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M. Mitchell Smith

M. Mitchell Smith

Professor, Microbiology, Immunology, and Cancer Biology

Primary Location
PO Box 800734
Primary Phone Number
434.924.2669
Email
[email protected]
Website
http://www.people.virginia.edu/%7Emms7r/

Bio & Overview

Academic Information

Department
Microbiology, Immunology, and Cancer Biology
Academic Title
Professor

Primary Education

  • BA, Biology, Johns Hopkins University, Baltimore MD, 1970
  • PhD, Biochemistry, Johns Hopkins University, Baltimore MD, 1976
  • Postdoc, Molecular Biology, Johns Hopkins University, Baltimore MD, 1977
  • Postdoc, Molecular Genetics, Edinburgh University, Edinburgh, Scotland, UK, 1980

Other Appointments

  • Cell Biology
  • Professor, MII
  • Professor, BMBG

Other Affiliations

  • Member, Molecular Genetics and Epigenetics Program
  • Professor, BIMS

Research Interests

Microbiology

Research Disciplines

  • Cancer Biology
  • Epigenetics
  • Genetics
  • Molecular Biology

Research Opportunities

  • Cancer Biology
  • Epigenetics
  • Genetics
  • Molecular Biology

Selected Publications

2018

Grant, M. J., Loftus, M. S., Stoja, A. P., Kedes, D. H., & Smith, M. (2018). Superresolution microscopy reveals structural mechanisms driving the nanoarchitecture of a viral chromatin tether. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(19), 4992-4997. doi:10.1073/pnas.1721638115

2015

Henikoff, S., & Smith, M. M. (2015). Histone Variants and Epigenetics. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 7(1). doi:10.1101/cshperspect.a019364

2012

Talbert, P. B., Ahmad, K., Almouzni, G., Ausio, J., Berger, F., Bhalla, P. L., . . . Henikoff, S. (2012). A unified phylogeny-based nomenclature for histone variants. EPIGENETICS & CHROMATIN, 5. doi:10.1186/1756-8935-5-7

Kim, J. -A., Hsu, J. -Y., Smith, M. M., & Allis, C. D. (2012). Mutagenesis of pairwise combinations of histone amino-terminal tails reveals functional redundancy in budding yeast. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(15), 5779-5784. doi:10.1073/pnas.1203453109

2011

Swensen, A. M., Herrington, J., Bugianesi, R. M., Dai, G., Haedo, R. J., Ratliff, K. S., . . . McManus, O. B. (2012). Characterization of the Substituted N-Triazole Oxindole TROX-1, a Small-Molecule, State-Dependent Inhibitor of Cav2 Calcium Channels. MOLECULAR PHARMACOLOGY, 81(3), 488-497. doi:10.1124/mol.111.075226

Santisteban, M. S., Hang, M., & Smith, M. M. (2011). Histone Variant H2A.Z and RNA Polymerase II Transcription Elongation. MOLECULAR AND CELLULAR BIOLOGY, 31(9), 1848-1860. doi:10.1128/MCB.01346-10

Jensen, K., Santisteban, M. S., Urekar, C., & Smith, M. M. (2011). Histone H2A.Z acid patch residues required for deposition and function. MOLECULAR GENETICS AND GENOMICS, 285(4), 287-296. doi:10.1007/s00438-011-0604-5

Hang, M., & Smith, M. M. (2011). Genetic Analysis Implicates the Set3/Hos2 Histone Deacetylase in the Deposition and Remodeling of Nucleosomes Containing H2A.Z. GENETICS, 187(4), 1053-U145. doi:10.1534/genetics.110.125419

2010

French, S. L., Sikes, M. L., Hontz, R. D., Osheim, Y. N., Lambert, T. E., El Hage, A., . . . Beyer, A. L. (2011). Distinguishing the Roles of Topoisomerases I and II in Relief of Transcription-Induced Torsional Stress in Yeast rRNA Genes. MOLECULAR AND CELLULAR BIOLOGY, 31(3), 482-494. doi:10.1128/MCB.00589-10

Baker, S. P., Phillips, J., Anderson, S., Qiu, Q., Shabanowitz, J., Smith, M. M., . . . Grant, P. A. (2010). Histone H3 Thr 45 phosphorylation is a replication-associated post-translational modification in S. cerevisiae. NATURE CELL BIOLOGY, 12(3), 294-U103. doi:10.1038/ncb2030