Solenski, Nina J.
Associate Professor, Neurology
- MD, Thomas Jefferson University
PO Box 800394
Mechanisms of cerebral ischemia
The aim of the research in this laboratory is to elucidate the role of oxygen free radicals during reversible focal ischemia by characterizing their temporal and spatial characteristics during and after ischemic conditions and by understanding their relationship to known excitatory amino acids and nitric oxide related mechanisms. Research focuses on elucidating specific targets of free radical species, including the role of neuronal mitochondria in acute ischemic damage. Specifically, these experiments couple the well-established technique, brain tissue microdialysis, to a reliable focal ischemia model in the rat. This experimental design allows for the in situ recovery of stable free radical adducts and the administration of pharmacological substances.