Rhinology Research

Current Projects

  • Mechanisms of Alcohol Sensitivity in Aspirin Exacerbated Respiratory Disease (AERD). A large percentage of patients with AERD, a severe upper and lower respiratory disease, report worsening symptoms after exposure to certain alcoholic beverages.  Our lab is currently evaluating mechanisms of this reaction.  We are pursuing both in vitro (lab) and in vivo (clinical patient) arms.  Our lab work involves exposing patient’s blood to a variety of chemical compounds to better understand the physiologic changes.  Additionally we are nearing completion of a protocol to evaluate real time changes in blood and urine products after patient exposure to red wine and components of red wine extract.

 

  • Oral Ifetroban to Treat Aspirin Exacerbated Respiratory Disease (AERD). Studies have indicated that platelets may play a large role in the inflammatory changes seen in patients with AERD.  Ifetroban is a drug that blocks the activity of thromboxane, a compound produced by platelets.   UVA is participating in a multi-institutional Phase 2 trial studying the efficacy of this drug in treating symptoms of AERD.  https://www.clinicaltrials.gov/ct2/show/NCT03028350/

 

  • Clinical Response to Rhinovirus Challenge. Rhinovirus infections are one of the most common causes of asthma exacerbations in children and adolescents.  We theorize that RV exposure to the nasal cavity and nasopharynx helps to modulate the immune reaction in asthmatics and atopics.  This is an NIH funded study where normal controls, atopics, and asthmatics will be inoculated with RV and their nasal responses will be evaluated and compared. https://www.clinicaltrials.gov/ct2/show/NCT02910401

 

  • Olfactory Outcomes in Chronic Rhinosinusitis: Changes in olfaction have a significant impact on patients with CRS, leading to decreased quality of life, enjoyment of food and drink, and decreased economic productivity. UVA is participating in a multi-institutional, prospective study evaluating smell in patients with CRS, as well as the impact of medical and surgical therapy on olfaction.

 

  • Quality Improvement in Chronic Rhinosinusitis: Quality improvement in CRS is garnering increasing attention. CRS is one of the most common of chronic diseases, and the management of CRS is known to have wide variability between geographic regions and providers. However, robust QI programs are rare nationwide. In conjunction with the American Rhinologic Society QI committee, the UVA Rhinology division is striving to understand the barriers to effective QI in CRS and to implement feasible solutions that promote high quality of care for all CRS patients.

 

  • Patient Reported Outcomes Measures in Chronic Sinusitis. We are continually evaluating the efficacy of a variety of medical and surgical treatments for chronic sinusitis.   Our data is routinely evaluated to determine the best possible options for our patients.

Grants

  • Spencer C. Payne, MD
    • 1U01AI123337 – Clinical Response To Rhinovirus Challenge In Human Asthmatics- Sub-Investigator
  • Jose L. Mattos, MD, MPH
    • American Academy of Otolaryngic Allergy Foundation Grant. “Impact of Eosinophilic Inflammation on Olfaction” – Principal Investigator
    • Engineering in Medicine Seed Grant. “Designing Compliant, Elastic Sensors for Spatial Mapping of Odor-Evoked Response Potentials at Human Olfactory Epithelium”. Co-Principal Investigator

Publications