Shen Publications
Francis H. Shen, MD
Author of the following articles:
For Patients:
1. Shen FH, Samartzis D, Andersson GBJ. Role of nonoperative treatment in mechanical axial low back pain. J Am Acad Orthop Surg. 2006;14:477-487.
2. Shen FH, Samartzis D, An HS. Summary Statement: Cellular Technologies in Spinal Fusions. Spine J. 2005;5:231S-239S.
3. Anderson DG, Yoon T, Shen FH, et al. Summary Statement: biologic repair or regeneration of the intervertebral disc. Spine J. 2005;5:304S.
4. Grauer JN, Jenis LG, Wang JC, Shen FH, Fishgrund JS, Phillips FM. Biologics for Spine Fusion: Summary Statement. Spine J. 2005;5:259S.
5. Shen FH, Samartzis D, Jenis L, An HS. Evaluation and surgical management of the rheumatoid neck. Spine J. 2004;4(6):689-700.
6. Samartzis D, Shen FH, Perez-Cruet MJ, Anderson DG. A historical perspective of minimally invasive spine surgery. Orthop Clin N Am. 2007;38:305-326.
7. Shen FH, Thompson PW. Sports Related Nerve Injuries. Hosp Phys. 2005;41(5):25-6.
8. Shen FH. Common Etiology for Low Back Pain. Hosp Phys. 2005;41(1):27-28.
9. Arlet V, Shilt J, Bersusky E, Abel M, Ouellet JA, Evans D, Menon KV, Kandziora F, Shen FH, Lamartina C, Adams M, Reddi V. Experience with an online prospective database on adolescent idiopathic scoliosis: development and implementation. 2008 Oct 2. [Epub ahead of print]
10. Samartzis D, Shen FH. Neck pain and its associated disorders: a complex conundrum. South Med J. 2008;101(9):877.
11. Samartzis D, Shen FH. Rapid Response: Haldeman Scott, Carroll Linda, Cassidy J David, Schubert Jon, et al. The Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders: Executive Summary. Spine 2008: 33(4S). South Med J 2008.
12. Samartzis D, Shen FH. Use of percutaneous vertebroplasty and kyphoplasty for the management of osteoporotic vertebral compression fractures. Rapid Responses to: Poole KES, Compston JE. Osteoporosis and its management. British Med J 2006; 333: 1251-1256. Published on line on 27 January 2007. http://www.bmj.com/cgi/eletters/333/7581/1251.
13. Shen FH, Samartzis D. Traumatic scoliosis. Lancet. 2005;365:910-911.
For Professionals:
Basic Science Research:
1. Feng G, Wan Y, Shen FH, et al. Nucleus pulposus explant culture model. J Orthop Res. 2008 Nov 24. [Epub ahead of print]
2. Wan Y, Feng G, Shen FH, Laurencin CT, Li X. Biphasic Scaffold for Annulus Fibrosus Tissue Regeneration. Biomaterials. 2008;29(6):643-52.
3. Cui M, Wan Y, Anderson DG, Shen FH, Leo BM, Laurencin CT, Balian G, Li X.. 2007 Best Paper Award: Mouse growth and differentiation factor-5 protein and DNA therapy potentiates intervertebral disc cell aggregation and chondrogenic gene expression. Spine J. 2008;8(2):287-95.
14. Wan Y, Feng G, Shen FH, Balian G, Laurencin CT, Li X. Novel Biodegradable Poly (1, 8-diol malate) (POM) for Annulus Fibrosus Regeneration. Macromol Biosci. 2007 Aug 8; [Epub ahead of print]
15. Zeng Q, Li X, Choi L, Beck G, Balian G, Shen FH. Stimulation of osteogenesis and angiogenesis in fat-derived stromal cells in vitro using recombinant growth and differentiation factor-5 (GDF-5). Bone. 2007;40(2):374-81.
16. Shen FH, Zeng Q, Lv Q, et al. 2006 Best Paper Award : Osteogenic differentiation of adipose-derived stromal cells treated with GDF-5 cultured on a novel three-dimensional sintered microsphere matrix. Spine J. 2006;6:615-23. Epub 2006 Oct 10.
17. Zeng Q, Li X, Choi L, Beck G, Balian G, Shen FH. Recombinant growth/differentiation factor-5 (GDF-5) stimulates osteogenic differentiation of fat-derived stromal cells in vitro. Connective Tis Res. 2006;47(5):264-70.
18. Samartzis D, Khanna N, Shen FH, An HS. An Update on Bone Morphogenetic Proteins and their Application in Spine Surgery. J Am Coll Surg. 2005;200:236-248.
19. Shen FH, Visger J, Balian G, et al. Systemically administered mesenchymal stromal cells transduced with insulin-like growth factor-I localize to a fracture site and potentiate healing. J Orthop Trauma 2002;16(9):651-659.
20. Li X, Cui M, Feng G, Ma SY, Shen FH, Laurencin CT, Balian G, Leo BM. Impaired extracellular matrix turnover in disc degeneration of a mouse model and treatment with growth and differentiation factor-5. Spine J. In press.
Degenerative Spine:
21. Samartzis D, Shen FH, Goldberg EJ, An HS. Is autograft the gold standard in achieving radiographic fusion in one-level anterior cervical discectomy and fusion with rigid anterior plate fixation? Spine. 2005;30:1756-61.
22. Shen FH, Samartzis D, Jenis L, An HS. Evaluation and surgical management of the rheumatoid neck. Spine J. 2004;4(6):689-700.
23. Samartzis D, Shen FH, Lyons M, et al. Does rigid instrumentation increase the fusion rate in one-level anterior cervical discectomy and fusion. Spine J. 2004;4(6):636-43.
24. Shen FH, Samartzis D, Khanna N, et al. Radiographic and clinical outcome of anterior cervical discectomy and fusion with and without direct uncovertebral joint decompression. Spine J. 2004;4(6):629-35.
25. Samartzis D, Shen FH, Matthews DK, et al. Comparison of allograft to autograft in multilevel anterior cervical discectomy and fusion with rigid plate fixation. Spine J 2003;3(6):451-459.
26. Shen FH, Samartzis D. Assessment of Lumbar Fusion: Importance of Dynamic Plain Standing X-rays, J Am Coll Surg. 27 May 2008, pages 955-956.
27. Jagannathan J, Chankaew E, Urban P, Dumont AS, Oskouian RJ, Sansur CA, Kern J, Peeler B, Elias WJ, Shen FH, Shaffrey ME, Whitehill R, Arlet V, Shaffrey CI. Cosmetic and functional outcomes following paramedian and anterolateral retroperitoneal access in anterior lumbar spine surgery. J Neurosurg Spine. 2008 Nov;9(5):454-65.
28. Bumpass D, Keller T, Marks I, Iwanik M, Arlet V, Shen FH. Implications of lumbar plexus anatomy for removal of total disc replacements through a posterior approach. Spine. 2008 Apr 20;33(9):E274-8.
29. Hunt T, Shen FH, Shaffrey CI, et al. Contralateral radiculopathy after transforaminal lumbar interbody fusion. Eur Spine J. 2007 May 9; [Epub ahead of print]
30. Hunt T, Shen FH, Arlet V. Technical Note: Expandable cage placement using a posterolateral approach in lumbar spine reconstructions. J Neurosurg Spine. 2006;5:271-274.
31. Shen FH, Samartzis D, Andersson GBJ. Role of nonoperative treatment in mechanical axial low back pain. J Am Acad Orthop Surg. 2006;14:477-487. Spinal Deformity and Reconstruction
32. Shen FH, Samartzis, D. Careful follow-up after “successful” surgery: postoperative spondylolisthesis following anterior cervical corpectomy and fusion with instrumentation. Surg Neurol. 2008 Feb 7 [Epub ahead of print].
Spinal Deformity:
33. Samartzis D, Herman J, Lubicky LP, Shen FH. Classification of congenitally fused cervical patterns in Klippel-Feil patients: epidemiology and role in the development of cervical spine-related symptoms. Spine 2006;31:E798-E804.
34. Samartzis D, Lubicky JP, Shen FH. “Bone Block” and congenital spine deformity. Diagnosis: Klippel-Feil syndrome with congenital scoliosis. Ann Acad Med Singapore. 2008;37(7):624.
35. Samartzis D, Kalluri P, Herman, J, Lubicky JP, Shen FH. The extent of fusion within the congenital Klippel-Feil segment. Spine. 2008;33(15):1637-42.
36. Samartzis D, Kalluri P, Herman J, Lubicky JP, Shen FH. 2008 Young Investigator’s Award: The role of congenitally fused cervical segments upon the space available for the cord and associated symptoms in Klippel-Feil patients. Spine. 2008 May 9. [Epub ahead of print]
37. Samartzis D, Herman, J, Lubicky JP, Shen FH. Sprengel’s Deformity in Klippel-Feil Syndrome. Spine. 2007 Aug 15;32(18):E512-6.
38. Samartzis D, Herman J, Lubicky J, Shen FH. Klippel-Feil Syndrome and Associated Abnormalities: the Necessity for a Multidisciplinary Approach in Patient Management. Spine J. 2007;7(1):135-137.
39. Samartzis D, Kalluri P, Herman J, Lubicky JP, Shen FH. Superior odontoid migration in the Klippel-Feil patient. Euro Spine J. 2006 Dec 15; [Epub ahead of print]; 2007;16(6):1489-97.
40. Samartzis D, Kalluri P, Herman J, Lubicky JP, Shen FH. Factors affecting the cervical space available for the cord in Klippel-Feil patients. Spine J. 2006;6(suppl):132S.
41. Samartzis D, Lubicky JP, Herman J, Prakash, Shen FH. Symptomatic Cervical Disc Herniation in a Pediatric Klippel-Feil Patient: the Risk of Neural Injury Associated with Extensive Congenitally Fused Vertebrae and a Hypermobile Segment. Spine. 2006;31:E335-E338.
42. Shen FH, Samartzis D, Herman J, Lubicky JP. Radiographic assessment of segmental motion at the atlantoaxial junction in the Klippel-Feil patient. Spine 2006;31:171-177.
43. Samartzis D, Herman J, Lubicky J, Shen FH. Severe Thoracic Kyphoscoliosis in a Klippel-Feil Patient with Complete Cervical Spine Fusion and Deformity – Primum Non Nocere. Spine J. 2006;6:723-4.
44. Samartzis D, Shen FH. Caudal Regression Syndrome. Ann Acad Med Singapore 2008;37(5):446-1
45. Arlet V, Shilt J, Bersusky E, Abel M, Ouellet JA, Evans D, Menon KV, Kandziora F, Shen F, Lamartina C, Adams M, Reddi V. Experience with an online prospective database on adolescent idiopathic scoliosis: development and implementation. 2008 Oct 2. [Epub ahead of print]
46. Shen FH, Lubicky JP. Surgical excision of the hemivertebra in congential scoliosis. J Am Coll Surg. 2004;199:652-3.
Minimally Invasive Spine Surgery:
47. Samartzis D, Shen FH, Perez-Cruet MJ, Anderson DG. A historical perspective. Orthop Clin N Am. 2007;38:305-326.
48. Shen FH, Samartzis D, Khanna AJ, Anderson DG. Minimally invasive techniques for lumbar interbody fusions. Orthop Clin N Am. 2007;38:373-386.
49. Anderson DG, Samartzis D, Shen FH, Tannoury C. Percutaneous instrumentation of the thoracic and lumbar spine. Orthop Clin N Am. 2007;401-108.
50. Samartzis D, Shen FH, Anderson DG. Preface. Orthop Clin North Am. 2007;38:xi-xii.
Spinal Trauma:
51. Orndorf D, Shen FH. Small caliber gunshot wound with fragment lodged in the thoracic foramen with partial Brown-Sequard Syndrome. Am J Orthop. 2008 Mar;37(3):E55-8.
52. Shen FH, Samartzis D. Successful Non-Operative Treatment of a Three-Column Thoracic Fracture in a Patient with Ankylosing Spondylitis: Existence and Clinical Significance of the Fourth-Column of the Spine. Spine. 2007 Jul 1;32(15):E423-E427.
53. Samartzis D, Shen FH, Khanna N, Fairbank JCT, An HS. Local anesthetic at the iliac crest donor-site for postoperative pain management in spine surgery patients. (Protocol) Cochrane Database of Systematic Reviews 2007, Issue 3. Art. No.: CD006635. DOI: 10.1002/14651858.CD006635.
54. Shen FH, Barr M, Samartzis D. Radiology Rounds: Lap belt injury in the pediatric patient. SpineLine. 2008;9:26-29.
55. Samartzis D, Shen FH. Use of percutaneous vertebroplasty and kyphoplasty for the management of osteoporotic vertebral compression fractures. Rapid Responses to: Poole KES, Compston JE. Osteoporosis and its management. British Med J 2006; 333: 1251-1256. Published on line on 27 January 2007. http://www.bmj.com/cgi/eletters/333/7581/1251.
56. Shen FH, Samartzis D. Surgical management of lower cervical spine fracture in ankylosing spondylitis. J Trauma. 2006:6:1005-9.
57. Samartzis D, Shen FH. What’s your call? Postoperative iliac-crest avulsion fracture. CMAJ. 2006;175:475-6.
58. Francke E, Thaller J, Leo B, Anderson DG, Shen FH, Kern J. The protective effects of a novel adenosine A2a analogue following traumatic spinal cord injury in a rat model. Spine J. 2005;5:22S.
59. Orndorff DG, Samartzis D, Whitehill R, Shen FH. Traumatic fracture-dislocation of C5 on C6 through a previously solid multi-level anterior cervical discectomy and fusion: a case report and review of the literature. Spine J 2006;6:55-60
60. Samartzis D, Anderson DG, Shen FH. Simultaneous noncontiguous spinal fractures in an ankylosing spondylitis patient. Spine. 2005;30:E711-E715.
61. Shen FH, Samartzis D. Cervical spine fracture in the ankylosing spondylitis patient. J Am Coll Surg. 2005;200:632-3.
62. Shen FH, Crowl A, Shuler T, Feldenzer J, et al. Delayed recognition of lumbosacral fracture dislocations in the multitrauma patient: the triad of transverse process fractures, unilateral renal contusion and lumbosacral fracture dislocation. J Trauma 2004;56(3)-700-705.
Spinal Tumors and Reconstructions:
63. Kelly BP, Shen FH, DiAngelo DJ, Arlet V, Schwab J. Biomechanical testing of a novel four-rod technique for lumbopelvic reconstruction. Spine. 2008 Jun 1;33(13):E400-6.
64. Shen FH, Marks I, Shaffrey CI, et al. Outstanding Paper Award 2007: Corpectomy and reconstruction of anterior vertebral body tumors with an expandable cage through a posterior only extracavitary approach. Spine J. 2008;8:229-239.
65. Samartzis D, Foster WC, Padgett D. Shen FH. Spondylectomy and Three-Column Reconstruction with the Stackable Carbon Fiber Reinforced Polymer Cage System and Posterior Instrumentation in a Patient with Giant Cell Tumor of the Lumbar Spine: A Case Illustration. Surgical Neurology. 2007 Jun 20; [Epub ahead of print]
66. Shen FH, Bhattacharijee S, Harper M, et al. Corpectomy and reconstruction of anterior vertebral body tumors with an expandable cage through a posterior only extracavitary approach. J Bone Min Res. 2005; 20(Suppl 2):73-4.
67. Shen FH, Foster WC, Harper M, Marks I, Arlet V. A Novel ‘Four-Rod Technique’ for Lumbopelvic Reconstruction: Theory and Technical Considerations. Spine. 2006;31(12):1395-401.
Selected Publications:
Award Winning Research :
1. 2008 Young Investigator’s Award: Samartzis D, Kalluri P, Herman J, Lubicky JP, Shen FH. : The role of congenitally fused cervical segments upon the space available for the cord and associated symptoms in Klippel-Feil patients. Spine. 2008 May 9. [Epub ahead of print]
2. 2007 Outstanding Paper – Clinical Science Award: Shen FH, Marks I, Shaffrey CI, et al. : Corpectomy and reconstruction of anterior vertebral body tumors with an expandable cage through a posterior only extracavitary approach. Spine J. 2008;8:229-239.
3. 2007 Best Paper Award – Basic Science Award: Cui M, Wan Y, Anderson DG, Shen FH, Leo BM, Laurencin CT, Balian G, Li X..: Mouse growth and differentiation factor-5 protein and DNA therapy potentiates intervertebral disc cell aggregation and chondrogenic gene expression. Spine J. 2008;8(2):287-95.
4. 2007 VOS Best Paper Award: Ma SY, Choi L, Li X, Mohammad K, McKenna R, Guise T, Shen FH. A novel isolated spinal metastases model using human breast cancer cells (MDA-MB-231). 60th Annual Meeting of the Virginia Orthopaedic Society. May 4 – 6, 2007. Charlottesville, VA.
5. 2006 Best Paper – Basic Science Award: Shen FH, Zeng Q, Lv Q, et al. : Osteogenic differentiation of adipose-derived stromal cells treated with GDF-5 cultured on a novel three-dimensional sintered microsphere matrix. Spine J. 2006;6:615-23. Epub 2006 Oct 10.