{"id":1302,"date":"2011-07-22T12:56:35","date_gmt":"2011-07-22T17:56:35","guid":{"rendered":"http:\/\/cphg.virginia.edu\/cphg\/?page_id=1302"},"modified":"2011-07-22T12:56:35","modified_gmt":"2011-07-22T17:56:35","slug":"malnutrition-project","status":"publish","type":"page","link":"https:\/\/med.virginia.edu\/genome-sciences\/malnutrition-project\/","title":{"rendered":"Genetics of Malnutrition"},"content":{"rendered":"

 <\/p>\n

\"Mirpur<\/a>There is no health problem more important than that of malnutrition in young children.\u00a0 Poor nutrition is linked to more than half of all child deaths worldwide.\u00a0 Nearly one third of children in the developing world are malnourished.\u00a0 Malnutrition in the first 2 years of life leads to irreversible damage to cognitive function and physical capacity, and is transmitted between generations as malnourished mothers give birth to low birth weight children.\u00a0 Stunting affects about one third of children under age 5 and occurs in large part in the critical age window from -9 to +24 months. \u00a0Currently known interventions, if extended to all children, are still only predicted to reduce the incidence of stunting by approximately 1\/3, highlighting the need for a greater understanding of the underlying mechanisms that contribute to growth faltering.<\/p>\n

We are exploring the hypothesis that genetic factors may contribute to a child\u2019s risk of stunting in an environmental context of poor sanitation and endemic disease.\u00a0 To address this hypothesis, we are carrying out a genome-wide association study (GWAS) in a well characterized cohort of children recruited in Dhaka, Bangladesh who, as part of the study will receive nutritional supplementation and medical treatment.\u00a0 Our genetic studies will then seek to identify those factors that determine how well a child responds to intervention.\u00a0 Knowledge of these genetic risk factors can potentially direct more targeted interventions as well as suggest novel approaches to addressing the problem of malnutrition.<\/p>\n

These studies are not possible without the collaboration of a number of colleagues here at University of Virginia (William Petri, Stephen Rich, Joe Mychaleckyj) as well as in Bangladesh (Tahmeed Ahmed, Rashidul Haque).<\/p>\n","protected":false},"excerpt":{"rendered":"

  There is no health problem more important than that of malnutrition in young children.\u00a0 Poor nutrition is linked to more than half of all child deaths worldwide.\u00a0 Nearly one third of children in the developing world are malnourished.\u00a0 Malnutrition in the first 2 years of life leads to irreversible damage to cognitive function and […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":81,"comment_status":"closed","ping_status":"closed","template":"education_template.php","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-1302","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nGenetics of Malnutrition - Department of Genome Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/genome-sciences\/malnutrition-project\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genetics of Malnutrition - 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