{"id":1731050,"date":"2025-06-17T11:17:56","date_gmt":"2025-06-17T15:17:56","guid":{"rendered":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/dr5e\/"},"modified":"2025-06-25T15:15:56","modified_gmt":"2025-06-25T19:15:56","slug":"dr5e","status":"publish","type":"faculty-listing","link":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/dr5e\/","title":{"rendered":"Rosin, Diane L."},"content":{"rendered":"<p>I am interested in understanding immune mechanisms  involved in acute and chronic kidney injury and the mechanisms that may  underlie the progression of acute to chronic kidney disease. The availability of a large array of  transgenic mice contributes important tools for teasing out these  mechanisms. We use a variety of in vivo  and in vitro models along with molecular, cell biological and immunological  methods to study kidney injury and to guide development of novel  pharmacological and cell based therapy approaches for modulating pathways that  contribute to kidney injury. Some of our  current work focuses on using ligands of adenosine 2A receptors and sphingosine  1-phosphate receptors to protect kidneys from insults that produce acute and chronic  kidney injury. In addition we are  exploring nanoparticle-mediated targeted delivery of drugs to the kidney as a novel  and possibly more selective treatment modality. &#013;&#010;&#013;&#010;Some of the models that we use include:&#013;&#010;&#013;&#010;1) Kidney ischemia-reperfusion injury as a model of acute  kidney injury&#013;&#010;&#013;&#010;2) Folic acid or aristolochic acid-induced kidney  fibrosis. Interstitial fibrosis  is one  of the hallmarks of chronic kidney disease&#013;&#010;&#013;&#010;3) Ischemia-reperfusion injury-induced fibrosis in mice  maintained for longer time periods as a model of progression from acute to  chronic kidney injury.&#013;&#010;&#013;&#010;4) Hypoxia- or LPS-induced injury in cultured renal  tubular epithelial cells, glomerular endothelial cells, and primary cultures of  kidney fibroblasts.<\/p>\n","protected":false},"featured_media":1734337,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"otheraff":[],"phd-degree":[],"primary":[2342],"research-discipline":[],"research-opportunity":[],"training-grant":[],"class_list":["post-1731050","faculty-listing","type-faculty-listing","status-publish","has-post-thumbnail","hentry","primary-pharmacology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Rosin, Diane L. - Research Faculty Directory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/dr5e\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rosin, Diane L. - Research Faculty Directory\" \/>\n<meta property=\"og:description\" content=\"I am interested in understanding immune mechanisms involved in acute and chronic kidney injury and the mechanisms that may underlie the progression of acute to chronic kidney disease. 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