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Michael K Keng

Michael K Keng

Associate Professor of Medicine, Medicine- Hematology and Oncology

Primary Location
UVA Emily Couric Clinical Cancer Center
1240 Lee St
Charlottesville, VA 22903
Primary Phone Number
Fax Number
434.244.7526

Bio & Overview

Clinical trials in hematologic malignancies, including myelodysplastic syndromes and leukemias with special interest in treating the elderly population, determining optimal combinations and timing of targeted agents in MDS and leukemia, and studying patient safety and quality improvement.

Academic Information

Department
Medicine- Hematology and Oncology

Primary Education

  • Clinical Fellowship, Hematology-Oncology, Cleveland Clinic, Cleveland, Ohionull
  • MD, Michigan State Universitynull
  • Residency, Internal Medicine, University of Southern California School of Medicinenull

Research Interests

Clinical trials in hematologic malignancies, including myelodysplastic syndromes and leukemias with special interest in treating the elderly population, determining optimal combinations and timing of targeted agents in MDS and leukemia, and studying patie

Selected Publications

2024

Tran, V., Salafian, K., Michaels, K., Jones, C., Reed, D., Keng, M., & El Chaer, F. (2024). MRD in Philadelphia Chromosome-Positive ALL: Methodologies and Clinical Implications. CURRENT HEMATOLOGIC MALIGNANCY REPORTS. doi:10.1007/s11899-024-00736-9

Garcia-Manero, G., Kazmierczak, M., Wierzbowska, A., Fong, C. Y., Keng, M. K., Ballinari, G., . . . Ades, L. (2024). Pracinostat combined with azacitidine in newly diagnosed adult acute myeloid leukemia (AML) patients unfit for standard induction chemotherapy: PRIMULA phase III study. LEUKEMIA RESEARCH, 140. doi:10.1016/j.leukres.2024.107480

2023

Altman, J. K., Zuckerman, T., Koprivnikar, J., Mccloskey, J., Kota, V., Keng, M., . . . Rowe, J. M. (2023). Aspacytarabine for the treatment of patients with AML unfit for intensive chemotherapy: a phase 2 study. BLOOD ADVANCES, 7(24), 7494-7500. doi:10.1182/bloodadvances.2023010943

Lantz, J., Pham, N., Jones, C., Reed, D., El Chaer, F., & Keng, M. (2024). Blinatumomab in Practice. CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 19(1), 1-8. doi:10.1007/s11899-023-00714-7

Gulleen, E. A., Holte, S., Zhang, Y., Mbarusha, I., Mubiru, D., Pedun, B., . . . Phipps, W. (2023). Etiology of Fever and Associated Outcomes Among Adults Receiving Chemotherapy for the Treatment of Solid Tumors in Uganda. OPEN FORUM INFECTIOUS DISEASES, 10(11). doi:10.1093/ofid/ofad508

Garcia, J. S., Flamand, Y., Penter, L., Keng, M., Tomlinson, B. K., Mendez, L. M., . . . Soiffer, R. J. (2023). Ipilimumab plus decitabine for patients with MDS or AML in posttransplant or transplant-naïve settings.. Blood, 141(15), 1884-1888. doi:10.1182/blood.2022017686

Van Galen, J., Maldonado, S., Grose, K., Bagley, F., Olivier, R., Van Hoose, J., . . . Volodin, L. (2023). Minimizing the risk of Clostridioides difficile infection as an early complication of autologous stem cell transplantation.. Antimicrobial stewardship & healthcare epidemiology : ASHE, 3(1), e158. doi:10.1017/ash.2023.424

Varadarajan, I., Pierce, E., Scheuing, L., Morris, A., El Chaer, F., & Keng, M. (2023). Post-Hematopoietic Cell Transplantation Relapsed Acute Lymphoblastic Leukemia: Current Challenges and Future Directions. ONCOTARGETS AND THERAPY, 16, 1-16. doi:10.2147/OTT.S274551

2022

Robinson, E. D., Keng, M. K., Thomas, T. D., Cox, H. L., Park, S. C., & Mathers, A. J. (2022). Reducing Repeat Blood Cultures in Febrile Neutropenia: A Single-Center Experience. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac521

Pierce, E., Mautner, B., Mort, J., Blewett, A., Morris, A., Keng, M., & El Chaer, F. (2022). MRD in ALL: Optimization and Innovations. CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 17(4), 69-81. doi:10.1007/s11899-022-00664-6

Ung, J., Tan, S. -F., Fox, T. E., Shaw, J. J. P., Vass, L. R., Costa-Pinheiro, P., . . . Loughran, T. P. (2022). Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia. BLOOD REVIEWS, 55. doi:10.1016/j.blre.2022.100950

2021

Courville, E. L., Shantzer, L., von Eckstaedt, H. C. V., Mellot, H., Keng, M., Sen, J., . . . El Chaer, F. (2022). Variant Acute Promyelocytic Leukemia Presenting Without Auer Rods Highlights the Need for Correlation with Cytogenetic Data in Leukemia Diagnosis. LABORATORY MEDICINE, 53(1), 95-99. doi:10.1093/labmed/lmab051

Riley, D. O., Schlefman, J. M., Von Eckstaedt, V. H. C. V., Morris, A. L., Keng, M. K., & El Chaer, F. (2021). Pegaspargase in Practice: Minimizing Toxicity, Maximizing Benefit. CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 16(3), 314-324. doi:10.1007/s11899-021-00638-0

Isaac, K. M., Reed, D. R., Desai, R. P., Williams, E., Balkrishnan, R., Keng, M. K., & Ballen, K. K. (2021). Epidemiology of acute myeloid leukemia in Virginia: Excellent survival outcomes for patients in rural Appalachia. CANCER REPORTS, 4(4). doi:10.1002/cnr2.1354

Wages, N. A., Reed, D. R., Keng, M. K., Conaway, M. R., & Petroni, G. R. (2021). Adapting isotonic dose-finding to a dynamic set of drug combinations with application to a phase I leukemia trial. CLINICAL TRIALS, 18(3), 314-323. doi:10.1177/1740774520983484

2020

Keng, M., Quinn, D., Cunningham, G., Bingham, J., Chiang, A., Eisinger, M., . . . Srivastava, P. (2020). ASCO Quality Training Program: A Five-Year Review. JCO ONCOLOGY PRACTICE, 16(10), 694-+. doi:10.1200/OP.20.00319

Reed, D. R., Sen, J. M., Pierce, E. J., Elsarrag, R. Z., & Keng, M. K. (2020). Gilteritinib: An FMS-like tyrosine kinase 3/AXL tyrosine kinase inhibitor for the treatment of relapsed or refractory acute myeloid leukemia patients. JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 26(5), 1200-1212. doi:10.1177/1078155220918006

El Chaer, F., Keng, M., & Ballen, K. K. (2020). MLL-Rearranged Acute Lymphoblastic Leukemia. CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 15(2), 83-89. doi:10.1007/s11899-020-00582-5

Schaeffer, C. V., Moran, T. E., Keng, M. K., Bateman, H. R., & DeGeorge, B. R. J. (2020). Granulocytic Sarcoma A Rare Cause of Wrist Pain. ANNALS OF PLASTIC SURGERY, 85(1), 29-32. doi:10.1097/SAP.0000000000002315

Reed, D., Sen, J., Lassiter, K., Thomas, T., Harr, E., Daniels, E., & Keng, M. (2020). Prospective Initiative to Reduce Mucosal Barrier Injuries and Bloodstream Infections in Patients With Hematologic Malignancy Receiving Inpatient Chemotherapy. JCO ONCOLOGY PRACTICE, 16(3), E306-E312. doi:10.1200/JOP.19.00344

2019

Mort, M. K., Sen, J. M., Morris, A. L., DeGregory, K. A., McLoughlin, E. M., Mort, J. F., . . . Keng, M. K. (2020). Evaluation of cardiomyopathy in acute myeloid leukemia patients treated with anthracyclines. JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 26(3), 680-687. doi:10.1177/1078155219873014

Man, L., Sen, J., Giordano, J., McLoughlin, E., Morris, A., DeGregory, K., . . . Keng, M. (2019). Multidisciplinary Effort to Decrease Time From Admission to Chemotherapy on an Inpatient Oncology Unit. JOURNAL OF ONCOLOGY PRACTICE, 15(8), E728-E732. doi:10.1200/JOP.18.00281

Reed, D. R., Elsarrag, R. Z., Morris, A. L., & Keng, M. K. (2019). Enasidenib in acute myeloid leukemia: clinical development and perspectives on treatment. CANCER MANAGEMENT AND RESEARCH, 11, 8073-8080. doi:10.2147/CMAR.S162784

Reed, D. R., Pierce, E. J., Sen, J. M., & Keng, M. K. (2019). A prospective study on urine alkalization with an oral regimen consisting of sodium bicarbonate and acetazolamide in patients receiving high-dose methotrexate. CANCER MANAGEMENT AND RESEARCH, 11, 8065-8072. doi:10.2147/CMAR.S190084

2018

Morris, A. L., Naeem, M., Murray, T., Sen, J., Thomas, T., Daniels, E., . . . Keng, M. (2018). Establishing an Antifungal Program to Reduce Invasive Fungal Infections in Patients With Acute Myeloid Leukemia Receiving Induction and Reinduction Chemotherapy. JOURNAL OF ONCOLOGY PRACTICE, 14(12), E770-E774. doi:10.1200/JOP.18.00307

Hathaway, L., Sen, J. M., & Keng, M. (2018). Impact of blinatumomab on patient outcomes in relapsed/refractory acute lymphoblastic leukemia: evidence to date. PATIENT-RELATED OUTCOME MEASURES, 9, 329-337. doi:10.2147/PROM.S149420

2017

Man, L. M., Morris, A. L., & Keng, M. (2017). New Therapeutic Strategies in Acute Lymphocytic Leukemia. CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 12(3), 197-206. doi:10.1007/s11899-017-0380-3

2016

Thomas, T., Reuss, J., Degennaro, G., Daniels, E., Li, J., Smolkin, M., & Keng, M. K. (2016). A prospective study of an inpatient febrile neutropenia clinical practice guideline in oncology patients.. J Clin Oncol, 34(7_suppl), 114. doi:10.1200/jco.2016.34.7_suppl.114

2015

Keng, M. K., Thallner, E. A., Elson, P., Ajon, C., Sekeres, J., Wenzell, C. M., . . . Sekeres, M. A. (2015). Reducing Time to Antibiotic Administration for Febrile Neutropenia in the Emergency Department. JOURNAL OF ONCOLOGY PRACTICE, 11(6), 450-+. doi:10.1200/JOP.2014.002733

Ornstein, M. C., Mukherjee, S., Keng, M., Elson, P., Tiu, R. V., Saunthararajah, Y., . . . Sekeres, M. A. (2015). Impact of vancomycin-resistant enterococcal bacteremia on outcome during acute myeloid leukemia induction therapy. LEUKEMIA & LYMPHOMA, 56(9), 2536-2542. doi:10.3109/10428194.2014.1003557

Nazha, A., Seastone, D. P., Keng, M., Hobson, S., Kalaycio, M., Maciejewski, J. P., & Sekeres, M. A. (2015). The Revised International Prognostic Scoring System (IPSS-R) is not predictive of survival in patients with secondary myelodysplastic syndromes. LEUKEMIA & LYMPHOMA, 56(12), 3437-3439. doi:10.3109/10428194.2015.1041391

2013

Keng, M. K., Wenzell, C. M., & Sekeres, M. A. (2013). A drug's life: the pathway to drug approval.. Clinical advances in hematology & oncology : H&O, 11(10), 646-655.

Keng, M. K., & Sekeres, M. A. (2013). Febrile Neutropenia in Hematologic Malignancies. CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 8(4), 370-378. doi:10.1007/s11899-013-0171-4

2012

Keng, M. K., & Sekeres, M. A. (2013). The race for survival in myelodysplastic syndromes. LEUKEMIA & LYMPHOMA, 54(2), 219-220. doi:10.3109/10428194.2012.726724

Ornstein, M., Mukherjee, S., Keng, M. K., Elson, P., Tiu, R. V., Saunthararajah, Y., . . . Sekeres, M. A. (2012). Vancomycin-Resistant Enterococcus (VRE) Bacteremia During Acute Myeloid Leukemia (AML) Induction Therapy Is an Independent Predictor of Poor Outcome. BLOOD, 120(21). doi:10.1182/blood.V120.21.1487.1487