Yingtang Shi
Associate Professor, Pharmacology
Pinn Hall, Room 5013
Charlottesville, VA 22908
Bio & Overview
Academic Information
- Department
- Pharmacology
Primary Education
- BS, Biology, East China Normal Universitynull
- MS, Physiology, East China Normal Universitynull
- MD, Anthropotomy and Histoembryology, Shanghai Jiao Tong University School of Medicinenull
Other Affiliations
- BIMS
Research Interests
Research Disciplines
- Molecular Pharmacology
- Neuroscience
- Physiology
- Translational Science
Research Opportunities
- Molecular Pharmacology
- Neuroscience
Selected Publications
2025
Araujo EV, Silva PE, Oliveira LM, Shi YT, Takakura AC, Mulkey DK* and Moreira TS*. Oxytocinergic signaling in the respiratory parafacial region increases activity of chemosensitive neurons and respiratory activity. J Physiol. 2025; 603(19):5827-5849. doi: 10.1113/JP287845
2024
Gonye EC, Shi Y, Li K, Clements R, Xu WH, Bayliss DA*. Intrinsic Molecular Proton Sensitivity Underlies GPR4 Effects on Retrotrapezoid Nucleus Neuronal Activation and CO2-Stimulated Breathing. J Neurosci. 2024; 44(36): e0799242024
2023
Souza GA, Stornetta DS, Shi YT, Lim E, Berry FE, Bayliss DA and Abbott SB* Neuromedin B-expressing neurons in retrotrapezoid nucleus regulate respiratory homeostasis and promote stable breathing in adult mice. J Neurosci. 2023,43(30):5501-5520.doi: 10.1523/JNEUROSCI.0386-23.2023.
2022
Moreira, T. S., Shi, Y., Sobrinho, C. R., Milla, B. M., Soto-Perez, J., Stornetta, D. S., . . . Bayliss, D. A. (2022). 5-HT7 receptors expressed in the mouse parafacial region are not required for respiratory chemosensitivity.. FASEB J, 36 Suppl 1. doi:10.1096/fasebj.2022.36.S1.R2540
Shi, Y., Sobrinho, C. R., Soto-Perez, J., Milla, B. M., Stornetta, D. S., Stornetta, R. L., . . . Bayliss, D. A. (2022). 5-HT7 receptors expressed in the mouse parafacial region are not required for respiratory chemosensitivity. JOURNAL OF PHYSIOLOGY-LONDON, 600(11), 2789-2811. doi:10.1113/JP282279
2021
Shi, Y., Stornetta, D. S., Reklow, R. J., Sahu, A., Wabara, Y., Nguyen, A., . . . Bayliss, D. A. (2021). A brainstem peptide system activated at birth protects postnatal breathing. NATURE, 589(7842), 426-+. doi:10.1038/s41586-020-2991-4
Li, K., Abbott, S. B. G., Shi, Y., Eggan, P., Gonye, E. C., & Bayliss, D. A. (2021). TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing. CELL REPORTS, 34(5). doi:10.1016/j.celrep.2021.108714
Li, K., Shi, Y., Gonye, E. C., & Bayliss, D. A. (2021). TRPM4 Contributes to Subthreshold Membrane Potential Oscillations in Multiple Mouse Pacemaker Neurons. ENEURO, 8(6). doi:10.1523/ENEURO.0212-21.2021
2019
Guyenet, P. G., Stornetta, R. L., Souza, G. M. P. R., Abbott, S. B. G., Shi, Y., & Bayliss, D. A. (2019). The Retrotrapezoid Nucleus: Central Chemoreceptor and Regulator of Breathing Automaticity. TRENDS IN NEUROSCIENCES, 2019; 42(11), 807-824. doi:10.1016/j.tins.2019.09.002
2017
Guyenet, P. G., Bayliss, D. A., Stornetta, R. L., Kanbar, R., Shi, Y., Holloway, B. B., . . . Wenker, I. C. (2018). Interdependent feedback regulation of breathing by the carotid bodies and the retrotrapezoid nucleus. JOURNAL OF PHYSIOLOGY-LONDON, 596(15), 3029-3042. doi:10.1113/JP274357
Shi, Y., Stornetta, R. L., Stornetta, D. S., Onengut-Gumuscu, S., Farber, E. A., Turner, S. D., . . . Bayliss, D. A. (2017). Neuromedin B Expression Defines the Mouse Retrotrapezoid Nucleus. JOURNAL OF NEUROSCIENCE, 37(48), 11744-11757. doi:10.1523/JNEUROSCI.2055-17.2017
2016
Shi, Y., Abe, C., Holloway, B. B., Shu, S., Kumar, N. N., Weaver, J. L., . . . Bayliss, D. A. (2016). Nalcn Is a "Leak" Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing. JOURNAL OF NEUROSCIENCE, 36(31), 8174-8187. doi:10.1523/JNEUROSCI.1096-16.2016
Yang, T., Zhang, H. -L., Liang, Q., Shi, Y., Mei, Y. -A., Barrett, P. Q., & Hu, C. (2016). Small-Conductance Ca2+-Activated Potassium Channels Negatively Regulate Aldosterone Secretion in Human Adrenocortical Cells. HYPERTENSION, 68(3), 785-+. doi:10.1161/HYPERTENSIONAHA.116.07094
Guyenet, P. G., Bayliss, D. A., Stornetta, R. L., Ludwig, M. -G., Kumar, N. N., Shi, Y., . . . Wenker, I. C. (2016). Proton detection and breathing regulation by the retrotrapezoid nucleus. JOURNAL OF PHYSIOLOGY-LONDON, 594(6), 1529-1551. doi:10.1113/JP271480
Warthen, D. M., Lambeth, P. S., Ottolini, M., Shi, Y., Barker, B. S., Gaykema, R. P., . . . Scott, M. M. (2016). Activation of Pyramidal Neurons in Mouse Medial Prefrontal Cortex Enhances Food-Seeking Behavior While Reducing Impulsivity in the Absence of an Effect on Food Intake. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 10. doi:10.3389/fnbeh.2016.00063
2015
Kumar, N. N., Velic, A., Soliz, J., Shi, Y., Li, K., Wang, S., . . . Bayliss, D. A. (2015). Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons. SCIENCE, 348(6240), 1255-1260. doi:10.1126/science.aaa0922
2013
Wang, S., Benamer, N., Zanella, S., Kumar, N. N., Shi, Y., Bevengut, M., . . . Bayliss, D. A. (2013). TASK-2 Channels Contribute to pH Sensitivity of Retrotrapezoid Nucleus Chemoreceptor Neurons. JOURNAL OF NEUROSCIENCE, 33(41), 16033-16044. doi:10.1523/JNEUROSCI.2451-13.2013
Kazmierczak, M., Zhang, X., Chen, B., Mulkey, D. K., Shi, Y., Wagner, P. G., . . . Jegla, T. (2013). External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor. JOURNAL OF GENERAL PHYSIOLOGY, 141(6), 721-735. doi:10.1085/jgp.201210938
Wang, S., Shi, Y., Shu, S., Guyenet, P. G., & Bayliss, D. A. (2013). Phox2b-Expressing Retrotrapezoid Neurons Are Intrinsically Responsive to H+ and CO2. JOURNAL OF NEUROSCIENCE, 33(18), 7756-7761. doi:10.1523/JNEUROSCI.5550-12.2013
2011
Shi, Y., & Liu, J. -P. (2011). Gdf11 Facilitates Temporal Progression of Neurogenesis in the Developing Spinal Cord. JOURNAL OF NEUROSCIENCE, 31(3), 883-893. doi:10.1523/JNEUROSCI.2394-10.2011
2010
Lazarenko, R. M., Fortuna, M. G., Shi, Y., Mulkey, D. K., Takakura, A. C., Moreira, T. S., . . . Bayliss, D. A. (2010). Anesthetic Activation of Central Respiratory Chemoreceptor Neurons Involves Inhibition of a THIK-1-Like Background K+ Current. JOURNAL OF NEUROSCIENCE, 30(27), 9324-9334. doi:10.1523/JNEUROSCI.1956-10.2010