{"id":1730950,"date":"2025-06-17T11:16:59","date_gmt":"2025-06-17T15:16:59","guid":{"rendered":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/jcm6t\/"},"modified":"2025-06-25T15:17:03","modified_gmt":"2025-06-25T19:17:03","slug":"jcm6t","status":"publish","type":"faculty-listing","link":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/jcm6t\/","title":{"rendered":"Mychaleckyj, Josyf (Joe) C."},"content":{"rendered":"<div>During the last 15   years biology has come of age as an information-based science, in some ways   playing catch-up to other quantitative disciplines. Data generation has become   easier, cheaper, and faster yielding exponential increases in sizes of data sets   and databases.\u00a0\u00a0The relative explosion during recent years coincides with the   rise of the internet, burgeoning and novel biomedical engineering and biophysics   methods and assays, and increasing public awareness and interest in contemporary   biomedical research.\u00a0\u00a0The sequencing of the Human Genome presaged this and   validated the concept of large-scale highly collaborative biological science   projects, familiar to physicists in particle discovery or astrophysics   research.\u00a0\u00a0It is clear that biology requires similarly inter-disciplinary   teams.<\/div>\n<div>\n<p>\u00a0Our work focuses on the   application of statistical, bioinformatic, and genomic methods to synthesize and   make sense of the large data sets emerging from human genetic susceptibility   mapping projects. Genome-wide association, massively parallel sequencing, and   microarray gene expression experiments provide the raw data for our highly   collaborative work and this provides many avenues for research encompassing   genetic epidemiology, application of new statistical methods, and   multi-dimensional data integration.  <\/p>\n<p>Our complex disease genetics specialty is diabetes and   diabetic nephropathy. Projects have included mapping and cloning susceptibility   genes for type 1, type 2, and MODY diabetes, diabetic nephropathy, and end stage   kidney disease, but has also included other interesting work in diverse areas   such as malnutrition, prostate cancer, stem cells, host-pathogen interactions,   and mouse pheromone memory.\u00a0<\/p><\/div>\n<div>Some of our current   projects include:<\/div>\n<div>\n<p>Statistical and bioinformatic   analysis collaboration with the Joslin Diabetes Center to study the genetic   factors that influence onset and progression of diabetic nephropathy in type 1   diabetes  <\/p>\n<p>Analysis   center for the MESA SHARe (Multi-ethnic Study of Atherosclerosis SNP Health   Association Resource) project. High throughput analysis, annotation, and   distribution of results from candidate wide (CWAS) and genome wide (GWAS)   analysis of 1000s of quantitative and qualitative traits related to subclinical   atherosclerosis and other complex phenotypes.  <\/p>\n<p>Mal-ED Network for Malnutrition and Enteric Disease: \u00a0Bill   and Melinda Gates Foundation funded project to understand the interaction of   genetic and infectious disease risk factors in malnutrition and enteric disease   based on molecular genetic and genomic risk profiles.  <\/p>\n<p>Vitamin Intervention for Stroke   Prevention (VISP): Analysis of genetic risk factors underlying ischemic and   recurrent stroke, and stroke-associated   biomarkers.<\/p>\n","protected":false},"featured_media":1734394,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"otheraff":[2460],"phd-degree":[],"primary":[2360],"research-discipline":[],"research-opportunity":[],"training-grant":[],"class_list":["post-1730950","faculty-listing","type-faculty-listing","status-publish","has-post-thumbnail","hentry","otheraff-genomic-sciences","primary-genome-sciences"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mychaleckyj, Josyf (Joe) C. - Research Faculty Directory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/jcm6t\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mychaleckyj, Josyf (Joe) C. - Research Faculty Directory\" \/>\n<meta property=\"og:description\" content=\"During the last 15 years biology has come of age as an information-based science, in some ways playing catch-up to other quantitative disciplines. 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