective Cohort Analysis.” Journal of Clinical Medicine, J Clin Med. 2019 Jul 16; 8(7). pii: E1036. doi: 10.3390/jcm8071036. PMID: 31315214.
  16. Barker AK, Duster M, Valentine S, Hess T, Archbald-Pannone L, Guerrant R, Safdar N.* “A randomized controlled trial of probiotics for Clostridium difficile infection in adults (PICO).” J Antimicrob Chemother. 2017 Nov 1; 72(11):3177-3180. doi: 10.1093/jac/dkx254. PMID: 28961980.
  17. David A. Nace, MD, MPH, CMD*, Laurie R. Archbald-Pannone, MD, MPH, Muhammad S. Ashraf, MBBS, Paul J. Drinka, MD, Elizabeth Frentzel, MPH, Swati Gaur, MD, MBA, CMD, Dheeraj Mahajan, MD, CMD, David R. Mehr, MD, MS, William C. Mercer, MD, CMD, Philip D. Sloane, MD, MPH, Robin L.P. Jump, MD, PhD, on behalf of the Infection Advisory Committee for AMDA—The Society of Post-Acute and Long-Term Care Medicine. “Special Article: Pneumococcal Vaccination Guidance for Post-Acute and Long-Term Care Settings: Recommendations From AMDA's Infection Advisory Committee.” Journal of the American Medical Directors Association 2017; 17(2):99-104. doi: 10.1016/j.jamda.2016.11.010. PMID: 28126142.
  18. Barker A, Duster M, Valentine S, Archbald-Pannone L, Guerrant R, Safdar N*. “Probiotics for Clostridium difficile infection in adults (PICO): Study protocol for a double-blind, randomized controlled trial.” Contemp Clin Trials. 2015; 44:26-32.
  19. Archbald-Pannone LR*, McMurry TL, Guerrant RL, Warren CA. “Delirium and other clinical factors with Clostridium difficile infection that predict mortality in hospitalized patients.” American Journal of Infection Control. 2015; 43(7):690-3. PMID: 25920706 PMCID: PMC4490980 DOI: 10.1016/j.ajic.2015.03.017. This article is featured in the “The Hospital Elder Life Program (HELP): Delirium Bibliography.” HELP is a comprehensive, evidence-based, patient-care program that provides optimal care for older persons in the hospital. Dr. Sharon K. Inouye and her colleagues at the Yale University School of Medicine originally designed HELP to prevent delirium among hospitalized older persons.
  20. Archbald-Pannone, LR*, Boone, JH, Carman, RJ, Lyerly, DM, Guerrant, RL. “Clostridium difficile ribotype 027 is most prevalent among inpatients admitted from long-term care facilities.” Journal of Hospital Infection. 2014;88:218-221. doi: 10.1016/j.jhin.2014.06.016. Epub 2014 Jul 30. PMID: 25228227.
  21. Boone JH*, Archbald-Pannone LR, Wickham KN, Carman RJ, Guerrant RL, Franck CT, Lyerly DM. “Ribotype 027 Clostridium difficile infections with measurable stool toxin have increased lactoferrin and are associated with a higher mortality.” Eur J Clin Microbiol Infect Dis. 2014; 33(6):1045-1051. PMID: 24449345.
  22. Archbald-Pannone, L*. “Survey of C. difficile-specific Infection Control Policies in Local Long-term Care Facilities.” International Journal of Clinical Medicine, Diarrhea and Diarrhea Associated Disease Special Issue (invited) 2014; 5(7):414-419. PMID: 24932422 Research has been featured in Annals of Long-term Care (ALTC) Quick Guide Series, “Quick Guide: Clostridium difficile Infection Control.” Annals of Long-term Care, 2014; 22(11).
  23. Archbald-Pannone, L*. “Quantitative fecal lactoferrin as a biomarker for severe C. difficile infection in hospitalized patients.” J. Geriatrics Palliative Care 2014; 2(1):3. PMID: 25401164
  24. Archbald-Pannone, L*. Sevilleja, J., Guerrant, R. “Diarrhea, Clostridium difficile, and Intestinal Inflammation in Residents of a Long-Term Care Facility.” Journal of the American Medical Directors Association 2010; 11(4):263-267. PMID: 20439046
  25. Archbald-Pannone, L*. Alcantara-Warren, C., Lyman, J., Guerrant, R. “Increased Incidence of Clostridium difficile Associated Diarrhea and Fluoroquinolone Use at the University of Virginia Health System.” University of Virginia Journal of Medicine 2009; 6:45-48.
  26. Pawlowski SW*, Archbald-Pannone L, Carman RJ, Alcantara-Warren C, Lyerly D, Genheimer CW, Gerding DN, Guerrant, RL. “Elevated levels of intestinal inflammation in Clostridium difficile infection associated with fluoroquinolone-resistant C. difficile.” Journal of Hospital Infection 2009; 73(2):185-7. doi: 10.1016/j.jhin.2009.05.013. PMID: 19709778.
  27. Amidou SA*, Obi C, Franasiak J, Archbald-Pannone L, Bessong P, Alcantara-Warren C, Guerrant R. “PCR detection of Clostridium difficile triose phosphate isomerase (tpi), toxin A (tcdA), toxin B (tcdB), binary toxin (cdtA, cdtB), and tcdC genes in Vhembe District, South Africa.”  Am J Trop Med Hyg 2008; 78(4):577-85. PMID: 18385352.
  28. Books and/or Chapters

2020      Clostridium difficile Infection in Long-Term Care Facilities, textbook. “C. difficile diagnostics in Long-term Care facilities” by Rishita Bollam, Nisa Desai, and Laurie Archbald-Pannone. Chapter 5, pages 45-51. Springer Publishing, ISBN: 978-3-03029771-8. Copyright 2020.

2019      Essential Orthopedics textbook, 2nd Edition, Section 1, Chapter 5: “Special Populations: Geriatrics by Laurie Archbald-Pannone”. Saunders Elsevier Publishing, ISBN: 978-0-323-56894-4. Copyright 2020.