{"id":1730527,"date":"2025-06-17T11:13:10","date_gmt":"2025-06-17T15:13:10","guid":{"rendered":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/"},"modified":"2026-03-20T06:31:06","modified_gmt":"2026-03-20T10:31:06","slug":"lc4zs","status":"publish","type":"faculty-listing","link":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/","title":{"rendered":"Columbus, Linda"},"content":{"rendered":"<p>Membrane proteins facilitate the transfer of information across lipid bilayers, comprise approximately 25% of a typical proteome, and represent over half of all drug targets. The membrane proteins that mediate interactions between bacterial pathogens and hosts are of particular interest to our laboratory. Invasive bacterial pathogens are responsible for many lethal diseases and epidemics, including plague and meningitis. Although these bacteria have diverse mechanisms of cellular invasion, all of the pathways rely upon interactions between host and bacterial membrane proteins.&#013;&#010;&#013;&#010;Our lab seeks to determine the structure and dynamics of membrane proteins involved in bacterial pathogenesis and to develop tools to accelerate membrane protein structure determination using a combination of site-directed spin labeling (SDSL), nuclear magnetic resonance (NMR) spectroscopy, and X-ray crystallography.<\/p>\n","protected":false},"featured_media":1734127,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"otheraff":[2401,2419,2396,2409,2414],"phd-degree":[2571],"primary":[2336],"research-discipline":[2487,2493,2494,2504,2508,2507,2506,2505],"research-opportunity":[2540,2546,2559,2557,2556],"training-grant":[2314,2312,2313,2315],"class_list":["post-1730527","faculty-listing","type-faculty-listing","status-publish","has-post-thumbnail","hentry","otheraff-arts-sciences","otheraff-chemical-and-structural-biology-program","otheraff-molecular-physiology-and-biological-physics","otheraff-mstp","otheraff-pharmacology","phd-degree-phd-biophysics","primary-chemistry","research-discipline-biochemistry","research-discipline-biophysics","research-discipline-biophysics-structural-biology","research-discipline-biotechnology","research-discipline-chemistry","research-discipline-infectious-diseases-biodefense","research-discipline-microbiology","research-discipline-structural-biology","research-opportunity-ro-biochemistry","research-opportunity-ro-biophysicsandstructuralbiology","research-opportunity-ro-chemistryandphysicsoflivingsystems","research-opportunity-ro-infectiousdiseases","research-opportunity-ro-microbiology","training-grant-biotechnology-training-grant","training-grant-training-in-cell-and-molecular-biology","training-grant-training-in-molecular-biophysics","training-grant-training-in-the-pharmacological-sciences"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Columbus, Linda - Research Faculty Directory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Columbus, Linda - Research Faculty Directory\" \/>\n<meta property=\"og:description\" content=\"Membrane proteins facilitate the transfer of information across lipid bilayers, comprise approximately 25% of a typical proteome, and represent over half of all drug targets. The membrane proteins that mediate interactions between bacterial pathogens and hosts are of particular interest to our laboratory. Invasive bacterial pathogens are responsible for many lethal diseases and epidemics, including [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/\" \/>\n<meta property=\"og:site_name\" content=\"Research Faculty Directory\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-20T10:31:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/lc4zs.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"96\" \/>\n\t<meta property=\"og:image:height\" content=\"120\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/\",\"url\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/\",\"name\":\"Columbus, Linda - Research Faculty Directory\",\"isPartOf\":{\"@id\":\"https:\/\/med.virginia.edu\/faculty\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/lc4zs.jpeg\",\"datePublished\":\"2025-06-17T15:13:10+00:00\",\"dateModified\":\"2026-03-20T10:31:06+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/#primaryimage\",\"url\":\"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/lc4zs.jpeg\",\"contentUrl\":\"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/lc4zs.jpeg\",\"width\":96,\"height\":120,\"caption\":\"Linda Columbus\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/med.virginia.edu\/faculty\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Columbus, Linda\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/med.virginia.edu\/faculty\/#website\",\"url\":\"https:\/\/med.virginia.edu\/faculty\/\",\"name\":\"Research Faculty Directory\",\"description\":\"University of Virginia School of Medicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/med.virginia.edu\/faculty\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Columbus, Linda - Research Faculty Directory","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/","og_locale":"en_US","og_type":"article","og_title":"Columbus, Linda - Research Faculty Directory","og_description":"Membrane proteins facilitate the transfer of information across lipid bilayers, comprise approximately 25% of a typical proteome, and represent over half of all drug targets. The membrane proteins that mediate interactions between bacterial pathogens and hosts are of particular interest to our laboratory. Invasive bacterial pathogens are responsible for many lethal diseases and epidemics, including [&hellip;]","og_url":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/","og_site_name":"Research Faculty Directory","article_modified_time":"2026-03-20T10:31:06+00:00","og_image":[{"width":96,"height":120,"url":"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/lc4zs.jpeg","type":"image\/jpeg"}],"twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/","url":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/","name":"Columbus, Linda - Research Faculty Directory","isPartOf":{"@id":"https:\/\/med.virginia.edu\/faculty\/#website"},"primaryImageOfPage":{"@id":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/#primaryimage"},"image":{"@id":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/#primaryimage"},"thumbnailUrl":"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/lc4zs.jpeg","datePublished":"2025-06-17T15:13:10+00:00","dateModified":"2026-03-20T10:31:06+00:00","breadcrumb":{"@id":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/#primaryimage","url":"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/lc4zs.jpeg","contentUrl":"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/lc4zs.jpeg","width":96,"height":120,"caption":"Linda Columbus"},{"@type":"BreadcrumbList","@id":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lc4zs\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/med.virginia.edu\/faculty\/"},{"@type":"ListItem","position":2,"name":"Columbus, Linda"}]},{"@type":"WebSite","@id":"https:\/\/med.virginia.edu\/faculty\/#website","url":"https:\/\/med.virginia.edu\/faculty\/","name":"Research Faculty Directory","description":"University of Virginia School of Medicine","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/med.virginia.edu\/faculty\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/faculty-listing\/1730527","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/faculty-listing"}],"about":[{"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/types\/faculty-listing"}],"version-history":[{"count":2,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/faculty-listing\/1730527\/revisions"}],"predecessor-version":[{"id":1732937,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/faculty-listing\/1730527\/revisions\/1732937"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/media\/1734127"}],"wp:attachment":[{"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/media?parent=1730527"}],"wp:term":[{"taxonomy":"otheraff","embeddable":true,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/otheraff?post=1730527"},{"taxonomy":"phd-degree","embeddable":true,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/phd-degree?post=1730527"},{"taxonomy":"primary","embeddable":true,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/primary?post=1730527"},{"taxonomy":"research-discipline","embeddable":true,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/research-discipline?post=1730527"},{"taxonomy":"research-opportunity","embeddable":true,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/research-opportunity?post=1730527"},{"taxonomy":"training-grant","embeddable":true,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/training-grant?post=1730527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}