Leonel Ampie, MD
Education
M.D., Georgetown University School of Medicine, 2017
Bachelor of Science, The City College of New York (Biology, Cum Laude), 2010
Email: LA2DE@virginia.edu
Research Interests and Experience
Neuro-Oncology, Neuro-Immunology, Cancer immunotherapy, basic immunology, immune-checkpoint inhibition, tumor vaccinology, glioblastoma-induced immunosuppression, Regulatory T-cell biology
Northwestern Memorial Hospital – 2014-2017 {Tumor Immunology, Mentors: Andrew T. Parsa, M.D., PhD., Orin Bloch, M.D.}
Barrow Neurological Institute – 2014 {Neurobiology, Mentor: Nader Sanai, M.D.}
Cincinnati Children’s Hospital – 2012 {Immunology, Mentor: Marc Rothenberg, M.D., Ph.D.}
M.D. Anderson Cancer Center – 2011 {Cancer Biology, Mentor: Francisco Esteva, M.D., PhD.}
Memorial Sloan Kettering Cancer Center – 2010 {Immunology, Mentor: Derek sant’Angelo, Ph.D.}
The City College of New York – 2010 {Biochemistry, Mentor: David Calhoun, Ph.D.}
Grant Funding
- AMA Foundation Seed Grant – 2016
Title: The role of Galectin-3 as an inducer of immunosuppression in patients with Glioblastoma
Principal Investigator: Ampie L
Sponsor: Bloch O
Amount of annual support (direct): $3,725 - Folger Cardiovascular Prevention Grant – 2016
Title: Assessing the prevalence of undiagnosed cases of familial hypercholesterolemia in the Medstar community-based health system
Principal Investigator: Ampie L
Sponsor: Vargas J
Amount of annual support (direct): $7,500 - Howard Hughes Medical Institute Research Training Fellowship Continued Support – 2015-2016
Title: Elucidating the roles of B7H1 and CTLA-4 in glioma-mediated immunosuppression
Principal Investigator: Ampie L
Sponsor: Parsa AT, Bloch O, James CD
Amount of annual support (direct): $41,000 - Howard Hughes Medical Institute Research Training Fellowship – 2014-2015
Title: Elucidating the roles of B7H1 and CTLA-4 in glioma-mediated immunosuppression
Principal Investigator: Ampie L
Sponsor: Parsa AT
Amount of annual support (direct): $41,000 - Medical Student Respiratory Research Fellowship – 2012
Title: Investigating the phenotypic role of WDR-36 in eosinophilic esophagitis
Principal Investigator: Ampie L
Sponsor: Rothenberg ME
Amount of annual support (direct): $5,500 - NIH RISE Predoctoral Fellowship – 2010 (Home institution: CCNY/Host institution: MSKCC)
Title: Investigating the role of zinc finger (BTB/POZ) transcription factors in the immune system
Principal Investigator: Ampie L
Sponsor: Sant’Angelo DB
Publications
Primary Spinal Cord Astrocytomas: Two-Center Clinical Experience of Low- and High-Grade Lesions
World Neurosurg. 2022 Nov;167:e1006-e1016. doi: 10.1016/j.wneu.2022.08.130. Epub 2022 Sep 5.ABSTRACTOBJECTIVE: Primary spinal cord astrocytomas are rare, fatal, and poorly studied.METHODS: This study included a 2-center, retrospective analysis of primary spinal…Characteristics of Patients Selected for Surgical Treatment of Spinal Meningioma
World Neurosurg. 2022 Sep;165:e680-e688. doi: 10.1016/j.wneu.2022.06.121. Epub 2022 Jun 30.ABSTRACTBACKGROUND: Spinal meningiomas are benign extra-axial tumors that can present with neurological deficits. Treatment partly depends on the degree of disability…Dural Convexity Chondroma Mimicking Meningioma in a Young Female
Cureus. 2021 Dec 26;13(12):e20715. doi: 10.7759/cureus.20715. eCollection 2021 Dec.ABSTRACTIntracranial meningeal convexity chondroma is a rare benign lesion hypothesized to stem from remnant chondrocyte precursors of embryonic origin. This lesion often…Oncolytic Virotherapy for Melanoma Brain Metastases, a Potential New Treatment Paradigm?
Brain Sci. 2021 Sep 23;11(10):1260. doi: 10.3390/brainsci11101260.ABSTRACTINTRODUCTION: Melanoma brain metastases remain a devastating disease process with poor prognosis. Recently, there has been a surge in studies demonstrating the efficacy of…Experimental animal models for the study of moyamoya disease
Neurosurg Focus. 2021 Sep;51(3):E4. doi: 10.3171/2021.5.FOCUS21282.ABSTRACTMoyamoya disease is a rare disorder of the cerebrovascular system affecting individuals in a bimodal age distribution and is characterized by progressive vascular stenosis of…