Membrane Channels & Receptors
Investigators at UVa are studying communication between cells, such as cardiac cells, through gap junction channels. Calcium channels are important in excitable cells including neurons and muscle cells. G protein coupled receptors are the most abundant drug targets, and UVa research seeks a better structural understanding of coupling G protein activation to ligand binding. Channels in the outer membranes of gram-negative bacteria are responsible for nutrient and antibiotic uptake and therefore important drug targets.