Jianjie Ma, PhD
Professor, Surgery
Charlottesville, Virginia 22903
Bio & Overview
Academic Information
- Department
- Surgery
Primary Education
- B.S., Physics, Wuhan University, 1983
- Ph.D., Physiology & Biophysics, Baylor College of Medicine, 1989
- Postdoctoral, Physiology & Biophysics, Rush University School of Medicine, 1991
Research Interests
Research Disciplines
- Biotechnology
- Cardiovascular Biology
- Cell and Developmental Biology
- Molecular and Cellular Physiology
- Translational Science
Research Opportunities
- Bioinformatics & Genomics
- Cancer Biology
- Development, Stem Cells & Regeneration
- Experimental Pathology
- Immunology
- Neuroimmunology
PhD Programs
- Cell Biology
- Experimental Pathology
Selected Publications
2026
Aldh3a1-mediated detoxification of reactive aldehydes contributes to distinct muscle responses to amyotrophic lateral sclerosis progression
Free Radical Biology and Medicine. 2026; 249: 469 - 488. DOI:10.1016/J.FREERADBIOMED.2026.03.037.
Humanized Citrullinated Histone H3 Monoclonal Antibody Improves Respiratory Function and Attenuates Neutrophil-Mediated Inflammation in a Rodent Model of Smoke Inhalation Lung Injury
Journal of the American College of Surgeons. 2026; 242(1): 1 - 12. DOI:10.1097/XCS.0000000000001620.
MG53 mediates skeletal muscle-liver cross-talk and enhances alcohol metabolism in alcoholic liver disease
Nature Communications. 2026; 17(1):. DOI:10.1038/S41467-026-69132-6.
MG53 protects against intestinal inflammation by inhibiting NLRP3 inflammasome activation
Frontiers in Pharmacology. 2026; 17:. DOI:10.3389/FPHAR.2026.1791509.
MG53 protects against septic cardiac dysfunction by ubiquitinating ATF2
Journal of Advanced Research. 2026; 79: 263 - 275. DOI:10.1016/J.JARE.2025.03.031.
Mitsugumin 53 protects against smoke inhalation lung injury via suppressing the proinflammatory response in a rat model
Free Radical Biology and Medicine. 2026; 248: 43 - 51. DOI:10.1016/J.FREERADBIOMED.2026.02.027.
TRIC-A Loss Sensitizes the Heart to β-Adrenergic Stress and Drives Cardiomyocyte Death and Fibrosis
Biomolecules. 2026; 16(2): 181. DOI:10.3390/BIOM16020181.
2025
A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis
Nature Communications. 2025; 16(1):. DOI:10.1038/S41467-025-62788-6.
BPS2025 - Adeno-associated virus-enforced ALDH3A1 expression protects myotubes against 4-HNE-induced cytotoxicity and restores MG53-mediated membrane repair
Biophysical Journal. 2025; 124(3 (Supp.)): 112a - 113a. DOI:10.1016/J.BPJ.2024.11.654.
BPS2025 - Lipid wasting and peroxidation contribute to impaired membrane repair function in skeletal muscle of ALS mice
Biophysical Journal. 2025; 124(3 (Supp.)): 113a. DOI:10.1016/J.BPJ.2024.11.656.
CitH3, a Druggable Biomarker for Human Diseases Associated with Acute NETosis and Chronic Immune Dysfunction
Pharmaceutics. 2025; 17(7): 809. DOI:10.3390/PHARMACEUTICS17070809.
Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury
Advanced Science. 2025; 12(18):. DOI:10.1002/ADVS.202413253.
Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury (Adv. Sci. 18/2025)
Advanced Science. 2025; 12(18):. DOI:10.1002/ADVS.202570132.
Corrigendum to “MG53 Protein-Mediated biomimetic nanotherapeutics for the treatment of acute myocardial infarction by driving the impaired plasma membrane resealing” [Chem. Eng. J. (2024) 157091]
Chemical Engineering Journal. 2025; 505: 159646. DOI:10.1016/J.CEJ.2025.159646.
Development of an Ophthalmic Hydrogel to Deliver MG53 and Promote Corneal Wound Healing
Pharmaceutics. 2025; 17(4): 526. DOI:10.3390/PHARMACEUTICS17040526.
Editorial: The role of autophagy in cardiovascular disease
Frontiers in Cell and Developmental Biology. 2025; 13:. DOI:10.3389/FCELL.2025.1697218.
Humanized Monoclonal Antibody Against Citrullinated Histone H3 Attenuates Myocardial Injury and Prevents Heart Failure in Rodent Models
Biomolecules. 2025; 15(8): 1196. DOI:10.3390/BIOM15081196.
Molecular mechanism on autophagy associated cardiovascular dysfunction in Drosophila melanogaster
Frontiers in Cell and Developmental Biology. 2025; 13:. DOI:10.3389/FCELL.2025.1512341.
Synergistic inhibition of CitH3 and S100A8/A9: A novel therapeutic strategy for mitigating sepsis-induced inflammation and lung injury
International Journal of Immunopathology and Pharmacology. 2025; 39:. DOI:10.1177/03946320251338661.
TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis
Molecular Therapy – Nucleic Acids. 2025; 36(1): 102460. DOI:10.1016/J.OMTN.2025.102460.
Treatment with MG53 ameliorates traumatic brain injury–associated acute kidney injury
The Journal of Trauma and Acute Care Surgery. 2025; 99(5): 732 - 739. DOI:10.1097/TA.0000000000004660.
TRIC-A Facilitates Sarcoplasmic Reticulum–Mitochondrial Ca2+ Signaling Crosstalk in Cardiomyocytes
Cells. 2025; 14(20): 1579. DOI:10.3390/CELLS14201579.
2024
AFM41a: A Novel PAD2 Inhibitor for Sepsis Treatment—Efficacy and Mechanism
International Journal of Biological Sciences. 2024; 20(13): 5043 - 5055. DOI:10.7150/IJBS.97166.
Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice
eLife. 2024; 12:. DOI:10.7554/ELIFE.92644.
Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice
eLife. 2024; 12:. DOI:10.7554/ELIFE.92644.4.
Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation
Nature Communications. 2024; 15(1):. DOI:10.1038/S41467-024-47067-0.
Loss of PADI2 and PADI4 ameliorates sepsis-induced acute lung injury by suppressing NLRP3+ macrophages
JCI Insight. 2024; 9(22):. DOI:10.1172/JCI.INSIGHT.181686.
MG53 binding to CAV3 facilitates activation of eNOS/NO signaling pathway to enhance the therapeutic benefits of bone marrow-derived mesenchymal stem cells in diabetic wound healing
International Immunopharmacology. 2024; 136: 112410. DOI:10.1016/J.INTIMP.2024.112410.
MG53 Mitigates Warm Ischemic Lung Injury in A Murine Model of Transplantation
Journal of Thoracic and Cardiovascular Surgery. 2024; 168(1): e13 - e26. DOI:10.1016/J.JTCVS.2023.10.056.
MG53 Protein-Mediated biomimetic nanotherapeutics for the treatment of acute myocardial infarction by driving the impaired plasma membrane resealing
Chemical Engineering Journal. 2024; 500: 157091. DOI:10.1016/J.CEJ.2024.157091.
MG53 suppresses tumor growth via transcriptional inhibition of KIF11 in pancreatic cancer
Translational Oncology. 2024; 50: 102118. DOI:10.1016/J.TRANON.2024.102118.
Mitsugumin 53 mitigation of ischemia–reperfusion injury in a mouse model
Journal of Thoracic and Cardiovascular Surgery. 2024; 167(3): e48 - e58. DOI:10.1016/J.JTCVS.2023.08.005.
2023
Abstract 1729: MG53 suppresses the tumor growth via transcriptional inhibiting the expression of KIF11 in pancreatic cancer
Cancer Research. 2023; 83(7_Supplement): 1729 - 1729. DOI:10.1158/1538-7445.AM2023-1729.
Activation of MG53 Enhances Cell Survival and Engraftment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Injured Hearts
Stem Cell Reviews and Reports. 2023; 19(7): 2420 - 2428. DOI:10.1007/S12015-023-10596-0.
Butyrate endows extraocular muscle stem cell-like transcriptomic patterns that ameliorate satellite cell depletion and denervation to slow ALS progression
Biophysical Journal. 2023; 122(3 (Supp.)): 27a. DOI:10.1016/J.BPJ.2022.11.370.
Cardiac-Specific Expression of Cre Recombinase Leads to Age-Related Cardiac Dysfunction Associated with Tumor-like Growth of Atrial Cardiomyocyte and Ventricular Fibrosis and Ferroptosis
International Journal of Molecular Sciences. 2023; 24(4): 3094. DOI:10.3390/IJMS24043094.
Interferon‐induced transmembrane protein 3 (IFITM3) limits lethality of SARS‐CoV‐2 in mice
EMBO Reports. 2023; 24(4):. DOI:10.15252/EMBR.202256660.
MG53 Mitigates Nitrogen Mustard-Induced Skin Injury
Cells. 2023; 12(14): 1915. DOI:10.3390/CELLS12141915.
Quantification of autophagy flux in isolated mouse skeletal muscle fibers with overexpression of fluorescent protein mCherry-EGFP-LC3
STAR Protocols. 2023; 4(1): 101871. DOI:10.1016/J.XPRO.2022.101871.
Transient depletion of macrophages alters local inflammatory response at the site of disc herniation in a transgenic mouse model
Osteoarthritis and Cartilage. 2023; 31(7): 894 - 907. DOI:10.1016/J.JOCA.2023.01.574.
2022
A Protocol for Immunohistochemistry and RNA In-situ Distribution within Early Drosophila Embryo
Journal of Visualized Experiments. 2022; . DOI:10.3791/61776.
A Protocol for Immunohistochemistry and RNA In-situ Distribution within Early Drosophila Embryo
Journal of Visualized Experiments. 2022; . DOI:10.3791/61776-V.
Abstract GS113: Inflammasome Primed Neutrophils Regulate Myocardial Infarction Induced Myelopoiesis
Circulation Research. 2022; 131(Suppl_1):. DOI:10.1161/RES.131.SUPPL_1.GS113.
CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy
Molecular Therapy. 2022; 30(1): 54 - 74. DOI:10.1016/J.YMTHE.2021.10.015.
Deficient Sarcolemma Repair in ALS: A Novel Mechanism with Therapeutic Potential
Cells. 2022; 11(20): 3263. DOI:10.3390/CELLS11203263.
Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis
Science Advances. 2022; 8(19):. DOI:10.1126/SCIADV.ABM5371.
Membrane-delimited signaling and cytosolic action of MG53 preserve hepatocyte integrity during drug-induced liver injury
Journal of Hepatology. 2022; 76(3): 558 - 567. DOI:10.1016/J.JHEP.2021.10.017.
MG53 attenuates nitrogen mustard‐induced acute lung injury
Journal of Cellular and Molecular Medicine. 2022; 26(7): 1886 - 1895. DOI:10.1111/JCMM.16917.
MG53 inhibits cellular proliferation and tumor progression in colorectal carcinoma
International Journal of Biological Sciences. 2022; 18(14): 5221 - 5229. DOI:10.7150/IJBS.67869.
MG53 Inhibits Necroptosis Through Ubiquitination-Dependent RIPK1 Degradation for Cardiac Protection Following Ischemia/Reperfusion Injury
Frontiers in Cardiovascular Medicine. 2022; 9:. DOI:10.3389/FCVM.2022.868632.
MG53 preserves mitochondrial integrity of cardiomyocytes during ischemia reperfusion-induced oxidative stress
Redox Biology. 2022; 54: 102357. DOI:10.1016/J.REDOX.2022.102357.
Mitochondrial Membrane Potential Identifies a Subpopulation of Mesenchymal Progenitor Cells to Promote Angiogenesis and Myocardial Repair
Cells. 2022; 11(10): 1713. DOI:10.3390/CELLS11101713.
Recombinant human MG53 protein attenuates brain lesion size in a large animal model of traumatic brain injury
The Journal of Trauma and Acute Care Surgery. 2022; 93(5): 613 - 619. DOI:10.1097/TA.0000000000003746.
Reply to: “Protection against acetaminophen-induced liver injury with MG53: Muscle-liver axis and necroptosis”
Journal of Hepatology. 2022; 77(2): 562 - 563. DOI:10.1016/J.JHEP.2022.04.024.
Retention of the NLRP3 Inflammasome–Primed Neutrophils in the Bone Marrow Is Essential for Myocardial Infarction–Induced Granulopoiesis
Circulation. 2022; 145(1): 31 - 44. DOI:10.1161/CIRCULATIONAHA.121.056019.
Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development
Bioactive Materials. 2022; 18: 104 - 115. DOI:10.1016/J.BIOACTMAT.2022.03.017.
The cell membrane repair protein MG53 modulates transcription factor NF-κB signaling to control kidney fibrosis
Kidney International. 2022; 101(1): 119 - 130. DOI:10.1016/J.KINT.2021.09.027.
The Prognostic Significance of FKBP1A and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma
International Journal of Molecular Sciences. 2022; 23(21): 12797. DOI:10.3390/IJMS232112797.
2021
A Rat Lung Transplantation Model of Warm Ischemia/Reperfusion Injury: Optimizations to Improve Outcomes
Journal of Visualized Experiments. 2021; . DOI:10.3791/62445.
A Rat Lung Transplantation Model of Warm Ischemia/Reperfusion Injury: Optimizations to Improve Outcomes
Journal of Visualized Experiments. 2021; . DOI:10.3791/62445-V.
Abstract 11086: MG53 Suppresses NfκB Activation to Mitigate Age-Related Heart Failure
Circulation. 2021; 144(Suppl_1):. DOI:10.1161/CIRC.144.SUPPL_1.11086.
Abstract 13835: MG53 Preserves Mitochondrial Integrity of Cardiomyocytes in Pre-Clinical Models of Ischemia Reperfusion-Induced Oxidative Stress
Circulation. 2021; 144(Suppl_1):. DOI:10.1161/CIRC.144.SUPPL_1.13835.
Abstract 13996: Retention of the NLRP3 Inflammasome-Primed Neutrophils in the Bone Marrow is Essential for Myocardial Infarction-Induced Granulopoiesis
Circulation. 2021; 144(Suppl_1):. DOI:10.1161/CIRC.144.SUPPL_1.13996.
Abstract MP221: Early Recruitment Of Neutrophils To The Ischemic Heart Is Orchestrated By Catecholamine-induced Demargination
Circulation Research. 2021; 129(Suppl_1):. DOI:10.1161/RES.129.SUPPL_1.MP221.
Abstract MP231: Long Non-coding Rna Camirt Plays A Sentinel Role In Aging-related Heart Failure Via Interaction With Phb2 To Modulate Mitophagy Signaling In The Heart
Circulation Research. 2021; 129(Suppl_1):. DOI:10.1161/RES.129.SUPPL_1.MP231.
Butyrate Feeding Reverses CypD-Related Mitoflash Phenotypes in Mouse Myofibers
International Journal of Molecular Sciences. 2021; 22(14): 7412. DOI:10.3390/IJMS22147412.
Cardiac effects and clinical applications of MG53
Cell & Bioscience. 2021; 11(1):. DOI:10.1186/S13578-021-00629-X.
Correction to: The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury
Stem Cell Research and Therapy. 2021; 12(1):. DOI:10.1186/S13287-021-02598-X.
Efficient precise in vivo base editing in adult dystrophic mice
Nature Communications. 2021; 12(1):. DOI:10.1038/S41467-021-23996-Y.
Meet Our Editorial Board Member
Current Chemical Biology. 2021; 15(1): 2 - 3. DOI:10.2174/221279681501210407102457.
MG53 as a Novel Therapeutic Protein to Treat Acute Lung Injury
Military Medicine. 2021; 186(Supplement_1): 339 - 345. DOI:10.1093/MILMED/USAA313.
MG53 Preserves Neuromuscular Junction Integrity and Alleviates ALS Disease Progression
Antioxidants. 2021; 10(10): 1522. DOI:10.3390/ANTIOX10101522.
MG53 suppresses NF-κB activation to mitigate age-related heart failure
JCI Insight. 2021; 6(17):. DOI:10.1172/JCI.INSIGHT.148375.
MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer
Molecular Cancer. 2021; 20(1):. DOI:10.1186/S12943-021-01418-3.
MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine
Cells. 2021; 10(1): 122. DOI:10.3390/CELLS10010122.
Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration
Current Opinion in Pharmacology. 2021; 59: 26 - 32. DOI:10.1016/J.COPH.2021.04.005.
Peptidylarginine Deiminases 2 Mediates Caspase-1-Associated Lethality in Pseudomonas aeruginosa Pneumonia-Induced Sepsis
Journal of Infectious Diseases. 2021; 223(6): 1093 - 1102. DOI:10.1093/INFDIS/JIAA475.
Recombinant Human MG53 Protein Protects Against Alkaline-Induced Corneal Injuries in Mice
Military Medicine. 2021; 186(Supplement_1): 486 - 490. DOI:10.1093/MILMED/USAA357.
Recombinant MG53 Protein Protects Mice from Lethal Influenza Virus Infection
American Journal of Respiratory and Critical Care Medicine. 2021; 203(2): 254 - 257. DOI:10.1164/RCCM.202007-2908LE.
TRIC-A regulates intracellular Ca2+ homeostasis in cardiomyocytes
Pflugers Archiv European Journal of Physiology. 2021; 473(3): 547 - 556. DOI:10.1007/S00424-021-02513-6.
2020
Calcium-dependent Protein Kinases in Malaria Parasite Development and Infection
Cell Transplantation. 2020; 29: 096368971988488. DOI:10.1177/0963689719884888.
Correction to: A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model
Cell & Bioscience. 2020; 10(1):. DOI:10.1186/S13578-020-00421-3.
Corrigendum to “A systematic comparison of exercise training protocols on animal models of cardiovascular capacity” [Life Sci. 217 (2019) 128–140]
Life Sciences. 2020; 254: 117757. DOI:10.1016/J.LFS.2020.117757.
MG53 Does Not Manifest the Development of Diabetes in db/db Mice
Diabetes. 2020; 69(5): 1052 - 1064. DOI:10.2337/DB19-0807.
MG53 protects against contrast-induced acute kidney injury by reducing cell membrane damage and apoptosis
Acta Pharmacologica Sinica. 2020; 41(11): 1457 - 1464. DOI:10.1038/S41401-020-0420-8.
MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling
Nature Communications. 2020; 11(1):. DOI:10.1038/S41467-020-17177-6.
Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration
Frontiers in Physiology. 2020; 11:. DOI:10.3389/FPHYS.2020.583393.
N‐acetylcysteine prevents oxidized low‐density lipoprotein‐induced reduction of MG53 and enhances MG53 protective effect on bone marrow stem cells
Journal of Cellular and Molecular Medicine. 2020; 24(1): 886 - 898. DOI:10.1111/JCMM.14798.
Nonalcoholic fatty liver disease experiences accumulation of hepatic liquid crystal associated with increasing lipophagy
Cell & Bioscience. 2020; 10(1):. DOI:10.1186/S13578-020-00414-2.
Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis
JCI Insight. 2020; 5(20):. DOI:10.1172/JCI.INSIGHT.138873.
TRIC-A Channel Maintains Store Calcium Handling by Interacting with Type 2 Ryanodine Receptor in Cardiac Muscle
Circulation Research. 2020; 126(4): 417 - 435. DOI:10.1161/CIRCRESAHA.119.316241.
TRIC-A Channel Modulates Ca2+ Homeostasis in Mitochondria
Biophysical Journal. 2020; 118(3 (Supp.)): 448a. DOI:10.1016/J.BPJ.2019.11.2502.
Use of the mesentery and peritoneum to facilitate the absorption of yolk sac nutrients into viscera of the developing chick: novel function for this organ
Mesentery and Peritoneum. 2020; 2: 1 - 1. DOI:10.21037/MAP.2019.03.01.
2019
A systematic comparison of exercise training protocols on animal models of cardiovascular capacity
Life Sciences. 2019; 217: 128 - 140. DOI:10.1016/J.LFS.2018.12.001.
Diabetes inhibits corneal epithelial cell migration and tight junction formation in mice and human via increasing ROS and impairing Akt signaling
Acta Pharmacologica Sinica. 2019; 40(9): 1205 - 1211. DOI:10.1038/S41401-019-0223-Y.
Dynamics expression of DmFKBP12/Calstabin during embryonic early development of Drosophila melanogaster
Cell & Bioscience. 2019; 9(1):. DOI:10.1186/S13578-019-0270-6.
Exercise-induced myokine FNDC5/irisin functions in cardiovascular protection and intracerebral retrieval of synaptic plasticity
Cell & Bioscience. 2019; 9(1):. DOI:10.1186/S13578-019-0294-Y.
Exogenous MG53 Protects Adult Mouse Cardiomyocytes by Preventing Mitochondria Damage in Response to Oxidative Stress
The FASEB Journal. 2019; 33(S1):. DOI:10.1096/FASEBJ.2019.33.1_SUPPLEMENT.833.3.
Extraocular muscle function is impaired in ryr3 −/− mice
The Journal of General Physiology. 2019; 151(7): 929 - 943. DOI:10.1085/JGP.201912333.
MG53 attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation via inhibiting TLR4/NF-κB pathway in vitro and in vivo
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019; 95: 109684. DOI:10.1016/J.PNPBP.2019.109684.
MG53 promotes corneal wound healing and mitigates fibrotic remodeling in rodents
Communications Biology. 2019; 2(1):. DOI:10.1038/S42003-019-0316-7.
MG53 Protein Protects Aortic Valve Interstitial Cells from Membrane Injury and Fibrocalcific Remodeling
The FASEB Journal. 2019; 33(S1):. DOI:10.1096/FASEBJ.2019.33.1_SUPPLEMENT.833.16.
MG53 Protein Protects Aortic Valve Interstitial Cells From Membrane Injury and Fibrocalcific Remodeling
Journal of the American Heart Association. 2019; 8(4):. DOI:10.1161/JAHA.118.009960.
Physical exercise: bulking up neurogenesis in human adults
Cell & Bioscience. 2019; 9(1):. DOI:10.1186/S13578-019-0337-4.
Spatiotemporal delivery of basic fibroblast growth factor to directly and simultaneously attenuate cardiac fibrosis and promote cardiac tissue vascularization following myocardial infarction
Journal of Controlled Release. 2019; 311-312: 233 - 244. DOI:10.1016/J.JCONREL.2019.09.005.
Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
Nature Communications. 2019; 10(1):. DOI:10.1038/S41467-019-12483-0.
The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury
Stem Cell Research and Therapy. 2019; 10(1):. DOI:10.1186/S13287-019-1433-4.
Thermosensitive, fast gelling, photoluminescent, highly flexible, and degradable hydrogels for stem cell delivery
Acta Biomaterialia. 2019; 83: 96 - 108. DOI:10.1016/J.ACTBIO.2018.10.038.
Topical Application of Recombinant Human MG53 Protein Facilitates Healing of Chronic Wounds in Diabetic Mice
The FASEB Journal. 2019; 33(S1):. DOI:10.1096/FASEBJ.2019.33.1_SUPPLEMENT.662.26.
2018
A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model
Cell & Bioscience. 2018; 8(1):. DOI:10.1186/S13578-018-0226-2.
Altered Eye Muscle Function in RYR3KO Mice
Biophysical Journal. 2018; 114(3 (Supp.)): 469a. DOI:10.1016/J.BPJ.2017.11.2585.
An Injectable Oxygen Release System to Augment Cell Survival and Promote Cardiac Repair Following Myocardial Infarction
Scientific Reports. 2018; 8(1):. DOI:10.1038/S41598-018-19906-W.
Calcium and CaSR/IP3R in prostate cancer development
Cell & Bioscience. 2018; 8(1):. DOI:10.1186/S13578-018-0217-3.
Calcium signaling: an underlying link between cardiac disease and carcinogenesis
Cell & Bioscience. 2018; 8(1):. DOI:10.1186/S13578-018-0236-0.
Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster
BMC Developmental Biology. 2018; 18(1):. DOI:10.1186/S12861-018-0167-3.
Irisin Protects Heart Against Ischemia-Reperfusion Injury Through a SOD2-Dependent Mitochondria Mechanism
Journal of Cardiovascular Pharmacology. 2018; 72(6): 259 - 269. DOI:10.1097/FJC.0000000000000608.
mTORC1 controls lysosomal Ca 2+ release through the two-pore channel TPC2
Science Signaling. 2018; 11(525):. DOI:10.1126/SCISIGNAL.AAO5775.
Quantum confined peptide assemblies with tunable visible to near-infrared spectral range
Nature Communications. 2018; 9(1):. DOI:10.1038/S41467-018-05568-9.
ROS-related mitochondrial dysfunction in skeletal muscle of an ALS mouse model during the disease progression
Pharmacological Research. 2018; 138: 25 - 36. DOI:10.1016/J.PHRS.2018.09.008.
Selective inhibitory effects of zinc on cell proliferation in esophageal squamous cell carcinoma through Orai1
The FASEB Journal. 2018; 32(1): 404 - 416. DOI:10.1096/FJ.201700227RRR.
Syncytium calcium signaling and macrophage function in the heart
Cell & Bioscience. 2018; 8(1):. DOI:10.1186/S13578-018-0222-6.
2017
A Bioinspired Alginate-Gum Arabic Hydrogel with Micro-/Nanoscale Structures for Controlled Drug Release in Chronic Wound Healing
ACS Applied Materials & Interfaces. 2017; 9(27): 22160 - 22175. DOI:10.1021/ACSAMI.7B04428.
A Function of ECM HF in the Oocyte Maturation
Mechanisms of Development. 2017; 145((Supp.)): S96 - S97. DOI:10.1016/J.MOD.2017.04.247.
Absence of physiological Ca2+ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation
Skeletal Muscle. 2017; 7(1):. DOI:10.1186/S13395-017-0123-0.
Characterization of tubular liquid crystal structure in embryonic stem cell derived embryoid bodies
Cell & Bioscience. 2017; 7(1):. DOI:10.1186/S13578-016-0130-6.
In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice
Circulation Research. 2017; 121(8): 923 - 929. DOI:10.1161/CIRCRESAHA.117.310996.
Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury
Science Translational Medicine. 2017; 9(418):. DOI:10.1126/SCITRANSLMED.AAO6298.
MG29 Interacts with Bin1 for Maintaining T-Tubule Structure in Skeletal Muscle Physiology and Regeneration
Biophysical Journal. 2017; 112(3 (Supp.)): 118a. DOI:10.1016/J.BPJ.2016.11.665.
MG53 Interacts with Cardiolipin to Protect Mitochondria from Ischemia-Reperfusion Induced Oxidative Stress
Biophysical Journal. 2017; 112(3 (Supp.)): 102a. DOI:10.1016/J.BPJ.2016.11.585.
MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress
Journal of Molecular and Cellular Cardiology. 2017; 112: 123 - 130. DOI:10.1016/J.YJMCC.2017.08.007.
MG53 Negatively Regulates NLRP3 to Inhibit Inflammation Associated with Tissue Injury
Biophysical Journal. 2017; 112(3 (Supp.)): 532a. DOI:10.1016/J.BPJ.2016.11.2876.
MG53-Mediated Protection in Heart Valve Biology
Biophysical Journal. 2017; 112(3 (Supp.)): 221a. DOI:10.1016/J.BPJ.2016.11.1220.
MG56, A Membrane Bound O-Acyltransferase Protein, Regulates Lipid Composition and Membrane Vesicle Size in Skeletal Muscle
Biophysical Journal. 2017; 112(3 (Supp.)): 85a - 86a. DOI:10.1016/J.BPJ.2016.11.505.
Mitsugumin 29 regulates t-tubule architecture in the failing heart
Scientific Reports. 2017; 7(1):. DOI:10.1038/S41598-017-05284-2.
Mitsugumin 53 Regulates Extracellular Ca 2+ Entry and Intracellular CA 2+ Release via Orai1 and RyR1 in Skeletal Muscle
Biophysical Journal. 2017; 112(3 (Supp.)): 98a. DOI:10.1016/J.BPJ.2016.11.568.
Optimizing Conditions for Calcium Phosphate Mediated Transient Transfection
Saudi Journal of Biological Sciences. 2017; 24(3): 622 - 629. DOI:10.1016/J.SJBS.2017.01.034.
Super-Resolution Image Reconstruction for High-Density Three-Dimensional Single-Molecule Microscopy
IEEE Transactions on Computational Imaging. 2017; 3(4): 763 - 773. DOI:10.1109/TCI.2017.2699425.
Sustained Release of a Peptide-Based Matrix Metalloproteinase-2 Inhibitor to Attenuate Adverse Cardiac Remodeling and Improve Cardiac Function Following Myocardial Infarction
Biomacromolecules. 2017; 18(9): 2820 - 2829. DOI:10.1021/ACS.BIOMAC.7B00760.
Transportation of liquid crystal and CaCO 3 vaterite crystal in chicken embryo and early postnatal development
Molecular Crystals and Liquid Crystals. 2017; 647(1): 373 - 384. DOI:10.1080/15421406.2017.1289652.
TRIM Family Proteins in Intracellular Vesicle Trafficking
Biophysical Journal. 2017; 112(3 (Supp.)): 239a. DOI:10.1016/J.BPJ.2016.11.1306.
Wip1-dependent modulation of macrophage migration and phagocytosis
Redox Biology. 2017; 13: 665 - 673. DOI:10.1016/J.REDOX.2017.08.006.
Zinc in Wound Healing Modulation
Nutrients. 2017; 10(1): 16. DOI:10.3390/NU10010016.
2016
Absence of Physiological Calcium Transients Triggers Mitochondrial ROS Production in Skeletal Muscle Following Denervation
Biophysical Journal. 2016; 110(3 (Supp.)): 311a. DOI:10.1016/J.BPJ.2015.11.1669.
Abstract 2612: Zinc inhibits Orai1-mediated Ca2+ signals and proliferation in esophageal cancer cells
Cancer Research. 2016; 76(14_Supplement): 2612 - 2612. DOI:10.1158/1538-7445.AM2016-2612.
Abstract 626: Oxidized Low-density Lipoprotein-induced Cell Membrane Damage in Bone Marrow Stem Cells is Independent of ROS Formation
Arteriosclerosis, Thrombosis, and Vascular Biology. 2016; 36(suppl_1):. DOI:10.1161/ATVB.36.SUPPL_1.626.
Autophagy, Innate Immunity and Tissue Repair in Acute Kidney Injury
International Journal of Molecular Sciences. 2016; 17(5): 662. DOI:10.3390/IJMS17050662.
CRISPR-mediated genome editing restores dystrophin expression and function in mdx mice
Molecular Therapy. 2016; 24(3): 564 - 569. DOI:10.1038/MT.2015.192.
Dual function of MG53 in membrane repair and insulin signaling
BMB Reports. 2016; 49(8): 414 - 423. DOI:10.5483/BMBREP.2016.49.8.079.
Fast Two Dimensional Superresolution Image Reconstruction Algorithm for Ultrahigh Emitter Density
Biophysical Journal. 2016; 110(3 (Supp.)): 170a. DOI:10.1016/J.BPJ.2015.11.945.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy. 2016; 12(1): 1 - 222. DOI:10.1080/15548627.2015.1100356.
Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1–Mediated Lipogenesis
Clinical Cancer Research. 2016; 22(21): 5337 - 5348. DOI:10.1158/1078-0432.CCR-15-2973.
Liver-specific NG37 overexpression leads to diet-dependent fatty liver disease accompanied by cardiac dysfunction
Genes and Nutrition. 2016; 11(1):. DOI:10.1186/S12263-016-0529-Z.
MG53 permeates through blood-brain barrier to protect ischemic brain injury
Oncotarget. 2016; 7(16): 22474 - 22485. DOI:10.18632/ONCOTARGET.7965.
MG53 Promotes Wound Healing and Reduces Scar Formation by Facilitating Cell Membrane Repair and Controlling Myofibroblast Differentiation
Biophysical Journal. 2016; 110(3 (Supp.)): 589a. DOI:10.1016/J.BPJ.2015.11.3145.
Mitsugumin 53 regulates extracellular Ca2+ entry and intracellular Ca2+ release via Orai1 and RyR1 in skeletal muscle
Scientific Reports. 2016; 6(1):. DOI:10.1038/SREP36909.
Quantifying Drug-Induced Nanomechanics and Mechanical Effects to Single Cardiomyocytes for Optimal Drug Administration To Minimize Cardiotoxicity
Langmuir. 2016; 32(7): 1909 - 1919. DOI:10.1021/ACS.LANGMUIR.5B04314.
Roles of Mitsugumin53 in Skeletal Muscle
Biophysical Journal. 2016; 110(3 (Supp.)): 600a. DOI:10.1016/J.BPJ.2015.11.3205.
Roles of the novel coiled-coil protein Rng10 in septum formation during fission yeast cytokinesis
Molecular Biology of the Cell. 2016; 27(16): 2528 - 2541. DOI:10.1091/MBC.E16-03-0156.
Sundew-Inspired Adhesive Hydrogels Combined with Adipose-Derived Stem Cells for Wound Healing
ACS Applied Materials & Interfaces. 2016; 8(3): 2423 - 2434. DOI:10.1021/ACSAMI.5B11811.
Zinc Binding to MG53 Facilitates Repair of Injury to Cell Membrane
Biophysical Journal. 2016; 110(3 (Supp.)): 589a. DOI:10.1016/J.BPJ.2015.11.3146.
Zinc Inhibits Orai1-Mediated Calcium Signals in Esophageal Cancer Cells
Biophysical Journal. 2016; 110(3 (Supp.)): 264a. DOI:10.1016/J.BPJ.2015.11.1443.