{"id":1731229,"date":"2025-06-17T11:19:39","date_gmt":"2025-06-17T15:19:39","guid":{"rendered":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/pay2x\/"},"modified":"2025-06-25T15:19:04","modified_gmt":"2025-06-25T19:19:04","slug":"pay2x","status":"publish","type":"faculty-listing","link":"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/pay2x\/","title":{"rendered":"Yates, Paul A."},"content":{"rendered":"<p>Our laboratory conducts basic and translational research  into the development and regulation of retinal ganglion cells (RGCs) and blood  vessels as they relate to retinal diseases including retinopathy of  prematurity, diabetic retinopathy, glaucoma, and macular degeneration.&#013;&#010; &#013;&#010;We are interested in the growth, branching and arbor  remodeling of RGC neurons, which connect the eye to the brain. What starts as a  disorganized set of connections from RGCs to their target, the superior  colliculus, reorganizes over the course of development into a highly specific  two dimensional retinotopic map that recapitulates the two dimensional spatial  arrangement of the RGCs in the retina. Ongoing projects are studying how  Ephrin-A dependent RGC axon-axon inhibition plays a role in determining arbor  location and size within the map, how competition for space determines initial  and final branching patterns on the axon, and the role of axonal degeneration  through the DR6 receptor and cell death in shaping the final map. Our hope is  that understanding how topographic patterning of retinal axons occurs will one  day permit successful eye transplantation.&#013;&#010;&#013;&#010;Aberrant growth of blood vessels leads to many eye diseases  such as retinopathy of prematurity, diabetic retinopathy and macular degeneration.  We are interested in creating new approaches for treatment of these blinding  diseases through projects that investigate stem cell therapies for repairing  damaged blood vessels and creating novel light activated drugs to focally treat  retinal vasculopathies. Basic research in the lab is also examining potential  similarities in the mechanisms and molecules that control vascular and axonal  branching by determining the role of Ephrins and VEGF in blood vessel growth at  the level of the capillary sprout within the retinal micro-vascular network.<\/p>\n","protected":false},"featured_media":1734499,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"otheraff":[2387,2392,2410,2412],"phd-degree":[2573,2566],"primary":[2375],"research-discipline":[2504,2512,2502],"research-opportunity":[2555,2563,2553],"training-grant":[],"class_list":["post-1731229","faculty-listing","type-faculty-listing","status-publish","has-post-thumbnail","hentry","otheraff-biomedical-engineering","otheraff-cardiovascular-research-center","otheraff-neuroscience","otheraff-pathology","phd-degree-phd-biomedicalengineering","phd-degree-phd-experimentalpathology","primary-ophthalmology","research-discipline-biotechnology","research-discipline-cardiovascular-biology","research-discipline-neuroscience","research-opportunity-ro-biotechnology","research-opportunity-ro-cardiovasculardisease","research-opportunity-ro-neuroscience"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Yates, Paul A. - Research Faculty Directory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/pay2x\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Yates, Paul A. - Research Faculty Directory\" \/>\n<meta property=\"og:description\" content=\"Our laboratory conducts basic and translational research into the development and regulation of retinal ganglion cells (RGCs) and blood vessels as they relate to retinal diseases including retinopathy of prematurity, diabetic retinopathy, glaucoma, and macular degeneration.&#013;&#010; &#013;&#010;We are interested in the growth, branching and arbor remodeling of RGC neurons, which connect the eye to the [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/pay2x\/\" \/>\n<meta property=\"og:site_name\" content=\"Research Faculty Directory\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-25T19:19:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/pay2x.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"100\" \/>\n\t<meta property=\"og:image:height\" content=\"106\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/pay2x\/\",\"url\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/pay2x\/\",\"name\":\"Yates, Paul A. - Research Faculty Directory\",\"isPartOf\":{\"@id\":\"https:\/\/med.virginia.edu\/faculty\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/pay2x\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/pay2x\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/pay2x.jpeg\",\"datePublished\":\"2025-06-17T15:19:39+00:00\",\"dateModified\":\"2025-06-25T19:19:04+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/pay2x\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/pay2x\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/med.virginia.edu\/faculty\/faculty-listing\/pay2x\/#primaryimage\",\"url\":\"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/pay2x.jpeg\",\"contentUrl\":\"https:\/\/med.virginia.edu\/faculty\/wp-content\/uploads\/sites\/45\/2025\/06\/pay2x.jpeg\",\"width\":100,\"height\":106,\"caption\":\"Paul A. 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