Tarek A. Abbas

Vela-Rodriguez, C., Yang, C., Alanen, H. I., Eki, R., Abbas, T. A., Maksimainen, M. M., . . . Lehtio, L. (2024). Oligomerization mediated by the D2 domain of DTX3L is critical for DTX3L-PARP9 reading function of mono-ADP-ribosylated androgen receptor. PROTEIN SCIENCE, 33(4). doi:10.1002/pro.4945

Vela-Rodríguez, C., Yang, C., Alanen, H. I., Eki, R., Abbas, T. A., Maksimainen, M. M., . . . Lehtiö, L. (2023). Oligomerisation mediated by the D2 domain of DTX3L is critical for DTX3L-PARP9 reading function of mono-ADP-ribosylated androgen receptor.. bioRxiv. doi:10.1101/2023.11.29.569193

Genetta, T. L., Hurwitz, J. C., Clark, E. A., Herold, B. T., Khalil, S., Abbas, T., & Larner, J. M. (2023). ZEB1 promotes non-homologous end joining double-strand break repair. NUCLEIC ACIDS RESEARCH, 51(18), 9863-9879. doi:10.1093/nar/gkad723

Yang, C., Wierbilowicz, K., Dworak, N. M., Bae, S. Y., Tengse, S. B., Abianeh, N., . . . Paschal, B. M. (2023). Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells. CANCER RESEARCH COMMUNICATIONS, 3(4), 592-606. doi:10.1158/2767-9764.CRC-23-0086

Meneveau, M. O., Vavolizza, R. D., Mohammad, A., Kumar, P., Manderfield, J. T., Callahan, C., . . . Bekiranov, S. (2023). A Step Toward Personalized Surgical Decision Making Machine Learning Predicts 1 Versus Numerous Melanoma Lymph Node Metastases Using RNA-sequencing. ANNALS OF SURGERY, 278(3), E589-E597. doi:10.1097/SLA.0000000000005761

Paulsen, T., Malapati, P., Shibata, Y., Wilson, B., Eki, R., Benamar, M., . . . Dutta, A. (2021). MicroDNA levels are dependent on MMEJ, repressed by c-NHEJ pathway, and stimulated by DNA damage. NUCLEIC ACIDS RESEARCH, 49(20), 11787-11799. doi:10.1093/nar/gkab984

Banerjee, D., Langberg, K., Abbas, S., Odermatt, E., Yerramothu, P., Volaric, M., . . . Kerur, N. (2021). A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-26240-9

Yang, C. -S., Jividen, K., Kamata, T., Dworak, N., Oostdyk, L., Remlein, B., . . . Paschal, B. M. (2021). Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-23055-6

Eki, R., She, J., Parlak, M., Benamar, M., Du, K. -P., Kumar, P., & Abbas, T. (2020). A robust CRISPR-Cas9-based fluorescent reporter assay for the detection and quantification of DNA double-strand break repair. NUCLEIC ACIDS RESEARCH, 48(21). doi:10.1093/nar/gkaa897

Abbas, T. (2021). The Role of Ubiquitination and SUMOylation in DNA Replication. CURRENT ISSUES IN MOLECULAR BIOLOGY, 40, 189-220. doi:10.21775/cimb.040.189

Jang, Y., Elsayed, Z., Eki, R., He, S., Du, K. -P., Abbas, T., & Kai, M. (2020). Intrinsically disordered protein RBM14 plays a role in generation of RNA:DNA hybrids at double-strand break sites. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(10), 5329-5338. doi:10.1073/pnas.1913280117

Leick, K. M., Rodriguez, A. B., Melssen, M. M., Benamar, M., Lindsay, R. S., Eki, R., . . . Slingluff, C. L. J. (2019). The Barrier Molecules Junction Plakoglobin, Filaggrin, and Dystonin Play Roles in Melanoma Growth and Angiogenesis. ANNALS OF SURGERY, 270(4), 712-722. doi:10.1097/SLA.0000000000003522

Shang, S., Yang, J., Jazaeri, A. A., Duval, A. J., Tufan, T., Fischer, N. L., . . . Adli, M. (2019). Chemotherapy-Induced Distal Enhancers Drive Transcriptional Programs to Maintain the Chemoresistant State in Ovarian Cancer. CANCER RESEARCH, 79(18), 4599-4611. doi:10.1158/0008-5472.CAN-19-0215

Olmez, I., Zhang, Y., Manigat, L., Benamar, M., Brenneman, B., Nakano, I., . . . Purow, B. (2018). Combined c-Met/Trk Inhibition Overcomes Resistance to CDK4/6 Inhibitors in Glioblastoma. CANCER RESEARCH, 78(15), 4360-4369. doi:10.1158/0008-5472.CAN-17-3124

Vanderdys, V., Allak, A., Guessous, F., Benamar, M., Read, P. W., Jameson, M. J., & Abbas, T. (2018). The Neddylation Inhibitor Pevonedistat (MLN4924) Suppresses and Radiosensitizes Head and Neck Squamous Carcinoma Cells and Tumors. MOLECULAR CANCER THERAPEUTICS, 17(2), 368-380. doi:10.1158/1535-7163.MCT-17-0083

Olmez, I., Brenneman, B., Xiao, A., Serbulea, V., Benamar, M., Zhang, Y., . . . Purow, B. (2017). Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms. CLINICAL CANCER RESEARCH, 23(22), 6958-6968. doi:10.1158/1078-0432.CCR-17-0803

Yang, C. -S., Jividen, K., Spencer, A., Dworak, N., Ni, L., Oostdyk, L. T., . . . Paschal, B. M. (2017). Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9. MOLECULAR CELL, 66(4), 503-+. doi:10.1016/j.molcel.2017.04.028

Biswas, K., Sarkar, S., Du, K., Brautigan, D. L., Abbas, T., & Larner, J. M. (2017). The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance. MOLECULAR CANCER RESEARCH, 15(6), 651-659. doi:10.1158/1541-7786.MCR-16-0466

Abbas, T., & Dutta, A. (2017). Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System. DNA REPLICATION: FROM OLD PRINCIPLES TO NEW DISCOVERIES, 1042, 421-454. doi:10.1007/978-981-10-6955-0_19

Benamar, M., Guessous, F., Du, K., Corbett, P., Obeid, J., Gioeli, D., . . . Abbas, T. (2016). Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma. EBIOMEDICINE, 10, 85-100. doi:10.1016/j.ebiom.2016.06.023

Heo, J., Eki, R., & Abbas, T. (2016). Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis. SEMINARS IN CANCER BIOLOGY, 36, 33-51. doi:10.1016/j.semcancer.2015.09.015

Sekhar, K. R., Benamar, M., Venkateswaran, A., Sasi, S., Penthala, N. R., Crooks, P. A., . . . Freeman, M. L. (2014). Targeting Nucleophosmin 1 Represents a Rational Strategy for Radiation Sensitization. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 89(5), 1106-1114. doi:10.1016/j.ijrobp.2014.04.012

Terai, K., Shibata, E., Abbas, T., & Dutta, A. (2013). Degradation of p12 Subunit by CRL4^Cdt2 E3 Ligase Inhibits Fork Progression after DNA Damage. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(42), 30509-30514. doi:10.1074/jbc.C113.505586

Abbas, T., Keaton, M., & Dutta, A. (2013). Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation SCF-FBXO11 turns off CRL4-Cdt2. CELL CYCLE, 12(14), 2175-2182. doi:10.4161/cc.25314

Abbas, T., Mueller, A. C., Shibata, E., Keaton, M., Rossi, M., & Dutta, A. (2013). CRL1-FBXO11 Promotes Cdt2 Ubiquitylation and Degradation and Regulates Pr-Set7/Set8-Mediated Cellular Migration. MOLECULAR CELL, 49(6), 1147-1158. doi:10.1016/j.molcel.2013.02.003

Abbas, T., Keaton, M. A., & Dutta, A. (2013). Genomic Instability in Cancer. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 3(2). doi:10.1101/cshperspect.a012914

Park, J., Long, D. T., Lee, K. Y., Abbas, T., Shibata, E., Negishi, M., . . . Dutta, A. (2013). The MCM8-MCM9 Complex Promotes RAD51 Recruitment at DNA Damage Sites To Facilitate Homologous Recombination. MOLECULAR AND CELLULAR BIOLOGY, 33(8), 1632-1644. doi:10.1128/MCB.01503-12

Van Rechem, C., Black, J. C., Abbas, T., Allen, A., Rinehart, C. A., Yuan, G. -C., . . . Whetstine, J. R. (2011). The SKP1-Cul1-F-box and Leucine-rich Repeat Protein 4 (SCF-FbxL4) Ubiquitin Ligase Regulates Lysine Demethylase 4A (KDM4A)/Jumonji Domain-containing 2A (JMJD2A) Protein. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(35), 30462-30470. doi:10.1074/jbc.M111.273508

Shibata, E., Abbas, T., Huang, X., Wohlschlegel, J. A., & Dutta, A. (2011). Selective Ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G Ubiquitin-Conjugating Enzymes via the CRL4^Cdt2 Ubiquitin Ligase Complex. MOLECULAR AND CELLULAR BIOLOGY, 31(15), 3136-3145. doi:10.1128/MCB.05496-11

Abbas, T., & Dutta, A. (2011). CRL4^Cdt2 Master coordinator of cell cycle progression and genome stability. CELL CYCLE, 10(2), 241-249. doi:10.4161/cc.10.2.14530

Abbas, T., Shibata, E., Park, J., Jha, S., Karnani, N., & Dutta, A. (2010). CRL4^Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation. MOLECULAR CELL, 40(1), 9-21. doi:10.1016/j.molcel.2010.09.014

Terai, K., Abbas, T., Jazaeri, A. A., & Dutta, A. (2010). CRL4^Cdt2 E3 Ubiquitin Ligase Monoubiquitinates PCNA to Promote Translesion DNA Synthesis. MOLECULAR CELL, 37(1), 143-149. doi:10.1016/j.molcel.2009.12.018