Hayden, Frederick G.
- BA, , Stanford University
- MD, , Stanford University
Antiviral agents for the prevention and treatment of respiratory viral infections
Our research activities have focused on the application of antiviral agents for the prevention and treatment of respiratory viral infections. The scope of studies ranges from in vitro assays of viral susceptibility and antiviral mechanisms of action to clinical trials involving experimentally induced and naturally occurring infections. For example, prior work established the effectiveness of intranasal interferons in preventing transmission of rhinovirus colds, the safety and pharmacology of rimantadine HCI, the transmission of drug- resistant influenza A viruses in families, the anti-rhinovirus mechanism of action and antiviral activity of soluble ICAM-1, and the antiviral activity and clinical use of influenza neuraminidase inhibitors; oseltamivir and zanamivir, and the anti-picornavirus agent, pleconaril. Areas of current investigation include application of nucleic acid hybridization to study picornavirus epidemiology, determining the phenotypic and genotypic basis of antiviral drug resistance in rhino and influenza viruses, clinical testing of the several candidate antiviral agents for influenza and rhinovirus infections, and studies of host inflammatory response modifying agents in the pathogenesis of rhinovirus infections.