{"id":1730971,"date":"2025-06-17T11:17:11","date_gmt":"2025-06-17T15:17:11","guid":{"rendered":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/rhh9pb\/"},"modified":"2025-06-25T15:29:05","modified_gmt":"2025-06-25T19:29:05","slug":"rhh9pb","status":"publish","type":"faculty-listing","link":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/rhh9pb\/","title":{"rendered":"Omoto, Ana Carolina"},"content":{"rendered":"

A major focus of my research program is to elucidate the role of brown adipose tissue (BAT)-derived extracellular vesicles in mediating the cardioprotective effects of the leptin\/melanocortin 4 receptor (MC4R) signaling pathway. Obesity is a well-established risk factor for ischemic heart disease, and emerging evidence suggests that targeting central energy-regulating pathways can yield systemic benefits beyond weight management. Given that MC4R agonists have already been approved by the FDA for the treatment of rare genetic forms of obesity, my studies aim to generate critical pre-clinical data on the potential repurposing of these agents to improve cardiac outcomes in obese patients. By investigating the molecular mechanisms by which BAT-derived extracellular vesicles contribute to interorgan communication and cardiac repair, my research seeks to identify novel therapeutic strategies that enhance heart function and metabolic health in the context of obesity and ischemic injury.<\/p>\n","protected":false},"featured_media":1734893,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"otheraff":[],"phd-degree":[],"primary":[2342],"research-discipline":[2512],"research-opportunity":[],"training-grant":[],"class_list":["post-1730971","faculty-listing","type-faculty-listing","status-publish","has-post-thumbnail","hentry","primary-pharmacology","research-discipline-cardiovascular-biology"],"acf":[],"yoast_head":"\nOmoto, Ana Carolina - Research Faculty Directory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/rhh9pb\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Omoto, Ana Carolina - Research Faculty Directory\" \/>\n<meta property=\"og:description\" content=\"A major focus of my research program is to elucidate the role of brown adipose tissue (BAT)-derived extracellular vesicles in mediating the cardioprotective effects of the leptin\/melanocortin 4 receptor (MC4R) signaling pathway. Obesity is a well-established risk factor for ischemic heart disease, and emerging evidence suggests that targeting central energy-regulating pathways can yield systemic benefits […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/rhh9pb\/\" \/>\n<meta property=\"og:site_name\" content=\"Research Faculty Directory\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-25T19:29:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/rhh9pb.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"203\" \/>\n\t<meta property=\"og:image:height\" content=\"203\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/rhh9pb\/\",\"url\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/rhh9pb\/\",\"name\":\"Omoto, Ana Carolina - Research Faculty Directory\",\"isPartOf\":{\"@id\":\"https:\/\/med.virginia.edu\/faculty\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/rhh9pb\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/rhh9pb\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/rhh9pb.jpeg\",\"datePublished\":\"2025-06-17T15:17:11+00:00\",\"dateModified\":\"2025-06-25T19:29:05+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/rhh9pb\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/rhh9pb\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/rhh9pb\/#primaryimage\",\"url\":\"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/rhh9pb.jpeg\",\"contentUrl\":\"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/rhh9pb.jpeg\",\"width\":203,\"height\":203,\"caption\":\"Ana Carolina Omoto\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/rhh9pb\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/med.virginia.edu\/faculty\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Omoto, Ana Carolina\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/med.virginia.edu\/faculty\/#website\",\"url\":\"https:\/\/med.virginia.edu\/faculty\/\",\"name\":\"Research Faculty Directory\",\"description\":\"University of Virginia School of Medicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/med.virginia.edu\/faculty\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Omoto, Ana Carolina - Research Faculty Directory","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/rhh9pb\/","og_locale":"en_US","og_type":"article","og_title":"Omoto, Ana Carolina - Research Faculty Directory","og_description":"A major focus of my research program is to elucidate the role of brown adipose tissue (BAT)-derived extracellular vesicles in mediating the cardioprotective effects of the leptin\/melanocortin 4 receptor (MC4R) signaling pathway. 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