Vaibhav Vagal, MD

Education

MD: Stony Brook University
BS: University of Cincinatti, Neuroscience

Email: QVJ3EP@uvahealth.org

Publications

Prolonged Venous Transit Is Associated with Unfavorable Functional Outcomes in Large Core Stroke

AJNR Am J Neuroradiol. 2025 Oct 16:ajnr.A9047. doi: 10.3174/ajnr.A9047. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: Large core acute ischemic stroke (AIS) caused by large vessel occlusion (LVO) is associated with…

Association between the Edinburgh CT and genetic diagnostic criteria for cerebral amyloid angiopathy-associated lobar intracerebral haemorrhage and recurrent intracerebral haemorrhage: an individual patient data meta-analysis

Lancet Neurol. 2025 Oct;24(10):828-839. doi: 10.1016/S1474-4422(25)00285-6.ABSTRACTBACKGROUND: Patients with lobar intracerebral haemorrhage and MRI biomarkers of cerebral amyloid angiopathy have a greater risk of recurrent intracerebral haemorrhage than patients without these…

Integrating perfusion imaging derived venous outflow and tissue-level collateral parameters in a comprehensive clinical model enhances prognostication in large vessel occlusion stroke

Neurotherapeutics. 2025 Sep;22(5):e00632. doi: 10.1016/j.neurot.2025.e00632. Epub 2025 Jul 5.ABSTRACTArterial inflow restoration and collateral status have been significantly correlated with functional outcomes in AIS-LVO patients undergoing mechanical thrombectomy (MT). CT perfusion…

Fast and Slow Recovery of Consciousness Following Traumatic Brain Injury

Neurocrit Care. 2025 Jun 27. doi: 10.1007/s12028-025-02304-2. Online ahead of print.ABSTRACTBACKGROUND: Consciousness recovery after severe traumatic brain injury (sTBI) can take minutes to years. Despite this variability, we hypothesized that…

The relative cerebral blood volume (rCBV) <42% is independently associated with prolonged hospitalization in anterior circulation large vessel occlusion

Neuroradiol J. 2025 May 31:19714009251348621. doi: 10.1177/19714009251348621. Online ahead of print.ABSTRACTBackgroundThe pretreatment rCBV <42% lesion volume on CT Perfusion (CTP) has recently been shown to predict 90-day functional outcomes in…

Prolonged Venous Transit as a Superior Predictor of Functional Outcomes in Successfully Reperfused Large Vessel Occlusions: Comparative Analysis With Cerebral Blood Volume Index and Hypoperfusion Intensity Ratio

J Am Heart Assoc. 2025 Apr 15;14(8):e039924. doi: 10.1161/JAHA.124.039924. Epub 2025 Apr 7.ABSTRACTBACKGROUND: Collateral status plays a crucial role in outcomes after acute ischemic stroke due to large vessel occlusion.…

Prolonged Venous Transit Independently Predicts Worse Functional Outcomes at Discharge in Successfully Reperfused Patients with Large Vessel Occlusion Stroke

Clin Neuroradiol. 2025 Sep;35(3):565-572. doi: 10.1007/s00062-025-01509-4. Epub 2025 Apr 1.ABSTRACTBACKGROUND AND PURPOSE: Venous outflow (VO) impairment predicts unfavorable outcomes in patients with acute ischemic stroke caused by large vessel occlusion…

Psychosocial Stress and Risk for Intracerebral Hemorrhage in the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) Study

J Am Heart Assoc. 2025 Mar 18;14(6):e024457. doi: 10.1161/JAHA.121.024457. Epub 2025 Mar 7.ABSTRACTBACKGROUND: Intracerebral hemorrhage (ICH) carries a 30-day mortality rate of 40% to 50% and a high burden of…

Hypoperfusion Intensity Ratio Less Than 0.4 Is Associated with Favorable Outcomes in Unsuccessfully Reperfused Acute Ischemic Stroke with Large-Vessel Occlusion

AJNR Am J Neuroradiol. 2025 Mar 4;46(3):483-488. doi: 10.3174/ajnr.A8518.ABSTRACTBACKGROUND AND PURPOSE: Endovascular thrombectomy is a standard treatment for acute ischemic stroke due to large-vessel occlusions (AIS-LVO), but a large minority…

Volume contracted state, mortality and functional outcomes in patients with acute ischaemic stroke due to large vessel occlusion

BMJ Neurol Open. 2025 Feb 4;7(1):e000974. doi: 10.1136/bmjno-2024-000974. eCollection 2025.ABSTRACTBACKGROUND: Acute ischaemic stroke (AIS) is a leading cause of mortality and disability globally, with volume contracted state (VCS), as indicated…

Larger Perfusion Mismatch Volume Is Associated With Longer Hospital Length of Stay in Medium Vessel Occlusion Stroke

J Neuroimaging. 2025 Jan-Feb;35(1):e70015. doi: 10.1111/jon.70015.ABSTRACTBACKGROUND AND PURPOSE: Prolonged length of stay (LOS) following a stroke is associated with unfavorable clinical outcomes. Factors predicting LOS in medium vessel occlusion (MeVO),…

AM-PAC 6-Clicks Basic Mobility and Daily Activities Scores Predict 90-Day Modified Rankin Score in Patients with Acute Ischemic Stroke Secondary to Large Vessel Occlusion

J Clin Med. 2024 Nov 25;13(23):7119. doi: 10.3390/jcm13237119.ABSTRACTBackground: The relative level of functional impairment in stroke patients is a significant determinant of post-acute care. The Activity Measure for Post Acute…

Prolonged Venous Transit on Perfusion Imaging Is Associated with Longer Lengths of Stay in Acute Large Vessel Occlusions

AJNR Am J Neuroradiol. 2025 May 2;46(5):887-891. doi: 10.3174/ajnr.A8611.ABSTRACTBACKGROUND AND PURPOSE: Prolonged venous transit (PVT+) is a marker of venous outflow; it is defined as the presence or absence of…

First-Line Treatment of Symptomatic Subocclusive Large-Vessel Stroke: Results of a Nationwide StrokeNet Survey

Stroke Vasc Interv Neurol. 2024 Jul;4(4):e001367. doi: 10.1161/SVIN.124.001367. Epub 2024 May 15.ABSTRACTBACKGROUND: Limited evidence is available for the treatment of acute symptomatic sub-occlusive lesions in ischemic stroke. We sought to…

Association of Pretreatment Perfusion Imaging Parameters with 90-Day Excellent Functional Outcomes in Anterior Circulation Distal Medium Vessel Occlusion Stroke

AJNR Am J Neuroradiol. 2025 May 2;46(5):892-899. doi: 10.3174/ajnr.A8584.ABSTRACTBACKGROUND AND PURPOSE: Acute ischemic strokes caused by distal medium vessel occlusions (DMVOs) represent a remarkable proportion of all stroke cases, yet…

CT perfusion derived relative cerebral blood volume < 42 % is negatively associated with poor functional outcomes at discharge in anterior circulation large vessel occlusion stroke

J Clin Neurosci. 2024 Dec;130:110907. doi: 10.1016/j.jocn.2024.110907. Epub 2024 Nov 13.ABSTRACTBACKGROUND AND AIM: Recent studies have shown that the CT Perfusion (CTP) parameter of rCBV < 42 % lesion volume…

Prolonged venous transit is associated with worse neurological recovery in successfully reperfused large vessel strokes

Ann Clin Transl Neurol. 2025 Jan;12(1):26-33. doi: 10.1002/acn3.52243. Epub 2024 Nov 11.ABSTRACTOBJECTIVE: Venous outflow (VO) impairment predicts unfavorable outcomes in patients with acute ischemic stroke caused by large vessel occlusion…

Severe Traumatic Brain Injury Outcomes in Patients with Premorbid Psychiatric Illness

World Neurosurg. 2025 Feb;194:123367. doi: 10.1016/j.wneu.2024.10.096. Epub 2024 Nov 18.ABSTRACTOBJECTIVE: Individuals with psychiatric illnesses (PIs) have increased rates of traumatic brain injury (TBI). Nonetheless, the influence of underlying PI on…

Role of Hypoperfusion Intensity Ratio in Vessel Occlusions: A Review on Safety and Clinical Outcomes

AJNR Am J Neuroradiol. 2025 Jun 3;46(6):1069-1081. doi: 10.3174/ajnr.A8557.ABSTRACTThe hypoperfusion intensity ratio (HIR) is a quantitative metric used in vascular occlusion imaging to evaluate the extent of brain tissue at…

Diagnostic Challenges in Neuro-Psychiatric Systemic Lupus Erythematosus: A Case of a Patient With Psychosis Secondary to Lupus Cerebritis in the Setting of a Steroid Taper

Cureus. 2024 Jul 13;16(7):e64484. doi: 10.7759/cureus.64484. eCollection 2024 Jul.ABSTRACTSystemic lupus erythematosus (SLE) is an autoimmune condition whereby autoantibodies target systemic tissues, causing manifestations of inflammation and tissue damage. Neurologic inflammation…

In reply to the letter to the editor regarding "Optic nerve sheath diameter is not a predictor of outcomes"

J Stroke Cerebrovasc Dis. 2024 Oct;33(10):107912. doi: 10.1016/j.jstrokecerebrovasdis.2024.107912. Epub 2024 Aug 6.NO ABSTRACTPMID:39097118 | DOI:10.1016/j.jstrokecerebrovasdis.2024.107912

Optic Nerve Sheath Diameter is not a predictor of functional outcomes in ICH Patients

J Stroke Cerebrovasc Dis. 2024 Aug;33(8):107831. doi: 10.1016/j.jstrokecerebrovasdis.2024.107831. Epub 2024 Jun 22.ABSTRACTOBJECTIVES: Optic nerve sheath diameter (ONSD) may serve as an early marker of increasing intracranial pressure resulting from intracerebral…

Higher blood glucose is associated with the severity of hemorrhagic transformation after endovascular therapy for stroke

J Stroke Cerebrovasc Dis. 2024 Aug;33(8):107823. doi: 10.1016/j.jstrokecerebrovasdis.2024.107823. Epub 2024 Jun 14.ABSTRACTOBJECTIVES: Hyperglycemia is associated with poor outcome in large vessel occlusion (LVO) stroke, with mechanism for this effect unknown.MATERIALS…

In-Hospital Amantadine Does Not Improve Outcomes After Severe Traumatic Brain Injury: An 11-Year Propensity-Matched Retrospective Analysis

World Neurosurg. 2023 Sep;177:e277-e287. doi: 10.1016/j.wneu.2023.06.034. Epub 2023 Jun 17.ABSTRACTBACKGROUND: Disruption of dopamine neurotransmission is associated with functional impairment after severe traumatic brain injury (sTBI). This has prompted the study…

Predicting traumatic brain injury outcomes using a posterior dominant rhythm

J Neurosurg. 2023 Jun 9;139(6):1523-1533. doi: 10.3171/2023.4.JNS23569. Print 2023 Dec 1.ABSTRACTOBJECTIVE: Predicting severe traumatic brain injury (sTBI) outcomes is challenging, and existing models have limited applicability to individual patients. This…

White Matter Lesion Severity is Associated with Intraventricular Hemorrhage in Spontaneous Intracerebral Hemorrhage

J Stroke Cerebrovasc Dis. 2020 May;29(5):104661. doi: 10.1016/j.jstrokecerebrovasdis.2020.104661. Epub 2020 Feb 28.ABSTRACTBACKGROUND: Intraventricular hemorrhage (IVH) and white matter lesion (WML) severity are associated with higher rates of death and disability…