{"id":1731035,"date":"2025-06-17T11:17:56","date_gmt":"2025-06-17T15:17:56","guid":{"rendered":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/cr2g\/"},"modified":"2025-06-25T15:15:25","modified_gmt":"2025-06-25T19:15:25","slug":"cr2g","status":"publish","type":"faculty-listing","link":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/cr2g\/","title":{"rendered":"Rembold, Christopher M."},"content":{"rendered":"

1) Activation of blood vessel smooth muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. \u00a0Most recently my laboratory has been interested in contractile mechanisms beyond calcium and myosin phosphorylation.\u00a0 Specifically, we found that the sustained phase of contraction was associated with stimulated actin polymerization.\u00a0 Prior increases in stimulated actin polymerization appear to increase the initial phase of subsequent contraction, a process we term force augmentation.\u00a0 We are studying the biochemical determinants of stimulated actin polymerization (paxillin and cofilin phosphorylation) and the biophysical sequelae of stimulated actin polymerization (changes in rheology such as noise temperature).\u00a0 Publications include:<\/p>\n

Rembold, C.M.\u00a0 Force suppression and the crossbridge cycle in swine carotid artery.\u00a0 American Journal of Physiology Cell Physiology, 293:1003-1009, 2007.
Rembold, C.M., Tejani, A,D. Ripley, M.L., Han, S.\u00a0 Paxillin phosphorylation, actin polymerization, noise temperature, and the sustained phase of swine carotid artery contraction.\u00a0 American Journal of Physiology Cell Physiology, 293:993-1002, 2007.Tejani, A.D., Rembold, C.M.\u00a0 Force augmentation and stimulated actin polymerization in swine carotid artery.\u00a0 American Journal of Physiology, in press, 2010.<\/p><\/blockquote>\n

Relaxation is typically thought to be the reversal of activation, i.e. deactivation, which is caused by a reduction in myosin phosphorylation.\u00a0 There is also a novel form of smooth muscle relaxation that does not involve deactivation mechanisms. Dr. Rembold’s group found that elevations in cyclic nucleotides such as cGMP and cAMP can reduce smooth muscle contraction despite elevated myosin phosphorylation. This process was termed force suppression.\u00a0 Dr. Rembold’s laboratory has concentrated on the mechanism responsible for force suppression. His group and others found that cyclic nucleotide-induced relaxation was associated with phosphorylation of a small heat shock protein 20 known as HSP20 or P20. His group also found that HSP20 phosphorylation was shown to specifically correlate with force suppression rather than the deactivation form of relaxation. A peptide of HSP20 was noted to have sequence homology with troponin I, the main regulatory protein in skeletal and cardiac muscle. The Peptide from this homology region bound thin filaments, reduced myosin ATPase activity, and relaxed skinned swine carotid artery.\u00a0 We are currently testing the hypothesis that binding of phosphorylated HSP20 to the smooth muscle thin filaments may turn off thin filaments so that phosphorylated myosin does not interact with the thin filament (i.e. a model similar to skeletal muscle troponin I). Publications include:<\/p>\n

Rembold C.M., Foster, B., Strauss, J., Wingard, C., Van Eyk, J.E. cGMP mediated phosphorylation of heat shock protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation. Journal of Physiology (London), 524:865-878, 2000. Meeks, M., Ripley, M., Jin, Z. Rembold C.M.,\u00a0\u00a0 Heat shock protein 20 mediated force suppression in forskolin relaxed swine carotid artery.\u00a0 Am J Physiology Cell Physiology,\u00a0 288:C633-C639, 2005. <\/p><\/blockquote>\n

3) I also study sleep apnea in children.\u00a0 Publications include:<\/p>\n

Suratt, P.M., Barth, J.T., Diamond, R., D\u2019Andrea, L., Nikova, M., Periello, V.A., Carskadon, M.A., Rembold, C.M.\u00a0 Reduced Time in Bed and Obstructive Sleep Disordered Breathing in Children are Associated with Cognitive Impairment.\u00a0 Pediatrics, 119:320-329, 2007.<\/p><\/blockquote>\n

4) Finally, I also study the use of carotid intimal medial thickness in the detection of preclinical atherosclerosis. Publications include: <\/p>\n

Stein, J.H., Korcatz, C.E., Hurst, R.T., Lonn, E., Kendall, C.B., Mohler, E.R., Naijar, S.S. Rembold, C.M., Post, W.S.\u00a0 Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: A consensus statement from the American society of echocardiography carotid intima-media thickness task force endorsed by the society for vascular medicine.\u00a0 Journal of the American Society of Echocardiography, 21:93-111, 2008.<\/p><\/blockquote>\n","protected":false},"featured_media":1734308,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"otheraff":[2392],"phd-degree":[],"primary":[2347],"research-discipline":[2509,2497],"research-opportunity":[],"training-grant":[],"class_list":["post-1731035","faculty-listing","type-faculty-listing","status-publish","has-post-thumbnail","hentry","otheraff-cardiovascular-research-center","primary-medicine-cardiovascular-medicine","research-discipline-physiology","research-discipline-translational-science"],"acf":[],"yoast_head":"\nRembold, Christopher M. - Research Faculty Directory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/cr2g\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rembold, Christopher M. - Research Faculty Directory\" \/>\n<meta property=\"og:description\" content=\"1) Activation of blood vessel smooth muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. \u00a0Most recently my laboratory has been interested in contractile mechanisms beyond calcium and myosin phosphorylation.\u00a0 Specifically, we found that the sustained phase of contraction was associated with stimulated actin polymerization.\u00a0 Prior increases in stimulated actin polymerization […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/cr2g\/\" \/>\n<meta property=\"og:site_name\" content=\"Research Faculty Directory\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-25T19:15:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/cr2g.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"100\" \/>\n\t<meta property=\"og:image:height\" content=\"121\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/faculty\\\/faculty-listing\\\/cr2g\\\/\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/faculty\\\/faculty-listing\\\/cr2g\\\/\",\"name\":\"Rembold, Christopher M. - Research Faculty Directory\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/faculty\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/faculty\\\/faculty-listing\\\/cr2g\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/faculty\\\/faculty-listing\\\/cr2g\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/med.virginia.edu\\\/faculty\\\/wp-content\\\/uploads\\\/sites\\\/45\\\/2025\\\/06\\\/cr2g.jpeg\",\"datePublished\":\"2025-06-17T15:17:56+00:00\",\"dateModified\":\"2025-06-25T19:15:25+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/faculty\\\/faculty-listing\\\/cr2g\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/med.virginia.edu\\\/faculty\\\/faculty-listing\\\/cr2g\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/faculty\\\/faculty-listing\\\/cr2g\\\/#primaryimage\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/faculty\\\/wp-content\\\/uploads\\\/sites\\\/45\\\/2025\\\/06\\\/cr2g.jpeg\",\"contentUrl\":\"https:\\\/\\\/med.virginia.edu\\\/faculty\\\/wp-content\\\/uploads\\\/sites\\\/45\\\/2025\\\/06\\\/cr2g.jpeg\",\"width\":100,\"height\":121,\"caption\":\"Christopher M. 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