Stevan W. Djuric, PhD

Research Professor, Pharmacology

Bio & Overview

Research Interests include the development of new therapeutics for immunoinflammatory or allergic diseases, the development of new enabling medicinal chemistry technologies including high throughput experimentation and parallel synthesis and closed loop systems for the design, synthesis, purification and bioassay of new drug molecules.

Academic Information

Department: Pharmacology

Research Interests

Pharmacology The development of new enabling technologies for drug discovery

Selected Publications

Sammler, E., Tonelli, F., Durborow, M., McNasby, J., Sherer, T., Ahmed, M., Djuric, S.W., Merchant, K., Reith, A., Schoepp, D., Klein, C., Padmanabhan, S. and Alessi, D.R. (2026), Addressing the Challenges of Translating LRRK2 Biology into Disease-Modifying Therapies: The LRRK2 Investigative Therapeutics Exchange Initiative. Mov Disord. https://doi.org/10.1002/mds.70397

Stevan W. Djuric, Danielle Schultz, and Eric Voight, "The Value of Academic and Industrial Collaborations in Drug Discovery," ACS Medicinal Chemistry Letters Article ASAP, 2026, DOI: 10.1021/acsmedchemlett.5c00786

Djuric, Stevan W., "Pharmaceutical Research - Academic Collaborations: An Insider’s Perspective." ACS Medicinal Chemistry Letters 2025 16 (5), 851-855, DOI: 10.1021/acsmedchemlett.5c00083

Talaty, N , Sawicki, J, Johnson, RW, Nacham, O and Djuric, SW Recent Developments in the Application of Analytical Spectrometric Techniques to Support Next-Generation Synthesis and Screening, ACS MedChem Letters in press (2023)

Djuric, Stevan W. "New Enabling Drug Discovery Technologies–Recent Progress: Virtual Special Issue." ACS Medicinal Chemistry Letters 14.10 (2023): 1304-1304.

Garner, Amanda L., and Stevan W. Djuric. "RNA: Opening New Doors in Medicinal Chemistry, a Special Issue." ACS Medicinal Chemistry Letters 12.6 (2021): 851-853.

Sawicki, James W., et al. "Rapid analytical characterization of high-throughput chemistry screens utilizing desorption electrospray ionization mass spectrometry." Reaction Chemistry & Engineering 4.9 (2019): 1589-1594

Tu, N. P., Dombrowski, A. W., Goshu, G. M., Vasudevan, A., Djuric, S. W., & Wang, Y. (2019). High‐Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads. Angewandte Chemie, 131(24), 8071-8075.

Ruggeri, Michele, Amanda W. Dombrowski, Stevan W. Djuric, and Ian Richard Baxendale. "Photochemical Flow Synthesis of 3 -Hydroxyazetidines.” ChemPhotoChem 3, no. 12 (2019): 1212-1218.

Ruggeri, M., Dombrowski, A. W., Djuric, S. W., & Baxendale, I. R. (2020). Rearrangement of 3-hydroxyazetidines into 2-oxazolines. The Journal of Organic Chemistry, 85(11), 7276-7286.

Garner, A. L., & Djuric, S. W. (2021). RNA: Opening New Doors in Medicinal Chemistry, a Special Issue. ACS Medicinal Chemistry Letters, 12(6), 851-853.

Accelerated multi-reagent copper catalysed coupling reactions in micro droplets and thin films, Iyer, Kiran; Yi, Jing; Bogdan, Andrew R.; Talaty, Nari; Djuric, Stevan W.; Cooks, R. Graham, Reaction Chemistry & Engineering (2018), Ahead of Print

Pd-PEPPSI-IPent-SiO2: A Supported Catalyst for Challenging Negishi Coupling Reactions in Flow Price, Gregory A.; Hassan, Abbas; Chandrasoma, Nalin; Bogdan, Andrew R.; Djuric, Stevan W.; Organ, Michael G. Angewandte Chemie, Int.Edition (2017), 56(43), 13347-13350

Are We There Yet? Applying Thermodynamic and Kinetic Profiling on Embryonic Ectoderm Development (EED) Hit-to-Lead Program Wang, Ying; Edalji, Rohinton P.; Panchal, Sanjay C.; Sun, Chaohong; Djuric, Stevan W.; Vasudevan, Anil. Journal of Medicinal Chemistry (2017), 60(20), 8321-8335.

Expedient Diels-Alder cycloadditions with ortho-quinodimethanes in a high temperature/pressure flow reactor Tsoung, Jennifer; Wang, Ying; Djuric, Stevan W. Reaction Chemistry & Engineering (2017), 2(4), 458-461.

Integrated Platform for Expedited Synthesis-Purification-Testing of Small Molecule Libraries Baranczak, Aleksandra; Tu, Noah P.; Marjanovic, Jasmina; Searle, Philip A.; Vasudevan, Anil; Djuric, Stevan W. ACS Medicinal Chemistry Letters (2017), 8(4), 461-465.

Journal of Medicinal Chemistry, Technological Advances: Highlights 2015-2016. Djuric, Stevan W.; Meanwell, Nicholas A. Journal of Medicinal Chemistry (2017), 60(1), 1-3.

Synthesis of Fused Pyrimidinone and Quinolone Derivatives in an Automated High Temperature and High Pressure Flow Reactor.Tsoung, Jennifer; Bogdan, Andrew R.; Kantor, Stanislaw; Wang, Ying; Charaschanya, Manwika; Djuric, Stevan W. Journal of Organic Chemistry (2016)

Automated library synthesis of cyclopropyl boronic esters employing diazomethane in a tube-in-tube flow reactor Koolman, Hannes F.; Kantor, Stanislaw; Bogdan, Andrew R.; Wang, Ying; Pan, Jeffrey Y. Djuric, Stevan W. Organic & Biomolecular Chemistry (2016), 14(27), 6591-6595.

High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences Bogdan, Andrew R.; Charaschanya, Manwika; Dombrowski, Amanda W.; Wang, Ying; Djuric, Stevan W. Organic Letters (2016), 18(8), 1732-1735

Continuous flow Negishi cross-couplings employing silica-supported Pd-PEPPSI- IPr precatalyst. Price, Gregory A.; Bogdan, Andrew R.; Aguirre, Ana L.; Iwai, Toshiyuki; Djuric, Stevan W.; Organ, Michael G. Catalysis Science & Technology (2016), 6(13), 4733-4742

Nucleophilic aromatic substitution of heterocycles using a high-temperature and high-pressure flow reactor. Charaschanya, Manwika; Bogdan, Andrew R.; Wang, Ying; Djuric, Stevan W. Tetrahedron Letters (2016), 57(9), 1035-1039.

Tandem Click-Suzuki reactions in a novel flow reactor incorporating immobilized and exchangeable reagents, Tu, Noah P.; Sarris, Kathy; Djuric, Stevan W. RSC Advances (2015), 5(7), 4754-4757.

A Low-Volume Flow Electrochemical Microreactor for Rapid and Automated Process Optimization Roth, G. P.; Stalder, R.; Long, T. R.; Sauer, D. R.; Djuric, S. W. J. Flow Chem. (2013) 3, 34-40.

Hit to Lead optimization of a novel class of squarate-containing polo-like kinase inhibitors, Zhang, Qingwei; Xia, Zhiren; Mitten, Michael J.; Lasko, Loren M.; Klinghofer, Vered; Bouska, Jennifer; Johnson, Eric F.; Penning, Thomas D.; Luo, Yan; Giranda, Vincent L.; Djuric, S.W et al Bioorganic & Medicinal Chemistry Letters (2012), 22(24), 7615-7622.

Contribution of indazolinone tautomers to kinase activity Vasudevan, Anil; Verzal, Mary K.; Villamil, Clara I.; Stewart, Kent D.; Abad-Zapatero, Cele; Oie, Tetsuro; and Djuric, Stevan W. Bioorganic & Medicinal Chemistry Letters (2012), 22(14), 4502-4505.

An integrated synthesis-purification system to accelerate the generation of compounds in pharmaceutical discovery, Hochlowski, Jill E.; Searle, Philip A.; Tu, Noah P.; Pan, Jeffrey Y.; Spanton, Stephen G.; Djuric, Stevan W. Journal of Flow Chemistry (2011), 1, 56-61

Small molecule library synthesis using segmented flow, Thompson, Christina M.; Poole, Jennifer L.; Cross, Jeffrey L.; Akritopoulou-Zanze, Irini; Djuric, Stevan W. Molecules (2011), 16, 9161- 9177.

Scaffold oriented synthesis. Part 4: Design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions , Akritopoulou- Zanze, Irini; Wakefield, Brian D.; Gasiecki, Alan; Kalvin, Douglas; Johnson, Eric F.; Kovar, Peter; Djuric, Stevan W. Bioorganic & Medicinal Chemistry Letters (2011), 21(5), 1480-1483

Scaffold oriented synthesis. Part 3: Design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions . Akritopoulou-Zanze, Irini; Wakefield, Brian D.; Gasiecki, Alan; Kalvin, Douglas; Johnson, Eric F.; Kovar, Peter; Djuric, Stevan W. Bioorganic & Medicinal Chemistry Letters (2011), 21(5), 1476-1479

LOPHTOR: a convenient flow-based photochemical reactor  Anil Vasudevan, Clara Villamil, Jonathan Trumbull, Jeff Olson, David Sutherland, Jeff Pan, Stevan Djuric Tetrahedron Letters, (2010), 51(31), 4007-40011