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Timothy P. Bender

Timothy P. Bender

Professor, Microbiology, Immunology, and Cancer Biology

Primary Location
Beirne Carter Center MR6-3707A
PO Box 801386
Charlottesville, VA 22908
Primary Phone Number
Fax Number
434.924.1221

Bio & Overview

Academic Information

Department
Microbiology, Immunology, and Cancer Biology
Academic Title
Professor

Primary Education

  • BA, Biology, Albion College, 1975
  • MS, Epidemiology, The University of Michigan, Ann Arbor, MI, 1977
  • PhD, Microbiology and Immunology, The University of Michigan, Ann Arbor, MI, 1983

Other Appointments

  • Professor, MII
  • Professor, MCDB
  • Professor, MOMD

Other Affiliations

  • Faculty Director, Flow Cytometry Facility, Immunology/Immunotherapy Program
  • Mentor, Microbiology
  • Beirne Carter Center for Immunology
  • Professor, BIMS

Research Interests

Immunology

Research Disciplines

  • Bioinformatics and Genomics
  • Cancer Biology
  • Epigenetics
  • Genetics
  • Immunology
  • Infectious Diseases/Biodefense
  • Microbiology
  • Molecular Biology

Research Opportunities

  • Bioinformatics & Genomics
  • Cancer Biology
  • Epigenetics
  • Genetics
  • Immunology
  • Infectious Diseases
  • Microbiology
  • Molecular Biology

Selected Publications

2020

Yao, M., Ventura, P. B., Jiang, Y., Rodriguez, F. J., Wang, L., Perry, J. S. A., . . . Zong, H. (2020). Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth. CELL, 180(3), 502-+. doi:10.1016/j.cell.2019.12.024

2019

Dziegielewski, J., Bonkowska, M. A., Poniecka, E. A., Heo, J., Du, K., Crittenden, R. B., . . . Larner, J. M. (2020). Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response. DNA REPAIR, 85. doi:10.1016/j.dnarep.2019.102737

Upadhye, A., Srikakulapu, P., Gonen, A., Hendrikx, S., Perry, H. M., Anh, N., . . . McNamara, C. A. (2019). Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis. CIRCULATION RESEARCH, 125(10), E55-E70. doi:10.1161/CIRCRESAHA.119.315786

Shikatani, E. A., Besla, R., Ensan, S., Upadhye, A., Khyzha, N., Li, A., . . . Robbins, C. S. (2019). c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells. CELL REPORTS, 27(8), 2304-+. doi:10.1016/j.celrep.2019.04.090

Gautam, S., Fioravanti, J., Zhu, W., Le Gall, J. B., Brohawn, P., Lacey, N. E., . . . Gattinoni, L. (2019). The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity. NATURE IMMUNOLOGY, 20(3), 337-+. doi:10.1038/s41590-018-0311-z

2018

Fahl, S. P., Daamen, A. R., Crittenden, R. B., & Bender, T. P. (2018). c-Myb Coordinates Survival and the Expression of Genes That Are Critical for the Pre-BCR Checkpoint. JOURNAL OF IMMUNOLOGY, 200(10), 3450-3463. doi:10.4049/jimmunol.1302303

2017

Tang, F., Zhang, P., Ye, P., Lazarski, C. A., Wu, Q., Bergin, I. L., . . . Zheng, P. (2017). A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice. ELIFE, 6. doi:10.7554/eLife.32497

Jayappa, K. D., Portell, C. A., Gordon, V. L., Capaldo, B. J., Bekiranov, S., Axelrod, M. J., . . . Weber, M. J. (2017). Microenvironmental agonists generate de novo phenotypic resistance to combined ibrutinib plus venetoclax in CLL and MCL (vol 14, pg 933, 2017). BLOOD ADVANCES, 1(19), 1537. doi:10.1182/bloodadvances.2017011148

Ziembik, M. A., Bender, T. P., Larner, J. M., & Brautigan, D. L. (2017). Functions of protein phosphatase-6 in NF-κB signaling and in lymphocytes. BIOCHEMICAL SOCIETY TRANSACTIONS, 45, 693-701. doi:10.1042/BST20160169

Jayappa, K. D., Portell, C. A., Gordon, V. L., Capaldo, B. J., Bekiranov, S., Axelrod, M. J., . . . Weber, M. J. (2017). Microenvironmental agonists generate de novo phenotypic resistance to combined ibrutinib plus venetoclax in CLL and MCL. BLOOD ADVANCES, 1(14), 933-946. doi:10.1182/bloodadvances.2016004176

2016

Xiao, C., Calado, D. P., Galler, G., Thai, T. -H., Patterson, H. C., Wang, J., . . . Rajewsky, K. (2016). MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb.. Cell, 165(4), 1027. doi:10.1016/j.cell.2016.04.056

2015

Rosenfeld, S. M., Perry, H. M., Gonen, A., Prohaska, T. A., Srikakulapu, P., Grewal, S., . . . McNamara, C. A. (2015). B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis. CIRCULATION RESEARCH, 117(3), E28-E39. doi:10.1161/CIRCRESAHA.117.306044

2013

Perry, H. M., Oldham, S. N., Fahl, S. P., Que, X., Gonen, A., Harmon, D. B., . . . McNamara, C. A. (2013). Helix-Loop-Helix Factor Inhibitor of Differentiation 3 Regulates Interleukin-5 Expression and B-1a B Cell Proliferation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(12), 2771-2779. doi:10.1161/ATVBAHA.113.302571

2012

Tewalt, E. F., Cohen, J. N., Rouhani, S. J., Guidi, C. J., Qiao, H., Fahl, S. P., . . . Engelhard, V. H. (2012). Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. BLOOD, 120(24), 4772-4782. doi:10.1182/blood-2012-04-427013

Perry, H. M., Bender, T. P., & McNamara, C. A. (2012). B cell subsets in atherosclerosis. FRONTIERS IN IMMUNOLOGY, 3. doi:10.3389/fimmu.2012.00373

2011

Bezman, N. A., Chakraborty, T., Bender, T., & Lanier, L. L. (2011). miR-150 regulates the development of NK and iNKT cells. The Journal of Cell Biology, 195(6), i7. doi:10.1083/jcb1956oia7

Bezman, N. A., Chakraborty, T., Bender, T., & Lanier, L. L. (2011). miR-150 regulates the development of NK and iNKT cells. JOURNAL OF EXPERIMENTAL MEDICINE, 208(13), 2717-2731. doi:10.1084/jem.20111386

Doran, A. C., Lipinski, M. J., Oldham, S. N., Garmey, J. C., Campbell, K. A., Skaflen, M. D., . . . McNamara, C. A. (2012). .B-Cell Aortic Homing and Atheroprotection Depend on Id3. CIRCULATION RESEARCH, 110(1), E1-U6. doi:10.1161/CIRCRESAHA.111.256438

Waldron, T., De Dominici, M., Soliera, A. R., Audia, A., Iacobucci, I., Lonetti, A., . . . Calabretta, B. (2012). c-Myb and its target Bmi1 are required for p190BCR/ABL leukemogenesis in mouse and human cells. LEUKEMIA, 26(4), 644-653. doi:10.1038/leu.2011.264

Matalova, E., Buchtova, M., Tucker, A. S., Bender, T. P., Janeckova, E., Lungova, V., . . . Smarda, J. (2011). Expression and characterization of c-Myb in prenatal odontogenesis. DEVELOPMENT GROWTH & DIFFERENTIATION, 53(6), 793-803. doi:10.1111/j.1440-169X.2011.01287.x

Gimferrer, I., Hu, T., Simmons, A., Wang, C., Souabni, A., Busslinger, M., . . . Alberola-Ila, J. (2011). Regulation of GATA-3 Expression during CD4 Lineage Differentiation. JOURNAL OF IMMUNOLOGY, 186(7), 3892-3898. doi:10.4049/jimmunol.1003505

Bender, T. P., Gonda, T. J., Frampton, J., Ness, S. A., & Ramsay, R. G. (2011). Professor Alan M Gewirtz (1949-2010) OBITUARY. ONCOGENE, 30(19), 2187. doi:10.1038/onc.2011.78

2010

Bender, T. P. (2010). A new window on c-Myb function. BLOOD, 116(8), 1190-1191. doi:10.1182/blood-2010-06-287300

Hu, T., Simmons, A., Yuan, J., Bender, T. P., & Alberola-Ila, J. (2010). The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage. NATURE IMMUNOLOGY, 11(5), 435-U98. doi:10.1038/ni.1865

Yuan, J., Crittenden, R. B., & Bender, T. P. (2010). c-Myb Promotes the Survival of CD4+CD8+ Double-Positive Thymocytes through Upregulation of Bcl-xL. JOURNAL OF IMMUNOLOGY, 184(6), 2793-2804. doi:10.4049/jimmunol.0902846