Xudong Joshua Li

Zhang, Y., Chi, J., Manley, B., Oh, E., Yang, H., Wang, J., & Li, X. (2024). Inflammatory Bowel Disease as a Risk Factor for Complications and Revisions Following Lumbar Discectomy. GLOBAL SPINE JOURNAL. doi:10.1177/21925682241270069

Biswas, R., Manley, B. J., Xiao, L., Siringan, M. J., Crichton, R. A., Stein, J. B., . . . Zhang, J. (2024). Reactive Oxygen Species Scavenging Capacity of Functional Fullerenes in Solution and in Macrophage Cells. ACS APPLIED NANO MATERIALS. doi:10.1021/acsanm.4c03467

Jin, L., Xiao, L., Manley, B. J., Oh, E. G., Huang, W., Zhang, Y., . . . Li, X. (2024). CCR2 monocytes as therapeutic targets for acute disc herniation and radiculopathy in mouse models. OSTEOARTHRITIS AND CARTILAGE, 32(1), 52-65. doi:10.1016/j.joca.2023.08.014

Xie, W., Xing, Y., Xiao, L., Zhang, P., Oh, R., Zhang, Y., . . . Li, X. (2023). Intervertebral Disc-on-a-Chip^MF: A New Model for Mouse Disc Culture via Integrating Mechanical Loading and Dynamic Media Flow. ADVANCED MATERIALS TECHNOLOGIES, 8(21). doi:10.1002/admt.202300606

Xiao, L., Matharoo, J., Chi, J., Ma, J., Chen, M., Manley, B., . . . Li, X. (2023). Transient depletion of macrophages alters local inflammatory response at the site of disc herniation in a transgenic mouse model. OSTEOARTHRITIS AND CARTILAGE, 31(7), 894-907. doi:10.1016/j.joca.2023.01.574

Xiao, L., Huang, R., Sulimai, N., Yao, R., Manley, B., Xu, P., . . . Li, X. (2022). Amine Functionalized Trimetallic Nitride Endohedral Fullerenes: A Class of Nanoparticle to Tackle Low Back/Leg Pain. ACS APPLIED BIO MATERIALS, 5(6), 2943-2955. doi:10.1021/acsabm.2c00269

Salahi, A., Rane, A., Xiao, L., Honrado, C., Li, X., Jin, L., & Swami, N. S. (2022). Single-cell assessment of the modulation of macrophage activation by ex vivo intervertebral discs using impedance cytometry. BIOSENSORS & BIOELECTRONICS, 210. doi:10.1016/j.bios.2022.114346

Yin, M., Xie, W., Xiao, L., Sung, S. -S. J., Ma, M., Jin, L., . . . Xu, B. (2022). Cyclic swelling enabled, electrically conductive 3D porous structures for microfluidic urinalysis devices. EXTREME MECHANICS LETTERS, 52. doi:10.1016/j.eml.2022.101631

Kamalapathy, P. N. N., Vatani, J., Raso, J., Hassanzadeh, H., & Li, X. (2022). How old is too old?: Matched analysis of geriatric patients undergoing anterior lumbar interbody fusion. CLINICAL NEUROLOGY AND NEUROSURGERY, 212. doi:10.1016/j.clineuro.2021.107090

Jin, L., Xiao, L., Ding, M., Pan, A., Balian, G., Sung, S. -S. J., & Li, X. J. (2022). Heterogeneous macrophages contribute to the pathology of disc herniation induced radiculopathy. SPINE JOURNAL, 22(4), 677-689. doi:10.1016/j.spinee.2021.10.014

Althoff, A. D., Kamalapathy, P., Vatani, J., Hassanzadeh, H., & Li, X. (2021). Osteoporosis is associated with increased minor complications following single level ALIF and PSIF: an analysis of 7,004 patients.. Journal of spine surgery (Hong Kong), 7(3), 269-276. doi:10.21037/jss-21-29

Gailey, C. D., Wang, E. J., Jin, L., Ahmadi, S., Brautigan, D. L., Li, X., . . . Scott, M. M. (2021). PhosphositeT674Amutation in kinesin family member3Afails to reproduce tissue and ciliary defects characteristic ofCILK1loss of function. DEVELOPMENTAL DYNAMICS, 250(2), 263-273. doi:10.1002/dvdy.252

Li, X. J., Lenke, L. G., Jin, L., Tuchman, A., Tan, L. A., Lehman, R. A., & Cerpa, M. (2020). Surgeon-specific risk stratification model for early complications after complex adult spinal deformity surgery. SPINE DEFORMITY, 8(1), 97-104. doi:10.1007/s43390-020-00047-y

Xing, Y., Zhang, P., Zhang, Y., Holzer, L., Xiao, L., He, Y., . . . Oberholzer, J. (2020). A multi-throughput mechanical loading system for mouse intervertebral disc. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 105. doi:10.1016/j.jmbbm.2020.103636

Kent, J. B., Jin, L., & Li, X. J. (2020). Quantifying Biofield Therapy through Biophoton Emission in a Cellular Model.. Journal of scientific exploration : a publication of the Society for Scientific Exploration, 34(3), 434-454. doi:10.31275/20201691

Yin, M., Xiao, L., Liu, Q., Kwon, S. -Y., Zhang, Y., Sharma, P. R., . . . Xu, B. (2019). 3D Printed Microheater Sensor-Integrated, Drug-Encapsulated Microneedle Patch System for Pain Management. ADVANCED HEALTHCARE MATERIALS, 8(23). doi:10.1002/adhm.201901170

Xiao, L., Huang, R., Zhang, Y., Li, T., Dai, J., Nannapuneni, N., . . . Li, X. (2019). A New Formyl Peptide Receptor-1 Antagonist Conjugated Fullerene Nanoparticle for Targeted Treatment of Degenerative Disc Diseases. ACS APPLIED MATERIALS & INTERFACES, 11(42), 38405-38416. doi:10.1021/acsami.9b11783

Aghdasi, B., Li, X., George, J., & Shen, F. H. (2019). Fixation techniques in revision spine surgery. Seminars in Spine Surgery, 31(2), 87-95. doi:10.1053/j.semss.2019.03.007

Xiao, L., Majumdar, R., Dai, J., Li, Y., Xie, L., Shen, F. H., . . . Li, X. (2019). Molecular Detection and Assessment of Intervertebral Disc Degeneration via a Collagen Hybridizing Peptide. ACS BIOMATERIALS SCIENCE & ENGINEERING, 5(4), 1661-1667. doi:10.1021/acsbiomaterials.9b00070

Dai, J., Xing, Y., Xiao, L., Li, J., Cao, R., He, Y., . . . Li, X. (2019). Microfluidic Disc-on-a-Chip Device for Mouse Intervertebral Disc-Pitching a Next-Generation Research Platform To Study Disc Degeneration. ACS BIOMATERIALS SCIENCE & ENGINEERING, 5(4), 2041-2051. doi:10.1021/acsbiomaterials.8b01522

Chen, D. Q., Shimer, A. L., Li, X., Hassanzadeh, H., Shen, F. H., & Singla, A. (2019). Unplanned Immediate Return to Operating Room After Spine Surgery Significance of Immediate Postoperative Radiographs. SPINE, 44(4), 258-262. doi:10.1097/BRS.0000000000002797

Tuchman, A., Tan, L. A., Shillingford, J. N., Li, X. J., & Riew, K. D. (2019). Dynamic changes in the reflex exam of patients with sub-axial cervical stenosis.. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 60, 84-87. doi:10.1016/j.jocn.2018.09.032

Lin, J. D., Tan, L. A., Tuchman, A., Li, X. J., Zhang, H., Ren, K., & Riew, K. D. (2019). Quantitative and qualitative analyses of spinal canal encroachment during cervical laminectomy using the kerrison rongeur versus High-Speed burr. BRITISH JOURNAL OF NEUROSURGERY, 33(2), 131-134. doi:10.1080/02688697.2018.1559274

Yerneni, K., Burke, J. F., Tuchman, A., Li, X. J., Metz, L. N., Lehman, R. A. J., . . . Tan, L. A. (2019). Topical tranexamic acid in spinal surgery: A systematic review and meta-analysis. JOURNAL OF CLINICAL NEUROSCIENCE, 61, 114-119. doi:10.1016/j.jocn.2018.10.121

Oshina, M., Oshima, Y., Tanaka, S., Tan, L. A., Li, X. J., Tuchman, A., & Riew, K. D. (2018). Utility of Oblique Sagittal Reformatted and Three-dimensional Surface Reconstruction Computed Tomography in Foraminal Stenosis Decompression.. Scientific reports, 8(1), 16011. doi:10.1038/s41598-018-34458-9

Horowitz, J. A., Puvanesarajah, V., Jain, A., Li, X. J., Shimer, A. L., Shen, F. H., & Hassanzadeh, H. (2018). Rheumatoid Arthritis Is Associated With an Increased Risk of Postoperative Infection and Revision Surgery in Elderly Patients Undergoing Anterior Cervical Fusion. SPINE, 43(17), E1040-E1044. doi:10.1097/BRS.0000000000002614

Tan, L. A., Yerneni, K., Tuchman, A., Li, X. J., Cerpa, M., Lehman, R. A., & Lenke, L. G. (2018). Utilization of the 3D-printed spine model for freehand pedicle screw placement in complex spinal deformity correction.. Journal of spine surgery (Hong Kong), 4(2), 319-327. doi:10.21037/jss.2018.05.16

Tan, L. A., Benkli, B., Tuchman, A., Li, X. J., Desai, N. N., Bottiglieri, T. S., . . . Lehman, R. A. J. (2018). High prevalence of greater trochanteric pain syndrome among patients presenting to spine clinic for evaluation of degenerative lumbar pathologies. JOURNAL OF CLINICAL NEUROSCIENCE, 53, 89-91. doi:10.1016/j.jocn.2018.04.030

Xiao, L., Hong, K., Roberson, C., Ding, M., Fernandez, A., Shen, F., . . . Li, X. (2018). Hydroxylated Fullerene: A Stellar Nanomedicine to Treat Lumbar Radiculopathy via Antagonizing TNF-α-lnduced Ion Channel Activation, Calcium Signaling, and Neuropeptide Production. ACS BIOMATERIALS SCIENCE & ENGINEERING, 4(1), 266-277. doi:10.1021/acsbiomaterials.7b00735

Ding, M., Jin, L., Xie, L., Park, S. H., Tong, Y., Wu, D., . . . Li, X. (2018). A Murine Model for Human ECO Syndrome Reveals a Critical Role of Intestinal Cell Kinase in Skeletal Development. CALCIFIED TISSUE INTERNATIONAL, 102(3), 348-357. doi:10.1007/s00223-017-0355-3

Yeh, C. -H., Chen, D., Aghdasi, B., Xiao, L., Ding, M., Jin, L., & Li, X. (2018). Link protein N-terminal peptide and fullerol promote matrix production and decrease degradation enzymes in rabbit annulus cells. CONNECTIVE TISSUE RESEARCH, 59(2), 191-200. doi:10.1080/03008207.2017.1330333

Li, T., Xiao, L., Yang, J., Ding, M., Zhou, Z., LaConte, L., . . . Li, X. (2017). Trimetallic Nitride Endohedral Fullerenes Carboxyl-Gd₃N@C₈₀: A New Theranostic Agent for Combating Oxidative Stress and Resolving Inflammation. ACS APPLIED MATERIALS & INTERFACES, 9(21), 17681-17687. doi:10.1021/acsami.7b04718

Xiao, L., Ding, M., Fernandez, A., Zhao, P., Jin, L., & Li, X. (2017). CURCUMIN ALLEVIATES LUMBAR RADICULOPATHY BY REDUCING NEUROINFLAMMATION, OXIDATIVE STRESS AND NOCICEPTIVE FACTORS. EUROPEAN CELLS & MATERIALS, 33, 279-293. doi:10.22203/eCM.v033a21

Tong, Y., Park, S. H., Wu, D., Xu, W., Guillot, S. J., Jin, L., . . . Fu, Z. (2017). An essential role of intestinal cell kinase in lung development is linked to the perinatal lethality of human ECO syndrome. FEBS LETTERS, 591(9), 1247-1257. doi:10.1002/1873-3468.12644

Jin, L., Ding, M., Oklopcic, A., Aghdasi, B., Xiao, L., Li, Z., . . . Li, X. (2017). Nanoparticle fullerol alleviates radiculopathy via NLRP3 inflammasome and neuropeptides. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 13(6), 2049-2059. doi:10.1016/j.nano.2017.03.015

Puvanesarajah, V., Jain, A., Shimer, A. L., Li, X., Singla, A., Shen, F., & Hassanzadeh, H. (2017). Complications and Mortality Following 1 to 2 Level Lumbar Fusion Surgery in Patients Above 80 Years of Age.. Spine, 42(6), 437-441. doi:10.1097/brs.0000000000001759

Xiao, L., Li, T., Ding, M., Yang, J., Rodriguez-Corrales, J., LaConte, S. M., . . . Li, X. (2017). Detecting Chronic Post-Traumatic Osteomyelitis of Mouse Tibia via an IL-13Rα2 Targeted Metallofullerene Magnetic Resonance Imaging Probe. BIOCONJUGATE CHEMISTRY, 28(2), 649-658. doi:10.1021/acs.bioconjchem.6b00708

Xiao, L., Ding, M., Zhang, Y., Chordia, M., Pan, D., Shimer, A., . . . Li, X. (2017). A Novel Modality for Functional Imaging in Acute Intervertebral Disk Herniation via Tracking Leukocyte Infiltration. MOLECULAR IMAGING AND BIOLOGY, 19(5), 703-713. doi:10.1007/s11307-016-1038-6

Xiao, L., Ding, M., Saadoon, O., Vess, E., Fernandez, A., Zhao, P., . . . Li, X. (2017). A novel culture platform for fast proliferation of human annulus fibrosus cells. CELL AND TISSUE RESEARCH, 367(2), 339-350. doi:10.1007/s00441-016-2497-4

Yeh, C. -H., Jin, L., Shen, F., Balian, G., & Li, X. J. (2016). miR-221 attenuates the osteogenic differentiation of human annulus fibrosus cells. SPINE JOURNAL, 16(7), 896-904. doi:10.1016/j.spinee.2016.03.026

Li, X. J., Jin, L., Hassanzadeh, H., & Shen, F. H. (2015). State of the art and future of stem cells in spine. Seminars in Spine Surgery, 27(2), 93-102. doi:10.1053/j.semss.2015.03.006

Chen, Z., Zhao, M., Liu, K., Wan, Y., Li, X., & Feng, G. (2014). Novel chitosan hydrogel formed by ethylene glycol chitosan, 1,6-diisocyanatohexan and polyethylene glycol-400 for tissue engineering scaffold: in vitro and in vivo evaluation. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 25(8), 1903-1913. doi:10.1007/s10856-014-5223-3

Yang, D., Wang, D., Shimer, A., Shen, F. H., Li, X., & Yang, X. (2014). Glutathione protects human nucleus pulposus cells from cell apoptosis and inhibition of matrix synthesis. CONNECTIVE TISSUE RESEARCH, 55(2), 132-139. doi:10.3109/03008207.2013.876421

Liu, Q., Cui, Q., Li, X. J., & Jin, L. (2014). The applications of buckminsterfullerene C₆₀ and derivatives in orthopaedic research. CONNECTIVE TISSUE RESEARCH, 55(2), 71-79. doi:10.3109/03008207.2013.877894

Yang, X., Jin, L., Yao, L., Shen, F. H., Shimer, A. L., & Li, X. (2014). Antioxidative nanofullerol prevents intervertebral disk degeneration. INTERNATIONAL JOURNAL OF NANOMEDICINE, 9, 2419-2430. doi:10.2147/IJN.S60853

Jin, L., Liu, Q., Scott, P., Zhang, D., Shen, F., Balian, G., & Li, X. (2014). Annulus Fibrosus Cell Characteristics Are a Potential Source of Intervertebral Disc Pathogenesis. PLOS ONE, 9(5). doi:10.1371/journal.pone.0096519

Werner, B. C., Li, X., & Shen, F. H. (2014). Stem cells in preclinical spine studies. SPINE JOURNAL, 14(3), 542-551. doi:10.1016/j.spinee.2013.08.031

Liang, H., Li, X., Shimer, A. L., Balian, G., & Shen, F. H. (2014). A novel strategy of spine defect repair with a degradable bioactive scaffold preloaded with adipose-derived stromal cells. SPINE JOURNAL, 14(3), 445-454. doi:10.1016/j.spinee.2013.09.045

Yang, X., Shang, H., Katz, A., & Li, X. (2013). A Modified Aggregate Culture for Chondrogenesis of Human Adipose-Derived Stem Cells Genetically Modified with Growth and Differentiation Factor 5. BIORESEARCH OPEN ACCESS, 2(4), 258-265. doi:10.1089/biores.2013.0014

Liu, Q., Jin, L., Mahon, B. H., Chordia, M. D., Shen, F. H., & Li, X. (2013). Novel Treatment of Neuroinflammation Against Low Back Pain by Soluble Fullerol Nanoparticles. SPINE, 38(17), 1443-1451. doi:10.1097/BRS.0b013e31828fc6b7

Liu, Q., Jin, L., Shen, F. H., Balian, G., & Li, X. J. (2013). Fullerol nanoparticles suppress inflammatory response and adipogenesis of vertebral bone marrow stromal cells-a potential novel treatment for intervertebral disc degeneration. SPINE JOURNAL, 13(11), 1571-1580. doi:10.1016/j.spinee.2013.04.004

Jin, L., Feng, G., Reames, D. L., Shimer, A. L., Shen, F. H., & Li, X. (2013). The effects of simulated microgravity on intervertebral disc degeneration. SPINE JOURNAL, 13(3), 235-242. doi:10.1016/j.spinee.2012.01.022

Jin, L., Shimmer, A. L., & Li, X. (2013). The challenge and advancement of annulus fibrosus tissue engineering. EUROPEAN SPINE JOURNAL, 22(5), 1090-1100. doi:10.1007/s00586-013-2663-2

Jin, L., & Li, X. (2013). Growth Differentiation Factor 5 Regulation in Bone Regeneration. CURRENT PHARMACEUTICAL DESIGN, 19(19), 3364-3373. doi:10.2174/1381612811319190003

Shen, F. H., Werner, B. C., Liang, H., Shang, H., Yang, N., Li, X., . . . Katz, A. J. (2013). Implications of adipose-derived stromal cells in a 3D culture system for osteogenic differentiation: an in vitro and in vivo investigation. SPINE JOURNAL, 13(1), 32-43. doi:10.1016/j.spinee.2013.01.002

Zhang, D., Jin, L., Reames, D. L., Shen, F. H., Shimer, A. L., & Li, X. (2013). Intervertebral Disc Degeneration and Ectopic Bone Formation in Apolipoprotein E Knockout Mice. JOURNAL OF ORTHOPAEDIC RESEARCH, 31(2), 210-217. doi:10.1002/jor.22216

Kapur, S. K., Wang, X., Shang, H., Yun, S., Li, X., Feng, G., . . . Katz, A. J. (2012). Human adipose stem cells maintain proliferative, synthetic and multipotential properties when suspension cultured as self-assembling spheroids. BIOFABRICATION, 4(2). doi:10.1088/1758-5082/4/2/025004

Liu, H., Yang, X., Zhang, Y., Dighe, A., Li, X., & Cui, Q. (2012). Fullerol antagonizes dexamethasone-induced oxidative stress and adipogenesis while enhancing osteogenesis in a cloned bone marrow mesenchymal stem cell. JOURNAL OF ORTHOPAEDIC RESEARCH, 30(7), 1051-1057. doi:10.1002/jor.22054

Jin, L., Wan, Y., Shimer, A. L., Shen, F. H., & Li, X. J. (2012). Intervertebral disk-like biphasic scaffold-demineralized bone matrix cylinder and poly(polycaprolactone triol malate)-for interbody spine fusion. JOURNAL OF TISSUE ENGINEERING, 3(1). doi:10.1177/2041731412454420

Yang, X., Wang, D., Hao, J., Gong, M., Arlet, V., Balian, G., . . . Li, X. J. (2011). Enhancement of Matrix Production and Cell Proliferation in Human Annulus Cells Under Bioreactor Culture. TISSUE ENGINEERING PART A, 17(11-12), 1595-1603. doi:10.1089/ten.tea.2010.0449

Yang, X., Wan, Y., Qiao, X., Arlet, V., & Li, X. (2010). Transcriptional alteration of matrix-related gene expression in cultured human disc cells by nanoparticles of a bismethanophosphonate fullerene. CELL BIOLOGY INTERNATIONAL, 34(8), 837-844. doi:10.1042/CBI20090382

Liang, H., Wang, K., Shimer, A. L., Li, X., Balian, G., & Shen, F. H. (2010). Use of a bioactive scaffold for the repair of bone defects in a novel reproducible vertebral body defect model. BONE, 47(2), 197-204. doi:10.1016/j.bone.2010.05.023

Deng, M., Nair, L. S., Nukavarapu, S. R., Jiang, T., Kanner, W. A., Li, X., . . . Laurencin, C. T. (2010). Dipeptide-based polyphosphazene and polyester blends for bone tissue engineering. BIOMATERIALS, 31(18), 4898-4908. doi:10.1016/j.biomaterials.2010.02.058

Feng, G., Yang, X., Shang, H., Marks, I. W., Shen, F. H., Katz, A., . . . Li, X. (2010). Multipotential Differentiation of Human Anulus Fibrosus Cells An in Vitro Study. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 92A(3), 675-685. doi:10.2106/JBJS.H.01672

Gong, M., Zhang, D., Wan, Y., Edmondson, B., Cui, Q., & Li, X. (2010). Engineered synovial joint condyle using demineralized bone matrix. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 30(4), 531-536. doi:10.1016/j.msec.2010.01.015