{"id":1606,"date":"2021-08-27T16:15:53","date_gmt":"2021-08-27T20:15:53","guid":{"rendered":"https:\/\/med.virginia.edu\/manoj-patel-lab\/?page_id=1606"},"modified":"2026-02-11T14:15:36","modified_gmt":"2026-02-11T19:15:36","slug":"publications","status":"publish","type":"page","link":"https:\/\/med.virginia.edu\/manoj-patel-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

PubMed list for Manoj K. Patel<\/a><\/p>\n

Selected Publications:<\/strong><\/em><\/p>\n

2026<\/strong><\/h3>\n

Reever CM, Boscia AR, Deutsch TCJ, Patel MP, Miralles RM, Kittur S, Fleischel EJ, Buo AML, Yorek MS, Meisler MH, Farber CR, and Patel MK. Base editing rescues seizures and sudden death in a SCN8A <\/em>mutation-associated developmental epileptic encephalopathy model. Journal of Clinical Investigation 136<\/em>(3): e196402. 2026. PMID: 41623181<\/a><\/p>\n

2025<\/strong><\/h3>\n

Zengeler KE, Hollis A, Deutsch TCJ, Samuels JD, Ennerfelt H, Moore KA, Steacy EJ, Sabapathy V, Sharma R, Patel MK, and Lukens JR. Inflammasome signaling in astrocytes modulates hippocampal plasticity.\u00a0Immunity<\/em> 58(6): 1519-1535. 2025. PMID: 40318630<\/a><\/p>\n

2024<\/strong><\/h3>\n

Miralles RM, Boscia AR, Kittur S, Hanflink JC, Panchal PS, Yorek MS, Deutsch TCJ, Reever CM, Vundela SR, Wengert ER, and Patel MK. Parvalbumin interneuron impairment causes synaptic transmission deficits and seizures in SCN8A developmental and epileptic encephalopathy.\u00a0JCI Insight <\/em>9(20): e181005. 2024. PMID:\u00a0 39435659<\/a><\/p>\n

Dube CJ, Zhang Y, Saha S, Lai M, Gibert MK, Escalante M, Hudson K, Wong D, Marcinkiewicz P, Yener U, Sun Y, Xu E, Sorot A, Mulcahy E, Kefas B, Hanif F, Guessous F, Vernon A, Patel MK, Schiff D, Zong H, Purow B, Holland E, Sonkusare S, Sontheimer H, Abounader R.\u00a0<\/span>Microenvironment T-Type calcium channels regulate neuronal and glial processes to promote glioblastoma growth.\u00a0bioRxiv<\/em>.<\/span>\u00a02024. <\/span>PMID: 39229003<\/a><\/span><\/p>\n

Miralles R, Patel MK.\u00a0<\/span>Unspooling the thread: VIP interneurons linked with autism spectrum disorder behaviors but not seizures in Dravet syndrome. Epilepsy Curr <\/span><\/em>24<\/span>(1)<\/span>:62-64. 2024<\/span>. PMID: 38327541<\/a><\/span><\/p>\n

2023<\/strong><\/h3>\n

Wenker IC, Patel MK.\u00a0<\/span>A water nymph’s curse and the serotonergic mechanism of postictal breathing dysfunction. Epilepsy Curr <\/span><\/em>23<\/span>(6)<\/span>:369-371.<\/span>\u00a02023. <\/span>PMID: 38269340<\/a><\/span><\/p>\n

Burke CT, Vitko I, Straub J, Nylund EO, Gawda A, Blair K, Sullivan KA, Ergun L, Ottolini M, Patel MK, Perez-Reyes E.\u00a0<\/span>EpiPro, a novel, synthetic, activity-regulated promoter that targets hyperactive neurons in epilepsy for gene therapy applications. Int J Mol Sci<\/span><\/em> 24<\/span>(19): 14467. 2023<\/span><\/span>. PMID: 37833914<\/a><\/span><\/p>\n

Wenker IC, Patel MK.\u00a0<\/span>Waiting to inhale: Preventing fatality from seizure-induced apnea. Epilepsy Curr <\/span><\/em>23<\/span>(3)<\/span>:185-187.<\/span> 2023. <\/span>PMID: 37334424<\/a><\/span><\/p>\n

2022<\/strong><\/h3>\n

Wenker IC, Boscia AR, Lewis C, Tariq A, Miralles RM, Hanflink JC, Saraf P, and Patel MK. Forebrain epileptiform activity is not required for seizure-induced apnea in a mouse model of Scn8a epilepsy.\u00a0Frontiers in Neural Circuits<\/em> 16: 1002013. 2022. PMID: <\/span>36160949<\/a><\/span><\/p>\n

Thompson JA, Miralles RM, Wengert ER, Wagley PK, Yu W, Wenker IC, and Patel MK. Astrocyte reactivity in a mouse model of SCN8A epileptic encephalopathy.\u00a0Epilepsia Open<\/em> 7(2): 280-292. 2022. PMID: 34826216<\/a><\/p>\n

Miralles R, Patel MK.\u00a0<\/span>That’s a wrap: Could controlling activity-regulated myelination prevent absence seizures? Epilepsy Curr <\/span><\/em>22<\/span>(6)<\/span>:395-397.<\/span> 2022. <\/span>PMID: 36426188<\/a><\/span><\/p>\n

Miralles RM, Patel MK.\u00a0<\/span>It takes two to tango: Channel interplay leads to paradoxical hyperexcitability in a loss-of-function epilepsy variant. Epilepsy Curr <\/span><\/em>22<\/span>(1)<\/span>:69-71<\/span>. 2022. PMID: 35233206<\/a><\/span><\/p>\n

2021<\/strong><\/h3>\n

Wengert ER, Miralles RM, Wedgwood KC, Wagley PK, Strohm SM, Panchal PS, Idrissi AM, Wenker IC, Thompson JA, Gaykema RP, and Patel MK. Somatostatin-positive interneurons contribute to seizures in SCN8A epileptic encephalopathy. Journal of Neuroscience<\/em> 41 (44): 9257-9273. 2021. PMID: 34544834<\/a><\/p>\n

Wenker IC, Teran F, Wengert ER, Wagley PK, Panchal PS, Blizzard E, Saraf P, Wagnon J, Goodkin HP, Meisler MH, Richerson G and Patel MK. Postictal death is associated with tonic phase apnea in a mouse model of SUDEP. Annals of Neurology<\/em> 89(5):1023-1035. 2021. PMID: 33604927<\/a>.<\/p>\n

Wengert ER, Wenker IC, Wagner E, Wagley PK, Gaykema RP, Shin JB and Patel MK. Adrenergic mechanisms of seizure-induced sudden death in a mouse model of SCN8A encephalopathy. Frontiers in Neuroscience<\/em> 15: 581048. 2021. PMID: 33762902<\/a><\/p>\n

Wenker IC, Blizzard EA, Wagley PK, Patel MK.\u00a0<\/span>Peri-ictal autonomic control of cardiac function and seizure-induced death. Front Neurosci <\/span><\/em>15<\/span>:795145. 2021. PM<\/span>ID: 35126041<\/a><\/span><\/p>\n

Wengert ER, Wagley PK, Strohm SM, Reza N, Wenker IC, Gaykema RP, Christiansen A, Liau G, Patel MK.\u00a0<\/span>Targeted Augmentation of Nuclear Gene Output (TANGO) of SCN1A rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome. Brain Res <\/span><\/em>1775<\/span>:147743<\/span>. 2021.<\/span>\u00a0PMID: 34843701<\/a><\/span><\/p>\n

Wengert ER, Patel MK.\u00a0<\/span>One size doesn’t fit all: Variant-specific effects in SCN8A encephalopathy. Epilepsy Curr<\/span><\/em> 21<\/span>(3)<\/span>:183-185. 2021<\/span><\/span>. PMID: 34867099<\/a><\/span><\/p>\n

Wengert ER, Patel MK.\u00a0<\/span>The role of the persistent sodium current in rpilepsy. Epilepsy Curr <\/span><\/em>21<\/span>(1)<\/span>:40-47.<\/span>\u00a02021. PMID: 33236643<\/a><\/p>\n

2019<\/strong><\/h3>\n

Wengert ER, Tronhjem CE, Wagnon JL, Johannesen KM, Petit H, Krey I, Saga AU, Panchal PS, Strohm SM, Lange J, Kamphausen SB, Rubboli G, Lemke JR, Gardella E, Patel MK, Meisler MH, M\u00f8ller RS. Biallelic inherited SCN8A variants, a rare cause of SCN8A-related developmental and epileptic encephalopathy. Epilepsia<\/em>. 60:2277-2285. 2019. PMID: 31625145<\/a>\u00a0 \u00a0 \u00a0Co-senior author with MHM & RSM.<\/p>\n

Wengert ER, Saga AU, Panchal PS, Barker BS, Patel MK. Prax330 reduces persistent and resurgent sodium channel currents and neuronal hyperexcitability of subiculum neurons in a mouse model of SCN8A epileptic encephalopathy. Neuropharmacology<\/em>. 158. 2019. PMID: 31278928<\/a><\/p>\n

Bunton-Stasyshyn RKA, Wagnon JL, Wengert ER, Barker BS, Faulkner A, Wagley PK, Bhatia K, Jones JM, Maniaci MR, Parent JM, Goodkin HP, Patel MK, Meisler MH.\u00a0<\/span>Prominent role of forebrain excitatory neurons in SCN8A encephalopathy.\u00a0Brain <\/span><\/em>142<\/span>(2)<\/span>:362-375<\/span>. 2019.\u00a0PMID: 30601941<\/a><\/span><\/p>\n

2018<\/strong><\/h3>\n

Cottrell GS, Soubrane CH, Hounshell JA, Lin H, Owenson V, Rigby M, Cox PJ, Barker BS, Ottolini M, Ince S, Bauer CC, Perez-Reyes E, Patel MK, Stevens EB, Stephens GJ. CACHD1 is an \u03b12\u03b4-like protein that modulates CaV3 voltage-gated calcium channel activity. J Neurosci<\/em>. Sep 4. 3572-15. 2018. PMID: 30181139<\/a><\/p>\n

Baker EM, Thompson CH, Hawkins NA, Wagnon JL, Wengert ER, Patel MK, George AL Jr, Meisler MH, Kearney JA.\u00a0<\/span>The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy.\u00a0Epilepsia <\/span><\/em>59<\/span>(6)<\/span>:1166-1176<\/span>. 2018.\u00a0PMID: 29782051<\/a><\/span><\/p>\n

Wagnon JL, Mencacci NE, Barker BS, Wengert ER, Bhatia KP, Balint B, Carecchio M, Wood NW, Patel MK, Meisler MH.\u00a0<\/span>Partial loss-of-function of sodium channel SCN8A in familial isolated myoclonus.\u00a0Hum Mutat<\/span><\/em>. 39<\/span>(7)<\/span>:965-969<\/span>. 2018. PMID: 29726066<\/a><\/span><\/p>\n

2017<\/strong><\/h3>\n

Gaykema RP, Newmyer BA, Ottolini M, Raje V, Warthen DM, Lambeth PS, Niccum M, Yao T, Huang Y, Schulman IG, Harris TE, Patel MK, Williams KW, Scott MM. Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight. J Clin Invest<\/em>. (3):1031-1045. 2017. PMID: 28218622<\/a><\/p>\n

Ottolini M, Barker BS, Gaykema RP, Meisler MH, Patel MK. Aberrant sodium channel currents and hyperexcitability of medial entorhinal cortex neurons in a mouse model of SCN8A encephalopathy. J Neurosci<\/em>. 37: 7643-7655. 2017. PMID: 28676574<\/a><\/p>\n

Barker BS, Nigam A, Ottolini M, Gaykema RP, Hargus NJ, Patel MK.\u00a0<\/span>Pro-excitatory alterations in sodium channel activity facilitate subiculum neuron hyperexcitability in temporal lobe epilepsy.\u00a0Neurobiol Dis<\/span><\/em>.\u00a0108<\/span>:183-194<\/span>. 2017.<\/span>\u00a0PMID: 28860087<\/a><\/span><\/p>\n

2016<\/strong><\/h3>\n

Barker BS, Ottolini M, Wagnon J, Meisler MH and Patel MK. The SCN8A encephalopathy mutation p.Ile1327Val displays elevated sensitivity to the anticonvulsant phenytoin. Epilepsia<\/em>. (9):1458-66. 2016. PMID: 27375106<\/a><\/p>\n

Wheeler MA, Smith CJ, Ottolini M, Barker BS, Purohit AM, Grippo RM, Gaykema RP, Spano AJ, Beenhakker MP, Kucenas S, Patel MK, Deppmann CD, G\u00fcler AD. Genetically targeted magnetic control of the nervous system. Nature Neuroscience<\/em>. 19(5):756-61. 2016. PMID: 26950006<\/a><\/p>\n

Warthen DM, Lambeth PS, Ottolini M, Shi Y, Barker BS, Gaykema RP, Newmyer BA, Joy-Gaba J, Ohmura Y, Perez-Reyes E, G\u00fcler AD, Patel MK and Scott MM. Activation of Pyramidal Neurons in Mouse Medial Prefrontal Cortex Enhances Food-Seeking Behavior While Reducing Impulsivity in the Absence of an Effect on Food Intake. Frontiers in Behavioral Neuroscience<\/em>. 10. 63. 2016. PMID: 27065827<\/a><\/p>\n

Alexandrou A, Brown A, Chapman M, Estacion M, Turner J, Mis M, Wilbrey A, Payne L, Gutteridge A, Cox P, Doyle R, Printzenhoff D, Lin Z, Marron B, West C, Swain N, Storer I, Stupple P, Castle N, Hounshell J, Rivara M, Randall A, Dib-Hajj S, Krafte D, Waxman S, Patel MK, Butt R, Stevens EB. Subtype-selective small molecule inhibitors reveal a fundamental role for Nav1.7 in nociceptor electrogenesis, axonal conduction and presynaptic release. PLOS ONE<\/em>, 11 (4). 2016. PMID: 27050761<\/a><\/p>\n

Park J, Yu YP, Zhou CY, Li KW, Wang D, Chang E, Kim DS, Vo B, Zhang X, Gong N, Sharp K, Steward O, Vitko I, Perez-Reyes E, Eroglu C, Barres B, Zaucke F, Feng G, Luo ZD.\u00a0<\/span>Central mechanisms mediating thrombospondin-4-induced pain states. J Biol Chem<\/span><\/em>. 291<\/span>(25)<\/span>:13335-48<\/span>. 2016. <\/span>PMID: 27129212<\/a><\/span><\/p>\n

Wagnon JL, Barker BS, Hounshell JA, Haaxma CA, Shealy A, Moss T, Parikh S, Messer RD, Patel MK, Meisler MH.\u00a0<\/span>Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy.\u00a0Ann Clin Transl Neurol<\/span><\/em>.\u00a03<\/span>(2)<\/span>:114-23<\/span>. 2016.<\/span>\u00a0PMID: 26900580<\/a><\/span><\/p>\n

2015<\/strong><\/h3>\n

L. Wagnon, B.S. Barker, J.A Hounshell, C. Haaxma, A. Shealy, T. Moss, S. Parikh, R.D. Messer, M.K. Patel and M.H. Meisler.\u00a0 Pathogenic mechanism of recurrent epileptogenic mutations of sodium channel SCN8A. Annals of Clinical and Translational Neurology<\/em>. 3(2):114-23. 2015. PMID: 26900580<\/a><\/p>\n

Zuliani V, Rapalli A, Patel MK, Rivara M.\u00a0<\/span>Sodium channel blockers: a patent review (2010 – 2014).\u00a0Expert Opin Ther Pat<\/span><\/em>. 25<\/span>(3)<\/span>:279-90<\/span>. 2015.\u00a0PMID: 25539043<\/a><\/span><\/p>\n

2013<\/strong><\/h3>\n

Hargus NJ, Nigam A, Bertram EH 3rd, Patel MK.\u00a0<\/span>Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis.\u00a0J Neurophysiol<\/span><\/em>. 110<\/span>(5)<\/span>:1144-57<\/span>. 2013.<\/span>\u00a0PMID: 23741036<\/a><\/span><\/p>\n

2012<\/strong><\/h3>\n

Hargus NJ, Jennings C, Perez-Reyes E, Bertram EH, Patel MK. Enhanced actions of adenosine in medial entorhinal cortex layer II stellate neurons in temporal lobe epilepsy are mediated via A1 receptor activation. Epilepsia<\/em> 53(1):168-76. 2012. PMID: 22126400<\/a><\/p>\n

Rivara M, Patel MK, Amori L, Zuliani V.\u00a0<\/span>Inhibition of NaV1.6 sodium channel currents by a novel series of 1,4-disubstituted-triazole derivatives obtained via copper-catalyzed click chemistry.\u00a0Bioorg Med Chem Lett<\/span><\/em>. 22<\/span>(20)<\/span>:6401-4<\/span>. 2012. PMID: 22981330<\/a><\/span><\/p>\n

Walls TH, Grindrod SC, Beraud D, Zhang L, Baheti AR, Dakshanamurthy S, Patel MK, Brown ML, MacArthur LH.\u00a0<\/span>Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent.\u00a0Bioorg Med Chem<\/span><\/em>.\u00a020<\/span>(17)<\/span>:5269-76<\/span>. 2012. PMID: 22863530<\/a><\/span><\/p>\n

2009<\/strong><\/h3>\n