{"id":1609,"date":"2021-08-27T16:20:24","date_gmt":"2021-08-27T20:20:24","guid":{"rendered":"https:\/\/med.virginia.edu\/manoj-patel-lab\/?page_id=1609"},"modified":"2023-03-21T10:30:26","modified_gmt":"2023-03-21T14:30:26","slug":"funding","status":"publish","type":"page","link":"https:\/\/med.virginia.edu\/manoj-patel-lab\/funding\/","title":{"rendered":"Funding"},"content":{"rendered":"<p><strong>NIH\/NINDS RO1NS122834-02S1 : <\/strong>Role of Brainstem Cardiorespiratory Neurons in SUDEP. 2\/2022 &#8211; 12\/2026.<br \/>\n<strong>NIH\/NINDS RO1NS120702<\/strong>:\u2013 Role of CACHD1 in Modulating Neuronal Hyperexcitability in Epilepsy. 7\/2021 \u2013 6\/2026.<br \/>\n<strong>NIH\/NINDS RO1NS103090<\/strong>: Pathogenesis of Epilepsy in a SCN8A Human Mutation Mouse Model.\u00a0 1\/2018-12\/2022.<br \/>\n<strong>Biomedical Innovations Fund (UVA): <\/strong>Preclinical Testing of Nav1.6 selective Sodium Channel Antagonists for the Suppression of Epileptic Seizures and the Prevention of SUDEP. Feb 2016 \u2013 Jan 2021.<br \/>\n<strong>Virginia Brain Institute Grant<\/strong> . Remote Suppression of Epileptic Seizures. 2\/1\/2017- 1\/31\/2018.<br \/>\n<strong>NIH\/NINDS R21NS080061<\/strong>: Na Channel Beta 4 as a Gene Therapy Target for Epilepsy. 7\/2012-6\/2014<br \/>\n<strong>NIH\/NINDS RO1NS075157<\/strong>: Sodium Channels and Neuronal Excitability in Chronic Limbic Epilepsy. 2\/2012-1\/2017<br \/>\n<strong>NIH\/NINDS R21NS061069<\/strong>: Development of Novel Antiepileptic Drugs. 2\/2009-1\/2011<br \/>\n<strong>Epilepsy Foundation of America<\/strong>: Alterations in Sodium Channels in Epileptogenesis. Jan 2011 &#8211; Dec \/2011<br \/>\n<strong>Alzheimer\u2019s and Related Diseases: <\/strong>Cleavage of sodium channel \u03b23 subunit by BACE1 and \u03b3-secretase modulates sodium channel activity in brain neurons. 8\/2008-7\/2009<br \/>\n<strong>American Heart Association Virginia Affiliate: <\/strong>\u03b2- Subunit Regulation of the Cardiac Sodium Channel. 7\/2002-6\/2004<br \/>\n<u><\/u><\/p>\n<p><strong><u>PHARMACEUTICAL GRANTS:<\/u><\/strong><br \/>\n<strong>Stoke Therapeutics: <\/strong>Evaluation of Stoke Therapeutics SCN1A ASO on seizures in Scn1a+\/- DS mice. April 2019 \u2013 April 2020.<br \/>\n<strong>Praxis Precision Medicine LLC. <\/strong>\u00a0Evaluation of PRAX-562 on seizure activity in N1768D heterozygous (D\/+) mice. Oct 2018 \u2013 Jan 2021<strong>.<\/strong><br \/>\n<strong>Xenon Pharmaceuticals:<\/strong> Testing Xenon Compound on Seizure Frequency in a Human Mutation Mouse Model of Epilepsy. \u00a0\u00a0\u00a0\u00a0 Mar 2016 \u2013 July 2016.<br \/>\n<strong>Pfizer GRD:<\/strong> Testing Nav1.7 Selective Compounds on Lamina II Dorsal Horn Projection Neurons in Adult Rat Spinal Cord. Sep 2011 \u2013 Dec 2015:<\/p>\n","protected":false},"excerpt":{"rendered":"<p>NIH\/NINDS RO1NS122834-02S1 : Role of Brainstem Cardiorespiratory Neurons in SUDEP. 2\/2022 &#8211; 12\/2026. NIH\/NINDS RO1NS120702:\u2013 Role of CACHD1 in Modulating Neuronal Hyperexcitability in Epilepsy. 7\/2021 \u2013 6\/2026. NIH\/NINDS RO1NS103090: Pathogenesis of Epilepsy in a SCN8A Human Mutation Mouse Model.\u00a0 1\/2018-12\/2022. Biomedical Innovations Fund (UVA): Preclinical Testing of Nav1.6 selective Sodium Channel Antagonists for the Suppression [&hellip;]<\/p>\n","protected":false},"author":1703,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-1609","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Funding - Manoj Patel Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/manoj-patel-lab\/funding\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Funding - Manoj Patel Lab\" \/>\n<meta property=\"og:description\" content=\"NIH\/NINDS RO1NS122834-02S1 : Role of Brainstem Cardiorespiratory Neurons in SUDEP. 2\/2022 &#8211; 12\/2026. 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