Leonel Ampie, MD


Leonel Ampie, MDM.D., Georgetown University School of Medicine, 2017
Bachelor of Science, The City College of New York (Biology, Cum Laude), 2010





Research Interests and Experience

Neuro-Oncology, Neuro-Immunology, Cancer immunotherapy, basic immunology, immune-checkpoint inhibition, tumor vaccinology, glioblastoma-induced immunosuppression, Regulatory T-cell biology

Northwestern Memorial Hospital – 2014-2017 {Tumor Immunology, Mentors: Andrew T. Parsa, M.D., PhD., Orin Bloch, M.D.}
Barrow Neurological Institute – 2014 {Neurobiology, Mentor: Nader Sanai, M.D.}
Cincinnati Children’s Hospital – 2012 {Immunology, Mentor: Marc Rothenberg, M.D., Ph.D.}
M.D. Anderson Cancer Center – 2011 {Cancer Biology, Mentor: Francisco Esteva, M.D., PhD.}
Memorial Sloan Kettering Cancer Center – 2010 {Immunology, Mentor: Derek sant’Angelo, Ph.D.}
The City College of New York – 2010 {Biochemistry, Mentor: David Calhoun, Ph.D.}

Grant Funding

  1.  AMA Foundation Seed Grant – 2016
    Title: The role of Galectin-3 as an inducer of immunosuppression in patients with Glioblastoma
    Principal Investigator: Ampie L
    Sponsor: Bloch O
    Amount of annual support (direct): $3,725
  2. Folger Cardiovascular Prevention Grant – 2016
    Title: Assessing the prevalence of undiagnosed cases of familial hypercholesterolemia in the Medstar community-based health system
    Principal Investigator: Ampie L
    Sponsor: Vargas J
    Amount of annual support (direct): $7,500
  3. Howard Hughes Medical Institute Research Training Fellowship Continued Support – 2015-2016
    Title: Elucidating the roles of B7H1 and CTLA-4 in glioma-mediated immunosuppression
    Principal Investigator: Ampie L
    Sponsor: Parsa AT, Bloch O, James CD
    Amount of annual support (direct): $41,000
  4. Howard Hughes Medical Institute Research Training Fellowship – 2014-2015
    Title: Elucidating the roles of B7H1 and CTLA-4 in glioma-mediated immunosuppression
    Principal Investigator: Ampie L
    Sponsor: Parsa AT
    Amount of annual support (direct): $41,000
  5. Medical Student Respiratory Research Fellowship – 2012
    Title: Investigating the phenotypic role of WDR-36 in eosinophilic esophagitis
    Principal Investigator: Ampie L
    Sponsor: Rothenberg ME
    Amount of annual support (direct): $5,500
  6. NIH RISE Predoctoral Fellowship – 2010 (Home institution: CCNY/Host institution: MSKCC)
    Title: Investigating the role of zinc finger (BTB/POZ) transcription factors in the immune system
    Principal Investigator: Ampie L
    Sponsor: Sant’Angelo DB


Glioblastoma may evade immune surveillance through primary cilia-dependent signaling in an IL-6 dependent manner

Front Oncol. 2023 Dec 18;13:1279923. doi: 10.3389/fonc.2023.1279923. eCollection 2023.ABSTRACTGlioblastoma is the most common, malignant primary brain tumor in adults and remains universally fatal. While immunotherapy has vastly improved the treatment…

Dorsal cervical approach for recurrent intradural anaplastic ependymoma

Neurosurg Focus Video. 2023 Oct 1;9(2):V2. doi: 10.3171/2023.6.FOCVID2396. eCollection 2023 Oct.ABSTRACTThe video demonstrates an operative approach to a recurrent cervical anaplastic ependymoma. MYCN-amplified anaplastic ependymomas are locally aggressive, recurrent, and…

The role of the dura mater in cerebral metastases

Neurosurg Focus. 2023 Aug;55(2):E17. doi: 10.3171/2023.5.FOCUS23229.ABSTRACTOBJECTIVE: The objective of this review was to describe the immunological changes that take place in the dura mater in response to metastatic disease that…

Human endogenous retrovirus K contributes to a stem cell niche in glioblastoma

J Clin Invest. 2023 Jul 3;133(13):e167929. doi: 10.1172/JCI167929.ABSTRACTHuman endogenous retroviruses (HERVs) are ancestral viral relics that constitute nearly 8% of the human genome. Although normally silenced, the most recently integrated…

The Era of Onyx Embolization: A Systematic and Literature Review of Preoperative Embolization Before Stereotactic Radiosurgery for the Management of Cerebral Arteriovenous Malformations

World Neurosurg. 2023 Feb;170:90-98. doi: 10.1016/j.wneu.2022.11.058. Epub 2022 Nov 14.ABSTRACTINTRODUCTION: The current treatment paradigm for intracranial arteriovenous malformations (AVMs) focuses on reducing the risk of intracranial hemorrhage using various therapeutic…

Primary Spinal Cord Astrocytomas: Two-Center Clinical Experience of Low- and High-Grade Lesions

World Neurosurg. 2022 Nov;167:e1006-e1016. doi: 10.1016/j.wneu.2022.08.130. Epub 2022 Sep 5.ABSTRACTOBJECTIVE: Primary spinal cord astrocytomas are rare, fatal, and poorly studied.METHODS: This study included a 2-center, retrospective analysis of primary spinal…

Characteristics of Patients Selected for Surgical Treatment of Spinal Meningioma

World Neurosurg. 2022 Sep;165:e680-e688. doi: 10.1016/j.wneu.2022.06.121. Epub 2022 Jun 30.ABSTRACTBACKGROUND: Spinal meningiomas are benign extra-axial tumors that can present with neurological deficits. Treatment partly depends on the degree of disability…

Radical supramaximal resection for newly diagnosed left-sided eloquent glioblastoma: safety and improved survival over gross-total resection

J Neurosurg. 2022 May 27;138(1):62-69. doi: 10.3171/2022.3.JNS212399. Print 2023 Jan 1.ABSTRACTOBJECTIVE: Supramaximal resection (SMR) has arisen as a possible surrogate to gross-total resection (GTR) to improve survival in newly diagnosed…

Immunological defense of CNS barriers against infections

Immunity. 2022 May 10;55(5):781-799. doi: 10.1016/j.immuni.2022.04.012.ABSTRACTNeuroanatomical barriers with physical, chemical, and immunological properties play an essential role in preventing the spread of peripheral infections into the CNS. A failure to…

Frailty is a risk factor for intracranial abscess and is associated with longer length of stay: a retrospective single institution case-control study

J Neurosurg Sci. 2024 Aug;68(4):422-427. doi: 10.23736/S0390-5616.22.05720-4. Epub 2022 Apr 13.ABSTRACTBACKGROUND: Intracranial abscess (IA) causes significant morbidity and mortality. The impact of baseline frailty status on post-operative outcomes of IA…

Dural Convexity Chondroma Mimicking Meningioma in a Young Female

Cureus. 2021 Dec 26;13(12):e20715. doi: 10.7759/cureus.20715. eCollection 2021 Dec.ABSTRACTIntracranial meningeal convexity chondroma is a rare benign lesion hypothesized to stem from remnant chondrocyte precursors of embryonic origin. This lesion often…

Syngeneic murine glioblastoma models: reactionary immune changes and immunotherapy intervention outcomes

Neurosurg Focus. 2022 Feb;52(2):E5. doi: 10.3171/2021.11.FOCUS21556.ABSTRACTGlioblastoma is the most common primary malignant brain neoplasm with dismal 10-year survival rates of < 1%. Despite promising preliminary results from several novel therapeutic…

Oncolytic Virotherapy for Melanoma Brain Metastases, a Potential New Treatment Paradigm?

Brain Sci. 2021 Sep 23;11(10):1260. doi: 10.3390/brainsci11101260.ABSTRACTINTRODUCTION: Melanoma brain metastases remain a devastating disease process with poor prognosis. Recently, there has been a surge in studies demonstrating the efficacy of…

Experimental animal models for the study of moyamoya disease

Neurosurg Focus. 2021 Sep;51(3):E4. doi: 10.3171/2021.5.FOCUS21282.ABSTRACTMoyamoya disease is a rare disorder of the cerebrovascular system affecting individuals in a bimodal age distribution and is characterized by progressive vascular stenosis of…

Spinal Epidural Abscess Patients Have Higher Modified Frailty Indexes Than Back Pain Patients on Emergency Room Presentation: A Single-Center Retrospective Case-Control Study

World Neurosurg. 2021 Aug;152:e610-e616. doi: 10.1016/j.wneu.2021.06.035. Epub 2021 Jun 12.ABSTRACTOBJECTIVE: Spinal epidural abscess (SEA) patients have increased medical comorbidities and risk factors for infection compared with those without SEA. However,…