Shyam Raghavan, M.D.

Syam Raghavan, M.D.
Assistant Professor of Pathology


Medical School: Stanford University School of Medicine, 2012
Residency:University of California San Francisco, Plastic and Reconstructive Surgery, 2012-2016
Stanford University School of Medicine, Anatomic Pathology, 2016-2019
Fellowships: Stanford University School of Medicine, Gastrointestinal Pathology, 2018-2019
Stanford University School of Medicine, Dermatopathology, 2019-2020


Dermatopathology; General surgical pathology with specialization in gastrointestinal pathology and soft tissue pathology


I have a particular interest in studying the molecular drivers of melanocytic neoplasia, but am also involved in the study of both soft tissue tumors as well as mesenchymal tumors of the gastrointestinal tract.


  1. Nguyen DN, Raghavan SS, Tashima LM, et al. Enhancement of poly(orthoester) microspheres for DNA vaccine delivery by blending with poly(ethylenimine). Biomaterials. 2008;29(18):2783-2793. doi:10.1016/j.biomaterials.2008.03.011
  2. Song TK, Harris EJ, Raghavan SS, Norton JA. Major blood vessel reconstruction during sarcoma surgery. Arch Surg. 2009;144(9):817-822. doi:10.1001/archsurg.2009.149
  3. Lee JT, Qiu M, Teshome M, Raghavan SS, Tedesco MM, Dalman RL. The Utility of Endovascular Simulation to Improve Technical Performance and Stimulate Continued Interest of Preclinical Medical Students in Vascular Surgery. Journal of Surgical Education. 2009;66(6):367-373. doi:10.1016/j.jsurg.2009.06.002
  4. Woon CYL, Kraus A, Raghavan SS, et al. Three-Dimensional-Construct Bioreactor Conditioning in Human Tendon Tissue Engineering. Tissue Engineering Part A. 2011;17(19-20):2561-2572. doi:10.1089/ten.tea.2010.0701
  5. Raghavan SS, Woon CYL, Kraus A, Megerle K, Pham H, Chang J. Optimization of human tendon tissue engineering: synergistic effects of growth factors for use in tendon scaffold repopulation. Plast Reconstr Surg. 2012;129(2):479-489. doi:10.1097/PRS.0b013e31823aeb94
  6. Raghavan SS, Woon CYL, Kraus A, et al. Human Flexor Tendon Tissue Engineering: Decellularization of Human Flexor Tendons Reduces Immunogenicity In Vivo. Tissue Engineering Part A. 2012;18(7-8):796-805. doi:10.1089/ten.tea.2011.0422
  7. Kraus A, Woon C, Raghavan SS, Megerle K, Pham H, Chang J. Co-Culture of Human Adipose-Derived Stem Cells with Tenocytes Increases Proliferation and Induces Differentiation into a Tenogenic Lineage: Plastic and Reconstructive Surgery. 2013;132(5):754e-766e. doi:10.1097/PRS.0b013e3182a48b46
  8. Raghavan SS, Peled AW, Hansen SL, Esserman LJ, Sbitany H. Approaches to microvascular breast reconstruction after total skin-sparing mastectomy: a comparison of techniques. Ann Plast Surg. 2015;74 Suppl 1:S46-51. doi:10.1097/SAP.0000000000000391
  9. Vaughn CJ, Raghavan SS, Hansen SL, Terry MJ. Obstacles to the Care of Patients With Multicomponent Volar Wrist Lacerations at a County Hospital: Annals of Plastic Surgery. 2016;76:S238-S240. doi:10.1097/SAP.0000000000000801
  10. Megerle K, Woon C, Kraus A, Raghavan SS, Pham H, Chang J. Flexor Tendon Sheath Engineering Using Decellularized Porcine Pericardium. Plastic and Reconstructive Surgery. 2016;138(4):630e-641e. doi:10.1097/prs.0000000000002459
  11. Raghavan SS, Kim J. Histopathologic approach to epidermotropic lymphocytic infiltrates. Seminars in Cutaneous Medicine and Surgery. 2018;37(1):56-60. doi:10.12788/j.sder.2018.003
  12. Raghavan SS, Hong EK, Kim YH, Kim J. Utility of CD30, Ki-67, and p53 in assisting with the diagnosis of mycosis fungoides with large cell transformation. Journal of Cutaneous Pathology. 2019;46(1):33-43. doi:10.1111/cup.13375
  13. Sceats LA, Sukerkar PA, Raghavan SS Esmaeili Shandiz A, Shelton A, Kin C. Fragility of Life: Recurrent Intestinal Perforation Due to Vascular Ehlers–Danlos Syndrome. Digestive Diseases and Sciences. Published online January 17, 2019. doi:10.1007/s10620-019-5467-3
  14. Renz M, Marjon N, Devereaux K, Raghavan SS, Folkins AK, Karam A. Immediate intraoperative sentinel lymph node analysis by frozen section is predictive of lymph node metastasis in endometrial cancer. J Robot Surg. Published online January 28, 2019. doi:10.1007/s11701-019-00928-z
  15. Hom J, Marwaha S, Postolova A, Raghavan SS et al. A Patient with Sjogren’s Syndrome and Subsequent Diagnosis of Inclusion Body Myositis and Light-Chain Amyloidosis. J Gen Intern Med. Published online March 18, 2019. doi:10.1007/s11606-019-04931-w
  16. Raghavan SS, Mooney KL, Folpe AL, Charville GW. OLIG2 is a marker of the fusion protein-driven neurodevelopmental transcriptional signature in alveolar rhabdomyosarcoma. Human Pathology. 2019;91:77-85. doi:10.1016/j.humpath.2019.07.003
  17. Raghavan SS, Peternel S, Mully TW, et al. Spitz melanoma is a distinct subset of spitzoid melanoma. Mod Pathol. Published online January 3, 2020. doi:10.1038/s41379-019-0445-z
  18. Alpert L, Al-Sabti R, Graham RP, Raghavan SS et al. Smooth muscle tumors of the gastrointestinal tract: an analysis of prognostic features in 407 cases. Mod Pathol. Published online February 12, 2020. doi:10.1038/s41379-020-0492-5
  19. Saleem A, Joshi R, Lei L, Raghavan SS et al. Novel IRF8 and PD-L1 molecular aberrations in systemic EBV-positive T-cell lymphoma of childhood. Human Pathology: Case Reports. 2020;19:200356. doi:10.1016/j.ehpc.2020.200356
  20. Raghavan SS, Clark M, Louie C, et al. Molecular profiling of a primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid. J Cutan Pathol. Published online May 1, 2020. doi:10.1111/cup.13733
  21. Raghavan SS, Saleem A, Wang JY, Rieger KE, Brown RA, Novoa RA. Diagnostic Utility of LEF1 Immunohistochemistry in Differentiating Deep Penetrating Nevi From Histologic Mimics. American Journal of Surgical Pathology. 2020;Publish Ahead of Print. doi:10.1097/PAS.0000000000001513
  22. Raghavan SS, Wang JY, Toland A, et al. Diffuse PRAME expression is highly specific for malignant melanoma in the distinction from clear cell sarcoma. J Cutan Pathol. Published online July 18, 2020. doi:10.1111/cup.13812