6/17/2025
Despite advancements in melanoma treatment with immune checkpoint blockade (ICB) and BRAF-targeted therapy, 40-65% of metastatic melanoma patients do not survive beyond five years. An observed 'obesity paradox' shows improved…
6/17/2025
How do tissues regenerate after damage? What are the mechanisms that allow cells to coordinate regeneration? The Worley lab combines experimental genetics, developmental biology, and single-cell transcriptomics to uncover the…
6/17/2025
MicroRNAs (miRNAs) are small , non-coding RNAs that post- transcriptionally control gene expression by directing either the degradation or translational repression of target mRNAs. miRNAs potentially regulate as many as…
6/17/2025
Analysis of the role of TGIFs during development. TGIF proteins are transcriptional repressors, which regulate TGFβ signaling and have been suggested to repress retinoid regulated gene expression. Mutations in human TGIF…
6/17/2025
The cardiovascular system is the first organ system to form in vertebrates and it is essential for embryonic survival. This system continually grows and remodels to meet the increasing energetic…
6/17/2025
We forge collaborative efforts at the dynamic intersection of biology, chemistry, and medicine, propelling forward the boundaries of scientific exploration. Our work revolves around the development of cutting-edge imaging tools,…
6/17/2025
6/17/2025
How gene expression is regulated in chromatin is a fundamental question in molecular biology. The transcription program is a major determinant of cell identity; transcriptional regulation is involved in many…
6/17/2025
Our lab has worked in several areas involving viral pathogenesis, host responses to infection, understanding immunogenicity, the control of viral gene expression and viral latency, and vaccine development. Recently, the…
6/17/2025
Protein abundance and post-translational modifications (PTMs) are tightly regulated to control cellular activities and developmental processes. Dysregulated protein function, either through abnormal protein levels or PTMs, disrupts normal cellular activities…
