Xin Li
Richard F. Edlich Professor of Biomedical Research, Plastic Surgery
Bio & Overview
Academic Information
- Department
- Plastic Surgery
Research Interests
Research Opportunities
- Cancer Biology
- Cellular and Molecular Metabolism
- Experimental Pathology
- Neuroscience
PhD Programs
- Neuroscience
Selected Publications
2026
Hydrogels in head and neck cancer: Innovations and translational advances in research and therapy
Biomaterials. 2026; 330: 124049. DOI:10.1016/J.BIOMATERIALS.2026.124049.
Vascular changes and their implications in lipedema
Frontiers in Cell and Developmental Biology. 2026; 14:. DOI:10.3389/FCELL.2026.1819443.
2025
Role of Fungi in Tumorigenesis: Promises and Challenges
Annual Review of Pathology: Mechanisms of Disease. 2025; 20(1): 459 - 482. DOI:10.1146/ANNUREV-PATHMECHDIS-111523-023524.
Succinate modulates oral dysbiosis and inflammation through a succinate receptor 1 dependent mechanism in aged mice
International Journal of Oral Science. 2025; 17(1):. DOI:10.1038/S41368-025-00376-6.
The IADR and AADOCR Policy Statement on Tobacco Industry–Funded Research
Journal of Dental Research. 2025; 104(8): 817 - 819. DOI:10.1177/00220345251326085.
2024
A novel SUCNR1 inhibitor alleviates dysbiosis through inhibition of host responses without direct interaction with host microbiota
Molecular Oral Microbiology. 2024; 39(2): 80 - 90. DOI:10.1111/OMI.12431.
Getting off tract: contributions of intraorgan microbiota to cancer in extraintestinal organs
Gut. 2024; 73(1): 175 - 185. DOI:10.1136/GUTJNL-2022-328834.
2023
Metformin regulates bone marrow stromal cells to accelerate bone healing in diabetic mice
eLife. 2023; 12:. DOI:10.7554/ELIFE.88310.
2022
Electronic cigarette use enriches periodontal pathogens
Molecular Oral Microbiology. 2022; 37(2): 63 - 76. DOI:10.1111/OMI.12361.
Electronic Cigarette Use Promotes a Unique Periodontal Microbiome
mBio. 2022; 13(1):. DOI:10.1128/MBIO.00075-22.
Intrahepatic microbes govern liver immunity by programming NKT cells
Journal of Clinical Investigation. 2022; 132(8):. DOI:10.1172/JCI151725.
Neuroinflammation: A Distal Consequence of Periodontitis
Journal of Dental Research. 2022; 101(12): 1441 - 1449. DOI:10.1177/00220345221102084.
Targeting the succinate receptor effectively inhibits periodontitis
Cell Reports. 2022; 40(12): 111389. DOI:10.1016/J.CELREP.2022.111389.
The Gut Microbiome, Metformin, and Aging
Annual Review of Pharmacology and Toxicology. 2022; 62(1): 85 - 108. DOI:10.1146/ANNUREV-PHARMTOX-051920-093829.
The mycobiome-immune axis: The next frontier in pancreatic cancer
Cancer Cell. 2022; 40(2): 120 - 122. DOI:10.1016/J.CCELL.2022.01.009.
The tumor mycobiome: A paradigm shift in cancer pathogenesis
Cell. 2022; 185(20): 3648 - 3651. DOI:10.1016/J.CELL.2022.09.013.
2021
Comparative Effects of E-Cigarette Aerosol on Periodontium of Periodontitis Patients
Frontiers in Oral Health. 2021; 2:. DOI:10.3389/FROH.2021.729144.
Diethyl Succinate Modulates Microglial Polarization and Activation by Reducing Mitochondrial Fission and Cellular ROS
Metabolites. 2021; 11(12): 854. DOI:10.3390/METABO11120854.
Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice
Communications Biology. 2021; 4(1):. DOI:10.1038/S42003-021-02413-6.
Microbial population shift and metabolic characterization of silver diamine fluoride treatment failure on dental caries
PLoS ONE. 2021; 16(3): e0242396. DOI:10.1371/JOURNAL.PONE.0242396.
Predicting Treatment Nonresponse in Hispanic/Latino Children Receiving Silver Diamine Fluoride for Caries Arrest: A Pilot Study Using Machine Learning
Frontiers in Oral Health. 2021; 2:. DOI:10.3389/FROH.2021.695759.
Progranulin promotes bone fracture healing via TNFR pathways in mice with type 2 diabetes mellitus
Annals of the New York Academy of Sciences. 2021; 1490(1): 77 - 89. DOI:10.1111/NYAS.14568.
Protective Measures against COVID-19: Dental Practice and Infection Control
Healthcare. 2021; 9(6): 679. DOI:10.3390/HEALTHCARE9060679.
Vaping, SARS-CoV-2, and Multisystem Inflammatory Syndrome: A Perfect Storm
Frontiers in Pediatrics. 2021; 9:. DOI:10.3389/FPED.2021.647925.
2020
Cross talk between drug‐resistant epilepsy and the gut microbiome
Epilepsia. 2020; 61(12): 2619 - 2628. DOI:10.1111/EPI.16744.
E-cigarettes use in the United States: reasons for use, perceptions, and effects on health
BMC Public Health. 2020; 20(1):. DOI:10.1186/S12889-020-09572-X.
Electronic Cigarette Aerosol Modulates the Oral Microbiome and Increases Risk of Infection
iScience. 2020; 23(3): 100884. DOI:10.1016/J.ISCI.2020.100884.
Identification of Differentially Methylated Regions Associated with a Knockout of SUV39H1 in Prostate Cancer Cells
Genes. 2020; 11(10): 1188. DOI:10.3390/GENES11101188.
Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations
Endocrinology and Metabolism. 2020; 35(1): 36 - 43. DOI:10.3803/ENM.2020.35.1.36.
Progranulin promotes diabetic fracture healing in mice with type 1 diabetes
Annals of the New York Academy of Sciences. 2020; 1460(1): 43 - 56. DOI:10.1111/NYAS.14208.
Standardized Arrabidaea chica Extract Shows Cytoprotective Effects in Zoledronic Acid-Treated Fibroblasts and Osteoblasts
Clinical, Cosmetic and Investigational Dentistry. 2020; Volume 12: 327 - 333. DOI:10.2147/CCIDE.S259158.
The Influences of Bioinformatics Tools and Reference Databases in Analyzing the Human Oral Microbial Community
Genes. 2020; 11(8): 878. DOI:10.3390/GENES11080878.
2019
Circulating IGF-1 promotes prostate adenocarcinoma via FOXO3A/BIM signaling in a double-transgenic mouse model
Oncogene. 2019; 38(36): 6338 - 6353. DOI:10.1038/S41388-019-0880-9.
Effects of APS Activates Hepatic Insulin Signaling in HFD-induced IR Mice
Journal of Molecular Endocrinology. 2019; DOI:10.1530/JME-19-0035.
Inhibition of Karyopherin beta 1 suppresses prostate cancer growth
Oncogene. 2019; 38(24): 4700 - 4714. DOI:10.1038/S41388-019-0745-2.
Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis
iScience. 2019; 16: 106 - 121. DOI:10.1016/J.ISCI.2019.05.020.
Targeting cellular metabolism to reduce head and neck cancer growth
Scientific Reports. 2019; 9(1):. DOI:10.1038/S41598-019-41523-4.
The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL
Nature. 2019; 574(7777): 264 - 267. DOI:10.1038/S41586-019-1608-2.
The Microbiome, Malignant Fungating Wounds, and Palliative Care
Frontiers in Cellular and Infection Microbiology. 2019; 9:. DOI:10.3389/FCIMB.2019.00373.
Virome and bacteriome: two sides of the same coin
Current Opinion in Virology. 2019; 37: 37 - 43. DOI:10.1016/J.COVIRO.2019.05.007.
2018
The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression
Cancer Discovery. 2018; 8(4): 403 - 416. DOI:10.1158/2159-8290.CD-17-1134.
2017
Inhibition of KPNA4 attenuates prostate cancer metastasis
Oncogene. 2017; 36(20): 2868 - 2878. DOI:10.1038/ONC.2016.440.
Metformin inhibits SUV39H1-mediated migration of prostate cancer cells
Oncogenesis. 2017; 6(5): e324 - e324. DOI:10.1038/ONCSIS.2017.28.
Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis
Nature Communications. 2017; 8(1):. DOI:10.1038/NCOMMS15621.
2016
Abstract 1526: KPNA4 promotes prostate cancer metastasis through TNFα/β mediated cytokine crosstalk in tumor microenvironment
Cancer Research. 2016; 76(14_Supplement): 1526 - 1526. DOI:10.1158/1538-7445.AM2016-1526.
Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation
Oncotarget. 2016; 7(26): 39556 - 39571. DOI:10.18632/ONCOTARGET.9005.