Stepan Capek, MD

Education

capek

Charles University in Prague – 2nd Faculty of Medicine, Czech Republic
Doctor of Medicine, 2013

Ph.D. Candidate in Neuroscience, Thesis: “Perineural tumor spread in pelvic cancer”, 2013-Present

Email: sc8vd@virginia.edu

Honors/Awards:

  • David Kline Peripheral Nerve Research Award for: “MR Elastography of peripheral nerves: a feasibility study” awarded by AANS/CNS Joint Section on Disorders of the Spine and Peripheral Nerves
  • 2007 – 2012 Merit scholarship for the 1st, 2nd, 4th and 5th year of the medical school
  • 2012 Sophia Foundation Scholarship
  • 2010 Erasmus Scholarship
  • 2009 – 2013 Academic Senate of Charles University in Prague – 2nd Faculty of Medicine, Czech Rep.
  • Member (2009-11) and Chairperson (2011-13) of the Student Chamber

Publications

The spectrum of brachial plexopathy from perineural spread of breast cancer

J Neurosurg. 2022 Feb 25:1-10. doi: 10.3171/2021.12.JNS211882. Online ahead of print.ABSTRACTOBJECTIVE: Perineural spread of breast cancer to the brachial plexus can lead to pain, sensory alterations, and upper-extremity weakness. Although…

Tele-robotics and artificial-intelligence in stroke care

J Clin Neurosci. 2020 Sep;79:129-132. doi: 10.1016/j.jocn.2020.04.125. Epub 2020 Aug 5.ABSTRACTIn the last forty years, the field of medicine has experienced dramatic shifts in technology-enhanced surgical procedures - from its…

A systematic review of endovascular stent-electrode arrays, a minimally invasive approach to brain-machine interfaces

Neurosurg Focus. 2020 Jul;49(1):E3. doi: 10.3171/2020.4.FOCUS20186.ABSTRACTOBJECTIVE: The goal of this study was to systematically review the feasibility and safety of minimally invasive neurovascular approaches to brain-machine interfaces (BMIs).METHODS: A systematic…

Understanding the Pathognomonic Tumefactive Appearance of Neurolymphomatosis: A Unifying Theory of Neurolymphoma

World Neurosurg. 2020 Sep;141:e490-e497. doi: 10.1016/j.wneu.2020.05.228. Epub 2020 May 31.ABSTRACTBACKGROUND: The diagnosis of peripheral neurolymphomatosis (NL) is difficult and often delayed, because patients can have isolated, nonspecific nerve symptoms. Magnetic…

Compressive epidural collection as an unusual complication of FESS for a pediatric mycetoma

Childs Nerv Syst. 2021 Jan;37(1):311-314. doi: 10.1007/s00381-020-04651-1. Epub 2020 May 15.ABSTRACTFunctional endoscopic sinus surgery (FESS) is a treatment of choice for fungal sinus ball (mycetoma), which is considered safe with…

Fulminant Reversible Cerebral Vasoconstriction Syndrome After Carotid Endarterectomy for Asymptomatic Stenosis

World Neurosurg. 2020 Feb;134:423-426. doi: 10.1016/j.wneu.2019.11.032. Epub 2019 Nov 13.ABSTRACTBACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) is a rare complication after carotid endarterectomy (CEA). Only a limited number of prior cases…

Hemorrhage Risk of Untreated Isolated Cerebral Cavernous Malformations

World Neurosurg. 2019 Nov;131:e557-e561. doi: 10.1016/j.wneu.2019.07.222. Epub 2019 Aug 7.ABSTRACTOBJECTIVE: Predicting future hemorrhage risk may allow better selection of patients with cerebral cavernous malformations (CCMs) who will likely benefit from…

Letter to the Editor Regarding "Perineural Spread Along Spinal and Obturator Nerves in Primary Vaginal Carcinoma: A Case Report"

World Neurosurg. 2018 Oct;118:381-382. doi: 10.1016/j.wneu.2018.05.206.NO ABSTRACTPMID:30248810 | DOI:10.1016/j.wneu.2018.05.206

Mathematical model of perineural tumor spread: a pilot study

Acta Neurochir (Wien). 2018 Mar;160(3):655-661. doi: 10.1007/s00701-017-3423-6. Epub 2017 Dec 21.ABSTRACTBACKGROUND: Perineural spread (PNS) of pelvic cancer along the lumbosacral plexus is an emerging explanation for neoplastic lumbosacral plexopathy (nLSP)…

Adapting Findings From Rare Peripheral Nerve Disorders Can Lead to Broad Applications in Neurosurgery

Neurosurgery. 2017 Sep 1;64(CN_suppl_1):52-58. doi: 10.1093/neuros/nyx306.NO ABSTRACTPMID:28899057 | DOI:10.1093/neuros/nyx306

Targeted fascicular biopsy of the brachial plexus: rationale and operative technique

Neurosurg Focus. 2017 Mar;42(3):E9. doi: 10.3171/2017.1.FOCUS16404.ABSTRACTOBJECTIVE Nerve biopsy is useful in the management of neuromuscular disorders and is commonly performed in distal, noncritical cutaneous nerves. In general, these procedures are…

Gastroesophageal junction carcinoma and brachial plexopathy: An anatomic explanation via perineural spread

Clin Anat. 2016 Sep;29(6):800-3. doi: 10.1002/ca.22708. Epub 2016 Mar 24.NO ABSTRACTPMID:26940157 | DOI:10.1002/ca.22708

Perineural Spread of Renal Cell Carcinoma: A Case Illustration with a Proposed Anatomic Mechanism and a Review of the Literature

World Neurosurg. 2016 May;89:728.e11-7. doi: 10.1016/j.wneu.2016.01.060. Epub 2016 Feb 2.ABSTRACTINTRODUCTION: Perineural spread (PNS) is an unusual mechanism of tumor extension and has been typically reported in squamous cell carcinoma, adenocystic…

Sequential imaging of intraneural sciatic nerve endometriosis provides insight into symptoms of cyclical sciatica

Acta Neurochir (Wien). 2016 Mar;158(3):507-12; discussion 512. doi: 10.1007/s00701-015-2683-2. Epub 2016 Jan 7.ABSTRACTEndometriosis of the nerve often remains an elusive diagnosis. We report the first case of intraneural lumbosacral plexus…

Perineural spread of pelvic malignancies to the lumbosacral plexus and beyond: clinical and imaging patterns

Neurosurg Focus. 2015 Sep;39(3):E14. doi: 10.3171/2015.7.FOCUS15209.ABSTRACTOBJECT Perineural spread along pelvic autonomie nerves has emerged as a logical, anatomical explanation for selected cases of neoplastic lumbosacral plexopathy (LSP) in patients with…

Targeted fascicular biopsy of the sciatic nerve and its major branches: rationale and operative technique

Neurosurg Focus. 2015 Sep;39(3):E12. doi: 10.3171/2015.6.FOCUS15213.ABSTRACTOBJECT Nerve biopsy is typically performed in distal, noncritical sensory nerves without using imaging to target the more involved regions. The yield of these procedures…

Magnetic resonance imaging evidence for perineural spread of endometriosis to the lumbosacral plexus: report of 2 cases

Neurosurg Focus. 2015 Sep;39(3):E15. doi: 10.3171/2015.6.FOCUS15208.ABSTRACTSciatic nerve endometriosis (EM) is a rare presentation of retroperitoneal EM. The authors present 2 cases of catamenial sciatica diagnosed as sciatic nerve EM. They…

Neural involvement in endometriosis: Review of anatomic distribution and mechanisms

Clin Anat. 2015 Nov;28(8):1029-38. doi: 10.1002/ca.22617. Epub 2015 Sep 9.ABSTRACTEndometriosis (EM) is an infrequent cause of peripheral neuropathy, most commonly sciatic. Perineural spread has recently been introduced as an alternate…

The subparaneurial compartment: A new concept in the clinicoanatomic classification of peripheral nerve lesions

Clin Anat. 2015 Oct;28(7):925-30. doi: 10.1002/ca.22589. Epub 2015 Jul 16.ABSTRACTBased on our experience in treating peripheral non-neural sheath derived pathology, we have identified a novel pattern of lesion progression along…

Tumefactive appearance of peripheral nerve involvement in hematologic malignancies: a new imaging association

Skeletal Radiol. 2015 Jul;44(7):1001-9. doi: 10.1007/s00256-015-2151-3. Epub 2015 Apr 29.ABSTRACTOBJECTIVE: In neurolymphomatosis (NL), the affected nerves are typically described to be enlarged and hyperintense on T2W MR sequences and to…

Perineural spread in pelvic malignancies can be an alternate explanation for pelvic bony metastases rather than hematogenous spread. A report of two cases

Skeletal Radiol. 2015 Sep;44(9):1365-70. doi: 10.1007/s00256-015-2143-3. Epub 2015 Apr 12.ABSTRACTWe propose that pelvic malignancies can spread to bone and cause bony metastases using nerves as conduits. We reviewed two cases…

An inferior alveolar intraneural cyst: a case example and an anatomical explanation to support the articular theory within cranial nerves

J Neurosurg. 2015 Jun;122(6):1433-7. doi: 10.3171/2014.12.JNS14798. Epub 2015 Feb 6.ABSTRACTThe authors describe the case of an intraneural ganglion cyst involving a cranial nerve (V3), which was found to have a…

Prostate cancer with perineural spread and dural extension causing bilateral lumbosacral plexopathy: case report

J Neurosurg. 2015 Apr;122(4):778-83. doi: 10.3171/2014.12.JNS141339. Epub 2015 Feb 6.ABSTRACTPerineural tumor spread in prostate cancer is emerging as a mechanism to explain select cases of neurological dysfunction and as a…

Perineural tumor spread to the muscle: An alternative for muscle metastasis?

Clin Anat. 2015 Jul;28(5):560-2. doi: 10.1002/ca.22485. Epub 2014 Dec 15.NO ABSTRACTPMID:25511297 | DOI:10.1002/ca.22485

Perineural spread of squamous cell carcinoma: from skin to skin through the brachial plexus

Clin Neurol Neurosurg. 2015 Jan;128:90-3. doi: 10.1016/j.clineuro.2014.11.004. Epub 2014 Nov 15.NO ABSTRACTPMID:25462103 | DOI:10.1016/j.clineuro.2014.11.004

Erratum to: Perineural tumor spread of bladder cancer causing lumbosacral plexopathy: an anatomic explanation

Acta Neurochir (Wien). 2015 Jan;157(1):153. doi: 10.1007/s00701-014-2285-4.NO ABSTRACTPMID:25413165 | DOI:10.1007/s00701-014-2285-4

Perineural tumor spread of bladder cancer causing lumbosacral plexopathy: an anatomic explanation

Acta Neurochir (Wien). 2014 Dec;156(12):2331-6. doi: 10.1007/s00701-014-2257-8. Epub 2014 Oct 22.ABSTRACTWe present two cases of biopsy-proven neoplastic lumbosacral plexopathy from perineural spread of bladder cancer: one patient presented with predominantly…

Recurrent rectal cancer causing lumbosacral plexopathy with perineural spread to the spinal nerves and the sciatic nerve: an anatomic explanation

Clin Anat. 2015 Jan;28(1):136-43. doi: 10.1002/ca.22450. Epub 2014 Aug 5.ABSTRACTSeveral groups have reported cases of rectal cancer with carcinomatous involvement of the lumbosacral plexus and sciatic, obturator, pudendal, or spinal…

Do cutaneous nerves cross the midline?

Clin Anat. 2015 Jan;28(1):96-100. doi: 10.1002/ca.22427. Epub 2014 Jun 26.ABSTRACTStandard cutaneous innervation maps show strict midline demarcation. Although authors of these maps accept variability of peripheral nerve distribution or occasionally…