{"id":556,"date":"2010-11-10T16:39:52","date_gmt":"2010-11-10T21:39:52","guid":{"rendered":"http:\/\/cphg.virginia.edu\/cphg\/?page_id=556"},"modified":"2019-02-11T17:10:37","modified_gmt":"2019-02-11T22:10:37","slug":"aaron-j-mackey","status":"publish","type":"page","link":"https:\/\/med.virginia.edu\/genome-sciences\/aaron-j-mackey\/","title":{"rendered":"Aaron J. Mackey"},"content":{"rendered":"<table style=\"width: 600px;\" border=\"0\" cellspacing=\"0\">\n<tbody>\n<tr valign=\"top\">\n<td style=\"width: 100px;\" valign=\"top\">\n<p><div id=\"attachment_581\" style=\"width: 110px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/med.virginia.edu\/cphg\/wp-content\/uploads\/sites\/353\/2010\/11\/A_Mackey31.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-581\" class=\"wp-image-581 size-full\" src=\"https:\/\/med.virginia.edu\/cphg\/wp-content\/uploads\/sites\/353\/2010\/11\/A_Mackey31.jpg\" alt=\"Aaron Mackey\" width=\"100\" height=\"140\" \/><\/a><p id=\"caption-attachment-581\" class=\"wp-caption-text\">Aaron Mackey<\/p><\/div><\/td>\n<td style=\"width: 400px;\" valign=\"top\">Degree(s):\u00a0PhD<br \/>\nGraduate School:\u00a0University of Virginia<br \/>\nPrimary Appointment:\u00a0Assistant Professor, Public Health Sciences<br \/>\n<strong>Research Interests:<\/strong><br \/>\nStatistical and computational genomics, including next-gen SNP discovery, comparative gene structure prediction, functional RNA-seq and ChIP-seq analyses.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Biomedical Sciences Graduate Program(s)<\/strong><\/p>\n<ul>\n<li><a href=\"http:\/\/www.healthsystem.virginia.edu\/internet\/bims_bmbg\/home.cfm\">Biochemistry, Molecular Biology and Genetics<\/a><\/li>\n<li><a href=\"http:\/\/www.healthsystem.virginia.edu\/internet\/bims_mii\/home.cfm\">Microbiology, Immunology and Infectious Diseases<\/a><\/li>\n<li><a href=\"http:\/\/www.healthsystem.virginia.edu\/internet\/bims_scbb\/home.cfm\">Structural, Computational Biology and Biophysics<\/a><\/li>\n<\/ul>\n<p><strong>Research Description<\/strong><br \/>\nThe advent of ultra-high throughput second-generation DNA sequencing has provided an ever-increasingly detailed view of the human genome, from both a structural and functional perspective. Our research leverages such genomic datasets to expose the biological processes underlying complex biology. Ongoing projects in the lab include: discovery of genetic polymorphisms associated with multigenic human diseases (type 1 diabetes and cancer); genomic studies of human immune system development and response to infectious disease; and the development of bioinformatic algorithms for sensitive and accurate consensus gene structure prediction across closely-related organisms (e.g.\u00a0Plasmodium, Drosophila, and primates). We also collaborate on a variety of functional genomics projects using &#8220;next-gen&#8221; sequencing methods for ChIP-seq, RNA-seq, MeDIP-seq, CLIP-seq, etc. For most projects, we develop and employ state-of-the art statistical machine learning methods, customized to integrate and interrogate genomic data specific to the particular experimental context.<\/p>\n<ul>\n<li>Tribolium Genome Sequencing Consortium. The genome of the model beetle and pest Tribolium castaneum. Nature. 2008 Apr 24;452(7190):949-55. Epub 2008 Mar 23. PubMed PMID: 18362917.<\/li>\n<li>Liu Q, Mackey AJ, Roos DS, Pereira FC. Evigan: a hidden variable model for integrating gene evidence for eukaryotic gene prediction. Bioinformatics. 2008 Mar 1;24(5):597-605. Epub 2008 Jan 10. PubMed PMID: 18187439.<\/li>\n<li>Chen F, Mackey AJ, Vermunt JK, Roos DS. Assessing performance of orthology detection strategies applied to eukaryotic genomes. PLoS One. 2007 Apr 18;2(4):e383. PubMed PMID: 17440619; PubMed Central PMCID: PMC1849888.<\/li>\n<li>Elsik CG, Mackey AJ, Reese JT, Milshina NV, Roos DS, Weinstock GM. Creating a honey bee consensus gene set. Genome Biol. 2007;8(1):R13. PubMed PMID: 17241472; PubMed Central PMCID: PMC1839126.<\/li>\n<\/ul>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=mackey%20aj%5BAuthor%5D&amp;cmd=DetailsSearch\">PubMed link for this faculty member<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Degree(s):\u00a0PhD Graduate School:\u00a0University of Virginia Primary Appointment:\u00a0Assistant Professor, Public Health Sciences Research Interests: Statistical and computational genomics, including next-gen SNP discovery, comparative gene structure prediction, functional RNA-seq and ChIP-seq analyses. Biomedical Sciences Graduate Program(s) Biochemistry, Molecular Biology and Genetics Microbiology, Immunology and Infectious Diseases Structural, Computational Biology and Biophysics Research Description The advent of ultra-high [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":81,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-556","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Aaron J. 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