6/17/2025
6/17/2025
Innate immunity provides the first line of defense against pathogens, which is critically important to limit their replication and spread. However, overactivation of innate immunity causes autoimmune diseases and may…
6/17/2025
All the way up to the 20th century, the human genome has been optimized to survive in environments characterized by fluctuations between periods of feast and famine. These survivor-genomes clash…
6/17/2025
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or StrokeAtherothrombosis, resulting from rupture or…
6/17/2025
Systems analysis has become a requirement for making sense of high-throughput data and for characterizing properties of biological networks. In order to extend these recent developments to medical applications, there…
6/17/2025
Much of our work focuses on cell signaling and mechanisms of lineage specification, differentiation and morphogenesis. Particular emphases have been on post-embryonic neural crest stem cells and their derivatives, including…
6/17/2025
The overarching goal of our research is functional understanding of molecular alterations in lung cancer. To that end, we determine impacts of genomic and transcriptomic alterations on tumor development and…
6/17/2025
Our lab develops methods based on microfluidic culture systems, bioanalytical techniques, and spatially resolved simulations to quantify the spatiotemporal dynamics of the inflammatory cascade and develop targeted therapies. This work…
6/17/2025
My laboratory aims to explore the physiological role of endoplasmic reticulum (ER) homeostasis (with a special focus on ER-associated degradation, ERAD) in the context of human diseases. We use genetic,…
6/17/2025
Humans are colonized with trillions of microorganisms, collectively termed the microbiota. Aside from providing a first line of defense to invading pathogens or aiding in digestion and metabolism, commensal microbes…
