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Harris Lab

Publications

Selected publications from the Harris lab (Harris lab trainees underlined)

For a full list of Dr. Harris’ publications please go to MyNCBI.

  1. Beretta M, Dai Y, Olzomer EM, Vancuylenburg CS, Santiago-Rivera JA, Philp AM, Hargett SR, Li K, Shah DP, Chen SY, Alexopoulos SJ, Li C, Harris TE, Lee B, Wathier M, Cermak JM, Tucker SP, Turner N, Bayliss DA, Philp A, Byrne FL, Santos WL, Hoehn KL. Liver-selective imidazolopyrazine mitochondrial uncoupler SHD865 reverses adiposity and glucose intolerance in mice. Diabetes. 2023 Oct 23:db230233  [PMID: 37870907]
  2. Heindel AJ, Brulet JW, Wang X, Founds MW, Libby AH, Bai DL, Lemke MC, Leace DM, Harris TE, Hafner M, Hsu KL. Chemoproteomic capture of RNA binding activity in living cells. Nat Comm. 2023 Oct 7;14(1):6282 [PMID: 37805600]
  3. Yeudall S, Upchurch CM, Seegren PV, Pavelec CM, Greulich J, Lemke MC, Harris TE, Desai BN, Hoehn KL, Leitinger N*. Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism. Sci Adv. 2022 Nov 25;8(47):eabq1984.  [PMID: 36417534]
  4. Granade ME, Hargett SR, Lank DS, Lemke MC, Luse MA, Isakson BA, Bochkis IM, Linden J, Harris TE. Feeding desensitizes A1 adenosine receptors in adipose through FOXO-1mediated transcriptional regulation. Mol Metab. 2022 Jul 7:101543. [PMID: 35811051]
  5. Granade ME, Manigat LC, Lemke MC, Purow BW, Harris TE Identification of ritanserin analogs that display DGK isoform specificity. Biochem Pharmacol. 2022 Jan 6 [PMID: 34999054]
  6. Bottermann K*, Granade ME, Oenarto V, Fischer JW, Harris TE* Atglistatin pretreatment preserves remote myocardium function following myocardial infarction. J. Cardiovasc. Pharmacol. Ther. 2021 May;26(3):289-297.[PMID: 33150796]. * Co-corresponding authors 
  7. Raje V, Ahern KW, Martinez BA, Howell NL, Oenarto V, Granade ME, Kim JW, Tundup S, Bottermann, K, Gödecke A, Keller SR, Kadl A, Bland ML, Harris TE Adipocyte lipolysis drives acute stress-induced insulin resistance. Sci Rep. 2020 Oct 23;10(1):18166. [PMID: 33097799].
  8. Ahern KW, Serbulea V, Wingrove CL, Palas ZT, Leitinger N, Harris TE. Regioisomer-independent quantification of fatty acid oxidation products by HPLC-ESI-MS/MS analysis of sodium adducts. Sci Rep. 2019 Aug 1;9(1):11197. [PMID: 31371760]
  9. Hennessy M, Granade ME, Hassaninasab A, Wang D, Kwiatek JM, Han GS, Harris TE, Carman GM*. Casein kinase II-mediated phosphorylation of lipin 1β phosphatidate phosphatase at Ser-285 and Ser-287 regulates its interaction with 14-3-3β protein. J Biol Chem. 2019 Jan 7. Feb 15;294(7):2365-2374. [PMID: 30617183]
  10. Granade, ME & Harris, TE Purification of Lipin and Measurement of Phosphatidic Acid Phosphatase Activity from Liposomes. Methods Enzymol. 2018; 607:373-388. [PMID: 30149866]
  11. Olmez I, Love S, Xiao A, Manigat L, Randolph P, McKenna BD, Neal BP, Boroda S, Li M, Brenneman B, Abounader R, Floyd D, Lee J, Nakano I, Godlewski J, Bronisz A, Sulman EP, Mayo M, Gioeli D, Weber M, Harris TE*, Purow B* . Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha. Neuro Oncol. 2018 Jan 22;20(2):192-202.  * Co-corresponding authors [PMID: 29048560]
  12. Boroda S, Takkellapati S, Lawrence RT, Entwisle SW, Pearson JM, Granade ME, Mullins GR, Eaton JM, Villén J, Harris TE. The Phosphatidic Acid-Binding, Polybasic Domain is responsible for the differences in the phosphoregulation of Lipins 1 and 3. J Biol Chem. 2017 Dec 15;292(50):20481-20493. [PMID: 28982975]
  13. Franks, CE, Campbell ST, Purow BW, Harris TE, Hsu KL. The ligand binding landscape of Diacylglycerol kinases. Cell Chem Biol. 2017 Jul 20; 24(7):870-880.e5. [PMID: 28712745]
  14. Boroda S, Niccum M, Raje V, Purow BW*, Harris TE*. Dual activities of ritanserin and R59022 as DGKα inhibitors and serotonin receptor antagonists. Biochem Pharmacol. 2017 Jan 1;123:29-39. * Co-corresponding authors [PMID: 27974147]
  15. Mullins GR, Wang L, Raje V, Sherwood SG, Grande RC, Boroda S, Eaton JM, Blancquert S, Roger PP, Leitinger N, Harris TE. Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17450-5. [PMID: 25422441]
  16. Eaton JM, Mullins GR, Brindley DN, Harris TE. Phosphorylation of lipin 1 and charge on the phosphatidic acid head group control its phosphatidic acid phosphatase activity and membrane association. J Biol Chem. 2013 Apr 5;288(14):9933-45. [PMID: 23426360]
  17. Kumar A, Lawrence Jr JC, Jung DY, Ko HJ, Keller SR, Kim JK, Magnuson MA, Harris TE. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole body glucose and lipid metabolism. Diabetes. 2010 Jun;59(6):1397-406. [PMID: 20332342]
  18. Wang, L, Lawrence Jr JC, Sturgill TW, Harris TE. Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR. J Biol Chem. 2009 May 29;284(22):14693-7. [PMID:19346248]
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