2019 Anderson Symposium Agenda

November 2:

Location for meals and meeting room will be communicated before the meeting commences

7:00-8:00 AM breakfast (Darden)

8:00-8:10 AM Rob Grainger, Welcome and general introduction

8:10-8:40 AM Veronica van Heyningen, Aniridia-PAX6 and Beyond, Meeting Introduction:  “Looking back and peering forward”

8:50-10:20 AM

  • Dominique Bremond-Gignac, Université Paris V Descartes, Hôpital Universitaire Necker: “Phenotype/Genotype correlation in aniridia”
  • Brian Brooks, National Institutes of Health, National Eye Institute: “Developmental gene profiling as a mechanism for identifying genes for uveal coloboma”
  • Melinda Duncan, University of Delaware: “Using genomics to elucidate mechanisms of acquired ocular disease in aniridia”

10:20 to 10:50 AM coffee

10:50-12:20

  • Seth Blackshaw, Johns Hopkins University “Building the retina one cell at a time”
  • Veronica van Heyningen, University College, London: “Complexities of PAX6 function from studies of aniridia, model systems and bioinformatic analysis.”
  • Zbynek Kozmik, Academy of Sciences of the Czech Republic: “The role of Pax6 and Meis transcription factors in vertebrate eye development”

12:20-1:20 PM Lunch (Darden)

1:20-3:20 PM

  • Hao Zhang, Northwestern University: “Visible light optical coherence tomography: new capabilities and new opportunities”
  • Xiaorong Liu: University of Virginia: “In vivo imaging of the retinal nerve fiber layer in mice”
  • Shukti Chakravarti, NYU Langone Health: “Novel genes and pathways important to the healthy and keratoconic cornea”
  • David FitzPatrick, University of Edinburgh, MRC Institute of Genetics and Molecular Medicine: “The role of MAB21L proteins in eye development and disease”

November 3:

8:00-10:00 AM

  • Ruth Ashery-Padan, Tel Aviv University: “Retinal pigmented epithelium development from the perspective of transcription factors and cis-regulatory elements”
  • Elena Semina, Medical College of Wisconsin: “Genetic factors in Peters anomaly”
  • Neil Lagali, Linköping University: “Genotype-phenotype studies of aniridia-associated keratopathy in European cohorts”
  • Kevin Gregory-Evans, University of British Columbia, Eye Care Centre: “Clinical conundrums in interpreting results of molecular genetic testing”

10:00-10:30 AM Coffee

10:30-12:30

  • Ales Cvekl, Albert Einstein College of Medicine: “Pax6 and gene regulatory networks of crystallin gene expression”
  • Ali Djalilian, University of Illinois College of Medicine: “Repurposing MEK inhibitors for therapeutically enhancing Pax6 expression in congenital aniridia.”
  • Cheryl Gregory-Evans, University of British Columbia, Eye Care Centre: “Therapeutic approaches targeting anterior chamber defects in the Pax6Sey/+ model of aniridia”
  • Arlene Drack, University of Iowa: “Gene therapy for genetic retinal disorders in mice and (hu)man”

12:30-1:30 PM Lunch (Darden)

1:30-3:00 PM

  • Peter Netland, University of Virginia: “Anterior Chamber Angle in Aniridia”
  • Marc Odrich, University of Virginia: “Ocular Surface and Aniridia”
  • Marla Weetall, PTC Therapeutics: “Development of a sensitive and selective assay to measure PAX6 protein using impression cytology”

3:00-3:30 PM Coffee

3:30-4:30 PM

  • Jim Lauderdale, University of Georgia: “Development of a cell-based approach to treat genetic keratopathy”
  • Rob Grainger, University of Virginia: “The role of Six3 in the gene hierarchy regulating eye formation and its contribution to lens formation and retinal patterning”

4:30-4:45 PM Meeting wrap-up

The John F. Anderson Memorial Lectures in Medicine

The John F. Anderson Memorial Lectureship was established in 1955 by Dr. John F. Anderson, a graduate in 1895 of the University of Virginia School of Medicine.  Through his most generous gift to the University, it has been possible to establish a lectureship in medical science and public health which will bring to this medical community the latest developments in these fields.

Dr. Anderson made many outstanding contributions to the science of medicine during his long career of service and leadership in public health, medical research, and medical production.  He died in North Brunswick, New Jersey, on September 29, 1958, at the age of 87.