{"id":1133,"date":"2018-09-14T08:06:14","date_gmt":"2018-09-14T12:06:14","guid":{"rendered":"https:\/\/med.virginia.edu\/manoj-patel-lab\/?page_id=1133"},"modified":"2025-12-03T10:01:56","modified_gmt":"2025-12-03T15:01:56","slug":"events","status":"publish","type":"page","link":"https:\/\/med.virginia.edu\/manoj-patel-lab\/events\/","title":{"rendered":"Research"},"content":{"rendered":"<p>The Patel lab focuses on understanding the cellular mechanisms by which seizures are initiated in <em>SCN8A<\/em> epileptic encephalopathy (DEE13). <em>SCN8A<\/em> EE is a severe genetic epilepsy syndrome caused by <em>de novo<\/em> mutations in the <em>SCN8A <\/em>gene, which codes for the voltage-gated sodium channel isoform Na<sub>v<\/sub>1.6. Our lab has two mouse models of patient-derived <em>SCN8A<\/em> mutations; N1768D (Scn8a<sup>D\/+<\/sup>), which allows global heterozygous expression of the N1768D pathogenic Scn8a variant and a conditional mouse in which the expression of R1872W (Scn8a<sup>w\/+<\/sup>) mutation is dependent on Cre recombinase. Using a variety of techniques including both <em>in vivo<\/em> and <em>in vitro<\/em> recordings to better understand the development and mechanisms of seizure initiation and seizure-induced death (SUDEP) in these mice.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div class=\"video-wrapper\"><iframe loading=\"lazy\" title=\"Manoj Patel, PhD: Using Gene Therapy to Tackle Pediatric Epilepsy.\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/IZ-XCAm-BM0?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The Patel lab focuses on understanding the cellular mechanisms by which seizures are initiated in SCN8A epileptic encephalopathy (DEE13). SCN8A EE is a severe genetic epilepsy syndrome caused by de novo mutations in the SCN8A gene, which codes for the voltage-gated sodium channel isoform Nav1.6. Our lab has two mouse models of patient-derived SCN8A mutations; [&hellip;]<\/p>\n","protected":false},"author":1694,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-1133","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research - Manoj Patel Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/manoj-patel-lab\/events\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - Manoj Patel Lab\" \/>\n<meta property=\"og:description\" content=\"The Patel lab focuses on understanding the cellular mechanisms by which seizures are initiated in SCN8A epileptic encephalopathy (DEE13). SCN8A EE is a severe genetic epilepsy syndrome caused by de novo mutations in the SCN8A gene, which codes for the voltage-gated sodium channel isoform Nav1.6. Our lab has two mouse models of patient-derived SCN8A mutations; [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/manoj-patel-lab\/events\/\" \/>\n<meta property=\"og:site_name\" content=\"Manoj Patel Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-03T15:01:56+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/manoj-patel-lab\\\/events\\\/\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/manoj-patel-lab\\\/events\\\/\",\"name\":\"Research - Manoj Patel Lab\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/manoj-patel-lab\\\/#website\"},\"datePublished\":\"2018-09-14T12:06:14+00:00\",\"dateModified\":\"2025-12-03T15:01:56+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/manoj-patel-lab\\\/events\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/med.virginia.edu\\\/manoj-patel-lab\\\/events\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/manoj-patel-lab\\\/events\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/med.virginia.edu\\\/manoj-patel-lab\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/manoj-patel-lab\\\/#website\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/manoj-patel-lab\\\/\",\"name\":\"Manoj Patel Lab\",\"description\":\"Manoj Patel Lab | University of Virginia School of Medicine site\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/med.virginia.edu\\\/manoj-patel-lab\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Research - Manoj Patel Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/med.virginia.edu\/manoj-patel-lab\/events\/","og_locale":"en_US","og_type":"article","og_title":"Research - Manoj Patel Lab","og_description":"The Patel lab focuses on understanding the cellular mechanisms by which seizures are initiated in SCN8A epileptic encephalopathy (DEE13). SCN8A EE is a severe genetic epilepsy syndrome caused by de novo mutations in the SCN8A gene, which codes for the voltage-gated sodium channel isoform Nav1.6. Our lab has two mouse models of patient-derived SCN8A mutations; [&hellip;]","og_url":"https:\/\/med.virginia.edu\/manoj-patel-lab\/events\/","og_site_name":"Manoj Patel Lab","article_modified_time":"2025-12-03T15:01:56+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/med.virginia.edu\/manoj-patel-lab\/events\/","url":"https:\/\/med.virginia.edu\/manoj-patel-lab\/events\/","name":"Research - Manoj Patel Lab","isPartOf":{"@id":"https:\/\/med.virginia.edu\/manoj-patel-lab\/#website"},"datePublished":"2018-09-14T12:06:14+00:00","dateModified":"2025-12-03T15:01:56+00:00","breadcrumb":{"@id":"https:\/\/med.virginia.edu\/manoj-patel-lab\/events\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/med.virginia.edu\/manoj-patel-lab\/events\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/med.virginia.edu\/manoj-patel-lab\/events\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/med.virginia.edu\/manoj-patel-lab\/"},{"@type":"ListItem","position":2,"name":"Research"}]},{"@type":"WebSite","@id":"https:\/\/med.virginia.edu\/manoj-patel-lab\/#website","url":"https:\/\/med.virginia.edu\/manoj-patel-lab\/","name":"Manoj Patel Lab","description":"Manoj Patel Lab | University of Virginia School of Medicine site","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/med.virginia.edu\/manoj-patel-lab\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/med.virginia.edu\/manoj-patel-lab\/wp-json\/wp\/v2\/pages\/1133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/med.virginia.edu\/manoj-patel-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/med.virginia.edu\/manoj-patel-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/manoj-patel-lab\/wp-json\/wp\/v2\/users\/1694"}],"replies":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/manoj-patel-lab\/wp-json\/wp\/v2\/comments?post=1133"}],"version-history":[{"count":7,"href":"https:\/\/med.virginia.edu\/manoj-patel-lab\/wp-json\/wp\/v2\/pages\/1133\/revisions"}],"predecessor-version":[{"id":1841,"href":"https:\/\/med.virginia.edu\/manoj-patel-lab\/wp-json\/wp\/v2\/pages\/1133\/revisions\/1841"}],"wp:attachment":[{"href":"https:\/\/med.virginia.edu\/manoj-patel-lab\/wp-json\/wp\/v2\/media?parent=1133"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/med.virginia.edu\/manoj-patel-lab\/wp-json\/wp\/v2\/tags?post=1133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}