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Jianjie Ma, PhD

Jianjie Ma, PhD

Professor, Surgery

Primary Location
81 Hospital Dr
Charlottesville, Virginia 22903

Bio & Overview

Dr. Ma's laboratory investigates the biology of MG53/TRIM72, a muscle-derived protein essential for cell membrane repair, and its physiological roles across skeletal muscle, cardiac, and other tissues. Ongoing projects apply MG53 biology to muscle aging and sarcopenia, virus-induced cardiopulmonary injuries, Alzheimer's disease, cancer, and diabetes, with the goal of developing MG53-based therapeutics for tissue repair and regenerative medicine. The lab combines CRISPR gene editing, AAV gene delivery, and advanced imaging with pharmaceutical partnerships to translate basic findings into treatments for human disease. As Director of the Division of Surgical Sciences (DOSS), Dr. Ma also fosters team-based, collaborative research and mentors junior surgeon-scientists across the Department of Surgery.

Academic Information

Department
Surgery

Primary Education

  • B.S., Physics, Wuhan University, 1983
  • Ph.D., Physiology & Biophysics, Baylor College of Medicine, 1989
  • Postdoctoral, Physiology & Biophysics, Rush University School of Medicine, 1991

Research Interests

Physiology & Biophysics

Research Disciplines

  • Biotechnology
  • Cardiovascular Biology
  • Cell and Developmental Biology
  • Molecular and Cellular Physiology
  • Translational Science

Research Opportunities

  • Bioinformatics & Genomics
  • Cancer Biology
  • Development, Stem Cells & Regeneration
  • Experimental Pathology
  • Immunology
  • Neuroimmunology

PhD Programs

  • Cell Biology
  • Experimental Pathology

Selected Publications

2026

Aldh3a1-mediated detoxification of reactive aldehydes contributes to distinct muscle responses to amyotrophic lateral sclerosis progression
Free Radical Biology and Medicine. 2026; 249: 469 - 488. DOI:10.1016/J.FREERADBIOMED.2026.03.037.

Humanized Citrullinated Histone H3 Monoclonal Antibody Improves Respiratory Function and Attenuates Neutrophil-Mediated Inflammation in a Rodent Model of Smoke Inhalation Lung Injury
Journal of the American College of Surgeons. 2026; 242(1): 1 - 12. DOI:10.1097/XCS.0000000000001620.

MG53 mediates skeletal muscle-liver cross-talk and enhances alcohol metabolism in alcoholic liver disease
Nature Communications. 2026; 17(1):. DOI:10.1038/S41467-026-69132-6.

MG53 protects against intestinal inflammation by inhibiting NLRP3 inflammasome activation
Frontiers in Pharmacology. 2026; 17:. DOI:10.3389/FPHAR.2026.1791509.

MG53 protects against septic cardiac dysfunction by ubiquitinating ATF2
Journal of Advanced Research. 2026; 79: 263 - 275. DOI:10.1016/J.JARE.2025.03.031.

Mitsugumin 53 protects against smoke inhalation lung injury via suppressing the proinflammatory response in a rat model
Free Radical Biology and Medicine. 2026; 248: 43 - 51. DOI:10.1016/J.FREERADBIOMED.2026.02.027.

TRIC-A Loss Sensitizes the Heart to β-Adrenergic Stress and Drives Cardiomyocyte Death and Fibrosis
Biomolecules. 2026; 16(2): 181. DOI:10.3390/BIOM16020181.

2025

A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis
Nature Communications. 2025; 16(1):. DOI:10.1038/S41467-025-62788-6.

BPS2025 - Adeno-associated virus-enforced ALDH3A1 expression protects myotubes against 4-HNE-induced cytotoxicity and restores MG53-mediated membrane repair
Biophysical Journal. 2025; 124(3 (Supp.)): 112a - 113a. DOI:10.1016/J.BPJ.2024.11.654.

BPS2025 - Lipid wasting and peroxidation contribute to impaired membrane repair function in skeletal muscle of ALS mice
Biophysical Journal. 2025; 124(3 (Supp.)): 113a. DOI:10.1016/J.BPJ.2024.11.656.

CitH3, a Druggable Biomarker for Human Diseases Associated with Acute NETosis and Chronic Immune Dysfunction
Pharmaceutics. 2025; 17(7): 809. DOI:10.3390/PHARMACEUTICS17070809.

Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury
Advanced Science. 2025; 12(18):. DOI:10.1002/ADVS.202413253.

Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury (Adv. Sci. 18/2025)
Advanced Science. 2025; 12(18):. DOI:10.1002/ADVS.202570132.

Corrigendum to “MG53 Protein-Mediated biomimetic nanotherapeutics for the treatment of acute myocardial infarction by driving the impaired plasma membrane resealing” [Chem. Eng. J. (2024) 157091]
Chemical Engineering Journal. 2025; 505: 159646. DOI:10.1016/J.CEJ.2025.159646.

Development of an Ophthalmic Hydrogel to Deliver MG53 and Promote Corneal Wound Healing
Pharmaceutics. 2025; 17(4): 526. DOI:10.3390/PHARMACEUTICS17040526.

Editorial: The role of autophagy in cardiovascular disease
Frontiers in Cell and Developmental Biology. 2025; 13:. DOI:10.3389/FCELL.2025.1697218.

Humanized Monoclonal Antibody Against Citrullinated Histone H3 Attenuates Myocardial Injury and Prevents Heart Failure in Rodent Models
Biomolecules. 2025; 15(8): 1196. DOI:10.3390/BIOM15081196.

Molecular mechanism on autophagy associated cardiovascular dysfunction in Drosophila melanogaster
Frontiers in Cell and Developmental Biology. 2025; 13:. DOI:10.3389/FCELL.2025.1512341.

Synergistic inhibition of CitH3 and S100A8/A9: A novel therapeutic strategy for mitigating sepsis-induced inflammation and lung injury
International Journal of Immunopathology and Pharmacology. 2025; 39:. DOI:10.1177/03946320251338661.

TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis
Molecular Therapy – Nucleic Acids. 2025; 36(1): 102460. DOI:10.1016/J.OMTN.2025.102460.

Treatment with MG53 ameliorates traumatic brain injury–associated acute kidney injury
The Journal of Trauma and Acute Care Surgery. 2025; 99(5): 732 - 739. DOI:10.1097/TA.0000000000004660.

TRIC-A Facilitates Sarcoplasmic Reticulum–Mitochondrial Ca2+ Signaling Crosstalk in Cardiomyocytes
Cells. 2025; 14(20): 1579. DOI:10.3390/CELLS14201579.

2024

AFM41a: A Novel PAD2 Inhibitor for Sepsis Treatment—Efficacy and Mechanism
International Journal of Biological Sciences. 2024; 20(13): 5043 - 5055. DOI:10.7150/IJBS.97166.

Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice
eLife. 2024; 12:. DOI:10.7554/ELIFE.92644.

Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice
eLife. 2024; 12:. DOI:10.7554/ELIFE.92644.4.

Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation
Nature Communications. 2024; 15(1):. DOI:10.1038/S41467-024-47067-0.

Loss of PADI2 and PADI4 ameliorates sepsis-induced acute lung injury by suppressing NLRP3+ macrophages
JCI Insight. 2024; 9(22):. DOI:10.1172/JCI.INSIGHT.181686.

MG53 binding to CAV3 facilitates activation of eNOS/NO signaling pathway to enhance the therapeutic benefits of bone marrow-derived mesenchymal stem cells in diabetic wound healing
International Immunopharmacology. 2024; 136: 112410. DOI:10.1016/J.INTIMP.2024.112410.

MG53 Mitigates Warm Ischemic Lung Injury in A Murine Model of Transplantation
Journal of Thoracic and Cardiovascular Surgery. 2024; 168(1): e13 - e26. DOI:10.1016/J.JTCVS.2023.10.056.

MG53 Protein-Mediated biomimetic nanotherapeutics for the treatment of acute myocardial infarction by driving the impaired plasma membrane resealing
Chemical Engineering Journal. 2024; 500: 157091. DOI:10.1016/J.CEJ.2024.157091.

MG53 suppresses tumor growth via transcriptional inhibition of KIF11 in pancreatic cancer
Translational Oncology. 2024; 50: 102118. DOI:10.1016/J.TRANON.2024.102118.

Mitsugumin 53 mitigation of ischemia–reperfusion injury in a mouse model
Journal of Thoracic and Cardiovascular Surgery. 2024; 167(3): e48 - e58. DOI:10.1016/J.JTCVS.2023.08.005.

2023

Abstract 1729: MG53 suppresses the tumor growth via transcriptional inhibiting the expression of KIF11 in pancreatic cancer
Cancer Research. 2023; 83(7_Supplement): 1729 - 1729. DOI:10.1158/1538-7445.AM2023-1729.

Activation of MG53 Enhances Cell Survival and Engraftment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Injured Hearts
Stem Cell Reviews and Reports. 2023; 19(7): 2420 - 2428. DOI:10.1007/S12015-023-10596-0.

Butyrate endows extraocular muscle stem cell-like transcriptomic patterns that ameliorate satellite cell depletion and denervation to slow ALS progression
Biophysical Journal. 2023; 122(3 (Supp.)): 27a. DOI:10.1016/J.BPJ.2022.11.370.

Cardiac-Specific Expression of Cre Recombinase Leads to Age-Related Cardiac Dysfunction Associated with Tumor-like Growth of Atrial Cardiomyocyte and Ventricular Fibrosis and Ferroptosis
International Journal of Molecular Sciences. 2023; 24(4): 3094. DOI:10.3390/IJMS24043094.

Interferon‐induced transmembrane protein 3 (IFITM3) limits lethality of SARS‐CoV‐2 in mice
EMBO Reports. 2023; 24(4):. DOI:10.15252/EMBR.202256660.

MG53 Mitigates Nitrogen Mustard-Induced Skin Injury
Cells. 2023; 12(14): 1915. DOI:10.3390/CELLS12141915.

Quantification of autophagy flux in isolated mouse skeletal muscle fibers with overexpression of fluorescent protein mCherry-EGFP-LC3
STAR Protocols. 2023; 4(1): 101871. DOI:10.1016/J.XPRO.2022.101871.

Transient depletion of macrophages alters local inflammatory response at the site of disc herniation in a transgenic mouse model
Osteoarthritis and Cartilage. 2023; 31(7): 894 - 907. DOI:10.1016/J.JOCA.2023.01.574.

2022

A Protocol for Immunohistochemistry and RNA In-situ Distribution within Early Drosophila Embryo
Journal of Visualized Experiments. 2022; . DOI:10.3791/61776.

A Protocol for Immunohistochemistry and RNA In-situ Distribution within Early Drosophila Embryo
Journal of Visualized Experiments. 2022; . DOI:10.3791/61776-V.

Abstract GS113: Inflammasome Primed Neutrophils Regulate Myocardial Infarction Induced Myelopoiesis
Circulation Research. 2022; 131(Suppl_1):. DOI:10.1161/RES.131.SUPPL_1.GS113.

CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy
Molecular Therapy. 2022; 30(1): 54 - 74. DOI:10.1016/J.YMTHE.2021.10.015.

Deficient Sarcolemma Repair in ALS: A Novel Mechanism with Therapeutic Potential
Cells. 2022; 11(20): 3263. DOI:10.3390/CELLS11203263.

Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis
Science Advances. 2022; 8(19):. DOI:10.1126/SCIADV.ABM5371.

Membrane-delimited signaling and cytosolic action of MG53 preserve hepatocyte integrity during drug-induced liver injury
Journal of Hepatology. 2022; 76(3): 558 - 567. DOI:10.1016/J.JHEP.2021.10.017.

MG53 attenuates nitrogen mustard‐induced acute lung injury
Journal of Cellular and Molecular Medicine. 2022; 26(7): 1886 - 1895. DOI:10.1111/JCMM.16917.

MG53 inhibits cellular proliferation and tumor progression in colorectal carcinoma
International Journal of Biological Sciences. 2022; 18(14): 5221 - 5229. DOI:10.7150/IJBS.67869.

MG53 Inhibits Necroptosis Through Ubiquitination-Dependent RIPK1 Degradation for Cardiac Protection Following Ischemia/Reperfusion Injury
Frontiers in Cardiovascular Medicine. 2022; 9:. DOI:10.3389/FCVM.2022.868632.

MG53 preserves mitochondrial integrity of cardiomyocytes during ischemia reperfusion-induced oxidative stress
Redox Biology. 2022; 54: 102357. DOI:10.1016/J.REDOX.2022.102357.

Mitochondrial Membrane Potential Identifies a Subpopulation of Mesenchymal Progenitor Cells to Promote Angiogenesis and Myocardial Repair
Cells. 2022; 11(10): 1713. DOI:10.3390/CELLS11101713.

Recombinant human MG53 protein attenuates brain lesion size in a large animal model of traumatic brain injury
The Journal of Trauma and Acute Care Surgery. 2022; 93(5): 613 - 619. DOI:10.1097/TA.0000000000003746.

Reply to: “Protection against acetaminophen-induced liver injury with MG53: Muscle-liver axis and necroptosis”
Journal of Hepatology. 2022; 77(2): 562 - 563. DOI:10.1016/J.JHEP.2022.04.024.

Retention of the NLRP3 Inflammasome–Primed Neutrophils in the Bone Marrow Is Essential for Myocardial Infarction–Induced Granulopoiesis
Circulation. 2022; 145(1): 31 - 44. DOI:10.1161/CIRCULATIONAHA.121.056019.

Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development
Bioactive Materials. 2022; 18: 104 - 115. DOI:10.1016/J.BIOACTMAT.2022.03.017.

The cell membrane repair protein MG53 modulates transcription factor NF-κB signaling to control kidney fibrosis
Kidney International. 2022; 101(1): 119 - 130. DOI:10.1016/J.KINT.2021.09.027.

The Prognostic Significance of FKBP1A and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma
International Journal of Molecular Sciences. 2022; 23(21): 12797. DOI:10.3390/IJMS232112797.

2021

A Rat Lung Transplantation Model of Warm Ischemia/Reperfusion Injury: Optimizations to Improve Outcomes
Journal of Visualized Experiments. 2021; . DOI:10.3791/62445.

A Rat Lung Transplantation Model of Warm Ischemia/Reperfusion Injury: Optimizations to Improve Outcomes
Journal of Visualized Experiments. 2021; . DOI:10.3791/62445-V.

Abstract 11086: MG53 Suppresses NfκB Activation to Mitigate Age-Related Heart Failure
Circulation. 2021; 144(Suppl_1):. DOI:10.1161/CIRC.144.SUPPL_1.11086.

Abstract 13835: MG53 Preserves Mitochondrial Integrity of Cardiomyocytes in Pre-Clinical Models of Ischemia Reperfusion-Induced Oxidative Stress
Circulation. 2021; 144(Suppl_1):. DOI:10.1161/CIRC.144.SUPPL_1.13835.

Abstract 13996: Retention of the NLRP3 Inflammasome-Primed Neutrophils in the Bone Marrow is Essential for Myocardial Infarction-Induced Granulopoiesis
Circulation. 2021; 144(Suppl_1):. DOI:10.1161/CIRC.144.SUPPL_1.13996.

Abstract MP221: Early Recruitment Of Neutrophils To The Ischemic Heart Is Orchestrated By Catecholamine-induced Demargination
Circulation Research. 2021; 129(Suppl_1):. DOI:10.1161/RES.129.SUPPL_1.MP221.

Abstract MP231: Long Non-coding Rna Camirt Plays A Sentinel Role In Aging-related Heart Failure Via Interaction With Phb2 To Modulate Mitophagy Signaling In The Heart
Circulation Research. 2021; 129(Suppl_1):. DOI:10.1161/RES.129.SUPPL_1.MP231.

Butyrate Feeding Reverses CypD-Related Mitoflash Phenotypes in Mouse Myofibers
International Journal of Molecular Sciences. 2021; 22(14): 7412. DOI:10.3390/IJMS22147412.

Cardiac effects and clinical applications of MG53
Cell & Bioscience. 2021; 11(1):. DOI:10.1186/S13578-021-00629-X.

Correction to: The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury
Stem Cell Research and Therapy. 2021; 12(1):. DOI:10.1186/S13287-021-02598-X.

Efficient precise in vivo base editing in adult dystrophic mice
Nature Communications. 2021; 12(1):. DOI:10.1038/S41467-021-23996-Y.

Meet Our Editorial Board Member
Current Chemical Biology. 2021; 15(1): 2 - 3. DOI:10.2174/221279681501210407102457.

MG53 as a Novel Therapeutic Protein to Treat Acute Lung Injury
Military Medicine. 2021; 186(Supplement_1): 339 - 345. DOI:10.1093/MILMED/USAA313.

MG53 Preserves Neuromuscular Junction Integrity and Alleviates ALS Disease Progression
Antioxidants. 2021; 10(10): 1522. DOI:10.3390/ANTIOX10101522.

MG53 suppresses NF-κB activation to mitigate age-related heart failure
JCI Insight. 2021; 6(17):. DOI:10.1172/JCI.INSIGHT.148375.

MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer
Molecular Cancer. 2021; 20(1):. DOI:10.1186/S12943-021-01418-3.

MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine
Cells. 2021; 10(1): 122. DOI:10.3390/CELLS10010122.

Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration
Current Opinion in Pharmacology. 2021; 59: 26 - 32. DOI:10.1016/J.COPH.2021.04.005.

Peptidylarginine Deiminases 2 Mediates Caspase-1-Associated Lethality in Pseudomonas aeruginosa Pneumonia-Induced Sepsis
Journal of Infectious Diseases. 2021; 223(6): 1093 - 1102. DOI:10.1093/INFDIS/JIAA475.

Recombinant Human MG53 Protein Protects Against Alkaline-Induced Corneal Injuries in Mice
Military Medicine. 2021; 186(Supplement_1): 486 - 490. DOI:10.1093/MILMED/USAA357.

Recombinant MG53 Protein Protects Mice from Lethal Influenza Virus Infection
American Journal of Respiratory and Critical Care Medicine. 2021; 203(2): 254 - 257. DOI:10.1164/RCCM.202007-2908LE.

TRIC-A regulates intracellular Ca2+ homeostasis in cardiomyocytes
Pflugers Archiv European Journal of Physiology. 2021; 473(3): 547 - 556. DOI:10.1007/S00424-021-02513-6.

2020

Calcium-dependent Protein Kinases in Malaria Parasite Development and Infection
Cell Transplantation. 2020; 29: 096368971988488. DOI:10.1177/0963689719884888.

Correction to: A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model
Cell & Bioscience. 2020; 10(1):. DOI:10.1186/S13578-020-00421-3.

Corrigendum to “A systematic comparison of exercise training protocols on animal models of cardiovascular capacity” [Life Sci. 217 (2019) 128–140]
Life Sciences. 2020; 254: 117757. DOI:10.1016/J.LFS.2020.117757.

MG53 Does Not Manifest the Development of Diabetes in db/db Mice
Diabetes. 2020; 69(5): 1052 - 1064. DOI:10.2337/DB19-0807.

MG53 protects against contrast-induced acute kidney injury by reducing cell membrane damage and apoptosis
Acta Pharmacologica Sinica. 2020; 41(11): 1457 - 1464. DOI:10.1038/S41401-020-0420-8.

MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling
Nature Communications. 2020; 11(1):. DOI:10.1038/S41467-020-17177-6.

Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration
Frontiers in Physiology. 2020; 11:. DOI:10.3389/FPHYS.2020.583393.

N‐acetylcysteine prevents oxidized low‐density lipoprotein‐induced reduction of MG53 and enhances MG53 protective effect on bone marrow stem cells
Journal of Cellular and Molecular Medicine. 2020; 24(1): 886 - 898. DOI:10.1111/JCMM.14798.

Nonalcoholic fatty liver disease experiences accumulation of hepatic liquid crystal associated with increasing lipophagy
Cell & Bioscience. 2020; 10(1):. DOI:10.1186/S13578-020-00414-2.

Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis
JCI Insight. 2020; 5(20):. DOI:10.1172/JCI.INSIGHT.138873.

TRIC-A Channel Maintains Store Calcium Handling by Interacting with Type 2 Ryanodine Receptor in Cardiac Muscle
Circulation Research. 2020; 126(4): 417 - 435. DOI:10.1161/CIRCRESAHA.119.316241.

TRIC-A Channel Modulates Ca2+ Homeostasis in Mitochondria
Biophysical Journal. 2020; 118(3 (Supp.)): 448a. DOI:10.1016/J.BPJ.2019.11.2502.

Use of the mesentery and peritoneum to facilitate the absorption of yolk sac nutrients into viscera of the developing chick: novel function for this organ
Mesentery and Peritoneum. 2020; 2: 1 - 1. DOI:10.21037/MAP.2019.03.01.

2019

A systematic comparison of exercise training protocols on animal models of cardiovascular capacity
Life Sciences. 2019; 217: 128 - 140. DOI:10.1016/J.LFS.2018.12.001.

Diabetes inhibits corneal epithelial cell migration and tight junction formation in mice and human via increasing ROS and impairing Akt signaling
Acta Pharmacologica Sinica. 2019; 40(9): 1205 - 1211. DOI:10.1038/S41401-019-0223-Y.

Dynamics expression of DmFKBP12/Calstabin during embryonic early development of Drosophila melanogaster
Cell & Bioscience. 2019; 9(1):. DOI:10.1186/S13578-019-0270-6.

Exercise-induced myokine FNDC5/irisin functions in cardiovascular protection and intracerebral retrieval of synaptic plasticity
Cell & Bioscience. 2019; 9(1):. DOI:10.1186/S13578-019-0294-Y.

Exogenous MG53 Protects Adult Mouse Cardiomyocytes by Preventing Mitochondria Damage in Response to Oxidative Stress
The FASEB Journal. 2019; 33(S1):. DOI:10.1096/FASEBJ.2019.33.1_SUPPLEMENT.833.3.

Extraocular muscle function is impaired in ryr3 −/− mice
The Journal of General Physiology. 2019; 151(7): 929 - 943. DOI:10.1085/JGP.201912333.

MG53 attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation via inhibiting TLR4/NF-κB pathway in vitro and in vivo
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019; 95: 109684. DOI:10.1016/J.PNPBP.2019.109684.

MG53 promotes corneal wound healing and mitigates fibrotic remodeling in rodents
Communications Biology. 2019; 2(1):. DOI:10.1038/S42003-019-0316-7.

MG53 Protein Protects Aortic Valve Interstitial Cells from Membrane Injury and Fibrocalcific Remodeling
The FASEB Journal. 2019; 33(S1):. DOI:10.1096/FASEBJ.2019.33.1_SUPPLEMENT.833.16.

MG53 Protein Protects Aortic Valve Interstitial Cells From Membrane Injury and Fibrocalcific Remodeling
Journal of the American Heart Association. 2019; 8(4):. DOI:10.1161/JAHA.118.009960.

Physical exercise: bulking up neurogenesis in human adults
Cell & Bioscience. 2019; 9(1):. DOI:10.1186/S13578-019-0337-4.

Spatiotemporal delivery of basic fibroblast growth factor to directly and simultaneously attenuate cardiac fibrosis and promote cardiac tissue vascularization following myocardial infarction
Journal of Controlled Release. 2019; 311-312: 233 - 244. DOI:10.1016/J.JCONREL.2019.09.005.

Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
Nature Communications. 2019; 10(1):. DOI:10.1038/S41467-019-12483-0.

The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury
Stem Cell Research and Therapy. 2019; 10(1):. DOI:10.1186/S13287-019-1433-4.

Thermosensitive, fast gelling, photoluminescent, highly flexible, and degradable hydrogels for stem cell delivery
Acta Biomaterialia. 2019; 83: 96 - 108. DOI:10.1016/J.ACTBIO.2018.10.038.

Topical Application of Recombinant Human MG53 Protein Facilitates Healing of Chronic Wounds in Diabetic Mice
The FASEB Journal. 2019; 33(S1):. DOI:10.1096/FASEBJ.2019.33.1_SUPPLEMENT.662.26.

2018

A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model
Cell & Bioscience. 2018; 8(1):. DOI:10.1186/S13578-018-0226-2.

Altered Eye Muscle Function in RYR3KO Mice
Biophysical Journal. 2018; 114(3 (Supp.)): 469a. DOI:10.1016/J.BPJ.2017.11.2585.

An Injectable Oxygen Release System to Augment Cell Survival and Promote Cardiac Repair Following Myocardial Infarction
Scientific Reports. 2018; 8(1):. DOI:10.1038/S41598-018-19906-W.

Calcium and CaSR/IP3R in prostate cancer development
Cell & Bioscience. 2018; 8(1):. DOI:10.1186/S13578-018-0217-3.

Calcium signaling: an underlying link between cardiac disease and carcinogenesis
Cell & Bioscience. 2018; 8(1):. DOI:10.1186/S13578-018-0236-0.

Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster
BMC Developmental Biology. 2018; 18(1):. DOI:10.1186/S12861-018-0167-3.

Irisin Protects Heart Against Ischemia-Reperfusion Injury Through a SOD2-Dependent Mitochondria Mechanism
Journal of Cardiovascular Pharmacology. 2018; 72(6): 259 - 269. DOI:10.1097/FJC.0000000000000608.

mTORC1 controls lysosomal Ca 2+ release through the two-pore channel TPC2
Science Signaling. 2018; 11(525):. DOI:10.1126/SCISIGNAL.AAO5775.

Quantum confined peptide assemblies with tunable visible to near-infrared spectral range
Nature Communications. 2018; 9(1):. DOI:10.1038/S41467-018-05568-9.

ROS-related mitochondrial dysfunction in skeletal muscle of an ALS mouse model during the disease progression
Pharmacological Research. 2018; 138: 25 - 36. DOI:10.1016/J.PHRS.2018.09.008.

Selective inhibitory effects of zinc on cell proliferation in esophageal squamous cell carcinoma through Orai1
The FASEB Journal. 2018; 32(1): 404 - 416. DOI:10.1096/FJ.201700227RRR.

Syncytium calcium signaling and macrophage function in the heart
Cell & Bioscience. 2018; 8(1):. DOI:10.1186/S13578-018-0222-6.

2017

A Bioinspired Alginate-Gum Arabic Hydrogel with Micro-/Nanoscale Structures for Controlled Drug Release in Chronic Wound Healing
ACS Applied Materials & Interfaces. 2017; 9(27): 22160 - 22175. DOI:10.1021/ACSAMI.7B04428.

A Function of ECM HF in the Oocyte Maturation
Mechanisms of Development. 2017; 145((Supp.)): S96 - S97. DOI:10.1016/J.MOD.2017.04.247.

Absence of physiological Ca2+ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation
Skeletal Muscle. 2017; 7(1):. DOI:10.1186/S13395-017-0123-0.

Characterization of tubular liquid crystal structure in embryonic stem cell derived embryoid bodies
Cell & Bioscience. 2017; 7(1):. DOI:10.1186/S13578-016-0130-6.

In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice
Circulation Research. 2017; 121(8): 923 - 929. DOI:10.1161/CIRCRESAHA.117.310996.

Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury
Science Translational Medicine. 2017; 9(418):. DOI:10.1126/SCITRANSLMED.AAO6298.

MG29 Interacts with Bin1 for Maintaining T-Tubule Structure in Skeletal Muscle Physiology and Regeneration
Biophysical Journal. 2017; 112(3 (Supp.)): 118a. DOI:10.1016/J.BPJ.2016.11.665.

MG53 Interacts with Cardiolipin to Protect Mitochondria from Ischemia-Reperfusion Induced Oxidative Stress
Biophysical Journal. 2017; 112(3 (Supp.)): 102a. DOI:10.1016/J.BPJ.2016.11.585.

MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress
Journal of Molecular and Cellular Cardiology. 2017; 112: 123 - 130. DOI:10.1016/J.YJMCC.2017.08.007.

MG53 Negatively Regulates NLRP3 to Inhibit Inflammation Associated with Tissue Injury
Biophysical Journal. 2017; 112(3 (Supp.)): 532a. DOI:10.1016/J.BPJ.2016.11.2876.

MG53-Mediated Protection in Heart Valve Biology
Biophysical Journal. 2017; 112(3 (Supp.)): 221a. DOI:10.1016/J.BPJ.2016.11.1220.

MG56, A Membrane Bound O-Acyltransferase Protein, Regulates Lipid Composition and Membrane Vesicle Size in Skeletal Muscle
Biophysical Journal. 2017; 112(3 (Supp.)): 85a - 86a. DOI:10.1016/J.BPJ.2016.11.505.

Mitsugumin 29 regulates t-tubule architecture in the failing heart
Scientific Reports. 2017; 7(1):. DOI:10.1038/S41598-017-05284-2.

Mitsugumin 53 Regulates Extracellular Ca 2+ Entry and Intracellular CA 2+ Release via Orai1 and RyR1 in Skeletal Muscle
Biophysical Journal. 2017; 112(3 (Supp.)): 98a. DOI:10.1016/J.BPJ.2016.11.568.

Optimizing Conditions for Calcium Phosphate Mediated Transient Transfection
Saudi Journal of Biological Sciences. 2017; 24(3): 622 - 629. DOI:10.1016/J.SJBS.2017.01.034.

Super-Resolution Image Reconstruction for High-Density Three-Dimensional Single-Molecule Microscopy
IEEE Transactions on Computational Imaging. 2017; 3(4): 763 - 773. DOI:10.1109/TCI.2017.2699425.

Sustained Release of a Peptide-Based Matrix Metalloproteinase-2 Inhibitor to Attenuate Adverse Cardiac Remodeling and Improve Cardiac Function Following Myocardial Infarction
Biomacromolecules. 2017; 18(9): 2820 - 2829. DOI:10.1021/ACS.BIOMAC.7B00760.

Transportation of liquid crystal and CaCO 3 vaterite crystal in chicken embryo and early postnatal development
Molecular Crystals and Liquid Crystals. 2017; 647(1): 373 - 384. DOI:10.1080/15421406.2017.1289652.

TRIM Family Proteins in Intracellular Vesicle Trafficking
Biophysical Journal. 2017; 112(3 (Supp.)): 239a. DOI:10.1016/J.BPJ.2016.11.1306.

Wip1-dependent modulation of macrophage migration and phagocytosis
Redox Biology. 2017; 13: 665 - 673. DOI:10.1016/J.REDOX.2017.08.006.

Zinc in Wound Healing Modulation
Nutrients. 2017; 10(1): 16. DOI:10.3390/NU10010016.

2016

Absence of Physiological Calcium Transients Triggers Mitochondrial ROS Production in Skeletal Muscle Following Denervation
Biophysical Journal. 2016; 110(3 (Supp.)): 311a. DOI:10.1016/J.BPJ.2015.11.1669.

Abstract 2612: Zinc inhibits Orai1-mediated Ca2+ signals and proliferation in esophageal cancer cells
Cancer Research. 2016; 76(14_Supplement): 2612 - 2612. DOI:10.1158/1538-7445.AM2016-2612.

Abstract 626: Oxidized Low-density Lipoprotein-induced Cell Membrane Damage in Bone Marrow Stem Cells is Independent of ROS Formation
Arteriosclerosis, Thrombosis, and Vascular Biology. 2016; 36(suppl_1):. DOI:10.1161/ATVB.36.SUPPL_1.626.

Autophagy, Innate Immunity and Tissue Repair in Acute Kidney Injury
International Journal of Molecular Sciences. 2016; 17(5): 662. DOI:10.3390/IJMS17050662.

CRISPR-mediated genome editing restores dystrophin expression and function in mdx mice
Molecular Therapy. 2016; 24(3): 564 - 569. DOI:10.1038/MT.2015.192.

Dual function of MG53 in membrane repair and insulin signaling
BMB Reports. 2016; 49(8): 414 - 423. DOI:10.5483/BMBREP.2016.49.8.079.

Fast Two Dimensional Superresolution Image Reconstruction Algorithm for Ultrahigh Emitter Density
Biophysical Journal. 2016; 110(3 (Supp.)): 170a. DOI:10.1016/J.BPJ.2015.11.945.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy. 2016; 12(1): 1 - 222. DOI:10.1080/15548627.2015.1100356.

Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1–Mediated Lipogenesis
Clinical Cancer Research. 2016; 22(21): 5337 - 5348. DOI:10.1158/1078-0432.CCR-15-2973.

Liver-specific NG37 overexpression leads to diet-dependent fatty liver disease accompanied by cardiac dysfunction
Genes and Nutrition. 2016; 11(1):. DOI:10.1186/S12263-016-0529-Z.

MG53 permeates through blood-brain barrier to protect ischemic brain injury
Oncotarget. 2016; 7(16): 22474 - 22485. DOI:10.18632/ONCOTARGET.7965.

MG53 Promotes Wound Healing and Reduces Scar Formation by Facilitating Cell Membrane Repair and Controlling Myofibroblast Differentiation
Biophysical Journal. 2016; 110(3 (Supp.)): 589a. DOI:10.1016/J.BPJ.2015.11.3145.

Mitsugumin 53 regulates extracellular Ca2+ entry and intracellular Ca2+ release via Orai1 and RyR1 in skeletal muscle
Scientific Reports. 2016; 6(1):. DOI:10.1038/SREP36909.

Quantifying Drug-Induced Nanomechanics and Mechanical Effects to Single Cardiomyocytes for Optimal Drug Administration To Minimize Cardiotoxicity
Langmuir. 2016; 32(7): 1909 - 1919. DOI:10.1021/ACS.LANGMUIR.5B04314.

Roles of Mitsugumin53 in Skeletal Muscle
Biophysical Journal. 2016; 110(3 (Supp.)): 600a. DOI:10.1016/J.BPJ.2015.11.3205.

Roles of the novel coiled-coil protein Rng10 in septum formation during fission yeast cytokinesis
Molecular Biology of the Cell. 2016; 27(16): 2528 - 2541. DOI:10.1091/MBC.E16-03-0156.

Sundew-Inspired Adhesive Hydrogels Combined with Adipose-Derived Stem Cells for Wound Healing
ACS Applied Materials & Interfaces. 2016; 8(3): 2423 - 2434. DOI:10.1021/ACSAMI.5B11811.

Zinc Binding to MG53 Facilitates Repair of Injury to Cell Membrane
Biophysical Journal. 2016; 110(3 (Supp.)): 589a. DOI:10.1016/J.BPJ.2015.11.3146.

Zinc Inhibits Orai1-Mediated Calcium Signals in Esophageal Cancer Cells
Biophysical Journal. 2016; 110(3 (Supp.)): 264a. DOI:10.1016/J.BPJ.2015.11.1443.