{"id":2443,"date":"2025-06-06T10:15:50","date_gmt":"2025-06-06T14:15:50","guid":{"rendered":"https:\/\/med.virginia.edu\/membrane-biology\/?p=2443"},"modified":"2026-05-22T16:57:40","modified_gmt":"2026-05-22T20:57:40","slug":"seham-ebrahim-bechara-kachar-nih-and-michael-purdys-major-collaborative-breakthrough-powered-by-memc","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/membrane-biology\/seham-ebrahim-bechara-kachar-nih-and-michael-purdys-major-collaborative-breakthrough-powered-by-memc\/","title":{"rendered":"Seham Ebrahim, Bechara Kachar (NIH), and Michael Purdy’s major collaborative breakthrough powered by MEMC"},"content":{"rendered":"

New Organelle Discovered: UVA and NIH Researchers Identify \u2018Hemifusomes\u2019 as a Key to Cellular Recycling<\/p>\n

In a groundbreaking study published in Nature Communications,<\/a> researchers from UVA’s Center for Membrane & Cell Physiology and the National Institutes of Health (NIH) have discovered a previously unknown cellular structure\u2014the hemifusome\u2014that could fundamentally reshape our understanding of how cells recycle their contents and sort and direct intracellular cargo.<\/p>\n

The discovery was co-led by Seham Ebrahim, PhD, a CMCP resident faculty member, and assistant professor in the Department of Molecular Physiology and Biological Physics at UVA, and Bechara Kachar, MD, chief of the Laboratory of Cell Structure and Dynamics at the NIH\u2019s National Institute on Deafness and Other Communication Disorders (NIDCD). It represents a major collaborative breakthrough powered by UVA\u2019s Molecular Electron Microscopy Core (MEMC), a state-of-the-art cryo-electron microscopy facility directed by Michael Purdy, PhD.<\/p>\n

\u201cThis is the first time anyone has visualized this structure inside cells,\u201d said Dr. Ebrahim. \u201cThe hemifusome is a brand-new organelle, and we believe it plays a central role in a newly discovered pathway for building multivesicular bodies\u2014key recycling centers within our cells.\u201d READ MORE<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

New Organelle Discovered: UVA and NIH Researchers Identify \u2018Hemifusomes\u2019 as a Key to Cellular Recycling In a groundbreaking study published in Nature Communications, researchers from UVA’s Center for Membrane & Cell Physiology and the National Institutes of Health (NIH) have discovered a previously unknown cellular structure\u2014the hemifusome\u2014that could fundamentally reshape our understanding of how cells […]<\/p>\n","protected":false},"author":431,"featured_media":2444,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[40],"class_list":["post-2443","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-intranet"],"acf":false,"yoast_head":"\nSeham Ebrahim, Bechara Kachar (NIH), and Michael Purdy's major collaborative breakthrough powered by MEMC - 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