{"id":7123,"date":"2025-02-28T14:38:32","date_gmt":"2025-02-28T14:38:32","guid":{"rendered":"https:\/\/med.virginia.edu\/mic\/?p=7123"},"modified":"2026-05-22T20:32:40","modified_gmt":"2026-05-22T20:32:40","slug":"cold-sore-discovery-ids-unknown-trigger-for-those-annoying-flare-ups","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/mic\/2025\/02\/28\/cold-sore-discovery-ids-unknown-trigger-for-those-annoying-flare-ups\/","title":{"rendered":"Cold Sore Discovery IDs Unknown Trigger for Those Annoying Flare-ups"},"content":{"rendered":"
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(l-r) Graduate Student, Patryk Krakowiak and Anna Cliffe, Ph.D.<\/p><\/div>\n

Scientists have a new target to prevent cold sores after University of Virginia School of Medicine researchers discovered an unexpected way the herpes virus re-activates in the body. The finding could also have important implications for genital herpes caused by the same virus.<\/p>\n<\/div>\n

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The discovery from UVA\u2019s\u00a0Anna Cliffe, PhD<\/strong>, and colleagues seems to defy common sense. She and her team found that the slumbering herpes virus will make a protein to trigger the body\u2019s immune response as part of its escape from dormancy. You\u2019d think this would be bad for the virus \u2014 that activating the body\u2019s antiviral defenses would be like poking a bear. But, instead, it\u2019s the opposite: The virus highjacks the antiviral process in infected neurons (nerve cells) to make the type of comeback nobody wants.<\/p>\n<\/div>\n

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\u201cOur findings identify the first viral protein required for herpes simplex virus to wake up from dormancy, and, surprisingly, this protein does so by triggering responses that should act against the virus,\u201d said Cliffe of UVA\u2019s Department of Microbiology, Immunology and Cancer Biology. \u201cThis is important because it gives us new ways to potentially prevent the virus from waking up and activating immune responses in the nervous system that could have negative consequences in the long term.\u201d<\/p>\n<\/div>\n

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Understanding Herpes Simplex Virus-Associated Disease<\/strong><\/p>\n<\/div>\n

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\"(l-r)<\/a>
(l-r) Researchers Matthew Flores and Sean Cuddy<\/figcaption><\/figure>\n<\/div>\n<\/div>\n
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Cold sores are caused primarily by herpes simplex virus 1 (HSV-1), one of two forms of the herpes virus. HSV-1 is very contagious, and more than 60% of people under 50 have been infected worldwide, the World Health Organization estimates. That\u2019s more than 3.8 billion people.<\/p>\n<\/div>\n

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In addition to causing cold sores, herpes simplex virus 1 can also cause genital herpes, a condition most often associated with HSV-1\u2019s cousin, herpes simplex virus 2. Now, however, there are more new cases of genital herpes in the United States caused by HSV-1 than HSV-2. Notably, the UVA researchers found that herpes simplex virus 2 also makes this same protein and may use a similar mechanism to reactivate. So UVA\u2019s new discovery may also lead to new treatments for genital herpes.<\/p>\n<\/div>\n

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In addition to cold sores and gential herpes, HSV-1 can also cause viral encephalitis (brain infammation) and has been linked to the development of Alzheimer\u2019s disease.<\/p>\n<\/div>\n

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Once HSV-1 makes its way into our bodies, it stays forever. Our immune systems can send it into hiding, allowing infected people to be symptom free. But stress, other infections and even sunburns are known to cause it to flare. UVA\u2019s new discovery adds another, surprising way it can spring back into action.<\/p>\n<\/div>\n

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The researchers found that while the virus can make a protein called UL12.5 to reactivate, the protein was not needed in the presence of another infection. The scientists believe this is because the infections trigger certain \u201csensing pathways\u201d that act as the home security system for neurons. Detection of a pathogen alone may be sufficient to trigger the herpes virus to begin replicating, the scientists believe, even in instances of \u201cabortive infections\u201d \u2014 when the immune system contains the new pathogen before it can replicate.<\/p>\n<\/div>\n

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\u201cWe were surprised to find that HSV-1 doesn\u2019t just passively wait for the right conditions to reactivate \u2014 it actively senses danger and takes control of the process,\u201d\u00a0researcher\u00a0Patryk Krakowiak<\/strong>\u00a0said. \u201cOur findings suggest that the virus may be using immune signals as a way to detect cellular stress \u2014 whether from neuron damage, infections or other threats \u2014 as a cue to escape its host and find a new one.\u201d<\/p>\n<\/div>\n

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With the new understanding of how herpes flares can be triggered, scientists may be able to target the protein to prevent them, the researchers say.<\/p>\n<\/div>\n

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\u201cWe are now following up on this work to investigate how the virus is highjacking this response and testing inhibitors of UL12.5 function,\u201d Cliffe said. \u201cCurrently, there are no therapies that can prevent the virus from waking up from dormancy, and this stage was thought to only use host proteins. Developing therapies that specifically act on a viral protein is an attractive approach that will likely have fewer side effects than targeting a host protein.\u201d<\/p>\n<\/div>\n

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Findings Published<\/strong><\/p>\n<\/div>\n

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The researchers have\u00a0published their findings<\/a>\u00a0in PNAS, the Proceedings of the National Academy of Sciences. The research team consisted of Patryk A. Krakowiak, Sean R. Cuddy, Matthew E. Flores, Abigail L. Whitford, Sara A. Dochnal, Aleksandra Babnis, Tsuyoshi Miyake, Marco Tigano, Daniel A. Engel and Cliffe. The scientists have no financial interest in the work.<\/p>\n<\/div>\n

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The research was supported by National Institute of Health grants R21AI171544, T32AI007046, T32GM008136 and R01AG085782, as well as the Owens Family Foundation, a UVA Global Infectious Disease Institute seed award and UVA Wagner Fellowships.<\/p>\n

Originally posted on UVA Health Connect<\/a> on 2\/27\/2025, written by Josh Barney<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Scientists have a new target to prevent cold sores after University of Virginia School of Medicine researchers discovered an unexpected way the herpes virus re-activates in the body. The finding could also have important implications for genital herpes caused by the same virus. 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