{"id":5431,"date":"2025-08-25T10:46:30","date_gmt":"2025-08-25T14:46:30","guid":{"rendered":"https:\/\/med.virginia.edu\/genome-sciences\/?p=5431"},"modified":"2026-05-22T16:24:30","modified_gmt":"2026-05-22T20:24:30","slug":"charles-farber-phd-and-abhijit-dighe-phd-awarded-3-4-million-nih-grant-to-unravel-genetic-drivers-of-osteoporosis","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/genome-sciences\/2025\/08\/25\/charles-farber-phd-and-abhijit-dighe-phd-awarded-3-4-million-nih-grant-to-unravel-genetic-drivers-of-osteoporosis\/","title":{"rendered":"Charles Farber, PhD, and Abhijit Dighe, PhD, Awarded $3.4 Million NIH Grant to Unravel Genetic Drivers of Osteoporosis"},"content":{"rendered":"<div class=\"entry-content\">\n<div id=\"attachment_49589\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-49589\" src=\"https:\/\/news.med.virginia.edu\/files\/2025\/08\/Abhijit-and-Farber-1x1-1.jpg\" alt=\"Abhijit and Farber head shots\" width=\"400\" height=\"400\" aria-describedby=\"caption-attachment-49589\" \/>\n<p id=\"caption-attachment-49589\" class=\"wp-caption-text\">Abhijit S. Dighe, PhD, (left) and Charles R. Farber, PhD<\/p>\n<\/div>\n<p>The University of Virginia has been awarded a new $3.4 million grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases to tackle one of the most pressing challenges in bone health: understanding the genetic factors that lead to osteoporosis.<\/p>\n<p>The research, led by <strong>Charles R. Farber, PhD<\/strong>, Professor and Chair of the <strong>UVA Department of Genome Sciences<\/strong>, and <strong>Abhijit S. Dighe, PhD<\/strong>, Assistant Professor of <strong>Genome Sciences<\/strong>, will leverage cutting-edge genomic tools, including context-specific expression quantitative trait loci (eQTL), to uncover how subtle, genetically regulated changes in gene expression influence bone mineral density (BMD)\u2014a key measure of bone strength and strong predictor of fracture risk.<\/p>\n<p>Osteoporosis affects millions of Americans, leading to debilitating fractures and enormous healthcare costs. Although genome-wide association studies have uncovered hundreds of genomic regions linked to BMD, most of these regions fall outside of protein-coding genes. This makes it challenging to identify which genes are truly driving population-level variation in BMD.<\/p>\n<p>The UVA researchers will apply state-of-the-art context-specific eQTL mapping\u2014capturing how genetic effects on gene expression depend on cell type, developmental stage, and environmental conditions\u2014together with single-cell transcriptomics and CRISPR-based functional screens to close this gap. Their goal is to move from statistical associations in the genome to clear biological mechanisms, ultimately revealing new targets for osteoporosis prevention and treatment.<\/p>\n<p>The research team also includes Quanjun Cui, MD, and Michael Hadeed, MD, from UVA\u2019s Department of Orthopaedic Surgery, who bring expertise in clinical orthopedics that will strengthen the translational impact of the project.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Abhijit S. Dighe, PhD, (left) and Charles R. Farber, PhD The University of Virginia has been awarded a new $3.4 million grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases to tackle one of the most pressing challenges in bone health: understanding the genetic factors that lead to osteoporosis. The research, led [&hellip;]<\/p>\n","protected":false},"author":1287,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[3,8],"tags":[191,187,181,196],"class_list":["post-5431","post","type-post","status-publish","format-standard","hentry","category-homepage-feed","category-people","tag-abhijit-dighe","tag-charles-farber","tag-genome-sciences","tag-intranet"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Charles Farber, PhD, and Abhijit Dighe, PhD, Awarded $3.4 Million NIH Grant to Unravel Genetic Drivers of Osteoporosis - Department of Genome Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/genome-sciences\/2025\/08\/25\/charles-farber-phd-and-abhijit-dighe-phd-awarded-3-4-million-nih-grant-to-unravel-genetic-drivers-of-osteoporosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Charles Farber, PhD, and Abhijit Dighe, PhD, Awarded $3.4 Million NIH Grant to Unravel Genetic Drivers of Osteoporosis - Department of Genome Sciences\" \/>\n<meta property=\"og:description\" content=\"Abhijit S. Dighe, PhD, (left) and Charles R. Farber, PhD The University of Virginia has been awarded a new $3.4 million grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases to tackle one of the most pressing challenges in bone health: understanding the genetic factors that lead to osteoporosis. 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