{"id":1218,"date":"2018-05-17T11:42:20","date_gmt":"2018-05-17T15:42:20","guid":{"rendered":"https:\/\/mstp.med.virginia.edu\/?p=1218"},"modified":"2022-11-18T18:01:30","modified_gmt":"2022-11-18T18:01:30","slug":"congratulations-dwyer-lab","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/mstp\/2018\/05\/17\/congratulations-dwyer-lab\/","title":{"rendered":"Congratulations, Dwyer Lab!"},"content":{"rendered":"<div id=\"attachment_1219\" style=\"width: 109px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1219\" class=\"wp-image-1219 size-full\" src=\"https:\/\/med.virginia.edu\/mstp\/wp-content\/uploads\/sites\/455\/2018\/05\/Jessica-Neville2-e1526580703482.jpg\" alt=\"Jessica Neville Little\" width=\"99\" height=\"110\" \/><p id=\"caption-attachment-1219\" class=\"wp-caption-text\">Jessica Neville Little<\/p><\/div>\n<p>Based in large part on the ongoing work of MSTP student <strong>Jessica Neville Little (G3)<\/strong>, the NIH recently funded an R21 award to Jessica\u2019s mentor, Dr. Noelle Dwyer. The Title of the Grant is \u201cLinking abscission defects to p53-dependent apoptosis in neural stem cells\u201d and Jessica summarized the goals of the award as follows: In a genetic model of microcephaly, loss of the kinesin Kif20b results in abnormal cytokinetic abscission in neural stem cells, apoptosis and<\/p>\n<div id=\"attachment_1222\" style=\"width: 110px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/mstp.med.virginia.edu\/files\/2018\/05\/ndwyer_1_1-1-e1526580628184.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1222\" class=\"wp-image-1222 size-full\" src=\"https:\/\/med.virginia.edu\/mstp\/wp-content\/uploads\/sites\/455\/2018\/05\/ndwyer_1_1-1-e1526580628184.jpg\" alt=\"Dr. Noelle Dwyer\" width=\"100\" height=\"110\" \/><\/a><p id=\"caption-attachment-1222\" class=\"wp-caption-text\">Dr. Noelle Dwyer<\/p><\/div>\n<p>reduced brain size. By crossing the Kif20b mutant to the p53 mutant mouse, we found that apoptosis and embryonic brain size is completely rescued. This grant seeks to investigate the cellular and molecular pathways that lead from Kif20b loss to p53 activation.<\/p>\n<p>Congratulations to both Jessica and her mentor, Dr. Noelle Dwyer!<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Based in large part on the ongoing work of MSTP student Jessica Neville Little (G3), the NIH recently funded an R21 award to Jessica\u2019s mentor, Dr. Noelle Dwyer. The Title of the Grant is \u201cLinking abscission defects to p53-dependent apoptosis in neural stem cells\u201d and Jessica summarized the goals of the award as follows: In [&hellip;]<\/p>\n","protected":false},"author":1777,"featured_media":1219,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_members_access_role":[],"_members_access_error":"","_links_to":"","_links_to_target":""},"categories":[3],"tags":[],"class_list":["post-1218","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlights-and-news"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Congratulations, Dwyer Lab! - MSTP: Medical Scientist Training Program<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/mstp\/2018\/05\/17\/congratulations-dwyer-lab\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Congratulations, Dwyer Lab! - MSTP: Medical Scientist Training Program\" \/>\n<meta property=\"og:description\" content=\"Based in large part on the ongoing work of MSTP student Jessica Neville Little (G3), the NIH recently funded an R21 award to Jessica\u2019s mentor, Dr. Noelle Dwyer. 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