Uma Nayak
Assistant Professor, Public Health Sciences
Hospital West Complex Rm: MSB-3244
Charlottesville,, VA
Bio & Overview
Academic Information
- Department
- Public Health Sciences
Primary Education
- Ph.D, Nutrition, Sri Padmavati Mahila Viswavidyalayam, India, 2000
Other Affiliations
- Genomic Sciences
Research Interests
Selected Publications
2023
Hendrick, J., Ma, J., Haughey, H., Coleman, R., Nayak, U., Kadl, A., . . . Petri, W. (2023). Pulmonary function and survival one year after dupilumab treatment of acute moderate to severe COVID-19: A follow up study from a Phase IIa trial. doi:10.1101/2023.09.01.23293947
Petri, W. A. O., Hossain, B., Kabir, M., So, H. H., Moreau, G. B., Nayak, U., . . . Gilchrist, C. A. (2023). Children develop Immunity to cryptosporidiosis in a high transmission intensity area.. medRxiv. doi:10.1101/2023.06.28.23292000
Kudtarkar, P., Costanzo, M. C., Sun, Y., Jang, D., Koesterer, R., Mychaleckyj, J. C., . . . Burtt, N. P. (2023). Leveraging type 1 diabetes human genetic and genomic data in the T1D knowledge portal. PLOS BIOLOGY, 21(8). doi:10.1371/journal.pbio.3002233
Suzuki, K., Hatzikotoulas, K., Southam, L., Taylor, H. J., Yin, X., Lorenz, K. M., . . . Zeggini, E. (2023). Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.. medRxiv. doi:10.1101/2023.03.31.23287839
Munday, R. M., Haque, R., Wojcik, G. L., Korpe, P., Nayak, U., Kirkpatrick, B. D., . . . Duggal, P. (2023). Genome-Wide Association Studies of Diarrhea Frequency and Duration in the First Year of Life in Bangladeshi Infants. JOURNAL OF INFECTIOUS DISEASES, 228(8), 979-989. doi:10.1093/infdis/jiad068
Kudtarkar, P., Costanzo, M. C., Sun, Y., Jang, D., Koesterer, R., Mychaleckyj, J. C., . . . Burtt, N. P. (2023). Leveraging type 1 diabetes human genetic and genomic data in the T1D Knowledge Portal.. bioRxiv. doi:10.1101/2023.02.03.526066
2022
Sasson, J., Donlan, A. N., Ma, J. Z., Haughey, H. M., Coleman, R., Nayak, U., . . . Petri, W. A. J. (2022). Safety and Efficacy of Dupilumab for the Treatment of Hospitalized Patients With Moderate to Severe Coronavirus Disease 2019: A Phase 2a Trial. OPEN FORUM INFECTIOUS DISEASES, 9(8). doi:10.1093/ofid/ofac343
Sasson, J., Donlan, A. N., Ma, J. Z., Haughey, H. M., Coleman, R., Nayak, U., . . . Petri, W. A. (2022). Safety and Efficacy of Dupilumab for the Treatment of Hospitalized Patients with Moderate to Severe COVID 19: A Phase IIa Trial.. medRxiv. doi:10.1101/2022.03.30.22273194
Munday, R. M., Haque, R., Jan, N. -J., Wojcik, G. L., Marie, C., Duchen, D., . . . Duggal, P. (2022). Genome-Wide Association Study of Campylobacter-Positive Diarrhea Identifies Genes Involved in Toxin Processing and Inflammatory Response. MBIO, 13(3). doi:10.1128/mbio.00556-22
2021
Lee, B., Kader, M. A., Colgate, E. R., Carmolli, M., Dickson, D. M., Diehl, S. A., . . . Kirkpatrick, B. D. (2021). Oral rotavirus vaccine shedding as a marker of mucosal immunity. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-01288-1
Donowitz, J. R., Pu, Z., Lin, Y., Alam, M., Ferdous, T., Shama, T., . . . Petri, W. A. J. (2022). Small Intestine Bacterial Overgrowth in Bangladeshi Infants Is Associated With Growth Stunting in a Longitudinal Cohort. AMERICAN JOURNAL OF GASTROENTEROLOGY, 117(1), 167-175. doi:10.14309/ajg.0000000000001535
Kabir, M., Alam, M., Nayak, U., Arju, T., Hossain, B., Tarannum, R., . . . Gilchrist, C. A. (2021). Nonsterile immunity to cryptosporidiosis in infants is associated with mucosal IgA against the sporozoite and protection from malnutrition. PLOS PATHOGENS, 17(6). doi:10.1371/journal.ppat.1009445
Zimmerman, K. D., Schurr, T. G., Chen, W. -M., Nayak, U., Mychaleckyj, J. C., Quet, Q., . . . Ramos, P. S. (2021). Genetic landscape of Gullah African Americans. AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 175(4), 905-919. doi:10.1002/ajpa.24333
Duchen, D., Haque, R., Chen, L., Wojcik, G., Korpe, P., Nayak, U., . . . Duggal, P. (2021). Host Genome-Wide Association Study of Infant Susceptibility to Shigella-Associated Diarrhea. INFECTION AND IMMUNITY, 89(6). doi:10.1128/IAI.00012-21
Carey, M. A., Medlock, G. L., Alam, M., Kabir, M., Uddin, M. J., Nayak, U., . . . Gilchrist, C. A. (2021). Megasphaera in the Stool Microbiota Is Negatively Associated With Diarrheal Cryptosporidiosis. CLINICAL INFECTIOUS DISEASES, 73(6), E1242-E1251. doi:10.1093/cid/ciab207
Graff, M., Justice, A. E., Young, K. L., Marouli, E., Zhang, X., Fine, R. S., . . . North, K. E. (2021). Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry. AMERICAN JOURNAL OF HUMAN GENETICS, 108(4), 564-582. doi:10.1016/j.ajhg.2021.02.011
Donowitz, J. R., Drew, J., Taniuchi, M., Platts-Mills, J. A., Alam, M., Ferdous, T., . . . Petri, W. A. (2021). Diarrheal Pathogens Associated With Growth and Neurodevelopment. CLINICAL INFECTIOUS DISEASES, 73(3), E683-E691. doi:10.1093/cid/ciaa1938
2020
Leslie, J. L., Weddle, E., Yum, L. K., Lin, Y., Jenior, M. L., Lee, B., . . . Petri, W. A. J. (2021). Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis. CLINICAL INFECTIOUS DISEASES, 72(11), E868-E871. doi:10.1093/cid/ciaa1409
Williams, F. B., Kader, A., Colgate, E. R., Dickson, D. M., Carmolli, M., Uddin, M. I., . . . Lee, B. (2021). Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh. JOURNAL OF INFECTIOUS DISEASES, 224(7), 1147-1151. doi:10.1093/infdis/jiaa101
2019
Mychaleckyj, J. C., Zhang, D., Nayak, U., Colgate, E. R., Carmolli, M., Dickson, D., . . . Petri, W. A. J. (2020). Association of breast milk gamma-linolenic acid with infant anthropometric outcomes in urban, low-income Bangladeshi families: a prospective, birth cohort study. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 74(5), 698-707. doi:10.1038/s41430-019-0498-6
Donowitz, J. R., Parikh, H. I., Taniuchi, M., Gilchrist, C. A., Haque, R., Kirkpatrick, B. D., . . . Petri, W. A. J. (2019). Increased Fecal Lactobacillus Is Associated With a Positive Glucose Hydrogen Breath Test in Bangladeshi Children. OPEN FORUM INFECTIOUS DISEASES, 6(7). doi:10.1093/ofid/ofz266
Moreau, G. B., Ramakrishnan, G., Cook, H. L., Fox, T. E., Nayak, U., Ma, J. Z., . . . Petri, W. A. J. (2019). Childhood growth and neurocognition are associated with distinct sets of metabolites. EBIOMEDICINE, 44, 597-606. doi:10.1016/j.ebiom.2019.05.043
2018
Mychaleckyj, J. C., Nayak, U., Colgate, E. R., Zhang, D., Carstensen, T., Ahmed, S., . . . Petri, W. A. J. (2018). Multiplex genomewide association analysis of breast milk fatty acid composition extends the phenotypic association and potential selection of FADS1 variants to arachidonic acid, a critical infant micronutrient. JOURNAL OF MEDICAL GENETICS, 55(7), 459-468. doi:10.1136/jmedgenet-2017-105134
Lee, B., Carmolli, M., Dickson, D. M., Colgate, E. R., Diehl, S. A., Uddin, M. I., . . . Kirkpatrick, B. D. (2018). Rotavirus-Specific Immunoglobulin A Responses Are Impaired and Serve as a Suboptimal Correlate of Protection Among Infants in Bangladesh. CLINICAL INFECTIOUS DISEASES, 67(2), 186-192. doi:10.1093/cid/ciy076
Lee, B., Dickson, D. M., deCamp, A. C., Colgate, E. R., Diehl, S. A., Uddin, M. I., . . . Kirkpatrick, B. D. (2018). Histo-Blood Group Antigen Phenotype Determines Susceptibility to Genotype-Specific Rotavirus Infections and Impacts Measures of Rotavirus Vaccine Efficacy. JOURNAL OF INFECTIOUS DISEASES, 217(9), 1399-1407. doi:10.1093/infdis/jiy054
2017
Ng, M. C. Y., Graff, M., Lu, Y., Justice, A. E., Mudgal, P., Liu, C. -T., . . . North, K. E. (2017). Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. PLOS GENETICS, 13(4). doi:10.1371/journal.pgen.1006719
Nayak, U., Kanungo, S., Zhang, D., Colgate, E. R., Carmolli, M. P., Dey, A., . . . Mychaleckyj, J. C. (2017). Influence of maternal and socioeconomic factors on breast milk fatty acid composition in urban, low-income families. MATERNAL AND CHILD NUTRITION, 13(4). doi:10.1111/mcn.12423
Mychaleckyj, J. C., Havt, A., Nayak, U., Pinkerton, R., Farber, E., Concannon, P., . . . Guerrant, R. L. (2017). Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions. MOLECULAR BIOLOGY AND EVOLUTION, 34(3), 559-574. doi:10.1093/molbev/msw249
2016
Liu, C. -T., Raghavan, S., Maruthur, N., Kabagambe, E. K., Hong, J., Ng, M. C. Y., . . . Meigs, J. B. (2016). Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. AMERICAN JOURNAL OF HUMAN GENETICS, 99(1), 56-75. doi:10.1016/j.ajhg.2016.05.006
Colgate, E. R., Haque, R., Dickson, D. M., Carmolli, M. P., Mychaleckyj, J. C., Nayak, U., . . . Kirkpatrick, B. D. (2016). Delayed Dosing of Oral Rotavirus Vaccine Demonstrates Decreased Risk of Rotavirus Gastroenteritis Associated With Serum Zinc: A Randomized Controlled Trial. CLINICAL INFECTIOUS DISEASES, 63(5), 634-641. doi:10.1093/cid/ciw346
Taniuchi, M., Platts-Mills, J. A., Begum, S., Uddin, M. J., Sobuz, S. U., Liu, J., . . . Houpt, E. R. (2016). Impact of enterovirus and other enteric pathogens on oral polio and rotavirus vaccine performance in Bangladeshi infants. VACCINE, 34(27), 3068-3075. doi:10.1016/j.vaccine.2016.04.080
2015
Mychaleckyj, J. C., Haque, R., Carmolli, M., Zhang, D., Colgate, E. R., Nayak, U., . . . Petri, W. A. J. (2016). Effect of substituting IPV for tOPV on immunity to poliovirus in Bangladeshi infants: An open-label randomized controlled trial. VACCINE, 34(3), 358-366. doi:10.1016/j.vaccine.2015.11.046
Naylor, C., Lu, M., Haque, R., Mondal, D., Buonomo, E., Nayak, U., . . . Petri, W. A. J. (2015). Environmental Enteropathy, Oral Vaccine Failure and Growth Faltering in Infants in Bangladesh. EBIOMEDICINE, 2(11), 1759-1766. doi:10.1016/j.ebiom.2015.09.036
Kirkpatrick, B. D., Colgate, E. R., Mychaleckyj, J. C., Hague, R., Dickson, D. M., Carmolli, M. P., . . . Petri, W. A. J. (2015). The "Performance of Rotavirus and Oral Polio Vaccines in Developing Countries" (PROVIDE) Study: Description of Methods of an Interventional Study Designed to Explore Complex Biologic Problems. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 92(4), 744-751. doi:10.4269/ajtmh.14-0518
2014
Ng, M. C. Y., Shriner, D., Chen, B. H., Li, J., Chen, W. -M., Guo, X., . . . Bowden, D. W. (2014). Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes. PLOS GENETICS, 10(8). doi:10.1371/journal.pgen.1004517
2013
Haque, R., Snider, C., Liu, Y., Ma, J. Z., Liu, L., Nayak, U., . . . Petri, W. A. J. (2014). Oral polio vaccine response in breast fed infants with malnutrition and diarrhea. VACCINE, 32(4), 478-482. doi:10.1016/j.vaccine.2013.11.056
Monda, K. L., Chen, G. K., Taylor, K. C., Palmer, C., Edwards, T. L., Lange, L. A., . . . Haiman, C. A. (2013). A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. NATURE GENETICS, 45(6), 690-+. doi:10.1038/ng.2608
Liu, C. -T., Monda, K. L., Taylor, K. C., Lange, L., Demerath, E. W., Palmas, W., . . . Fox, C. S. (2013). Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci. PLOS GENETICS, 9(8). doi:10.1371/journal.pgen.1003681
Langefeld, C. D., Sajuthi, S., Divers, J., Huang, Y., Nayak, U., Chen, W. -M., . . . Ramos, P. S. (2013). Identification Of Autoimmune Disease Risk Alleles That Are Under Recent Selection In The Sea Island Gullah African Americans. ARTHRITIS AND RHEUMATISM, 65, S60-S61. Retrieved from https://www.webofscience.com/
Ramos, P. S., Titus, N., Sajuthi, S., Divers, J., Huang, Y., Nayak, U., . . . Langefeld, C. D. (2013). Identification Of Autoimmune Disease Genes In Regions Under Selection In The Gullah African American Population Of South Carolina. ARTHRITIS AND RHEUMATISM, 65, S61. Retrieved from https://www.webofscience.com/
2012
Ram, M., Gupte, N., Nayak, U., Kinikar, A. A., Khandave, M., Shankar, A. V., . . . Gupta, A. (2012). Growth patterns among HIV-exposed infants receiving nevirapine prophylaxis in Pune, India. BMC INFECTIOUS DISEASES, 12. doi:10.1186/1471-2334-12-282
Mychaleckyj, J. C., Craven, T., Nayak, U., Buse, J., Crouse, J. R., Elam, M., . . . Ginsberg, H. N. (2012). Reversibility of Fenofibrate Therapy-Induced Renal Function Impairment in ACCORD Type 2 Diabetic Participants. DIABETES CARE, 35(5), 1008-1014. doi:10.2337/dc11-1811
2011
Gupta, A., Chandrasekhar, A., Gupte, N., Patil, S., Bhosale, R., Sambarey, P., . . . Byramjee Jeejeebhoy Medical College–Johns Hopkins University Study Group. (2011). Symptom screening among HIV-infected pregnant women is acceptable and has high negative predictive value for active tuberculosis.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 53(10), 1015-1018. doi:10.1093/cid/cir605
Singh, H. K., Gupte, N., Kinikar, A., Bharadwaj, R., Sastry, J., Suryavanshi, N., . . . Gupta, A. (2011). High Rates of All-cause and Gastroenteritis-related Hospitalization Morbidity and Mortality among HIV-exposed Indian Infants. BMC INFECTIOUS DISEASES, 11. doi:10.1186/1471-2334-11-193