Brent DeGeorge, MD, PhD

Dr. DeGeorge graduated summa cum laude from The College of William and Mary and attended Jefferson Medical College and Thomas Jefferson University where he completed his medical education and a Ph.D. in Molecular Pharmacology and Structural Biology.  He then completed his residency training in the Department of Plastic Surgery at the University of Virginia.  Dr. DeGeorge went on to complete fellowship training in Hand and Microvascular Surgery in the Department of Orthopaedic Surgery at the Mayo Clinic.  He returns to the University of Virginia to join the faculty at the UVA Hand Center.  Dr. DeGeorge’s areas of expertise include brachial plexus and peripheral nerve surgery and hand, wrist, and forearm reconstruction following trauma.  He also specializes in microsurgery and arthroscopy of the upper extremity.  His research interests include articular cartilage repair and regeneration techniques, patient-reported outcomes research, and allograft tendon, cartilage, and dermis.  Dr. DeGeorge has received numerous awards for his research and academic excellence.

Contact

Office Location:
UVA Hand Center
Fontaine Research Park
415 Ray C. Hunt Dr, 3rd Floor
Mailing Address:
Box 800159 HSC
Dept Orthopaedic Surgery
University of Virginia
Charlottesville, VA 22908

Clinical Office Phone:
434.982.HAND (4263)
Office Fax:
434.924.0782

Appointments

Assistant Professor
Department of Plastic and Reconstructive Surgery

Specialty and Subspecialty

Specialty: Plastic Surgery

Subspecialty: Upper Extremity Surgery

Special Expertise

Microvascular Surgery
Brachial Plexus Surgery
Arthroscopy

Education

Education: 2003-2010
MD, Jefferson Medical College, Philadelphia, PA
PhD, Molecular Pharmacology and Structural Biology, Thomas Jefferson University, Philadelphia, PA
1999-2003
BS, Neuroscience, The College of William and Mary, Williamsburg, VA

Residency: 2015-2016
Chief Resident in Plastic Surgery, University of Virginia,
Charlottesville, VA
2010-2015
Resident in Plastic Surgery, University of Virginia, Charlottesville, VA

Fellowship: 2016-2017
Fellow in Hand Surgery, Department of Orthopaedic Surgery, Mayo
Clinic, Rochester, MN

Awards

2017 AAOS/OREF/ORS Clinician Scholar Career Development Program Participant
2016 Raymond F. Morgan, MD Resident Research Award
2013 Southeastern Society of Plastic and Reconstructive Surgeons Glancy Outstanding Research Award
2010 Summa Cum Laude Graduate, Jefferson Medical College
2010 Jefferson Medical College Annual Research Award
2009 Alpha Omega Alpha Honor Medical Society Membership
2008 Jefferson College of Graduate Studies Outstanding Thesis Award
2007 Excellence in Science Award in Translational Medicine at Thomas Jefferson University
2006 American Heart Association Pre-doctoral Fellowship Award
2005 Sigma Xi Honor Society Annual Research Award

Research Description

Dr. DeGeorge’s main research interest is tissue engineering for cartilage repair and regeneration as well as allograft tendon, bone, and dermis. He has presented his work at numerous meetings including the American Society for Surgery of the Hand and American Association for Hand Surgery.

Publications

DeGeorge BR Jr., Archual AJ, Morgan RF. Enhanced Informed Consent in Hand Surgery: Techniques to Improve the Informed Consent Process. Annals of Plastic Surgery. 2017.

DeGeorge BR Jr., Becker HA, Faryna J, Spinner RJ, Bishop AT, Shin AY. Outcomes of Brachialis Muscle Transfer to Restore Finger Flexion in Traumatic Lower Trunk Brachial Plexus Palsy. Plastic and Reconstructive Surgery. 2017. E-publication ahead of print.

DeGeorge BR Jr., Bo N, Salopek LS, Pineros-Fernandez A, Rodeheaver GT, Peirce-Cottler S, Hu S, Cottler PS, Campbell CA. Advanced imaging techniques for the investigation of acellular dermal matrix biointegration. Plastic and Reconstructive Surgery. 2017. E-publication ahead of print.

DeGeorge BR Jr, Olenczak JB, Pineros-Fernandez A, Morgan RF, M.D.; Cottler PS, Drake DB. Abdominal Wall Allograft: Preclinical biomechanical investigation of a novel reconstructive adjunct. Annals of Plastic Surgery. 2016.

DeGeorge BR Jr, Campbell CA. Techniques to refine the upper outer breast aesthetic subunit in alloplastic breast reconstruction: The lateral capsular flap.
Plast Surg. 2016 Summer; 24(2):83-8.

DeGeorge BR Jr., Olenczak JB, Drake DB, Lin KY, Morgan RF, Cottler PS, Campbell, CA.* Evaluation of Sidestream Darkfield Microscopy for Real-Time Imaging Acellular Dermal Matrix Revascularization. Annals of Plastic Surgery. 2016.

Lee AC, Drake DB, DeGeorge BR Jr.* Medical Student and Primary Care Physician Perception of the Surgical Management of Upper- and Lower-Extremity Peripheral Nerve Entrapment. Annals of Plastic Surgery. 2016 Jan 21.

DeGeorge BR Jr, Holland MC, Drake DB.* The impact of conflict of interest in abdominal wall reconstruction with acellular dermal matrix. Annals of Plastic Surgery. 2015 Feb;74(2):242-7.

Tilt A, DeGeorge BR Jr, Furlow LT Jr, Drake DB.* A surgeon’s historical perspective: Dr. Leonard Furlow on the early years of human composite flexor tendon allografts. Annals of Plastic Surgery. 2014 Aug;73(2):121-3.

DeGeorge BR Jr, Rodeheaver GT, Drake DB.* Operative technique for human composite flexor tendon allograft procurement and engraftment. Annals of Plastic Surgery. 2014;72(6):S191-7.

Tholpady SS, DeGeorge BR Jr, Campbell CA.* The effect of local rho-kinase inhibition on murine wound healing. Annals of Plastic Surgery. 2014;72(6):S213-9.

DeGeorge BR Jr, Rodeheaver GT, Drake DB.* The biophysical characteristics of human composite flexor tendon allograft for upper extremity reconstruction. Annals of Plastic Surgery. 2014;72(6):S184-90.

Drake DB, Tilt AC, DeGeorge BR Jr.* Acellular flexor tendon allografts: a new horizon for tendon reconstruction. Journal of Hand Surgery. 2013 Dec;38(12):2491-5.

Mericli AF, Bell D, DeGeorge BR Jr, Drake DB.* The single fascial incision modification of the “open-book” component separation repair: a 15-year experience. Annals of Plastic Surgery. 2013 Aug;71(2):203-8.

Hanna KR, DeGeorge BR Jr, Mericli AF, Lin KY, Drake DB.* Comparison study of two types of expander-based breast reconstruction: acellular dermal matrix-assisted versus total submuscular placement. Annals of Plastic Surgery. 2013 Jan;70(1):10-5.

Feiner EC, Chung P, Jasmin JF, Zhang J, Whitaker-Menezes D, Myers V, Song J, Feldman EW, Funakoshi H, Degeorge BR Jr, Yelamarty RV, Koch WJ, Lisanti MP, McTiernan CF, Cheung JY, Bristow MR, Chan TO, Feldman AM.* Left ventricular dysfunction in murine models of heart failure and in failing human heart is associated with a selective decrease in the expression of caveolin-3. Journal of Cardiac Failure. 2011 Mar;17(3):253-63.

Chan TO, Funakoshi H, Song J, Zhang XQ, Wang J, Chung PH, DeGeorge BR Jr, Li X, Zhang J, Herrmann DE, Diamond M, Hamad E, Houser SR, Koch WJ, Cheung JY, Feldman AM.* Cardiac-restricted overexpression of the A(2A)-adenosine receptor in FVB mice transiently increases contractile performance and rescues the heart failure phenotype in mice overexpressing the A(1)-adenosine receptor. Clinical and Translational Science. 2008 Sep;1(2):126-33.

Degeorge BR Jr, Rosenberg M, Eckstein V, Gao E, Herzog N, Katus HA, Koch WJ, Frey N, Most P.* BMP-2 and FGF-2 synergistically facilitate adoption of a cardiac phenotype in somatic bone marrow c-kit+/Sca-1+ stem cells. Clinical and Translational Science. 2008 Sep;1(2):116-25.

Martini JS, Raake P, Vinge LE, DeGeorge BR Jr, Chuprun JK, Harris DM, Gao E, Eckhart AD, Pitcher JA, Koch WJ.* Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. Proceedings of the National Academy of Sciences. 2008 Aug 26;105(34):12457-62.

Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, DeGeorge BR Jr, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW 2nd, Koch WJ.* G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure. Circulation Research. 2008 Aug 15;103(4):413-22.

DeGeorge BR Jr, Koch WJ.* Gi/o signaling and its potential role in cardioprotection. Expert Review of Cardiovascular Therapy. 2008 Jul;6(6):785-7.

DeGeorge BR Jr, Gao E, Boucher M, Vinge LE, Martini JS, Raake PW, Chuprun JK, Harris DM, Kim GW, Soltys S, Eckhart AD, Koch WJ.* Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress. Circulation. 2008 Mar 18;117(11):1378-87.

Degeorge KC, Degeorge BR Jr, Testa JS, Rothstein JL.* Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor. Journal of Inflammation. 2008 Feb 27;5:3.

Völkers M, Loughrey CM, Macquaide N, Remppis A, DeGeorge BR Jr, Wegner FV, Friedrich O, Fink RH, Koch WJ, Smith GL, Most P.* S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium. 2007 Feb;41(2):135-43.

DeGeorge BR Jr, Koch WJ.* Beta blocker specificity: a building block toward personalized medicine. Journal of Clinical Investigation. 2007 Jan;117(1):86-9.

Most P, Seifert H, Gao E, Funakoshi H, Völkers M, Heierhorst J, Remppis A, Pleger ST, DeGeorge BR Jr, Eckhart AD, Feldman AM, Koch WJ.* Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction. Circulation. 2006 Sep 19;114(12):1258-68.

Higuchi Y, Chan TO, Brown MA, Zhang J, DeGeorge BR Jr, Funakoshi H, Gibson G, McTiernan CF, Kubota T, Jones WK, Feldman AM.* Cardioprotection afforded by NF-kappaB ablation is associated with activation of Akt in mice overexpressing TNF-alpha. American Journal of Physiology Heart and Circulatory Physiology. 2006 Feb;290(2):H590-8.