{"id":219,"date":"2015-08-07T18:39:59","date_gmt":"2015-08-07T18:39:59","guid":{"rendered":"https:\/\/med.virginia.edu\/genetically-engineered-murine-model-core\/?page_id=219"},"modified":"2019-04-26T15:45:16","modified_gmt":"2019-04-26T19:45:16","slug":"cre-flox-flp-mice","status":"publish","type":"page","link":"https:\/\/med.virginia.edu\/genetically-engineered-murine-model-core\/research\/cre-flox-flp-mice\/","title":{"rendered":"Cre Flox Flp Mice"},"content":{"rendered":"

Cre\/Flox\/Flp Mice on Grounds<\/h3>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/tr>\n
Strain<\/b><\/i><\/td>\nBackground<\/i><\/b><\/td>\nPromoter\/Exp.<\/i><\/b><\/td>\nOriginal Source
\n<\/i><\/b><\/td>\n		Lab<\/i><\/b><\/td>\n<\/tr>\n
<\/td>\n<\/tr>\n
(1) Widespread\/germline deleter<\/td>\n<\/tr>\n
Tg(EIIa-Cre)C5379Lmgd\/J<\/td>\nB6.FVB<\/td>\nEIIa<\/td>\nJax 003724<\/td>\nDavid Wotton<\/td>\n<\/tr>\n
Tg(MMTV-Cre)4Mam\/J<\/td>\nB6129F1<\/td>\nMMTV<\/td>\nJax 003553<\/td>\nTom Parsons<\/td>\n<\/tr>\n
Hsp70-Cre<\/td>\n<\/td>\nHsp70<\/td>\n<\/td>\nScott Zeitlin<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
(2) Inducible<\/td>\n<\/tr>\n
Tg(Mx1-cre)1Cgn\/J<\/td>\nB6.Cg<\/td>\nMx1 (plpC or interferon)<\/td>\nJax 003556<\/td>\nAdam Goldfarb<\/td>\n<\/tr>\n
Tg(Cre\/Esr1)5Amc\/J<\/td>\nB6.Cg<\/td>\nCMV(tamoxifen)<\/td>\nJax 004682<\/td>\nGary Owens Xiaowei Lu Jing Yu<\/td>\n<\/tr>\n
Tg(Sp7-tTA,tetO- EGFP\/Cre)1Amc\/J<\/td>\nB6.Cg<\/td>\nSp7 (Dox), “Tet-Off”, osteoblast<\/td>\nJax 006361<\/td>\nGreg Clines<\/td>\n<\/tr>\n
Tg(Atoh1-CreER-IRES-AP)1Sbk<\/td>\nFVB<\/td>\nAtonal homolog 1 (tamoxifen)<\/td>\nMMRRC 029581-UNC<\/td>\nXiaowei Lu<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
(3) Knock-in<\/td>\n<\/tr>\n
CD19-Cre<\/td>\nB6, B6;129, 129<\/td>\nCD19<\/td>\nJax 004126<\/td>\nTim Bender<\/td>\n<\/tr>\n
Mb1-Cre<\/td>\nB6;129;BALB\/c<\/td>\nMb1<\/td>\n<\/td>\nTim Bender<\/td>\n<\/tr>\n
Th<tm1(Cre)Te\/Kieg><\/td>\nB6.129X1<\/td>\nTyrosine hydroxylase<\/td>\nEMMA 00254<\/td>\nRuth Stornetta<\/td>\n<\/tr>\n
Chat<tm1(Cre)Lowl>\/J<\/td>\nB6;129S6<\/td>\nCholine acetyltransferase<\/td>\nJax 006410<\/td>\nRuth Stornetta<\/td>\n<\/tr>\n
Foxg1tm1(cre)Skm<\/sup>\/J<\/td>\n129.Cg<\/td>\nFoxhead box g1<\/td>\nJax 004337<\/td>\nXiaowei Lu<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
(4) Tissue\/cell specific<\/td>\n<\/tr>\n
SMHC-Cre<\/td>\n<\/td>\nSmooth myosin heavy chain<\/td>\n<\/td>\nGary Owens<\/td>\n<\/tr>\n
SM22-Cre<\/td>\n<\/td>\nSmooth muscle 22<\/td>\n<\/td>\nGary Owens<\/td>\n<\/tr>\n
SMHC-Cre\/EGFP<\/td>\n<\/td>\nSmooth myosin heavy chain<\/td>\n<\/td>\nGary Owens<\/td>\n<\/tr>\n
Col a1(I)2.3 Cre<\/td>\nFVB<\/td>\nCollagen 1a1<\/td>\n<\/td>\nGreg Clines<\/td>\n<\/tr>\n
TgN(MCK-Cre)<\/td>\nB6.FVB<\/td>\nMuscle creatine kinase<\/td>\n<\/td>\nThurl Harris<\/td>\n<\/tr>\n
Tg(Fabp4-Cre)1Rev\/J<\/td>\nB6.Cg<\/td>\nFatty acid binding protein 4<\/td>\nJax 005069<\/td>\nThurl Harris<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
CD21-Cre3a<\/td>\nB6.Cg<\/td>\nimmature mIgM+ mIgD- bone marrow cells<\/td>\nJax 006368<\/td>\nTim Bender<\/td>\n<\/tr>\n
Lck-Cre<\/td>\nB6;129<\/td>\nT-lineage cells<\/td>\n<\/td>\nTim Bender<\/td>\n<\/tr>\n
CD4-Cre<\/td>\nB6;129<\/td>\nDN4 and DP thymocytes<\/td>\n<\/td>\nTim Bender<\/td>\n<\/tr>\n
Distal lck-Cre<\/td>\nB6;DBAs<\/td>\nSP thymocytes<\/td>\n<\/td>\nTim Bender<\/td>\n<\/tr>\n
IgG alpha-Cre<\/td>\n<\/td>\nB cell<\/td>\n<\/td>\nTom Parsons<\/td>\n<\/tr>\n
LysM-Cre<\/td>\n<\/td>\nMacrophage<\/td>\n<\/td>\nTom Parsons<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Tg(Alb-Cre)<\/td>\nB6.Cg<\/td>\nAlbumin<\/td>\nJax 003574<\/td>\nDavid Wotton<\/td>\n<\/tr>\n
Math1-Cre<\/td>\n<\/td>\nAtonal homolog 1<\/td>\n<\/td>\nXiaowei Lu<\/td>\n<\/tr>\n
Tg(Pax2-cre)1Akg<\/td>\nCD-1<\/td>\nPax2<\/td>\nMMRRC 010560-UNC<\/td>\nXiaowei Lu<\/td>\n<\/tr>\n
HB9-Cre<\/td>\n<\/td>\nMotor neuron<\/td>\n<\/td>\nJeh-Ping Liu<\/td>\n<\/tr>\n
Nestin-Cre<\/td>\n<\/td>\nRat nestin<\/td>\n<\/td>\nJeh-Ping Liu<\/td>\n<\/tr>\n
Isl1-Cre<\/td>\n<\/td>\nIsl1 txn factor<\/td>\n<\/td>\nJeh-Ping Liu<\/td>\n<\/tr>\n
CaMKII-Cre (R1, L7, R4)<\/td>\n<\/td>\nCa\/Cal kinase II<\/td>\n<\/td>\nScott Zeitlin<\/td>\n<\/tr>\n
Tg(Sox2-Cre)1Amc\/J<\/td>\nB6CBA<\/td>\nSRY-box containing gene 2<\/td>\nJax 004783<\/td>\nDavid Wotton<\/td>\n<\/tr>\n
Tg(Pbsn-Cre)4Prb<\/td>\nB6.D2<\/td>\nRat probasin<\/td>\nNCI 01XF5<\/td>\nTom Parsons<\/td>\n<\/tr>\n
B6.Cg-Shhtm1(EGFP\/cre)Cjt<\/sup><\/i>\/J<\/span><\/td>\nB6 congenic<\/td>\nLung epithelium<\/td>\nJax 005622<\/td>\nJohn Fu<\/td>\n<\/tr>\n
B6.129X1-Twist2tm1.1(cre)Dor<\/sup><\/i>\/J<\/span><\/td>\nB6 congenic<\/td>\nMesenchyme<\/td>\nJax 008712<\/td>\nJohn Fu<\/td>\n<\/tr>\n
B6.129S-Sftpctm1(cre\/ERT2)Blh<\/sup><\/i>\/J<\/span><\/td>\nB6 congenic<\/td>\nLung alveolar epithelial cells (inducible Cre)<\/td>\nJax 028054<\/td>\nKwon Park<\/td>\n<\/tr>\n
B6N.129S6(Cg)-Scgb1a1tm1(cre\/ERT)Blh<\/sup><\/i>\/J<\/span><\/td>\nB6N congenic<\/td>\nLung Clara cells (inducible Cre)<\/td>\nJax 016225<\/td>\nJax<\/td>\n<\/tr>\n
Tg(Scgb1a1-cre)1Tauc<\/td>\nB6<\/td>\nLung Clara cells<\/td>\nEM:02464<\/td>\nEMMA<\/td>\n<\/tr>\n
(5)\u00a0Flox<\/td>\n<\/tr>\n
RUNX1<\/td>\n<\/td>\n<\/td>\n<\/td>\nAdam Goldfarb<\/td>\n<\/tr>\n
KLF4<\/td>\n<\/td>\n<\/td>\n<\/td>\nGary Owens<\/td>\n<\/tr>\n
TGF\u03b2<\/td>\n<\/td>\n<\/td>\n<\/td>\nGary Owens<\/td>\n<\/tr>\n
PDGF\u00a0\u03b2 receptor<\/td>\n<\/td>\n<\/td>\n<\/td>\nGary Owens<\/td>\n<\/tr>\n
PDGF\u00a0\u03b2 chain<\/td>\n<\/td>\n<\/td>\n<\/td>\nGary Owens<\/td>\n<\/tr>\n
TGIF<\/td>\n<\/td>\n<\/td>\n<\/td>\nDavid Wotton<\/td>\n<\/tr>\n
ETAR<\/td>\nB6;129<\/td>\nEndothelin A receptor<\/td>\n<\/td>\nGreg Clines<\/td>\n<\/tr>\n
Mybf\/f<\/sup> (c-Myb)<\/td>\nB6, B6;129<\/td>\nExon II<\/td>\n<\/td>\nTim Bender<\/td>\n<\/tr>\n
Mybl2f\/f<\/sup> (B-Myb)<\/td>\nB6;129<\/td>\nExon II-IV<\/td>\n<\/td>\nTim Bender<\/td>\n<\/tr>\n
Rictor<\/td>\n<\/td>\n<\/td>\n<\/td>\nThurl Harris<\/td>\n<\/tr>\n
Hoxc8<\/td>\n<\/td>\n<\/td>\n<\/td>\nJeh-Ping Liu<\/td>\n<\/tr>\n
Hoxc6<\/td>\n<\/td>\n<\/td>\n<\/td>\nJeh-Ping Liu<\/td>\n<\/tr>\n
Gt(ROSA)26Sortm1Sor<\/sup>\/J<\/td>\n129S<\/td>\nLoxP-STOP-LoxP-LacZ<\/td>\nJax 003310<\/td>\nTom Parsons Gary Owens Roy Ogle<\/td>\n<\/tr>\n
Gt(ROSA)26Sortm1(EYFP)\/Cos<\/sup>\/J<\/td>\nB6<\/td>\nLoxP-STOP-LoxP-EYFP<\/td>\nJax 006148<\/td>\nTom Parsons<\/td>\n<\/tr>\n
Gt(ROSA)26Sortm1(Luc)Kael<\/sup>\/J<\/td>\nFVB.129S6(B6)<\/td>\nLoxP-STOP-LoxP-Luciferase<\/td>\nJax 005125<\/td>\n<\/td>\n<\/tr>\n
Id3<\/td>\nB6-Cg<\/td>\nfloxed<\/td>\n<\/td>\nColeen McNamara<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
(6) Flp<\/td>\n<\/tr>\n
Tg(ACTFLPe)9205Dym\/J<\/td>\nB6.Cg<\/td>\nHuman \u03b2-actin<\/td>\nJax 005703<\/td>\nXiaowei Lu<\/td>\n<\/tr>\n
Tg(CAG-FLPo)1Afst\/Mmucd<\/td>\nC57BL\/6N<\/td>\nCodon-optimized FLP<\/td>\nMMRRC 036512-UCD<\/td>\nAriel Gomez<\/td>\n<\/tr>\n
Tg(PGK1-FLPo)10Sykr\/J<\/td>\nB6(C3)<\/td>\nCodon-optimized FLP<\/td>\nJax 011065<\/td>\nKevin Lynch<\/td>\n<\/tr>\n
Gt(Rosa)26Sortm1(FLP1)Dym\/RainJ<\/td>\nB6.129S4<\/td>\nKI<\/td>\nJax 009086<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n(7)Tg\/KO Mice<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
FVB-Tg(Pbsn-AKT1)9Wrs<\/td>\nFVB<\/td>\nProbasin-AKT1<\/td>\nNCI 01XJ7<\/td>\nBryce Paschel<\/td>\n<\/tr>\n
Rho GDI alpha<\/td>\n50% 129SV, 25% DBA2, 25% C57BL\/6<\/td>\nKO<\/td>\nJun Miyoshi<\/td>\nDan Theodorescu<\/td>\n<\/tr>\n
Rho GDI beta<\/td>\n50% 129SV, 25% DBA2, 25% C57BL\/6<\/td>\nKO<\/td>\nJun Miyoshi<\/td>\nDan Theodorescu<\/td>\n<\/tr>\n
\n

B6.129P2-Apoetm1Unc<\/sup><\/i>\/J<\/p>\n<\/td>\n

B6.129<\/td>\nKO<\/td>\n\n

Jax 002052<\/p>\n<\/td>\n

Coleen McNamara<\/td>\n<\/tr>\n
\n

B6.129S-Id3tm1Zhu<\/sup><\/i>\/J<\/p>\n<\/td>\n

B6.129<\/td>\nKO<\/td>\n\n

Jax 006301<\/p>\n<\/td>\n

Coleen McNamara<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Cre\/Flox\/Flp Mice on Grounds Strain Background Promoter\/Exp. Original Source Lab (1) Widespread\/germline deleter Tg(EIIa-Cre)C5379Lmgd\/J B6.FVB EIIa Jax 003724 David Wotton Tg(MMTV-Cre)4Mam\/J B6129F1 MMTV Jax 003553 Tom Parsons Hsp70-Cre Hsp70 Scott Zeitlin (2) Inducible Tg(Mx1-cre)1Cgn\/J B6.Cg Mx1 (plpC or interferon) Jax 003556 Adam Goldfarb Tg(Cre\/Esr1)5Amc\/J B6.Cg CMV(tamoxifen) Jax 004682 Gary Owens Xiaowei Lu Jing Yu Tg(Sp7-tTA,tetO- […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":442,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-219","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nCre Flox Flp Mice - Genetically Engineered Murine Model (GEMM) Core<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/genetically-engineered-murine-model-core\/research\/cre-flox-flp-mice\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cre Flox Flp Mice - Genetically Engineered Murine Model (GEMM) Core\" \/>\n<meta property=\"og:description\" content=\"Cre\/Flox\/Flp Mice on Grounds Strain Background Promoter\/Exp. Original Source Lab (1) Widespread\/germline deleter Tg(EIIa-Cre)C5379Lmgd\/J B6.FVB EIIa Jax 003724 David Wotton Tg(MMTV-Cre)4Mam\/J B6129F1 MMTV Jax 003553 Tom Parsons Hsp70-Cre Hsp70 Scott Zeitlin (2) Inducible Tg(Mx1-cre)1Cgn\/J B6.Cg Mx1 (plpC or interferon) Jax 003556 Adam Goldfarb Tg(Cre\/Esr1)5Amc\/J B6.Cg CMV(tamoxifen) Jax 004682 Gary Owens Xiaowei Lu Jing Yu Tg(Sp7-tTA,tetO- […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/genetically-engineered-murine-model-core\/research\/cre-flox-flp-mice\/\" \/>\n<meta property=\"og:site_name\" content=\"Genetically Engineered Murine Model (GEMM) Core\" \/>\n<meta property=\"article:modified_time\" content=\"2019-04-26T19:45:16+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/genetically-engineered-murine-model-core\\\/research\\\/cre-flox-flp-mice\\\/\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/genetically-engineered-murine-model-core\\\/research\\\/cre-flox-flp-mice\\\/\",\"name\":\"Cre Flox Flp Mice - Genetically Engineered Murine Model (GEMM) Core\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/genetically-engineered-murine-model-core\\\/#website\"},\"datePublished\":\"2015-08-07T18:39:59+00:00\",\"dateModified\":\"2019-04-26T19:45:16+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/genetically-engineered-murine-model-core\\\/research\\\/cre-flox-flp-mice\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/med.virginia.edu\\\/genetically-engineered-murine-model-core\\\/research\\\/cre-flox-flp-mice\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/genetically-engineered-murine-model-core\\\/research\\\/cre-flox-flp-mice\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/med.virginia.edu\\\/genetically-engineered-murine-model-core\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Resources and References\",\"item\":\"https:\\\/\\\/med.virginia.edu\\\/genetically-engineered-murine-model-core\\\/research\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Cre Flox Flp Mice\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/genetically-engineered-murine-model-core\\\/#website\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/genetically-engineered-murine-model-core\\\/\",\"name\":\"Genetically Engineered Murine Model (GEMM) Core\",\"description\":\"University of Virginia School of Medicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/med.virginia.edu\\\/genetically-engineered-murine-model-core\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Cre Flox Flp Mice - Genetically Engineered Murine Model (GEMM) Core","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/med.virginia.edu\/genetically-engineered-murine-model-core\/research\/cre-flox-flp-mice\/","og_locale":"en_US","og_type":"article","og_title":"Cre Flox Flp Mice - Genetically Engineered Murine Model (GEMM) Core","og_description":"Cre\/Flox\/Flp Mice on Grounds Strain Background Promoter\/Exp. 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