{"id":1731031,"date":"2025-06-17T11:17:45","date_gmt":"2025-06-17T15:17:45","guid":{"rendered":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sz5j\/"},"modified":"2025-06-25T15:24:32","modified_gmt":"2025-06-25T19:24:32","slug":"sz5j","status":"publish","type":"faculty-listing","link":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sz5j\/","title":{"rendered":"Redemann, Stefanie"},"content":{"rendered":"<p>All eukaryotic cells divide by assembling a microtubule-based spindle machinery that equally segregates chromosomes between daughter cells. The faithful segregation of chromosomes during cell division is essential as errors in this process have severe implications for development, health and survival of the organism. One major outcome of chromosome segregation errors in mitosis is tumor initiation and progression. Analysis of cancer cell karyotypes revealed that aneuploidy, an abnormal number of chromosomes, is an extremely common feature, with 70 \u2013 95% of cancers from the most commonly affected organs being aneuploid. Aneuploidy is associated with poor patient prognosis, metastasis, and resistance to chemotherapeutics. Chromosome segregation errors during meiosis, are the leading cause of early pregnancy loss and infertility. &#010;&#010;Our aim is to understand the key molecular and mechanical principles and mechanisms of spindle assembly and chromosome segregation in meiosis and mitosis. We address this by using a combination of cutting-edge imaging technologies, such as large-scale 3D electron tomography and spinning disc live-cell microscopy, as well CRISPR and other genetic tools  in tissue culture cells, mouse Oocytes and C. elegans embryos. &#010;&#010;For more information about Dr. Redemann:&#010;https:\/\/journals.biologists.com\/jcs\/article\/134\/23\/jcs259556\/273552\/Cell-scientist-to-watch-Stefanie-Redemann<\/p>\n","protected":false},"featured_media":1734731,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"otheraff":[],"phd-degree":[2571,2568,2565,2572],"primary":[2335],"research-discipline":[2513,2493,2494,2488,2498,2490,2516,2509,2505],"research-opportunity":[2546,2541,2549,2559,2543,2560],"training-grant":[2314,2313],"class_list":["post-1731031","faculty-listing","type-faculty-listing","status-publish","has-post-thumbnail","hentry","phd-degree-phd-biophysics","phd-degree-phd-cellbiology","phd-degree-phd-pharmacology","phd-degree-phd-physiology","primary-molecular-physiology-and-biological-physics","research-discipline-biology","research-discipline-biophysics","research-discipline-biophysics-structural-biology","research-discipline-cancer-biology","research-discipline-cell-and-developmental-biology","research-discipline-molecular-biology","research-discipline-molecular-physiology-and-biological-physics","research-discipline-physiology","research-discipline-structural-biology","research-opportunity-ro-biophysicsandstructuralbiology","research-opportunity-ro-cancerbiology","research-opportunity-ro-cellbiology","research-opportunity-ro-chemistryandphysicsoflivingsystems","research-opportunity-ro-molecularbiology","research-opportunity-ro-physiologicalbasisofhumandisease","training-grant-biotechnology-training-grant","training-grant-training-in-molecular-biophysics"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Redemann, Stefanie - Research Faculty Directory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sz5j\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Redemann, Stefanie - Research Faculty Directory\" \/>\n<meta property=\"og:description\" content=\"All eukaryotic cells divide by assembling a microtubule-based spindle machinery that equally segregates chromosomes between daughter cells. The faithful segregation of chromosomes during cell division is essential as errors in this process have severe implications for development, health and survival of the organism. 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