Jeffrey Hakim MD


M.D. and Ph.D., Mayo Clinic Medical Scientist Training Program, Rochester, MN, 2008-2017

B.S. in Biochemistry and Molecular Biology, 2008
Michigan State University, East Lansing, MI
High Honors Graduate



Research Interests

Tissue engineering and regenerative medicine and their applications to neurological disease.


Mayo Langan M.D.-Ph.D. Fellowship, 2010-2017
Awarded Distinguished Poster Award for Graduate Student at the Mayo Clinic Young Investigator Research Symposium, 2014
Travel Award for oral and poster presentation at the ANA Annual Meeting, 2015


Nailed Through Superior Sagittal Sinus: A Case Report and Surgical Considerations

Oper Neurosurg (Hagerstown). 2023 Mar 1;24(3):e223-e227. doi: 10.1227/ons.0000000000000509. Epub 2022 Nov 18.ABSTRACTBACKGROUND AND IMPORTANCE: We report a case of nail gun-related penetrating brain injury, puncturing through the anterior third of…

Giant pituitary macroadenoma of stem cell origin: illustrative case

J Neurosurg Case Lessons. 2021 Mar 8;1(10):CASE2122. doi: 10.3171/CASE2122. eCollection 2021 Mar 8.ABSTRACTBACKGROUND: Giant pituitary macroadenomas with a diameter >4 cm are rare tumors, accounting for only about 5% of…

Defining Spatial Relationships Between Spinal Cord Axons and Blood Vessels in Hydrogel Scaffolds

Tissue Eng Part A. 2021 Jun;27(11-12):648-664. doi: 10.1089/ten.TEA.2020.0316. Epub 2021 Jun 1.ABSTRACTPositively charged oligo(poly(ethylene glycol) fumarate) (OPF+) hydrogel scaffolds, implanted into a complete transection spinal cord injury (SCI), facilitate a…

Combinatorial tissue engineering partially restores function after spinal cord injury

J Tissue Eng Regen Med. 2019 May;13(5):857-873. doi: 10.1002/term.2840. Epub 2019 Mar 20.ABSTRACTHydrogel scaffolds provide a beneficial microenvironment in transected rat spinal cord. A combinatorial biomaterials-based strategy provided a microenvironment…

GDNF Schwann cells in hydrogel scaffolds promote regional axon regeneration, remyelination and functional improvement after spinal cord transection in rats

J Tissue Eng Regen Med. 2018 Jan;12(1):e398-e407. doi: 10.1002/term.2431. Epub 2017 Jun 26.ABSTRACTPositively-charged oligo[poly(ethylene glycol)fumarate] (OPF+ ) is a biodegradable hydrogel used for spinal cord injury repair. We compared scaffolds…

Micro vs. macrodiscectomy: Does use of the microscope reduce complication rates?

Clin Neurol Neurosurg. 2017 Jan;152:28-33. doi: 10.1016/j.clineuro.2016.11.010. Epub 2016 Nov 13.ABSTRACTOBJECTIVE: A single level discectomy is one of the most common procedures performed by spine surgeons. While some practitioners utilize…

Positively Charged Oligo[Poly(Ethylene Glycol) Fumarate] Scaffold Implantation Results in a Permissive Lesion Environment after Spinal Cord Injury in Rat

Tissue Eng Part A. 2015 Jul;21(13-14):2099-114. doi: 10.1089/ten.TEA.2015.0019.ABSTRACTPositively charged oligo[poly(ethylene glycol) fumarate] (OPF+) scaffolds loaded with Schwann cells bridge spinal cord injury (SCI) lesions and support axonal regeneration in rat.…

Hemisection spinal cord injury in rat: the value of intraoperative somatosensory evoked potential monitoring

J Neurosci Methods. 2012 Nov 15;211(2):179-84. doi: 10.1016/j.jneumeth.2012.08.024. Epub 2012 Sep 6.ABSTRACTTechniques used to produce partial spinal cord injuries in animal models have the potential for creating variability in lesions.…

Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice

J Clin Invest. 2010 Dec;120(12):4207-19. doi: 10.1172/JCI36858. Epub 2010 Nov 8.ABSTRACTAmputation as a result of impaired wound healing is a serious complication of diabetes. Inadequate angiogenesis contributes to poor wound…