{"id":1730694,"date":"2025-06-17T11:14:37","date_gmt":"2025-06-17T15:14:37","guid":{"rendered":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lg8zr\/"},"modified":"2025-09-19T06:41:06","modified_gmt":"2025-09-19T10:41:06","slug":"lg8zr","status":"publish","type":"faculty-listing","link":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lg8zr\/","title":{"rendered":"Guo, Lian-Wang"},"content":{"rendered":"<p>The Guo lab studies vascular wall remodeling and retinal degeneration, with a focus on the role of histone-code readers and writers in driving cell phenotypic transitions. We aim to uncover new therapeutic targets for intervention to avert pathogenic cell states. Our research follows a trajectory from mechanistic investigation to therapeutic translation. For example, we are investigating epigenetic dysregulations underlying post-surgery vascular wall thickening and stenosis; we are also pioneering precision delivery strategies for chromatin-modulating &#034;epi-drugs&#034; in collaboration with surgeons and engineers. One innovative approach involves developing bio-adhesive nanoparticles suitable for painting on vein grafts to maintain graft patency. Another strategy is tailored for suppressing post-angioplasty restenosis by crafting injectable biomembrane-camouflaged delivery systems that home onto lesion sites. These initiatives have led to approved and pending patents. Our overarching goal is to tackle challenging medical issues by targeting dysregulated epigenetic mechanisms through seamless transitions from bench discoveries to translational innovations.<\/p>\n","protected":false},"featured_media":1735536,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"otheraff":[2392,2439,2465],"phd-degree":[2572],"primary":[2324],"research-discipline":[2493,2512,2496,2491,2515,2490,2516,2536,2497,2537],"research-opportunity":[2563,2549,2548,2544,2560],"training-grant":[],"class_list":["post-1730694","faculty-listing","type-faculty-listing","status-publish","has-post-thumbnail","hentry","otheraff-cardiovascular-research-center","otheraff-ophthalmology","otheraff-surgery","phd-degree-phd-physiology","primary-surgery","research-discipline-biophysics","research-discipline-cardiovascular-biology","research-discipline-epigenetics","research-discipline-experimental-pathology","research-discipline-molecular-and-cellular-physiology","research-discipline-molecular-biology","research-discipline-molecular-physiology-and-biological-physics","research-discipline-retinal-neuroscience","research-discipline-translational-science","research-discipline-vascular-epigentics","research-opportunity-ro-cardiovasculardisease","research-opportunity-ro-cellbiology","research-opportunity-ro-epigenetics","research-opportunity-ro-experimentalpathology","research-opportunity-ro-physiologicalbasisofhumandisease"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Guo, Lian-Wang - Research Faculty Directory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/lg8zr\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Guo, Lian-Wang - Research Faculty Directory\" \/>\n<meta property=\"og:description\" content=\"The Guo lab studies vascular wall remodeling and retinal degeneration, with a focus on the role of histone-code readers and writers in driving cell phenotypic transitions. 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