{"id":1731125,"date":"2025-06-17T11:18:44","date_gmt":"2025-06-17T15:18:44","guid":{"rendered":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/"},"modified":"2025-06-20T10:38:49","modified_gmt":"2025-06-20T14:38:49","slug":"sjs5c","status":"publish","type":"faculty-listing","link":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/","title":{"rendered":"Sung, Sun-Sang J"},"content":{"rendered":"

Lupus nephritis is an autoimmune disease manifesting as compromised kidney function. Glomerular destruction is a major disease hallmark. Using an autoimmune mouse model of lupus nephritis, we found that extensive macrophage infiltration occurs in animals with severe proteinuria. Macrophage expression of PD-L1 induces proteinuria. Furthermore, macrophages produce TNF which initiates cytokine and chemokine production by podocytes and mesangial cells. This cytokine milieu is detrimental to the integrity of the glomerulus. Studies are performed to study the functional roles of podocytes and mesangial cells in the pathogenesis of lupus nephritis and to identify cytokine and surface receptors as therapeutic targets.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"otheraff":[2389,2453],"phd-degree":[],"primary":[2330],"research-discipline":[],"research-opportunity":[],"training-grant":[],"class_list":["post-1731125","faculty-listing","type-faculty-listing","status-publish","hentry","otheraff-immunology-immunotherapy-program","otheraff-inflammation-and-regeneration","primary-medicine"],"acf":[],"yoast_head":"\nSung, Sun-Sang J - Research Faculty Directory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sung, Sun-Sang J - Research Faculty Directory\" \/>\n<meta property=\"og:description\" content=\"Lupus nephritis is an autoimmune disease manifesting as compromised kidney function. Glomerular destruction is a major disease hallmark. Using an autoimmune mouse model of lupus nephritis, we found that extensive macrophage infiltration occurs in animals with severe proteinuria. Macrophage expression of PD-L1 induces proteinuria. Furthermore, macrophages produce TNF which initiates cytokine and chemokine production by […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/\" \/>\n<meta property=\"og:site_name\" content=\"Research Faculty Directory\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-20T14:38:49+00:00\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/\",\"url\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/\",\"name\":\"Sung, Sun-Sang J - Research Faculty Directory\",\"isPartOf\":{\"@id\":\"https:\/\/med.virginia.edu\/faculty\/#website\"},\"datePublished\":\"2025-06-17T15:18:44+00:00\",\"dateModified\":\"2025-06-20T14:38:49+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/med.virginia.edu\/faculty\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Sung, Sun-Sang J\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/med.virginia.edu\/faculty\/#website\",\"url\":\"https:\/\/med.virginia.edu\/faculty\/\",\"name\":\"Research Faculty Directory\",\"description\":\"University of Virginia School of Medicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/med.virginia.edu\/faculty\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Sung, Sun-Sang J - Research Faculty Directory","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/","og_locale":"en_US","og_type":"article","og_title":"Sung, Sun-Sang J - Research Faculty Directory","og_description":"Lupus nephritis is an autoimmune disease manifesting as compromised kidney function. Glomerular destruction is a major disease hallmark. Using an autoimmune mouse model of lupus nephritis, we found that extensive macrophage infiltration occurs in animals with severe proteinuria. Macrophage expression of PD-L1 induces proteinuria. Furthermore, macrophages produce TNF which initiates cytokine and chemokine production by […]","og_url":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/","og_site_name":"Research Faculty Directory","article_modified_time":"2025-06-20T14:38:49+00:00","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/","url":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/","name":"Sung, Sun-Sang J - Research Faculty Directory","isPartOf":{"@id":"https:\/\/med.virginia.edu\/faculty\/#website"},"datePublished":"2025-06-17T15:18:44+00:00","dateModified":"2025-06-20T14:38:49+00:00","breadcrumb":{"@id":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/sjs5c\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/med.virginia.edu\/faculty\/"},{"@type":"ListItem","position":2,"name":"Sung, Sun-Sang J"}]},{"@type":"WebSite","@id":"https:\/\/med.virginia.edu\/faculty\/#website","url":"https:\/\/med.virginia.edu\/faculty\/","name":"Research Faculty Directory","description":"University of Virginia School of Medicine","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/med.virginia.edu\/faculty\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/faculty-listing\/1731125","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/faculty-listing"}],"about":[{"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/types\/faculty-listing"}],"version-history":[{"count":1,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/faculty-listing\/1731125\/revisions"}],"predecessor-version":[{"id":1732835,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/faculty-listing\/1731125\/revisions\/1732835"}],"wp:attachment":[{"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/media?parent=1731125"}],"wp:term":[{"taxonomy":"otheraff","embeddable":true,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/otheraff?post=1731125"},{"taxonomy":"phd-degree","embeddable":true,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/phd-degree?post=1731125"},{"taxonomy":"primary","embeddable":true,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/primary?post=1731125"},{"taxonomy":"research-discipline","embeddable":true,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/research-discipline?post=1731125"},{"taxonomy":"research-opportunity","embeddable":true,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/research-opportunity?post=1731125"},{"taxonomy":"training-grant","embeddable":true,"href":"https:\/\/med.virginia.edu\/faculty\/wp-json\/wp\/v2\/training-grant?post=1731125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}