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Sue A. Brown

Sue A. Brown

Professor, Medicine- Endocrinology and Metabolism

Primary Location
PO Box 801420
Primary Phone Number
Fax Number
434.924.9616

Bio & Overview

Dr. Brown's recent research has focused on new treatment options for type 1 diabetes. She has been a principal investigator on multiple trials focused on type 1 diabetes. She is currently active in clinical trials conducted within the Center for Diabetes Technology. These research programs are aimed at further identifying factors of glycemic variability in people with type 1 diabetes, particularly glucose changes surrounding exercise, meals and the menstrual cycle. The Center for Diabetes Technology is active in developing automated insulin delivery systems in people with type 1 diabetes. Dr. Brown was the study chair for a randomized-controlled multi-site US trial on automated insulin delivery that ultimately led to FDA approval of a system in current use in the US. She has previously been a principal investigator on an NIH K23 mentored clinical research award focusing on the effects of lactation on bone physiology.

Academic Information

Department
Medicine- Endocrinology and Metabolism
Academic Title
Associate Professor

Primary Education

  • Fellowship, Endocrinology, University of North Carolinanull
  • MD, University of Virginianull
  • Residency, Internal Medicine, University of North Carolinanull

Research Interests

Treatment options for type 1 diabetes with a focus on automated insulin delivery systems; Osteoporosis and bone metabolism;

Selected Publications

2024

Kovatchev, B., Castillo, A., Pryor, E., Kollar, L. L., Barnett, C. L., Deboer, M. D., & Brown, S. A. (2024). Neural-Net Artificial Pancreas: A Randomized Crossover Trial of a First-in-Class Automated Insulin Delivery Algorithm. DIABETES TECHNOLOGY & THERAPEUTICS, 26(6), 375-382. doi:10.1089/dia.2023.0469

Colmegna, P., Mcfadden, R., Fabris, C., Lobo, B., Nass, R., Oliveri, M. C., . . . Kovatchev, B. (2024). Adaptive Biobehavioral Control: A Pilot Analysis of Human-Machine Coadaptation in Type 1 Diabetes. DIABETES TECHNOLOGY & THERAPEUTICS. doi:10.1089/dia.2023.0399

2023

Montaser, E., Breton, M. D., Brown, S. A., DeBoer, M. D., Kovatchev, B., & Farhy, L. S. (2023). Predicting Immunological Risk for Stage 1 and Stage 2 Diabetes Using a 1-Week CGM Home Test, Nocturnal Glucose Increments, and Standardized Liquid Mixed Meal Breakfasts, with Classification Enhanced by Machine Learning. DIABETES TECHNOLOGY & THERAPEUTICS, 25(9), 631-642. doi:10.1089/dia.2023.0064

2022

Sherr, J. L., Bode, B. W., Forlenza, G. P., Laffel, L. M., Schoelwer, M. J., Buckingham, B. A., . . . Ly, T. T. (2022). Safety and Glycemic Outcomes With a Tubeless Automated Insulin Delivery System in Very Young Children With Type 1 Diabetes: A Single-Arm Multicenter Clinical Trial. DIABETES CARE, 45(8), 1907-1910. doi:10.2337/dc21-2359

Polonsky, W. H., Hood, K. K., Levy, C. J., MacLeish, S. A., Hirsch, I. B., Brown, S. A., . . . Ly, T. T. (2022). How introduction of automated insulin delivery systems may influence psychosocial outcomes in adults with type 1 diabetes: Findings from the first investigation with the Omnipod? 5 System. DIABETES RESEARCH AND CLINICAL PRACTICE, 190. doi:10.1016/j.diabres.2022.109998

Corbett, J. P., Hsu, L., Brown, S. A., Kollar, L., Vleugels, K., Buckingham, B., . . . Lal, R. A. (2022). Smartwatch gesture-based meal reminders improve glycaemic control. DIABETES OBESITY & METABOLISM, 24(8), 1667-1670. doi:10.1111/dom.14737

Ekhlaspour, L., Raghinaru, D., Forlenza, G. P., Isganaitis, E., Kudva, Y. C., Lam, D. W., . . . Brown, S. A. (2023). Outcomes in Pump- and CGM-Baseline Use Subgroups in the International Diabetes Closed-Loop Trial. JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY, 17(4), 935-942. doi:10.1177/19322968221089361

Levy, C. J., O'Malley, G., Raghinaru, D., Kudva, Y. C., Laffel, L. M., Pinsker, J. E., . . . Brown, S. A. (2022). Insulin Delivery and Glucose Variability Throughout the Menstrual Cycle on Closed Loop Control for Women with Type 1 Diabetes. DIABETES TECHNOLOGY & THERAPEUTICS, 24(5), 357-361. doi:10.1089/dia.2021.0431

Garg, S. K., Kipnes, M., Castorino, K., Bailey, T. S., Akturk, H. K., Welsh, J. B., . . . Beck, S. E. (2022). Accuracy and Safety of Dexcom G7 Continuous Glucose Monitoring in Adults with Diabetes. DIABETES TECHNOLOGY & THERAPEUTICS, 24(6), 373-380. doi:10.1089/dia.2022.0011

Ekhlaspour, L., Town, M., Raghinaru, D., Lum, J. W., Brown, S. A., & Buckingham, B. A. (2022). Glycemic Outcomes in Baseline Hemoglobin A1C Subgroups in the International Diabetes Closed-Loop Trial. DIABETES TECHNOLOGY & THERAPEUTICS, 24(8), 588-591. doi:10.1089/dia.2021.0524

Berget, C., Sherr, J. L., DeSalvo, D. J., Kingman, R. S., Stone, S. L., Brown, S. A., . . . Forlenza, G. P. (2022). Clinical Implementation of the Omnipod 5 Automated Insulin Delivery System: Key Considerations for Training and Onboarding People With Diabetes.. Clinical diabetes : a publication of the American Diabetes Association, 40(2), 168-184. doi:10.2337/cd21-0083

2021

Kudva, Y. C., Laffel, L. M., Brown, S. A., Raghinaru, D., Pinsker, J. E., Ekhlaspour, L., . . . Gonder-Frederick, L. (2021). Patient-Reported Outcomes in a Randomized Trial of Closed-Loop Control: The Pivotal International Diabetes Closed-Loop Trial. DIABETES TECHNOLOGY & THERAPEUTICS, 23(10), 673-683. doi:10.1089/dia.2021.0089

Pinsker, J. E., Church, M. M., Brown, S. A., Voelmle, M. K., Bode, B. W., Narron, B., . . . Ly, T. T. (2022). Clinical Evaluation of a Novel CGM-Informed Bolus Calculator with Automatic Glucose Trend Adjustment. DIABETES TECHNOLOGY & THERAPEUTICS, 24(1), 18-25. doi:10.1089/dia.2021.0140

Brown, S. A., Forlenza, G. P., Bode, B. W., Pinsker, J. E., Levy, C. J., Criego, A. B., . . . Ly, T. T. (2021). Multicenter Trial of a Tubeless, On-Body Automated Insulin Delivery System With Customizable Glycemic Targets in Pediatric and Adult Participants With Type 1 Diabetes. DIABETES CARE, 44(7), 1630-1640. doi:10.2337/dc21-0172

O'Malley, G., Messer, L. H., Levy, C. J., Pinsker, J. E., Forlenza, G. P., Isganaitis, E., . . . Brown, S. A. (2021). Clinical Management and Pump Parameter Adjustment of the Control-IQ Closed-Loop Control System: Results from a 6-Month, Multicenter, Randomized Clinical Trial. DIABETES TECHNOLOGY & THERAPEUTICS, 23(4), 245-252. doi:10.1089/dia.2020.0472

Ozaslan, B., Brown, S. A., Pinnata, J., Barnett, C. L., Carr, K., Wakeman, C. A., . . . Breton, M. D. (2022). Safety and Feasibility Evaluation of Step Count Informed Meal Boluses in Type 1 Diabetes: A Pilot Study. JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY, 16(3), 670-676. doi:10.1177/1932296821997917

Isganaitis, E., Raghinaru, D., Ambler-Osborn, L., Pinsker, J. E., Buckingham, B. A., Wadwa, R. P., . . . Laffel, L. M. (2021). Closed-Loop Insulin Therapy Improves Glycemic Control in Adolescents and Young Adults: Outcomes from the International Diabetes Closed-Loop Trial. DIABETES TECHNOLOGY & THERAPEUTICS, 23(5), 342-349. doi:10.1089/dia.2020.0572

Forlenza, G. P., Buckingham, B. A., Brown, S. A., Bode, B. W., Levy, C. J., Criego, A. B., . . . Ly, T. T. (2021). First Outpatient Evaluation of a Tubeless Automated Insulin Delivery System with Customizable Glucose Targets in Children and Adults with Type 1 Diabetes. DIABETES TECHNOLOGY & THERAPEUTICS, 23(6), 410-424. doi:10.1089/dia.2020.0546

Bisio, A., Gonder-Frederick, L., McFadden, R., Chernavvsky, D., Voelmle, M., Pajewski, M., . . . Brown, S. A. (2022). The Impact of a Recently Approved Automated Insulin Delivery System on Glycemic, Sleep, and Psychosocial Outcomes in Older Adults With Type 1 Diabetes: A Pilot Study. JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY, 16(3), 663-669. doi:10.1177/1932296820986879

Patel, R. M., Bazydlo, L., Brown, S. A., & Dalkin, A. C. (2021). Vitamin D Replacement in Adults: Current Strategies in Clinical Management. PRACTICAL GASTROENTEROLOGY, 45(5), 16-+. Retrieved from https://www.webofscience.com/

2020

Bisio, A., Brown, S. A., McFadden, R., Pajewski, M., Yu, P. L., DeBoer, M., . . . Gonder-Frederick, L. (2021). Sleep and diabetes-specific psycho-behavioral outcomes of a new automated insulin delivery system in young children with type 1 diabetes and their parents. PEDIATRIC DIABETES, 22(3), 495-502. doi:10.1111/pedi.13164

Garcia-Tirado, J., Brown, S. A., Laichuthai, N., Colmegna, P., Koravi, C. L. K., Ozaslan, B., . . . Breton, M. D. (2021). Anticipation of Historical Exercise Patterns by a Novel Artificial Pancreas System Reduces Hypoglycemia During and After Moderate-Intensity Physical Activity in People with Type 1 Diabetes. DIABETES TECHNOLOGY & THERAPEUTICS, 23(4), 277-285. doi:10.1089/dia.2020.0516

Kovatchev, B., Anderson, S. M., Raghinaru, D., Kudva, Y. C., Laffel, L. M., Levy, C., . . . Beck, R. W. (2020). Randomized Controlled Trial of Mobile Closed-Loop Control (vol 43, pg 607, 20200). DIABETES CARE, 43(6), 1366. doi:10.2337/dc20-er06

Schoelwer, M. J., Robic, J. L., Gautier, T., Fabris, C., Carr, K., Clancy-Oliveri, M., . . . Breton, M. D. (2020). Safety and Efficacy of Initializing the Control-IQ Artificial Pancreas System Based on Total Daily Insulin in Adolescents with Type 1 Diabetes. DIABETES TECHNOLOGY & THERAPEUTICS, 22(8), 594-601. doi:10.1089/dia.2019.0471

Kovatchev, B. P., Brown, S. A., & Beck, R. W. (2020). Multicenter Trial of Closed-Loop Control in Type 1 Diabetes Reply. NEW ENGLAND JOURNAL OF MEDICINE, 382(6), 578. Retrieved from https://www.webofscience.com/

Kovatchev, B., Anderson, S. M., Raghinaru, D., Kudva, Y. C., Laffel, L. M., Levy, C., . . . Beck, R. W. (2020). Randomized Controlled Trial of Mobile Closed-Loop Control. DIABETES CARE, 43(3), 607-615. doi:10.2337/dc19-1310

Kovatchev, B. P., Kollar, L., Anderson, S. M., Barnett, C., Breton, M. D., Carr, K., . . . Brown, S. A. (2020). Evening and overnight closed-loop control versus 24/7 continuous closed-loop control for type 1 diabetes: a randomised crossover trial. LANCET DIGITAL HEALTH, 2(2), E64-E73. doi:10.1016/S2589-7500(19)30218-3

2019

Beck, R. W., Brown, S. A., Lum, J. W., & Kovatchev, B. P. (2020). Nonadjunctive Use of Continuous Glucose Monitoring: The End of Fingersticks?. DIABETES TECHNOLOGY & THERAPEUTICS, 22(2), 67-68. doi:10.1089/dia.2019.0387

Brown, S. A., Kovatchev, B. P., Raghinaru, D., Lum, J. W., Buckingham, B. A., Kudva, Y. C., . . . Beck, R. W. (2019). Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes. NEW ENGLAND JOURNAL OF MEDICINE, 381(18), 1707-1717. doi:10.1056/NEJMoa1907863

Anderson, S. M., Buckingham, B. A., Breton, M. D., Robic, J. L., Barnett, C. L., Wakeman, C. A., . . . Kovatchev, B. P. (2019). Hybrid Closed-Loop Control Is Safe and Effective for People with Type 1 Diabetes Who Are at Moderate to High Risk for Hypoglycemia. DIABETES TECHNOLOGY & THERAPEUTICS, 21(6), 356-363. doi:10.1089/dia.2019.0018

Brown, S. A., Basu, A., & Kovatchev, B. P. (2019). Beyond HbA1c: using continuous glucose monitoring metrics to enhance interpretation of treatment effect and improve clinical decision-making. DIABETIC MEDICINE, 36(6), 679-687. doi:10.1111/dme.13944

Anderson, S. M., Dassau, E., Raghinaru, D., Lum, J., Brown, S. A., Pinsker, J. E., . . . Kovatchev, B. P. (2019). The International Diabetes Closed-Loop Study: Testing Artificial Pancreas Component Interoperability. DIABETES TECHNOLOGY & THERAPEUTICS, 21(2), 73-80. doi:10.1089/dia.2018.0308

2018

Ozaslan, B., Patek, S. D., Grabman, J. H., Shepard, J. A., Dassau, E., Breton, M. D., . . . Gonder-Frederick, L. (2018). Body Mass Index Effect on Differing Responses to Psychological Stress in Blood Glucose Dynamics in Patients With Type 1 Diabetes.. Journal of diabetes science and technology, 12(3), 657-664. doi:10.1177/1932296818758103

2017

Dassau, E., Pinsker, J. E., Kudva, Y. C., Brown, S. A., Gondhalekar, R., Man, C. D., . . . Doyle, F. J. I. I. I. (2017). Twelve-Week 24/7 Ambulatory Artificial Pancreas With Weekly Adaptation of Insulin Delivery Settings: Effect on Hemoglobin A1c and Hypoglycemia. DIABETES CARE, 40(12), 1719-1726. doi:10.2337/dc17-1188

Brown, S. A., Breton, M. D., Anderson, S. M., Kollar, L., Keith-Hynes, P., Levy, C. J., . . . Kovatchev, B. P. (2017). Overnight Closed-Loop Control Improves Glycemic Control in a Multicenter Study of Adults With Type 1 Diabetes. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 102(10), 3674-3682. doi:10.1210/jc.2017-00556

Brown, S. A., Abbas, S., Davies, M. -A., Bunupuradah, T., Sohn, A. I. I., Technau, K. -G., . . . Wools-Kaloustian, K. (2017). Pediatric Cancer Burden and Treatment Resources Within the Pediatric IeDEA Consortium. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 76(1), 60-64. doi:10.1097/QAI.0000000000001453

Clark, D. B., Chung, T., Martin, C. S., Hasler, B. P., Fitzgerald, D. H., Luna, B., . . . Nagel, B. J. (2017). Adolescent Executive Dysfunction in Daily Life: Relationships to Risks, Brain Structure and Substance Use. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 11. doi:10.3389/fnbeh.2017.00223

Saunders, C., Brown, S. A., Bygstad, B., Dennis, A. R., Ferran, C., Galletta, D., . . . Sarker, S. (2017). Goals, Values, and Expectations of the AIS Family of Journals. JOURNAL OF THE ASSOCIATION FOR INFORMATION SYSTEMS, 18(9), 633-647. doi:10.17705/1jais.00468

2016

Kovatchev, B., Cheng, P., Anderson, S. M., Pinsker, J. E., Boscari, F., Buckingham, B. A., . . . Beck, R. W. (2017). Feasibility of Long-Term Closed-Loop Control: A Multicenter 6-Month Trial of 24/7 Automated Insulin Delivery. DIABETES TECHNOLOGY & THERAPEUTICS, 19(1), 18-+. doi:10.1089/dia.2016.0333

Gonder-Frederick, L. A., Grabman, J. H., Kovatchev, B., Brown, S. A., Patek, S., Basu, A., . . . Doyle, F. J. (2016). Is Psychological Stress a Factor for Incorporation Into Future Closed-Loop Systems?. Journal of diabetes science and technology, 10(3), 640-646. doi:10.1177/1932296816635199

Anderson, S. M., Raghinaru, D., Pinsker, J. E., Boscari, F., Renard, E., Buckingham, B. A., . . . Kovatchev, B. (2016). Multinational Home Use of Closed-Loop Control Is Safe and Effective. DIABETES CARE, 39(7), 1143-1150. doi:10.2337/dc15-2468

2015

Brown, S. A., Jiang, B., McElwee-Malloy, M., Wakeman, C., & Breton, M. D. (2015). Fluctuations of Hyperglycemia and Insulin Sensitivity Are Linked to Menstrual Cycle Phases in Women With T1D.. Journal of diabetes science and technology, 9(6), 1192-1199. doi:10.1177/1932296815608400

Dassau, E., Brown, S. A., Basu, A., Pinsker, J. E., Kudva, Y. C., Gondhalekar, R., . . . Doyle, F. J. I. I. I. (2015). Adjustment of Open-Loop Settings to Improve Closed-Loop Results in Type 1 Diabetes: A Multicenter Randomized Trial. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 100(10), 3878-3886. doi:10.1210/jc.2015-2081

Brown, S. A., Kovatchev, B. P., Breton, M. D., Anderson, S. M., Keith-Hynes, P., Patek, S. D., . . . Cobelli, C. (2015). Multinight "Bedside" Closed-Loop Control for Patients with Type 1 Diabetes. DIABETES TECHNOLOGY & THERAPEUTICS, 17(3), 203-209. doi:10.1089/dia.2014.0259

2014

Kovatchev, B. P., Renard, E., Cobelli, C., Zisser, H. C., Keith-Hynes, P., Anderson, S. M., . . . Doyle, F. J. I. I. I. (2014). Safety of Outpatient Closed-Loop Control: First Randomized Crossover Trials of a Wearable Artificial Pancreas. DIABETES CARE, 37(7), 1789-1796. doi:10.2337/dc13-2076

Bornstein, S., Brown, S. A., Le, P. T., Wang, X., DeMambro, V., Horowitz, M. C., . . . Rosen, C. J. (2014). FGF-21 and Skeletal Remodeling During and After Lactation in C57BL/6J Mice. ENDOCRINOLOGY, 155(9), 3516-3526. doi:10.1210/en.2014-1083

Breton, M. D., Brown, S. A., Karvetski, C. H., Kollar, L., Topchyan, K. A., Anderson, S. M., & Kovatchev, B. P. (2014). Adding Heart Rate Signal to a Control-to-Range Artificial Pancreas System Improves the Protection Against Hypoglycemia During Exercise in Type 1 Diabetes. DIABETES TECHNOLOGY & THERAPEUTICS, 16(8), 506-511. doi:10.1089/dia.2013.0333

2013

Kovatchev, B. P., Renard, E., Cobelli, C., Zisser, H. C., Keith-Hynes, P., Anderson, S. M., . . . Doyle, F. J. I. I. I. (2013). Feasibility of Outpatient Fully Integrated Closed-Loop Control First studies of wearable artificial pancreas. DIABETES CARE, 36(7), 1851-1858. doi:10.2337/dc12-1965