{"id":189,"date":"2015-11-13T12:20:12","date_gmt":"2015-11-13T17:20:12","guid":{"rendered":"https:\/\/med.virginia.edu\/pathology\/?page_id=189"},"modified":"2026-04-13T12:13:52","modified_gmt":"2026-04-13T16:13:52","slug":"james-d-gorham-m-d-ph-d","status":"publish","type":"page","link":"https:\/\/med.virginia.edu\/pathology\/contact\/james-d-gorham-m-d-ph-d\/","title":{"rendered":"James D. Gorham, M.D., Ph.D."},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"Portrait alignnone wp-image-887 size-medium\" src=\"https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2015\/11\/GorhamJim-225x300.jpg\" alt=\"James D. Gorham, M.D., Ph.D.\" width=\"225\" height=\"300\" srcset=\"https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2015\/11\/GorhamJim-225x300.jpg 225w, https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2015\/11\/GorhamJim-e1528208397192-113x150.jpg 113w, https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2015\/11\/GorhamJim-768x1024.jpg 768w\" sizes=\"(max-width: 225px) 100vw, 225px\" \/><br \/>\nProfessor of Pathology<br \/>\nMedical Director, Transfusion Medicine Service<\/p>\n<h4 class=\"fontsize14\">EDUCATION:<\/h4>\n<p><strong>Medical School:<\/strong>\u00a0New York University, 1985 &#8211; 1992, MD PhD<br \/>\n<strong>Residency:<\/strong>\u00a0Laboratory Medicine, Washington University School of Medicine \/ Barnes Hospital, 1992-1998<\/p>\n<h4 class=\"fontsize14\">CLINICAL:<\/h4>\n<p>Blood Banking and Transfusion Medicine<br \/>\nLaboratory Medicine<\/p>\n<h4 class=\"fontsize14\">RESEARCH:<\/h4>\n<p><span class=\"A1\">Factors affecting blood storage; Immune tolerance and autoimmunity; Immunology of the liver; Mouse genetics.<\/span><\/p>\n<h4 class=\"fontsize14\">SELECTED REFERENCES:<\/h4>\n<ul>\n<li>Martin I, Katus MC, Martin C-L B, Szczepiorkowski ZM, <strong>Gorham JD<\/strong>, Dunbar NM. Rapid ADAMTS13 availability impacts treatment for microangiopathic hemolytic anemia and thrombocytopenia. <strong><em>J of Clin Apheresis<\/em><\/strong> <em>In Press<\/em>.<strong>2015<\/strong><\/li>\n<li>Krishnaswamy JK, Singh A, Uthaman G, Wu R, Gorrepati P, Sales-Nacimento M, Gallman A, Liu D, Calabro S, Xu L, Raney P, Srivastava A, <strong>Gorham JD<\/strong>, Kleeberger S, Heinz LX, M\u00fcller AC, Bennett KL, Superti-Furga G, Cassel S, Sutterwala FS, Williams A, Flavell RA, Eisenbarth S. Coincidental loss of Dock8 function in Nlrp10-deficient and C3H\/HeJ mice results in defective dendritic cell migration. <strong><em>Proc Natl Acad Sci (USA)<\/em><\/strong>.112:3056-61. <strong>2015<\/strong><\/li>\n<li>Celaj S, Gleeson MW, Deng J, O\u2019Toole G, Hampton TH, Toft MF, Morrison HG, Sogin ML, Putra J, Suriawinata AA,<strong>Gorham JD<\/strong>. The microbiota regulates susceptibility to Fas-mediated acute hepatic injury. <strong><em>Lab Invest<\/em><\/strong> 94:938-49. <strong>2014<\/strong><\/li>\n<li>Maria A, English KA, <strong>Gorham JD<\/strong>. Appropriate development of the liver Treg compartment is modulated by the microbiota and requires TGF-\u03b2 and MyD88. <strong><em>J Immunol Res<\/em><\/strong> 2014:279736. <strong>2014<\/strong><\/li>\n<li>Cripps JG, Wang J, Maria A, Blumenthal I, <strong>Gorham JD<\/strong>: Th1 cells induce the accumulation of myeloid derived suppressor cells in the inflamed <em>Tgfb1<\/em> knockout mouse liver. <strong><em>Hepatology<\/em><\/strong> 52:1350-1359. <strong>2010<\/strong><\/li>\n<li>Cripps JG, Celaj S, Burdick M, Strieter RM, <strong>Gorham JD<\/strong>: Liver inflammation in a mouse model of Th1 hepatitis despite the absence of invariant NKT cells or the Th1 chemokine receptors CXCR3 and CCR5. <strong><em>Lab Invest<\/em><\/strong>92:1461-1471. <strong>2012<\/strong><\/li>\n<li><strong>Gorham JD<\/strong>, Ranson MS, Smith JC, Gorham BJ, Muirhead K-A: 1 + 1 = 3: Development and Validation of a SNP-Based Algorithm to Identify Genetic Contributions from Three Distinct Inbred Mouse Strains. <strong><em>J Biomolec Techniques<\/em><\/strong> 23:136-146. <strong>2012<\/strong><\/li>\n<li>Cripps JG and <strong>Gorham JD<\/strong>: MDSC in autoimmunity. <strong><em>Internat Immunopharm<\/em><\/strong> 11: 789-793 [Invited review].<strong>2011<\/strong><\/li>\n<li>\u00a0Manns MP, Czaja AJ, <strong>Gorham JD<\/strong>, Krawitt EL, Mieli-Vergani G, Vergani D, Vierling JM: Practice Guidelines: diagnosis and management of autoimmune hepatitis. <strong><em>Hepatology<\/em><\/strong>; 51:2193-2213 [American Association for the Study of Liver Disease Practice Guidelines]. <strong>2010<\/strong><\/li>\n<\/ul>\n<h4>BOOK CHAPTERS<\/h4>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0 <strong>Gorham JD<\/strong>: \u201cAdaptive immunity in the liver\u201d in <em>Liver Immunology: Principles and Practice<\/em> ME Gershwin, JM Vierling, and MP Manns, ed. (2007), Humana Press, Totowa, NJ, USA<\/p>\n<p>A current list of Dr. Gorham&#8217;s journal publications can be obtained from\u00a0 <a class=\"external-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Gorham%2C+James+D%5BFull+Author+Name%5D\">PubMed.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Professor of Pathology Medical Director, Transfusion Medicine Service EDUCATION: Medical School:\u00a0New York University, 1985 &#8211; 1992, MD PhD Residency:\u00a0Laboratory Medicine, Washington University School of Medicine \/ Barnes Hospital, 1992-1998 CLINICAL: Blood Banking and Transfusion Medicine Laboratory Medicine RESEARCH: Factors affecting blood storage; Immune tolerance and autoimmunity; Immunology of the liver; Mouse genetics. SELECTED REFERENCES: Martin [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":14,"menu_order":15,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-189","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>James D. Gorham, M.D., Ph.D. - Department of Pathology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/pathology\/contact\/james-d-gorham-m-d-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"James D. 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