{"id":94,"date":"2022-05-25T17:07:01","date_gmt":"2022-05-25T17:07:01","guid":{"rendered":"https:\/\/med.virginia.edu\/kibbelab\/?page_id=94"},"modified":"2026-03-11T17:01:54","modified_gmt":"2026-03-11T21:01:54","slug":"research","status":"publish","type":"page","link":"https:\/\/med.virginia.edu\/kibbe-tsihlis-lab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<p>The main focus of the Kibbe-Tsihlis Lab is to further our understanding of nitric oxide (NO) vascular biology so that NO-based therapies can be developed to improve patient care.<\/p>\n<p>RESEARCH<br \/>\nThe following are areas of active research in our laboratory:<br \/>\n\u2022 Generate nanoscale therapies to prevent non-compressible torso hemorrhage<br \/>\n\u2022 Synthesize biocompatible, elastomeric, polymer-based customizable stents<br \/>\n\u2022 Implement new atraumatic therapies to remove atherosclerotic plaque<br \/>\n\u2022 Develop and evaluate innovative, systemically-delivered, targeted nanotherapies to prevent restenosis, atherosclerosis, and inhalation burn injury<br \/>\n\u2022 Design and characterize novel NO-releasing films, gels, and prosthetic materials<br \/>\n\u2022 Understand how NO regulates the ubiquitin-proteasome pathway<br \/>\n\u2022 Create sustainable long-term release of NO for in vivo therapies<br \/>\n\u2022 Evaluate NO-based therapies in diabetes and metabolic syndrome<br \/>\n\u2022 Determine the role sex and hormones play on the effects of therapies in the vasculature<\/p>\n<p>Research in the Kibbe-Tsihlis Lab is funded by the National Institutes of Health, the US Department of Defense, and the US Department of Veterans Affairs.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The main focus of the Kibbe-Tsihlis Lab is to further our understanding of nitric oxide (NO) vascular biology so that NO-based therapies can be developed to improve patient care. RESEARCH The following are areas of active research in our laboratory: \u2022 Generate nanoscale therapies to prevent non-compressible torso hemorrhage \u2022 Synthesize biocompatible, elastomeric, polymer-based customizable [&hellip;]<\/p>\n","protected":false},"author":1777,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-94","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research - Kibbe-Tsihlis Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/kibbe-tsihlis-lab\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - Kibbe-Tsihlis Lab\" \/>\n<meta property=\"og:description\" content=\"The main focus of the Kibbe-Tsihlis Lab is to further our understanding of nitric oxide (NO) vascular biology so that NO-based therapies can be developed to improve patient care. 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