Publications

KEY PUBLICATIONS

Transcription factor KROX20 marks epithelial stem cell ancestors for hair follicle 2024 JCI cover for Ghotbi et al formation. Ghotbi E, Tchegnon E, Chen Z, Li S, Shipman T, Wang Y, Raman J, Zhang Y, McKay RM, Liao CP, Le LQ. J Clin Invest. 2024 Oct 3:e180160. PMID: 39361422

STING activation reprograms the microenvironment to sensitize NF1-related malignant peripheral nerve sheath tumors to immunotherapy. Somatilaka BN, Madana L, Sadek A, Chen Z, Chandrasekaran S, McKay RM, Le LQ. J Clin Invest. 2024 Mar 19:e176748. PMC11093615

Econazole selectively induces cell death in NF1-homozygous mutant tumor cells. Lakes YB, Moye SL, Mo J, Tegtmeyer M, Nehme R, Charlton M, Salinas G, McKay RM, Eggan K, Le LQ. Cell Rep Med. 2023 Dec 19;4(12):101309. doi: 10.1016/j.xcrm.2023.101309. PMC10772348

Basement membrane proteins in extracellular matrix characterize NF1 neurofibroma Somatilaka et al., 2024, JCI cover development and response to MEK inhibitor. Jiang C, Kumar A, Yu Z, Shipman T, Wang Y, McKay RM, Xing C, Le LQ. J Clin Invest. 2023 Jun 15;133(12):e168227. doi: 10.1172/JCI168227. PMC10266775

Epithelial stem cell homeostasis in Meibomian gland development, dysfunction, and dry eye disease. Tchegnon E, Liao CP, Ghotbi E, Shipman T, Wang Y, McKay RM, Le LQ. JCI Insight. 2021 Oct 22;6(20):e151078. doi: 10.1172/ jci.insight.151078. PMC8564894

Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins. Mo J, Anastasaki C, Chen Z, Shipman T, Papke J, Yin K, Gutmann DH, Le LQ. J Clin Invest. 2021 Jan 4;131(1): e139807. doi: 10.1172/JCI139807. PMC7773354

Schwannoma development is 2020 cover of JCI Insight mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling. Chen Z, Li S, Mo J, Hawley E, Wang Y, He Y, Brosseau JP, Shipman T, Clapp DW, Carroll TJ, Le LQ. JCI Insight. 2020 Oct 15;5(20):e141514. doi: 10.1172/jci.insight.141514. PMC7605536

Overcoming BET inhibitor resistance in malignant peripheral nerve sheath tumors. Cooper JM, Patel AJ, Chen Z, Liao CP, Chen K, Mo J, Wang Y, Le LQ. Clin Cancer Res. 2019 Jun 1;25(11):3404-3416. doi: 10.1158/1078-0432.CCR-18-2437. PMC6548569

NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation. Brosseau JP, Liao CP, Wang Y, Ramani V, Vandergriff T, Lee M, Patel A, Ariizumi K, Le LQ. Nat Commun. 2018 Nov 27;9(1):5014. doi: 10.1038/s41467-018-07452-y. PMC6258697

Spatiotemporal loss of NF1 in Schwann cell lineage leads to different types of cutaneous neurofibroma susceptible to modification by the Hippo pathway. Chen Z, Mo J, Brosseau JP, Shipman T, Wang Y, Liao CP, Cooper JM, Allaway RJ, Gosline SJC, Guinney J, Carroll TJ, Le LQ. Cancer Discov. 2019 Jan;9(1):114-129. doi: 10.1158/2159-8290.CD-18-0151. PMC6328325

Identification of hair shaft 2017 cover of Genes and Development progenitors that create a niche for hair pigmentation. Liao CP, Booker RC, Morrison SJ, Le LQ. Genes Dev. 2017 Apr 15;31(8):744-756. doi: 10.1101/gad.298703.117. PMC5435888

The role of the nerve microenvironment for neurofibroma development. Liao CP, Pradhan S, Chen Z, Patel AJ, Booker RC, Le LQ. Oncotarget. 2016 Sep 20;7(38):61500-61508. doi: 10.18632/ oncotarget.11133. PMC5308667

Chen Z, Liu C, Patel AJ, Liao CP, Wang Y, Le LQ. Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma. Cancer Cell. 2014 Nov 10;26(5):695-706. doi: 10.1016/j.ccell.2014.09.009. PMC4254535

Patel AJ, Liao CP, Chen Z, Liu C, Wang Y, Le LQ. BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction. Cell Rep. 2014 Jan 16;6(1):81-92. doi: 10.1016/j.celrep.2013.12.001. PMC3904298

Chau V, Lim SK, Mo W, Liu C, Patel AJ, McKay RM, Wei S, Posner BA, De Brabander JK, Williams NS, Parada LF, Le LQ. Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors. Cancer Res. 2014 Jan 15;74(2):586-97. doi: 10.1158/0008-5472.CAN-13-1934. PMC3947005

Chen Z, Pradhan S, Liu C, Le LQ. Skin-derived precursors as a source of progenitors for cutaneous nerve regeneration. Stem Cells. 2012 Oct;30(10):2261-70. doi: 10.1002/stem.1186. PMC3448815

Le LQ, Liu C, Shipman T, Chen Z, Suter U, Parada LF. Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development. Cancer Res. 2011 Jul 1;71(13):4686-95. doi: 10.1158/0008-5472.CAN-10-4577. PMC3145496

Le LQ, Shipman T, Burns DK, Parada LF. Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas. Cell Stem Cell. 2009 May 8;4(5):453-63. doi: 10.1016/j.stem.2009.03.017. PMC2737469

PUBLICATIONS

2024

Malignant melanoma arising in a pre-existing cutaneous neurofibroma from a patient with NF1. Moye SL, Knowles A, Vandergriff T, Le LQ. JAAD Case Reports. 2024 October 14: published online. In press.

Transcription factor KROX20 marks epithelial stem cells for hair follicle formation. Ghotbi E, Tchegnon E, Chen Z, Li S, Shipman T, Wang Y, Raman J, Zhang Y, McKay RM, Liao CP, Le LQ. J Clin Invest. 2024 Oct 3:e180160. PMID: 39361422

Effect of NFX-179 MEK inhibitor on cutaneous neurofibromas in persons with neurofibromatosis type 1. Sarin KY, Bradshaw M, O’Mara C, Shahryari J, Kincaid J, Kempers S, Tu JH, Dhawan S, DuBois J, Wilson D, Horwath P, de Souza MP, Powala C, Kochendoerfer GG, Plotkin SR, Webster GF, Le LQ. Sci Adv. 2024 May 3;10(18):eadk4946. PMC11062565

Stem cell modeling of nervous system tumors. Furnari FB, Anastasaki C, Bian S, Fine HA, Koga T, Le LQ, Rodriguez FJ, Gutmann DH. Dis Model Mech. 2024 Feb 1;17(2):dmm050533. doi: 10.1242/dmm.050533. PMC10886724

Multiparametric whole-body MRI of patients with Neurofibromatosis Type 1: spectrum of imaging findings. Thakur U, Ramachandran S, Mazal AT, Cheng J, Le LQ, Chhabra A. Skeletal Radiol. 2024. Aug 6.doi: 10.1007/s00256-024-04765-6. PMID: 39105762

Association of plexiform and diffuse neurofibromas with malignant peripheral nerve sheath tumor in NF I patients: a whole-body MRI assessment. Attia S, Guirguis M, Le LQ, Chhabra A. Skeletal Radiol. 2024 Apr;53(4):769-777. doi: 10.1007/s00256-023-04497-z. PMID: 37903998

2023

A call for discovery and therapeutic development for cutaneous neurofibromas. Blakeley JO, Le LQ, Lee SY, Ly I, Rhodes SD, Romo CG, Sarin KY, Staedtke V, Steensma MR, Wolkenstein P; 2022 NTAP Cutaneous Neurofibroma Symposium Participants. J Invest Dermatol. 2023 Aug;143(8):1351-1357. doi: 10.1016/j.jid.2022.11.027. PMID: 37354152

Existing and developing preclinical models for Neurofibromatosis Type 1-Related Cutaneous Neurofibromas. Staedtke V, Topilko P, Le LQ, Grimes K, Largaespada DA, Cagan RL, Steensma MR, Stemmer-Rachamimov A, Blakeley JO, Rhodes SD, Ly I, Romo CG, Lee SY, Serra E. J Invest Dermatol. 2023 Aug;143(8):1378-1387. doi: 10.1016/j.jid.2023.01.042. PMID: 37330719

Cutaneous neurofibroma JID Cover 2023 heterogeneity: factors that influence tumor burden in Neurofibromatosis Type 1. Jiang C, McKay RM, Lee SY, Romo CG, Blakeley JO, Haniffa M, Serra E, Steensma MR, Largaespada D, Le LQ. J Invest Dermatol. 2023 Aug;143(8):1369-1377. doi: 10.1016/j.jid.2022.12.027. PMID: 37318402

Basement membrane proteins in extracellular matrix characterize NF1 neurofibroma development and response to MEK inhibitor. Jiang C, Kumar A, Yu Z, Shipman T, Wang Y, McKay RM, Xing C, Le LQ. J Clin Invest. 2023 Jun 15;133(12):e168227. doi: 10.1172/JCI168227. PMCID: PMC10266775

Whole central and peripheral nervous system mice dissection. Rhéaume K, Chen Z, Wang Y, Plante C, Hewa Bostanthirige D, Lévesque M, Geha S, Le LQ, Brosseau JP. J Vis Exp. 2023 Feb 24;(192). doi: 10.3791/64974. PMID: 36912549

2022

Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1. Anastasaki C, Mo J, Chen JK, Chatterjee J, Pan Y, Scheaffer SM, Cobb O, Monje M, Le LQ, Gutmann DH. Nat Commun. 2022 May 19;13(1):2785. doi: 10.1038/s41467-022-30466-6. PMC9120229

Malignant peripheral nerve sheath tumor: models, biology, and translation. Somatilaka BN, Sadek A, McKay RM, Le LQ. Oncogene. 2022 Apr;41(17):2405-2421. doi: 10.1038/s41388-022-02290-1. PMC9035132

Scoliosis in Neurofibromatosis Type 1 on whole-body magnetic resonance imaging: frequency and association with intraspinal and paraspinal tumors. Haider S, Le LQ, Cho G, Xi Y, Chhabra A. J Comput Assist Tomogr. 2022 Mar-Apr 01;46(2):231-235. doi: 10.1097/RCT.0000000000001263. PMID: 35297579

Neurofibromin and suppression of tumorigenesis: beyond the GAP. Mo J, Moye SL, McKay RM, Le LQ. Oncogene. 2022 Feb;41(9):1235-1251. doi: 10.1038/s41388-021-02156-y. PMC9063229

2021

Training physician-scientists for Cover of JID 2021 - Training and Retaining Physician Scientists careers in investigative dermatology, Li S, Yancey KB, Cruz PD Jr, Le LQ. JID Innovations. 2021 Oct 19;2(1):100061. doi: 10.1016/j.xjidi.2021.100061. PMC8801527

The research techniques made simple series: lasting and future impact on investigative dermatology. Johnson JL, Brown SJ, Le LQ, Udey MC. J Invest Dermatol. 2021 Dec;141(12):2761-2764. doi: 10.1016/j.jid.2021.09.016. PMID: 34802548

Insights into the pathogenesis of NF1-associated neoplasms. Bui A, Jiang C, McKay RM, Klesse LJ, Le LQ. JID Innovations. 2021 Sep;1(3):100044. doi: 10.1016/j.xjidi.2021.100044. Epub 2021 Aug 20. PMC8486282

Tumorigenesis in neurofibromatosis type 1: role of the microenvironment. Jiang C, McKay RM, Le LQ. Oncogene. 2021 Sep;40(39):5781-5787. doi: 10.1038/s41388-021-01979-z. PMC8713356

Human cutaneous neurofibroma matrisome revealed by single-cell RNA sequencing. Brosseau JP, Sathe AA, Wang Y, Nguyen T, Glass DA 2nd, Xing C, Le LQ. Acta Neuropathol Commun. 2021 Jan 7;9(1):11. doi: 10.1186/s40478-020-01103-4. PMCID7792184

2020

Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling. Chen Z, Li S, Mo J, Hawley E, Wang Y, He Y, Brosseau JP, Shipman T, Clapp DW, Carroll TJ, Le LQ. JCI Insight. 2020 Oct 15;5(20):e141514. doi: 10.1172/jci.insight.141514. PMC7605536

Ashy dermatosis-like hyperpigmentation in a patient taking hydroxyurea. Li S, Arvisais-Anhalt S, Vandergriff T, Le LQ. JAAD Case Rep. 2020 Jun 25;6(9):797-800. doi: 10.1016/j.jdcr.2020.06.030. eCollection 2020 Sep. PMC7452229

Management of cutaneous neurofibroma: current therapy and future directions. Chamseddin BH, Le LQ. Neurooncol Adv. 2019 Dec 16;2(Suppl 1):i107-i116. doi: 10.1093/noajnl/vdz034. eCollection 2020 Jul. PMC7317049

Translating current basic research into future therapies for neurofibromatosis type 1. Brosseau JP, Liao CP, Le LQ. Br J Cancer. 2020 Jul;123(2):178-186. doi: 10.1038/s41416-020-0903-x. PMC7374719

2019

New insights into the neurofibroma tumor cells of origin. Li S, Chen Z, Le LQ. Neurooncol Adv. 2019 Nov 10;2(Suppl1):i13-i22. doi: 10.1093/noajnl/vdz044. PMC7317055

Heterozygous tumor suppressor microenvironment in cancer development. Brosseau JP, Le LQ. Trends Cancer. 2019 Sep;5(9):541-546. doi: 10.1016/j.trecan.2019.07.004. PMC6724550

Robust surgical approach for cutaneous neurofibroma in neurofibromatosis type 1. Chamseddin BH, Hernandez L, Solorzano D, Vega J, Le LQ. JCI Insight. 2019 Apr 30;5(11):e128881. doi: 10.1172/jci.insight.128881. PMC6629109

Double-stranded RNA sensing determines epithelial cell identity. Liao CP, Tchegnon E, Le LQ. J Invest Dermatol. 2019 Jan;139(1):17-19. doi: 10.1016/j.jid.2018.08.008. PMID: 30579424

Diffusion-weighted imaging and diffusion tensor imaging as adjuncts to conventional MRI for the diagnosis and management of peripheral nerve sheath tumors: current perspectives and future directions. Mazal AT, Ashikyan O, Cheng J, Le LQ, Chhabra A. Eur Radiol. 2019 Aug;29(8):4123-4132. doi: 10.1007/s00330-018-5838-8. PMID: 30535638

2018

The biology of cutaneous Neurology Cover - 2018 neurofibromas: consensus recommendations for setting research priorities. Brosseau JP, Pichard DC, Legius EH, Wolkenstein P, Lavker RM, Blakeley JO, Riccardi VM, Verma SK, Brownell I, Le LQ. Neurology. 2018 Jul 10;91(2 Suppl 1):S14-S20. doi: 10.1212/WNL.0000000000005788. PMC9703338

2017 – previous

Identification of hair shaft progenitors that create a niche for hair pigmentation. Liao CP, Booker RC, Morrison SJ, Le LQ. Genes Dev. 2017 Apr 15;31(8):744-756. doi: 10.1101/gad.298703.117. PMC5435888

Tumor segmentation of whole-body magnetic resonance imaging in neurofibromatosis type 1 patients: tumor burden correlates. Heffler MA, Le LQ, Xi Y, Chhabra A. Skeletal Radiol. 2017 Jan;46(1):93-99. doi: 10.1007/s00256-016-2522-4. PMID: 27815599

Defining the research landscape for dermal neurofibromas. Le LQ, Kesterson RA, Gutmann DH. Oncol Times. 2016 Sep 25;38(18):14-15. doi: 10.1097/01.cot.0000502634.14826.10. PMC8486293

Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma. Chen Z, Liu C, Patel AJ, Liao CP, Wang Y, Le LQ. Cancer Cell. 2014 Nov 10;26(5):695-706. doi: 10.1016/j.ccell.2014.09.009. PMC4254535

BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction. Patel AJ, Liao CP, Chen Z, Liu C, Wang Y, Le LQ. Cell Rep. 2014 Jan 16;6(1):81-92. doi: 10.1016/j.celrep.2013.12.001. PMC3904298

Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors. Chau V, Lim SK, Mo W, Liu C, Patel AJ, McKay RM, Wei S, Posner BA, De Brabander JK, Williams NS, Parada LF, Le LQ. Cancer Res. 2014 Jan 15;74(2):586-97. doi: 10.1158/0008-5472.CAN-13-1934. PMC3947005

CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors. Mo W, Chen J, Patel A, Zhang L, Chau V, Li Y, Cho W, Lim K, Xu J, Lazar AJ, Creighton CJ, Bolshakov S, McKay RM, Lev D, Le LQ, Parada LF. Cell. 2013 Feb 28;152(5):1077-90. doi: 10.1016/j.cell.2013.01.053. PMC3594500

Skin-derived precursors as a source of progenitors for cutaneous nerve regeneration. Chen Z, Pradhan S, Liu C, Le LQ. Stem Cells. 2012 Oct;30(10):2261-70. doi: 10.1002/stem.1186. PMC3448815

Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development. Le LQ, Liu C, Shipman T, Chen Z, Suter U, Parada LF. Cancer Res. 2011 Jul 1;71(13):4686-95. doi: 10.1158/0008-5472.CAN-10-4577. PMC3145496

Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas. Le LQ, Shipman T, Burns DK, Parada LF. Cell Stem Cell. 2009 May 8;4(5):453-63. doi: 10.1016/j.stem.2009.03.017. PMC2737469

Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. Ganesan AK, Ho H, Bodemann B, Petersen S, Aruri J, Koshy S, Richardson Z, Le LQ, Krasieva T, Roth MG, Farmer P, White MA. PLoS Genet. 2008 Dec;4(12):e1000298. doi: 10.1371/journal.pgen. 1000298. PMC2585813

Tumor microenvironment and neurofibromatosis type I: connecting the GAPs. Le LQ, Parada LF. Oncogene. 2007 Jul 12;26(32):4609-16. doi: 10.1038/sj.onc.1210261. PMC2760340

Positron emission tomography cover of 2002 Cancer Cell issue imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene. Le LQ, Kabarowski JHS, Wang S, Nguyen K, Gambhir SS, Witte ON. Cancer Cell. 2002 May 1(4):381-391. doi: 10.1016/s1535-6108(02)00058-2. PMID: 12086852

Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome. Le LQ, Kabarowski JH, Weng Z, Satterthwaite AB, Harvill ET, Jensen ER, Miller JF, Witte ON. Immunity. 2001 May;14(5):561-71. doi: 10.1016/ s1074-7613(01)00145-5. PMID: 11371358

Direct genetic demonstration of G alpha 13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement. Kabarowski JH, Feramisco JD, Le LQ, Gu JL, Luoh SW, Simon MI, Witte ON. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12109-14. doi: 10.1073/pnas.97.22.12109. PMC17302

A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Weng Z, Fluckiger AC, Nisitani S, Wahl MI, Le LQ, Hunter CA, Fernal AA, Le Beau MM, Witte ON. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12334-9. doi: 10.1073/pnas.95.21.12334. PMC22832

Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. Lieberman JR, Le LQ, Wu L, Finerman GA, Berk A, Witte ON, Stevenson S. J Orthop Res. 1998 May;16(3):330-9. doi: 10.1002/jor.1100160309. PMID: 9671928