Molly A. Hughes
Professor, Medicine- Infectious Diseases and International Health
MR-6, Room 1525
Charlottesville, VA 22908
Bio & Overview
Academic Information
- Department
- Medicine- Infectious Diseases and International Health
- Academic Title
- Associate Professor
Primary Education
- BS, Chemistry, summa cum laude, Bucknell University, 1986
- MD/PhD, Pharmacology, Vanderbilt University, 1996
Other Appointments
- Associate Professor, Microbiology, Immunology, and Cancer Biology
- Assistant Professor, MII
Other Affiliations
- BIMS
Research Interests
Research Disciplines
- Microbiology
Research Opportunities
- Infectious Diseases
- Microbiology
PhD Programs
- Microbiology
Selected Publications
2023
Cui, Z., Crawford, M. A., Rumble, B. A., Krogh, M. M., Hughes, M. A., & Letteri, R. A. (2023). Antimicrobial Peptide-Poly(ethylene glycol) Conjugates: Connecting Molecular Architecture, Solution Properties, and Functional Performance. ACS POLYMERS AU, 4(1), 45-55. doi:10.1021/acspolymersau.3c00026
Crawford, M. A., Lascols, C., Lomonaco, S., Timme, R. E., Fisher, D. J., Anderson, K., . . . Hughes, M. A. (2023). Enterobacterales draft genome sequences: 15 historical (1998-2004) and 30 contemporary (2015-2016) clinical isolates from Pakistan. MICROBIOLOGY RESOURCE ANNOUNCEMENTS. doi:10.1128/MRA.00163-23
Lascols, C., Cherney, B., Conley, A. B., Rishishwar, L., Crawford, M. A., Morse, S. A., . . . Sue, D. (2023). Investigation of multidrug-resistant plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates from Pakistan. FRONTIERS IN MICROBIOLOGY, 14. doi:10.3389/fmicb.2023.1192097
2022
Crawford, M. A., Ward, A. E., Gray, V., Bailer, P., Fisher, D. J., Kubicka, E., . . . Hughes, M. A. (2022). Disparate Regions of the Human Chemokine CXCL10 Exhibit Broad-Spectrum Antimicrobial Activity against Biodefense and Antibiotic-Resistant Bacterial Pathogens. ACS INFECTIOUS DISEASES. doi:10.1021/acsinfecdis.2c00456
2021
Dunphy, L. J., Kolling, G. L., Jenior, M. L., Carroll, J., Attai, A. E., Farnoud, F., . . . Papin, J. A. (2021). Multidimensional Clinical Surveillance of Pseudomonas aeruginosa Reveals Complex Relationships between Isolate Source, Morphology, and Antimicrobial Resistance. MSPHERE, 6(4). doi:10.1128/mSphere.00393-21
Cui, Z., Luo, Q., Bannon, M. S., Gray, V. P., Bloom, T. G., Clore, M. F., . . . Letteri, R. A. (2021). Molecular engineering of antimicrobial peptide (AMP)-polymer conjugates. BIOMATERIALS SCIENCE, 9(15), 5069-5091. doi:10.1039/d1bm00423a
Callahan, V., Hawks, S., Crawford, M. A., Lehman, C. W., Morrison, H. A., Ivester, H. M., . . . Kehn-Hall, K. (2021). The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent Manner. VIRUSES-BASEL, 13(6). doi:10.3390/v13061062
2020
Lomonaco, S., Crawford, M. A., Lascols, C., Fisher, D. J., Anderson, K., Hodge, D. R., . . . Sharma, S. K. (2020). Draft Genome Sequences of Two Extensively Drug-Resistant Strains of Acinetobacter baumannii Isolated from Clinical Samples in Pakistan. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 9(20). doi:10.1128/MRA.00026-20
2019
Lomonaco, S., Lascols, C., Crawford, M. A., Anderson, K., Hodge, D. R., Fisher, D. J., . . . Sharma, S. K. (2019). Draft Genome Sequences of Antimicrobial-Resistant Shigella Clinical Isolates from Pakistan. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 8(30). doi:10.1128/MRA.00500-19
Iqbal, N. T., Syed, S., Kabir, F., Jamil, Z., Akhund, T., Qureshi, S., . . . Ali, A. (2019). Pathobiome driven gut inflammation in Pakistani children with Environmental Enteric Dysfunction. PLOS ONE, 14(8). doi:10.1371/journal.pone.0221095
2018
Crawford, M. A., Margulieux, K. R., Singh, A., Nakamoto, R. K., & Hughes, M. A. (2019). Mechanistic insights and therapeutic opportunities of antimicrobial chemokines. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 88, 119-128. doi:10.1016/j.semcdb.2018.02.003
Iqbal, N. T., Sadiq, K., Syed, S., Akhund, T., Umrani, F., Ahmed, S., . . . Ali, S. A. (2018). Promising Biomarkers of Environmental Enteric Dysfunction: A Prospective Cohort study in Pakistani Children. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-21319-8
Dunbar, J., Pillai, S., Wunschel, D., Dickens, M., Morse, S. A., Franz, D., . . . Hodge, D. (2018). Perspective on Improving Environmental Monitoring of Biothreats. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 6. doi:10.3389/fbioe.2018.00147
Lomonaco, S., Crawford, M. A., Lascols, C., Timme, R. E., Anderson, K., Hodge, D. R., . . . Sharma, S. K. (2018). Resistome of carbapenem-and colistin-resistant Klebsiella pneumoniae clinical isolates. PLOS ONE, 13(6). doi:10.1371/journal.pone.0198526
2017
Crawford, M. A., Fisher, D. J., Leung, L. M., Lomonaco, S., Lascols, C., Cannatelli, A., . . . Hughes, M. A. (2017). CXC Chemokines Exhibit Bactericidal Activity against Multidrug-Resistant Gram-Negative Pathogens. MBIO, 8(6). doi:10.1128/mBio.01549-17
Ali, A., Zaman, U., Mahmud, S., Zahid, G. -E. -S., Kazi, M., Petri, W. A., . . . Hughes, M. A. (2017). Impact of maternal respiratory infections on low birth weight - a community based longitudinal study in an urban setting in Pakistan. BMC PREGNANCY AND CHILDBIRTH, 17. doi:10.1186/s12884-017-1275-y
Tucker, J. D., Hughes, M. A., Durvasula, R. V., Vinetz, J. M., McGovern, V. P., Schultz, R., . . . Taylor, T. E. (2017). Measuring Success in Global Health Training: Data From 14 Years of a Postdoctoral Fellowship in Infectious Diseases and Tropical Medicine. CLINICAL INFECTIOUS DISEASES, 64(12), 1768-1772. doi:10.1093/cid/cix242
Margulieux, K. R., Liebov, B. K., Tirumala, V. S. K. K. S., Singh, A., Bushweller, J. H., Nakamoto, R. K., & Hughes, M. A. (2017). Bacillus anthracis Peptidoglycan Integrity Is Disrupted by the Chemokine CXCL10 through the FtsE/X Complex. FRONTIERS IN MICROBIOLOGY, 8. doi:10.3389/fmicb.2017.00740
2016
Crawford, M. A., Timme, R., Lomonaco, S., Lascols, C., Fisher, D. J., Sharma, S. K., . . . Hughes, M. A. (2016). Genome Sequences of Multidrug-Resistant, Colistin-Susceptible and-Resistant Klebsiella pneumoniae Clinical Isolates from Pakistan. GENOME ANNOUNCEMENTS, 4(6). doi:10.1128/genomeA.01419-16
Margulieux, K. R., Fox, J. W., Nakamoto, R. K., & Hughes, M. A. (2016). CXCL10 Acts as a Bifunctional Antimicrobial Molecule against Bacillus anthracis. MBIO, 7(3). doi:10.1128/mBio.00334-16
Ali, A., Akhund, T., Warraich, G. J., Aziz, F., Rahman, N., Umrani, F. A., . . . Hughes, M. A. (2016). Respiratory Viruses Associated With Severe Pneumonia in Children Under 2 Years Old in a Rural Community in Pakistan. JOURNAL OF MEDICAL VIROLOGY, 88(11), 1882-1890. doi:10.1002/jmv.24557
Shakoor, S., Shafaq, H., Hasan, R., Qureshi, S. M., Dojki, M., Hughes, M. A., . . . Khan, E. (2016). BARRIERS TO IMPLEMENTATION OF OPTIMAL LABORATORY BIOSAFETY PRACTICES IN PAKISTAN. HEALTH SECURITY, 14(4), 214-219. doi:10.1089/hs.2016.0031
Mal, P. B., Farooqi, J., Irfan, S., Hughes, M. A., & Khan, E. (2016). Reduced susceptibility to chlorhexidine disinfectant among New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae and other multidrug-resistant organisms: Report from a tertiary care hospital in Karachi, Pakistan. INDIAN JOURNAL OF MEDICAL MICROBIOLOGY, 34(3), 346-349. doi:10.4103/0255-0857.188338
2015
Heysell, S. K., & Hughes, M. A. (2016). Listeria monocytogenes Endovascular Graft Infection. OPEN FORUM INFECTIOUS DISEASES, 3(1). doi:10.1093/ofid/ofv203
Schutte, K. M., Fisher, D. J., Burdick, M. D., Mehrad, B., Mathers, A. J., Mann, B. J., . . . Hughes, M. A. (2016). Escherichia coli Pyruvate Dehydrogenase Complex Is an Important Component of CXCL10-Mediated Antimicrobial Activity. INFECTION AND IMMUNITY, 84(1), 320-328. doi:10.1128/IAI.00552-15
Cincotta, M. C., Coffey, K. C., Moonah, S. N., Uppal, D., & Hughes, M. A. (2015). Case Report of Granulicatella adiacens as a Cause of Bacterascites. CASE REPORTS IN INFECTIOUS DISEASES, 2015. doi:10.1155/2015/132317
Wang, J., Bartelt, L., Yu, D., Joshi, A., Weinbaum, B., Pierson, T., . . . Donowitz, G. (2015). Primary Cutaneous Cryptococcosis Treated with Debridement and Fluconazole Monotherapy in an Immunosuppressed Patient: A Case Report and Review of the Literature. CASE REPORTS IN INFECTIOUS DISEASES, 2015. doi:10.1155/2015/131356
2014
Ghanchi, N. K., Khan, E., Farooqi, J. Q., Fasih, N., Dojki, M., & Hughes, M. A. (2014). Knowledge and practices of laboratory workers on standardized antimicrobial susceptibility testing and biosafety practices to prevent the spread of superbugs in Pakistan. AMERICAN JOURNAL OF INFECTION CONTROL, 42(9), 1022-1024. doi:10.1016/j.ajic.2014.06.006
2013
Barua, S., Iyer, J. K., Larabee, J. L., Raisley, B., Hughes, M. A., Coggeshall, K. M., & Ballard, J. D. (2013). Toxin Inhibition of Antimicrobial Factors Induced by Bacillus anthracis Peptidoglycan in Human Blood. INFECTION AND IMMUNITY, 81(10), 3693-3702. doi:10.1128/IAI.00709-13
2011
Crawford, M. A., Lowe, D. E., Fisher, D. J., Stibitz, S., Plaut, R. D., Beaber, J. W., . . . Hughes, M. A. (2011). Identification of the bacterial protein FtsX as a unique target of chemokine-mediated antimicrobial activity against Bacillus anthracis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(41), 17159-17164. doi:10.1073/pnas.1108495108
2010
Crawford, M. A., Burdick, M. D., Glomski, I. J., Boyer, A. E., Barr, J. R., Mehrad, B., . . . Hughes, M. A. (2010). Interferon-Inducible CXC Chemokines Directly Contribute to Host Defense against Inhalational Anthrax in a Murine Model of Infection. PLOS PATHOGENS, 6(11). doi:10.1371/journal.ppat.1001199